{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:36:35Z","timestamp":1787027795837,"version":"build-2736575974"},"reference-count":241,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["1049959"],"award-info":[{"award-number":["1049959"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Despite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemorrhagic stroke, but approaches are still in their infancy. In this review, we discuss the regenerative phenomena occurring in animal models and human ICH, provide results related to cellular and molecular mechanisms of the repair process including by microglia, and review potential methods to promote tissue regeneration in ICH. We aim to stimulate research involving tissue restoration after ICH.<\/jats:p>","DOI":"10.3390\/cells10102513","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T09:59:15Z","timestamp":1632391155000},"page":"2513","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8184-8147","authenticated-orcid":false,"given":"Ruiyi","family":"Zhang","sequence":"first","affiliation":[{"name":"The Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, AB T3A 4X9, Canada"},{"name":"The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhou","family":"Xue","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2600-3563","authenticated-orcid":false,"given":"Voon Wee","family":"Yong","sequence":"additional","affiliation":[{"name":"The Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, AB T3A 4X9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0140-6736(18)31878-6","article-title":"Intracerebral haemorrhage: Current approaches to acute management","volume":"392","author":"Cordonnier","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1474-4422(09)70340-0","article-title":"Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: A systematic review and meta-analysis","volume":"9","author":"Luitse","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5853\/jos.2016.00024","article-title":"Intracerebral Hemorrhage: Large Disease Burden but Less Therapeutic Progress","volume":"19","author":"Kang","year":"2017","journal-title":"J. Stroke"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5853\/jos.2016.00864","article-title":"Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update","volume":"19","author":"An","year":"2017","journal-title":"J. Stroke"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.wneu.2018.04.181","article-title":"Minimally Invasive Surgery is Superior to Conventional Craniotomy in Patients with Spontaneous Supratentorial Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis","volume":"115","author":"Xia","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1161\/STROKEAHA.118.020688","article-title":"Minimally Invasive Surgery for Intracerebral Hemorrhage","volume":"49","author":"Scaggiante","year":"2018","journal-title":"Stroke"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0140-6736(19)30195-3","article-title":"Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): A randomised, controlled, open-label, blinded endpoint phase 3 trial","volume":"393","author":"Hanley","year":"2019","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S1474-4422(20)30364-1","article-title":"Neuroinflammation in intracerebral haemorrhage: Immunotherapies with potential for translation","volume":"19","author":"Xue","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.tins.2014.08.008","article-title":"Axon plasticity in the mammalian central nervous system after injury","volume":"37","author":"Chen","year":"2014","journal-title":"Trends Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1089\/089771503322686085","article-title":"Plasticity following injury to the adult central nervous system: Is recapitulation of a developmental state worth promoting?","volume":"20","author":"Emery","year":"2003","journal-title":"J. Neurotrauma"},{"key":"ref_11","first-page":"9","article-title":"Adult neurogenesis and neuroplasticity","volume":"24","author":"Taupin","year":"2006","journal-title":"Restor. Neurol. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/nrneurol.2017.139","article-title":"Achievements and obstacles of remyelinating therapies in multiple sclerosis","volume":"13","author":"Stangel","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/glia.22432","article-title":"Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men","volume":"61","author":"Behrendt","year":"2013","journal-title":"Glia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41593-020-0588-8","article-title":"Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory","volume":"23","author":"Wang","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8116","DOI":"10.3390\/ijms21218116","article-title":"Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A Review","volume":"21","author":"Uyeda","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"dev176974","DOI":"10.1242\/dev.176974","article-title":"Repair, regenerate and reconstruct: Meeting the state-of-the-art","volume":"146","author":"Reuter","year":"2019","journal-title":"Development"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.neuro.28.051804.101459","article-title":"Adult neurogenesis in the mammalian central nervous system","volume":"28","author":"Ming","year":"2005","journal-title":"Annu Rev. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/S0140-6736(09)60371-8","article-title":"Intracerebral haemorrhage","volume":"373","author":"Qureshi","year":"2009","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1055\/s-0036-1582132","article-title":"Stages of the Inflammatory Response in Pathology and Tissue Repair after Intracerebral Hemorrhage","volume":"36","author":"Askenase","year":"2016","journal-title":"Semin. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neulet.2007.08.039","article-title":"Increase in neurogenesis and neuroblast migration after a small intracerebral hemorrhage in rats","volume":"425","author":"Masuda","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuroscience.2011.12.008","article-title":"The increased expression of metabotropic glutamate receptor 5 in subventricular zone neural progenitor cells and enhanced neurogenesis in a rat model of intracerebral hemorrhage","volume":"202","author":"Xu","year":"2012","journal-title":"Neuroscience"},{"key":"ref_22","first-page":"303","article-title":"Endogenous neurogenesis after intracerebral hemorrhage","volume":"27","author":"Otero","year":"2012","journal-title":"Histol. Histopathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1179\/016164103771953934","article-title":"Temporal changes of neurogenesis in the mouse hippocampus after experimental subarachnoid hemorrhage","volume":"25","author":"Mino","year":"2003","journal-title":"Neurol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1080\/14737175.2019.1623671","article-title":"Intracerebral hemorrhage: An update on diagnosis and treatment","volume":"19","author":"Hostettler","year":"2019","journal-title":"Expert Rev. Neurother."