{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:58:40Z","timestamp":1791644320437,"version":"4.3.4"},"reference-count":123,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBA(UBACyT 2018-2021), ANPCyT-PICT2019"],"award-info":[{"award-number":["UBA(UBACyT 2018-2021), ANPCyT-PICT2019"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CEMIC Universitary Institute","award":["Norberto Quirno Foundation"],"award-info":[{"award-number":["Norberto Quirno Foundation"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Diabetic kidney disease (DKD) is a frequent, potentially devastating complication of diabetes mellitus. Several factors are involved in its pathophysiology. At a cellular level, diabetic kidney disease is associated with many structural and functional alterations. Autophagy is a cellular mechanism that transports intracytoplasmic components to lysosomes to preserve cellular function and homeostasis. Autophagy integrity is essential for cell homeostasis, its alteration can drive to cell damage or death. Diabetic kidney disease is associated with profound autophagy dysregulation. Autophagy rate and flux alterations were described in several models of diabetic kidney disease. Some of them are closely linked with disease progression and severity. Some antidiabetic agents have shown significant effects on autophagy. A few of them have also demonstrated to modify disease progression and improved outcomes in affected patients. Other drugs also target autophagy and are being explored for clinical use in patients with diabetic kidney disease. The modulation of autophagy could be relevant for the pharmacological treatment and prevention of this disease in the future. Therefore, this is an evolving area that requires further experimental and clinical research. Here we discuss the relationship between autophagy and Diabetic kidney disease and the potential value of autophagy modulation as a target for pharmacological intervention.<\/jats:p>","DOI":"10.3390\/cells10092497","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T08:04:23Z","timestamp":1632211463000},"page":"2497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Autophagy Dysregulation in Diabetic Kidney Disease: From Pathophysiology to Pharmacological Interventions"],"prefix":"10.3390","volume":"10","author":[{"given":"Claudio D.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Instituto de Bioquimica y Medicina Molecular Prof. Alberto Boveris (UBA-CONICET), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires C1113 AAD, Argentina"},{"name":"Instituto Universitario del Centro de Educacion Medica e Investigacion Clinica (IUC-CEMIC-CONICET), Facultad de Medicina, Instituto Universitario CEMIC, Buenos Aires C1430 EFA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Paula","family":"Carro Negueruela","sequence":"additional","affiliation":[{"name":"Instituto Universitario del Centro de Educacion Medica e Investigacion Clinica (IUC-CEMIC-CONICET), Facultad de Medicina, Instituto Universitario CEMIC, Buenos Aires C1430 EFA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Nicora Santamarina","sequence":"additional","affiliation":[{"name":"Instituto Universitario del Centro de Educacion Medica e Investigacion Clinica (IUC-CEMIC-CONICET), Facultad de Medicina, Instituto Universitario CEMIC, Buenos Aires C1430 EFA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Resnik","sequence":"additional","affiliation":[{"name":"Instituto de Bioquimica y Medicina Molecular Prof. Alberto Boveris (UBA-CONICET), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires C1113 AAD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2456-747X","authenticated-orcid":false,"given":"Maria I.","family":"Vaccaro","sequence":"additional","affiliation":[{"name":"Instituto de Bioquimica y Medicina Molecular Prof. Alberto Boveris (UBA-CONICET), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires C1113 AAD, Argentina"},{"name":"Instituto Universitario del Centro de Educacion Medica e Investigacion Clinica (IUC-CEMIC-CONICET), Facultad de Medicina, Instituto Universitario CEMIC, Buenos Aires C1430 EFA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4161\/auto.7.1.13044","article-title":"The emerging role of autophagy in the pathophysiology of diabetes mellitus","volume":"7","author":"Lee","year":"2011","journal-title":"Autophagy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. 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