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJM200105103441907","article-title":"Spontaneous intracerebral hemorrhage","volume":"344","author":"Qureshi","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0140-6736(13)61953-4","article-title":"Global and regional burden of stroke during 1990\u20132010: Findings from the Global Burden of Disease Study 2010","volume":"383","author":"Feigin","year":"2014","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1631\/jzus.B1200332","article-title":"Epidemiological and clinical characteristics of 266 cases of intracerebral hemorrhage in Hangzhou, China","volume":"14","author":"Hu","year":"2013","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.expneurol.2008.08.010","article-title":"White matter injury in young and aged rats after intracerebral hemorrhage","volume":"214","author":"Wasserman","year":"2008","journal-title":"Exp. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3174\/ajnr.A6038","article-title":"Predicting Motor Outcome in Acute Intracerebral Hemorrhage","volume":"40","author":"Puig","year":"2019","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrd.2017.115","article-title":"Remyelination therapies: A new direction and challenge in multiple sclerosis","volume":"16","author":"Plemel","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12975-015-0445-3","article-title":"After Intracerebral Hemorrhage, Oligodendrocyte Precursors Proliferate and Differentiate Inside White-Matter Tracts in the Rat Striatum","volume":"7","author":"Joseph","year":"2016","journal-title":"Transl. Stroke Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2045-8118-11-18","article-title":"Vascular disruption and blood-brain barrier dysfunction in intracerebral hemorrhage","volume":"11","author":"Keep","year":"2014","journal-title":"Fluids Barriers CNS"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-3-211-09469-3_15","article-title":"Blood-brain barrier function in intracerebral hemorrhage","volume":"105","author":"Keep","year":"2008","journal-title":"Acta Neurochir. Suppl."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.brainres.2007.08.028","article-title":"Cerebral angiogenesis after collagenase-induced intracerebral hemorrhage in rats","volume":"1175","author":"Tang","year":"2007","journal-title":"Brain Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/jcbfm.2008.37","article-title":"Neurogenesis after primary intracerebral hemorrhage in adult human brain","volume":"28","author":"Shen","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"293","DOI":"10.5114\/fn.2018.80862","article-title":"Neurogenesis in adult human brain after hemorrhage and ischemic stroke","volume":"56","author":"Stepien","year":"2018","journal-title":"Folia Neuropathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/jnr.21303","article-title":"Activation of endogenous neural stem cells in the adult human brain following subarachnoid hemorrhage","volume":"85","author":"Sgubin","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/brain\/awz393","article-title":"Microglia and macrophage phenotypes in intracerebral haemorrhage injury: Therapeutic opportunities","volume":"143","author":"Bai","year":"2020","journal-title":"Brain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5853\/jos.2019.02236","article-title":"Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets","volume":"22","author":"Tschoe","year":"2020","journal-title":"J. Stroke"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/01.WCB.0000037880.62590.28","article-title":"Inflammation and infection in clinical stroke","volume":"22","author":"Emsley","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/acn3.50842","article-title":"Rapid neuroinflammatory changes in human acute intracerebral hemorrhage","volume":"6","author":"Shtaya","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/brain\/awm095","article-title":"Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage","volume":"130","author":"Wang","year":"2007","journal-title":"Brain"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0304-3940(00)00971-X","article-title":"Intracerebral injection of autologous whole blood in rats: Time course of inflammation and cell death","volume":"283","author":"Xue","year":"2000","journal-title":"Neurosci. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jneuroim.2005.04.016","article-title":"Immune pre-activation exacerbates hemorrhagic brain injury in immature mouse brain","volume":"165","author":"Xue","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12974-018-1140-6","article-title":"Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK\/JNK\/p38 MAPK pathway after intracerebral hemorrhage in mice","volume":"15","author":"Chen","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s10072-014-1657-0","article-title":"NF-kappaB activation and cell death after intracerebral hemorrhage in patients","volume":"35","author":"Zhang","year":"2014","journal-title":"Neurol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1177\/0271678X16666551","article-title":"Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage","volume":"37","author":"Li","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41423-019-0223-3","article-title":"The benefits of neuroinflammation for the repair of the injured central nervous system","volume":"16","author":"Yong","year":"2019","journal-title":"Cell Mol. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41582-019-0184-2","article-title":"The pro-remyelination properties of microglia in the central nervous system","volume":"15","author":"Lloyd","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fnins.2016.00061","article-title":"Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia\/Macrophage","volume":"10","author":"Yang","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.nbd.2017.03.016","article-title":"Alternative activation-skewed microglia\/macrophages promote hematoma resolution in experimental intracerebral hemorrhage","volume":"103","author":"Chang","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/jnc.12974","article-title":"Cleaning up after ICH: The role of Nrf2 in modulating microglia function and hematoma clearance","volume":"133","author":"Zhao","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fimmu.2017.00112","article-title":"Inflammatory Regulation by Driving Microglial M2 Polarization: Neuroprotective Effects of Cannabinoid Receptor-2 Activation in Intracerebral Hemorrhage","volume":"8","author":"Lin","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13041-016-0225-3","article-title":"Alternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage","volume":"9","author":"Min","year":"2016","journal-title":"Mol. Brain"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.intimp.2019.04.029","article-title":"Inhibition of fibrin formation reduces neuroinflammation and improves long-term outcome after intracerebral hemorrhage","volume":"72","author":"Li","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1161\/STROKEAHA.118.024578","article-title":"Enhancement of Hematoma Clearance With CD47 Blocking Antibody in Experimental Intracerebral Hemorrhage","volume":"50","author":"Jing","year":"2019","journal-title":"Stroke"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1007\/s12035-016-9785-6","article-title":"Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage","volume":"54","author":"Zhang","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1177\/0271678X20923551","article-title":"Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update","volume":"40","author":"Ren","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/1673-5374.224372","article-title":"Astrocytes in the cerebral cortex play a role in the spontaneous motor recovery following experimental striatal hemorrhage","volume":"13","author":"Neves","year":"2018","journal-title":"Neural. Regen. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive gliosis and the multicellular response to CNS damage and disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/0-387-30128-3_11","article-title":"The collagenous wound healing scar in the injured central nervous system inhibits axonal regeneration","volume":"557","author":"Hermanns","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/glia.22723","article-title":"Beneficial effects of gfap\/vimentin reactive astrocytes for axonal remodeling and motor behavioral recovery in mice after stroke","volume":"62","author":"Liu","year":"2014","journal-title":"Glia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/jcbfm.2009.257","article-title":"Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice","volume":"30","author":"Hayakawa","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1469-7580.2010.01330.x","article-title":"Astrocyte phenotypes and their relationship to myelination","volume":"219","author":"Nash","year":"2011","journal-title":"J. Anat."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"dev182279","DOI":"10.1242\/dev.182279","article-title":"Neuronal and glial regulation of CNS angiogenesis and barriergenesis","volume":"147","author":"Biswas","year":"2020","journal-title":"Development"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Nutma, E., van Gent, D., Amor, S., and Peferoen, L.A.N. (2020). Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System. Cells, 9.","DOI":"10.3390\/cells9030600"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1052-3057(99)80032-9","article-title":"Early cellular events in the penumbra of human spontaneous intracerebral hemorrhage","volume":"8","author":"Mackenzie","year":"1999","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1161\/STROKEAHA.117.018120","article-title":"Neutrophil-Lymphocyte Ratio and Perihematomal Edema Growth in Intracerebral Hemorrhage","volume":"48","author":"Gusdon","year":"2017","journal-title":"Stroke"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1161\/STROKEAHA.116.013627","article-title":"Neutrophil-to-Lymphocyte Ratio Predicts the Outcome of Acute Intracerebral Hemorrhage","volume":"47","author":"Lattanzi","year":"2016","journal-title":"Stroke"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/s41467-017-00770-7","article-title":"Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage","volume":"8","author":"Zhao","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jneuroim.2018.07.003","article-title":"Neuroinflammatory responses in experimental and human stroke lesions","volume":"323","author":"Wimmer","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e16211","DOI":"10.1097\/MD.0000000000016211","article-title":"Neutrophil-lymphocyte ratio predicts the outcome of intracerebral hemorrhage: A meta-analysis","volume":"98","author":"Liu","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1177\/0271678X16648712","article-title":"Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia\/macrophage polarization through the IL-10\/GSK3beta\/PTEN axis","volume":"37","author":"Zhou","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.intimp.2014.06.037","article-title":"Regulatory T cells inhibit microglia activation and protect against inflammatory injury in intracerebral hemorrhage","volume":"22","author":"Yang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1474-4422(05)70283-0","article-title":"Mechanisms of brain injury after intracerebral haemorrhage","volume":"5","author":"Xi","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3171\/jns.1996.84.1.0091","article-title":"Edema from intracerebral hemorrhage: The role of thrombin","volume":"84","author":"Lee","year":"1996","journal-title":"J. Neurosurg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1161\/STROKEAHA.107.508911","article-title":"Effects of thrombin on neurogenesis after intracerebral hemorrhage","volume":"39","author":"Yang","year":"2008","journal-title":"Stroke"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3171\/2012.8.JNS112152","article-title":"Thrombin-triggered angiogenesis in rat brains following experimental intracerebral hemorrhage","volume":"117","author":"Zhou","year":"2012","journal-title":"J. Neurosurg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1161\/STROKEAHA.108.533281","article-title":"Thrombin and brain recovery after intracerebral hemorrhage","volume":"40","author":"Hua","year":"2009","journal-title":"Stroke"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1538-7836.2006.01788.x","article-title":"Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells","volume":"4","author":"Tarzami","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1055\/s-2007-991535","article-title":"Inhibition of angiogenesis by small-molecule antagonists of protease-activated receptor-1","volume":"33","author":"Tsopanoglou","year":"2007","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2018.12.003","article-title":"Thrombin promotes pericyte coverage by Tie2 activation in a rat model of intracerebral hemorrhage","volume":"1708","author":"Hu","year":"2019","journal-title":"Brain Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1471-4159.2003.01268.x","article-title":"The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: Deleterious or protective?","volume":"84","author":"Xi","year":"2003","journal-title":"J. Neurochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/ana.10553","article-title":"Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases","volume":"53","author":"Power","year":"2003","journal-title":"Ann. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35081571","article-title":"Metalloproteinases in biology and pathology of the nervous system","volume":"2","author":"Yong","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.brainres.2010.02.054","article-title":"Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions","volume":"1326","author":"Lischper","year":"2010","journal-title":"Brain Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1179\/174313208X341102","article-title":"Matrix metalloproteinases in intracerebral hemorrhage","volume":"30","author":"Xue","year":"2008","journal-title":"Neurol. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1161\/STROKEAHA.110.596718","article-title":"Molecular pathophysiology of cerebral hemorrhage: Secondary brain injury","volume":"42","author":"Aronowski","year":"2011","journal-title":"Stroke"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"10281","DOI":"10.1523\/JNEUROSCI.2806-06.2006","article-title":"Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice","volume":"26","author":"Xue","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000341686","article-title":"Matrix metalloproteinases in human spontaneous intracerebral hemorrhage: An update","volume":"34","author":"Montaner","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/STROKEAHA.112.673590","article-title":"Association of molecular markers with perihematomal edema and clinical outcome in intracerebral hemorrhage","volume":"44","author":"Li","year":"2013","journal-title":"Stroke"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/brain\/awh489","article-title":"Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage","volume":"128","author":"Wang","year":"2005","journal-title":"Brain"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neuroscience.2012.11.008","article-title":"Activation of cerebral recovery by matrix metalloproteinase-9 after intracerebral hemorrhage","volume":"230","author":"Lei","year":"2013","journal-title":"Neuroscience"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.07.005","article-title":"Matrix metalloproteinase-9: Dual role and temporal profile in intracerebral hemorrhage","volume":"23","author":"Chang","year":"2014","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1161\/STROKEAHA.107.495820","article-title":"Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism","volume":"39","author":"Hayakawa","year":"2008","journal-title":"Stroke"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.neuropharm.2011.06.026","article-title":"HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats","volume":"61","author":"Ohnishi","year":"2011","journal-title":"Neuropharmacology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"508","DOI":"10.4049\/jimmunol.170.1.508","article-title":"Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: Effects of TLR \u201chomotolerance\u201d versus \u201cheterotolerance\u201d on NF-kappa B signaling pathway components","volume":"170","author":"Dobrovolskaia","year":"2003","journal-title":"J. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1189\/jlb.1206751","article-title":"Receptor for advanced glycation end products (RAGE) in a dash to the rescue: Inflammatory signals gone awry in the primal response to stress","volume":"82","author":"Herold","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroscience.2012.10.054","article-title":"Effects of high-mobility group box1 on cerebral angiogenesis and neurogenesis after intracerebral hemorrhage","volume":"229","author":"Lei","year":"2013","journal-title":"Neuroscience"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1161\/STROKEAHA.114.006825","article-title":"Activation of the high-mobility group box 1 protein-receptor for advanced glycation end-products signaling pathway in rats during neurogenesis after intracerebral hemorrhage","volume":"46","author":"Lei","year":"2015","journal-title":"Stroke"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2015.03.032","article-title":"HMGB1 may act via RAGE to promote angiogenesis in the later phase after intracerebral hemorrhage","volume":"295","author":"Lei","year":"2015","journal-title":"Neuroscience"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1080\/14728222.2019.1676416","article-title":"Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders","volume":"23","author":"Leitner","year":"2019","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1161\/STROKEAHA.113.001038","article-title":"Toll-like receptor 4 antagonist attenuates intracerebral hemorrhage-induced brain injury","volume":"44","author":"Wang","year":"2013","journal-title":"Stroke"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2015.11.045","article-title":"Brain recovery mediated by toll-like receptor 4 in rats after intracerebral hemorrhage","volume":"1632","author":"Lei","year":"2016","journal-title":"Brain Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3171\/jns.1998.88.6.1058","article-title":"Early metabolic alterations in edematous perihematomal brain regions following experimental intracerebral hemorrhage","volume":"88","author":"Wagner","year":"1998","journal-title":"J. Neurosurg."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1161\/01.STR.31.3.726","article-title":"Diffusion-weighted MRI and proton MR spectroscopic imaging in the study of secondary neuronal injury after intracerebral hemorrhage","volume":"31","author":"Carhuapoma","year":"2000","journal-title":"Stroke"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.3375817","article-title":"Lactate-supported synaptic function in the rat hippocampal slice preparation","volume":"240","author":"Schurr","year":"1988","journal-title":"Science"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/sj.jcbfm.9600174","article-title":"Lactate: The ultimate cerebral oxidative energy substrate?","volume":"26","author":"Schurr","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/jcbfm.2013.81","article-title":"Functional astrocyte-neuron lactate shuttle in a human stem cell-derived neuronal network","volume":"33","author":"Tarczyluk","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0183-1","article-title":"Lactate potentiates angiogenesis and neurogenesis in experimental intracerebral hemorrhage","volume":"50","author":"Zhou","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/75586","article-title":"A common polymorphism acts as an intragenic modifier of mutant p53 behaviour","volume":"25","author":"Marin","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1093","article-title":"The codon 72 polymorphic variants of p53 have markedly different apoptotic potential","volume":"33","author":"Dumont","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/sj.cdd.4401415","article-title":"The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death","volume":"11","author":"Bonafe","year":"2004","journal-title":"Cell Death Differ."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1038\/sj.onc.1209367","article-title":"Polymorphisms in the p53 pathway","volume":"25","author":"Pietsch","year":"2006","journal-title":"Oncogene"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/cdd.2016.109","article-title":"Neovascularization and functional recovery after intracerebral hemorrhage is conditioned by the Tp53 Arg72Pro single-nucleotide polymorphism","volume":"24","author":"Rodriguez","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4103\/1673-5374.205085","article-title":"Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage","volume":"12","author":"Campos","year":"2017","journal-title":"Neural. Regen. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"421821","DOI":"10.1155\/2013\/421821","article-title":"Role of STAT3 in cancer metastasis and translational advances","volume":"2013","author":"Kamran","year":"2013","journal-title":"Biomed. Res. Int"},{"key":"ref_119","first-page":"793","article-title":"Activation of signal transducer and activator of transcription 3 signaling attenuates neurogenesis in a rat model of intracerebral hemorrhage","volume":"30","author":"Haitao","year":"2018","journal-title":"Turk. Neurosurg."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.expneurol.2011.06.006","article-title":"Myelin associated inhibitors: A link between injury-induced and experience-dependent plasticity","volume":"235","author":"Akbik","year":"2012","journal-title":"Exp. Neurol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrn1956","article-title":"Glial inhibition of CNS axon regeneration","volume":"7","author":"Yiu","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s12031-019-01365-1","article-title":"Nogo-A\/Pir-B\/TrkB Signaling Pathway Activation Inhibits Neuronal Survival and Axonal Regeneration After Experimental Intracerebral Hemorrhage in Rats","volume":"69","author":"Liu","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: Cell fate control and signal integration in development","volume":"284","author":"Rand","year":"1999","journal-title":"Science"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/WNR.0000000000001614","article-title":"Intracerebral hemorrhage influences hippocampal neurogenesis and neurological function recovery via Notch1 signaling","volume":"32","author":"Chen","year":"2021","journal-title":"Neuroreport"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3389\/fphar.2019.01079","article-title":"Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage","volume":"10","author":"Shao","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1212\/WNL.0000000000008627","article-title":"Statins for neuroprotection in spontaneous intracerebral hemorrhage","volume":"93","author":"Chen","year":"2019","journal-title":"Neurology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association\/American Stroke Association","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1161\/STR.0000000000000046","article-title":"Guidelines for the primary prevention of stroke: A statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Meschia","year":"2014","journal-title":"Stroke"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1474-4422(09)70058-4","article-title":"Lipid management in the prevention of stroke: Review and updated meta-analysis of statins for stroke prevention","volume":"8","author":"Amarenco","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa061894","article-title":"High-dose atorvastatin after stroke or transient ischemic attack","volume":"355","author":"Amarenco","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1161\/STROKEAHA.112.655894","article-title":"Statin therapy and the risk of intracerebral hemorrhage: A meta-analysis of 31 randomized controlled trials","volume":"43","author":"McKinney","year":"2012","journal-title":"Stroke"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/jnnp-2018-318483","article-title":"Statins and the risk of intracerebral haemorrhage in patients with stroke: Systematic review and meta-analysis","volume":"90","author":"Ziff","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.eclinm.2019.02.007","article-title":"Statins and Risk of Intracerebral Haemorrhage in a Stroke-Free Population: A Nationwide Danish Propensity Score Matched Cohort Study","volume":"8","author":"Ribe","year":"2019","journal-title":"EClinicalMedicine"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-0028-1082064","article-title":"Use of statins for the treatment of spontaneous intracerebral hemorrhage: Results of a pilot study","volume":"70","year":"2009","journal-title":"Cent. Eur. Neurosurg."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1161\/STROKEAHA.108.544395","article-title":"Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage","volume":"40","author":"Karki","year":"2009","journal-title":"Stroke"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3171\/jns.2004.101.1.0104","article-title":"Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats","volume":"101","author":"Seyfried","year":"2004","journal-title":"J. Neurosurg."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4236\/wjns.2012.22011","article-title":"Statins Enhance Expression of Growth Factors and Activate the PI3K\/Akt-mediated Signaling Pathway after Experimental Intracerebral Hemorrhage","volume":"2","author":"Yang","year":"2012","journal-title":"World J. Neurosci"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3171\/2010.7.JNS10163","article-title":"Vascular recovery promoted by atorvastatin and simvastatin after experimental intracerebral hemorrhage: Magnetic resonance imaging and histological study","volume":"114","author":"Yang","year":"2011","journal-title":"J. Neurosurg."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.neuropharm.2017.10.021","article-title":"Simvastatin accelerates hematoma resolution after intracerebral hemorrhage in a PPARgamma-dependent manner","volume":"128","author":"Wang","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1179\/174313209X385680","article-title":"Minocycline reduces intracerebral hemorrhage-induced brain injury","volume":"31","author":"Wu","year":"2009","journal-title":"Neurol. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/cns.13220","article-title":"Minocycline reduces intracerebral hemorrhage-induced white matter injury in piglets","volume":"25","author":"Yang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1523\/JNEUROSCI.21-08-02580.2001","article-title":"Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia","volume":"21","author":"Tikka","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1038\/cddis.2013.54","article-title":"Minocycline selectively inhibits M1 polarization of microglia","volume":"4","author":"Kobayashi","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/STROKEAHA.115.012236","article-title":"Selective Sphingosine-1-Phosphate Receptor 1 Modulation Attenuates Experimental Intracerebral Hemorrhage","volume":"47","author":"Sun","year":"2016","journal-title":"Stroke"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1674-8301(11)60040-7","article-title":"Effects of minocycline on the expression of NGF and HSP70 and its neuroprotection role following intracerebral hemorrhage in rats","volume":"25","author":"Pu","year":"2011","journal-title":"J. Biomed. Res."},{"key":"ref_146","first-page":"595","article-title":"Effects of minocycline on apoptosis and angiogenesis-related protein expression in a rat model of intracerebral hemorrhage","volume":"7","author":"Wang","year":"2012","journal-title":"Neural. Regen. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1161\/STROKEAHA.117.018658","article-title":"Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial","volume":"48","author":"Fouda","year":"2017","journal-title":"Stroke"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/ene.13403","article-title":"Minocycline and matrix metalloproteinase inhibition in acute intracerebral hemorrhage: A pilot study","volume":"24","author":"Chang","year":"2017","journal-title":"Eur. J. Neurol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.neuropharm.2016.11.006","article-title":"Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases","volume":"113","author":"Dev","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jneuroim.2012.12.005","article-title":"Fingolimod phosphate promotes the neuroprotective effects of microglia","volume":"256","author":"Noda","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1161\/STROKEAHA.117.018505","article-title":"Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway","volume":"48","author":"Qin","year":"2017","journal-title":"Stroke"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2019.04.031","article-title":"FTY720 attenuates iron deposition and glial responses in improving delayed lesion and long-term outcomes of collagenase-induced intracerebral hemorrhage","volume":"1718","author":"Yang","year":"2019","journal-title":"Brain Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s12264-015-1532-2","article-title":"Fingolimod alters inflammatory mediators and vascular permeability in intracerebral hemorrhage","volume":"31","author":"Li","year":"2015","journal-title":"Neurosci. Bull."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.expneurol.2012.12.009","article-title":"Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage","volume":"241","author":"Rolland","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/08923973.2019.1566361","article-title":"Modulating acute neuroinflammation in intracerebral hemorrhage: The potential promise of currently approved medications for multiple sclerosis","volume":"41","author":"Napier","year":"2019","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/jamaneurol.2014.1065","article-title":"Fingolimod for the treatment of intracerebral hemorrhage: A 2-arm proof-of-concept study","volume":"71","author":"Fu","year":"2014","journal-title":"JAMA Neurol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1161\/STROKEAHA.119.027134","article-title":"Siponimod (BAF-312) Attenuates Perihemorrhagic Edema And Improves Survival in Experimental Intracerebral Hemorrhage","volume":"50","author":"Bobinger","year":"2019","journal-title":"Stroke"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3214350","DOI":"10.1155\/2020\/3214350","article-title":"A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH","volume":"2020","author":"Bobinger","year":"2020","journal-title":"Oxid Med. Cell Longev."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1399-5618.2006.00344.x","article-title":"Decreased risk of suicides and attempts during long-term lithium treatment: A meta-analytic review","volume":"8","author":"Baldessarini","year":"2006","journal-title":"Bipolar. Disord."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.brainresbull.2019.07.019","article-title":"Lithium chloride promoted hematoma resolution after intracerebral hemorrhage through GSK-3beta-mediated pathways-dependent microglia phagocytosis and M2-phenotype differentiation, angiogenesis and neurogenesis in a rat model","volume":"152","author":"Li","year":"2019","journal-title":"Brain Res. Bull."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.trsl.2019.12.006","article-title":"Lithium treatment mitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signaling in mice","volume":"217","author":"Li","year":"2020","journal-title":"Transl. Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/STROKEAHA.115.010920","article-title":"Role of Erythrocyte CD47 in Intracerebral Hematoma Clearance","volume":"47","author":"Ni","year":"2016","journal-title":"Stroke"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s12975-019-00745-4","article-title":"CD47 Blocking Antibody Accelerates Hematoma Clearance After Intracerebral Hemorrhage in Aged Rats","volume":"11","author":"Tao","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1089\/ten.tea.2014.0139","article-title":"Nerve regeneration and functional recovery by collagen-binding brain-derived neurotrophic factor in an intracerebral hemorrhage model","volume":"21","author":"Guan","year":"2015","journal-title":"Tissue Eng. Part A"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1016\/j.biomaterials.2011.01.039","article-title":"The promotion of neurological recovery in an intracerebral hemorrhage model using fibrin-binding brain derived neurotrophic factor","volume":"32","author":"Han","year":"2011","journal-title":"Biomaterials"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"117069","DOI":"10.1016\/j.jns.2020.117069","article-title":"Mouse nerve growth factor promotes neurological recovery in patients with acute intracerebral hemorrhage: A proof-of-concept study","volume":"418","author":"An","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.3727\/096368913X672154","article-title":"Multiple cell transplantation based on an intraparenchymal approach for patients with chronic phase stroke","volume":"22","author":"Chen","year":"2013","journal-title":"Cell Transplant."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.clineuro.2012.04.030","article-title":"Autologous bone marrow mononuclear cell implantation for intracerebral hemorrhage-a prospective clinical observation","volume":"115","author":"Li","year":"2013","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.3892\/etm.2016.3811","article-title":"Cell therapy for cerebral hemorrhage: Five year follow-up report","volume":"12","author":"Chang","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4252\/wjsc.v9.i8.133","article-title":"Phase I\/II randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke","volume":"9","author":"Tsang","year":"2017","journal-title":"World J. Stem. Cells"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"618","DOI":"10.4252\/wjsc.v7.i3.618","article-title":"Stem cell therapy in intracerebral hemorrhage rat model","volume":"7","author":"Cordeiro","year":"2015","journal-title":"World J. Stem. Cells"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neuint.2017.02.006","article-title":"Neural stem cell therapy for neurodegenerative disorders: The role of neurotrophic support","volume":"106","author":"Marsh","year":"2017","journal-title":"Neurochem. Int."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1177\/0963689718773363","article-title":"Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage","volume":"27","author":"Gao","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4103\/2319-4170.113226","article-title":"Stem cell-based therapy in neural repair","volume":"36","author":"Hsu","year":"2013","journal-title":"Biomed. J."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"298","DOI":"10.4103\/1673-5374.177739","article-title":"Human neural stem cells promote proliferation of endogenous neural stem cells and enhance angiogenesis in ischemic rat brain","volume":"11","author":"Ryu","year":"2016","journal-title":"Neural. Regen. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.expneurol.2013.03.009","article-title":"Neuro-immune interactions of neural stem cell transplants: From animal disease models to human trials","volume":"260","author":"Giusto","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"21860","DOI":"10.1002\/jcp.28750","article-title":"Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer\u2019s disease by upregulating IGF-2","volume":"234","author":"Wu","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1007\/s11033-020-05457-9","article-title":"Potential of stem cell therapy in intracerebral hemorrhage","volume":"47","author":"Huang","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.2174\/0929867325666180111101410","article-title":"Mesenchymal Stem Cell Therapy in Intracerebral Haemorrhagic Stroke","volume":"25","author":"Bedini","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3892\/mmr.2012.997","article-title":"Therapeutic effect of mesenchymal stem cells in rats with intracerebral hemorrhage: Reduced apoptosis and enhanced neuroprotection","volume":"6","author":"Wang","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10059-013-2306-9","article-title":"Transplantation of bone marrow stromal cells enhances nerve regeneration of the corticospinal tract and improves recovery of neurological functions in a collagenase-induced rat model of intracerebral hemorrhage","volume":"36","author":"Liang","year":"2013","journal-title":"Mol. Cells"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"133","DOI":"10.14348\/molcells.2017.2251","article-title":"Therapeutic Benefits of Mesenchymal Stromal Cells in a Rat Model of Hemoglobin-Induced Hypertensive Intracerebral Hemorrhage","volume":"40","author":"Ding","year":"2017","journal-title":"Mol. Cells"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000477122","article-title":"Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1\/2 and PI3K\/Akt Pathways in Intracerebral Hemorrhage","volume":"42","author":"Cui","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1161\/01.STR.0000236025.44089.e1","article-title":"Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats","volume":"37","author":"Kobayashi","year":"2006","journal-title":"Stroke"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nm850","article-title":"Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease","volume":"9","author":"Gill","year":"2003","journal-title":"Nat. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneuroim.2010.04.010","article-title":"Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity","volume":"225","author":"Xing","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.06.002","article-title":"Effects of GDNF-Transfected Marrow Stromal Cells on Rats with Intracerebral Hemorrhage","volume":"28","author":"Deng","year":"2019","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"104748","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104748","article-title":"Effect of MicroRNA-126a-3p on Bone Marrow Mesenchymal Stem Cells Repairing Blood-brain Barrier and Nerve Injury after Intracerebral Hemorrhage","volume":"29","author":"Wang","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1073\/pnas.0911647107","article-title":"Unique multipotent cells in adult human mesenchymal cell populations","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3390\/cells1041045","article-title":"Regenerative Effects of Mesenchymal Stem Cells: Contribution of Muse Cells, a Novel Pluripotent Stem Cell Type that Resides in Mesenchymal Cells","volume":"1","author":"Wakao","year":"2012","journal-title":"Cells"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.reth.2020.04.011","article-title":"Regenerative potential of pluripotent nontumorgenetic stem cells: Multilineage differentiating stress enduring cells (Muse cells)","volume":"15","author":"Cao","year":"2020","journal-title":"Regen. Ther."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00221-016-4818-y","article-title":"Neuro-regeneration therapy using human Muse cells is highly effective in a mouse intracerebral hemorrhage model","volume":"235","author":"Shimamura","year":"2017","journal-title":"Exp. Brain Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2018.12.042","article-title":"Intravenous administration of human adipose-derived stem cells ameliorates motor and cognitive function for intracerebral hemorrhage mouse model","volume":"1711","author":"Kuramoto","year":"2019","journal-title":"Brain Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/j.1755-5949.2012.00382.x","article-title":"Transplantation of adipose-derived stem cells is associated with neural differentiation and functional improvement in a rat model of intracerebral hemorrhage","volume":"18","author":"Chen","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"14372","DOI":"10.1002\/jcb.28693","article-title":"Adipose-derived mesenchymal stem cells stereotactic transplantation alleviate brain edema from intracerebral hemorrhage","volume":"120","author":"Zhang","year":"2019","journal-title":"J. Cell Biochem."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nn0706-859","article-title":"Fractalkine: Moving from chemotaxis to neuroprotection","volume":"9","author":"Re","year":"2006","journal-title":"Nat. Neurosci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"11792","DOI":"10.1523\/JNEUROSCI.3588-08.2008","article-title":"Chemokine action in the nervous system","volume":"28","author":"Miller","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"10896","DOI":"10.1073\/pnas.95.18.10896","article-title":"Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia","volume":"95","author":"Harrison","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3389\/fnins.2019.00462","article-title":"Overexpression of CX3CR1 in Adipose-Derived Stem Cells Promotes Cell Migration and Functional Recovery After Experimental Intracerebral Hemorrhage","volume":"13","author":"Li","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2012.01.024","article-title":"Therapeutic effect of human umbilical tissue-derived cell treatment in rats with experimental intracerebral hemorrhage","volume":"1444","author":"Yang","year":"2012","journal-title":"Brain Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1227\/01.NEU.0000371983.06278.B3","article-title":"Umbilical cord-derived mesenchymal stem cells with forced expression of hepatocyte growth factor enhance remyelination and functional recovery in a rat intracerebral hemorrhage model","volume":"67","author":"Liu","year":"2010","journal-title":"Neurosurgery"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1161\/01.STR.0000083698.20199.1F","article-title":"Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage","volume":"34","author":"Jeong","year":"2003","journal-title":"Stroke"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1634\/stemcells.2006-0409","article-title":"Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model","volume":"25","author":"Lee","year":"2007","journal-title":"Stem. Cells"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1111\/j.1582-4934.2011.01259.x","article-title":"Intracerebral transplantation of foetal neural stem cells improves brain dysfunction induced by intracerebral haemorrhage stroke in mice","volume":"15","author":"Wang","year":"2011","journal-title":"J. Cell Mol. Med."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Qin, J., Ma, X., Qi, H., Song, B., Wang, Y., Wen, X., Wang, Q.M., Sun, S., Li, Y., and Zhang, R. (2015). Transplantation of Induced Pluripotent Stem Cells Alleviates Cerebral Inflammation and Neural Damage in Hemorrhagic Stroke. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129881"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neulet.2013.05.007","article-title":"Transplantation of human neuro-epithelial-like stem cells derived from induced pluripotent stem cells improves neurological function in rats with experimental intracerebral hemorrhage","volume":"548","author":"Qin","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.stem.2020.09.014","article-title":"Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges","volume":"27","author":"Yamanaka","year":"2020","journal-title":"Cell Stem. Cell"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fcell.2020.00455","article-title":"Use of Stem Cell Extracellular Vesicles as a \u201cHolistic\u201d Approach to CNS Repair","volume":"8","author":"Branscome","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1007\/s12035-019-01663-0","article-title":"The Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in Treatment of Neurodegenerative Diseases","volume":"56","author":"Gorabi","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/0271678X17708917","article-title":"Exosomes promote restoration after an experimental animal model of intracerebral hemorrhage","volume":"38","author":"Lopez","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3171\/2018.2.JNS171475","article-title":"Multipotent mesenchymal stromal cell-derived exosomes improve functional recovery after experimental intracerebral hemorrhage in the rat","volume":"131","author":"Han","year":"2018","journal-title":"J. Neurosurg."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.2147\/DDDT.S255828","article-title":"Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization","volume":"14","author":"Duan","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12031-018-1041-2","article-title":"Role of Exosomes Derived from miR-133b Modified MSCs in an Experimental Rat Model of Intracerebral Hemorrhage","volume":"64","author":"Shen","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.copbio.2016.04.021","article-title":"Hydrogels for brain repair after stroke: An emerging treatment option","volume":"40","author":"Nih","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41563-018-0083-8","article-title":"Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke","volume":"17","author":"Nih","year":"2018","journal-title":"Nat. Mater."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3389\/fbioe.2020.00785","article-title":"Injectable Gelatin Hydrogel Suppresses Inflammation and Enhances Functional Recovery in a Mouse Model of Intracerebral Hemorrhage","volume":"8","author":"Xu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1007\/s12035-015-9441-6","article-title":"Preclinical Studies of Stem Cell Transplantation in Intracerebral Hemorrhage: A Systemic Review and Meta-Analysis","volume":"53","author":"Hu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s12975-019-00721-y","article-title":"Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage","volume":"11","author":"Lim","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Schneider, A., Garlick, J.A., and Egles, C. (2008). Self-assembling peptide nanofiber scaffolds accelerate wound healing. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001410"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.nano.2014.05.012","article-title":"A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage","volume":"11","author":"Sang","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.nano.2015.12.387","article-title":"A self-assembly peptide nanofibrous scaffold reduces inflammatory response and promotes functional recovery in a mouse model of intracerebral hemorrhage","volume":"12","author":"Zhang","year":"2016","journal-title":"Nanomedicine"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12974-021-02101-6","article-title":"Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: Microglia-astrocyte involvement in remyelination","volume":"18","author":"Zheng","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/STR.0000000000000069","article-title":"Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals from the American Heart Association\/American Stroke Association","volume":"46","author":"Hemphill","year":"2015","journal-title":"Stroke"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/1747493020968424","article-title":"Canadian stroke best practice recommendations: Management of Spontaneous Intracerebral Hemorrhage, 7th Edition Update 2020","volume":"16","author":"Castellucci","year":"2021","journal-title":"Int. J. Stroke"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1177\/1545968319893294","article-title":"Early Mobilization of Mild-Moderate Intracerebral Hemorrhage Patients in a Stroke Center: A Randomized Controlled Trial","volume":"34","author":"Yen","year":"2020","journal-title":"Neurorehabil. Neural. Repair."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.jocn.2011.10.021","article-title":"A prospective, randomized, single-blinded trial on the effect of early rehabilitation on daily activities and motor function of patients with hemorrhagic stroke","volume":"19","author":"Bai","year":"2012","journal-title":"J. Clin. Neurosci."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1161\/STROKEAHA.114.005661","article-title":"Randomized controlled trial of early rehabilitation after intracerebral hemorrhage stroke: Difference in outcomes within 6 months of stroke","volume":"45","author":"Liu","year":"2014","journal-title":"Stroke"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s12028-017-0425-4","article-title":"Functional Improvement Among Intracerebral Hemorrhage (ICH) Survivors up to 12 Months Post-injury","volume":"27","author":"Sreekrishnan","year":"2017","journal-title":"Neurocrit. Care"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.expneurol.2010.09.009","article-title":"Skilled reaching training promotes astroglial changes and facilitated sensorimotor recovery after collagenase-induced intracerebral hemorrhage","volume":"227","author":"Mestriner","year":"2011","journal-title":"Exp. Neurol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"159184","DOI":"10.1155\/2013\/159184","article-title":"Motor Skill Training Promotes Sensorimotor Recovery and Increases Microtubule-Associated Protein-2 (MAP-2) Immunoreactivity in the Motor Cortex after Intracerebral Hemorrhage in the Rat","volume":"2013","author":"Santos","year":"2013","journal-title":"ISRN Neurol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/1545968310395602","article-title":"Rehabilitation promotes recovery after whole blood-induced intracerebral hemorrhage in rats","volume":"25","author":"MacLellan","year":"2011","journal-title":"Neurorehabil. Neural. Repair."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.brainres.2008.11.038","article-title":"Delayed rehabilitation lessens brain injury and improves recovery after intracerebral hemorrhage in rats","volume":"1251","author":"Auriat","year":"2009","journal-title":"Brain Res."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbr.2010.04.025","article-title":"Rehabilitation after intracerebral hemorrhage in rats improves recovery with enhanced dendritic complexity but no effect on cell proliferation","volume":"214","author":"Auriat","year":"2010","journal-title":"Behav. Brain Res."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1177\/1545968313517758","article-title":"Rehabilitation improves behavioral recovery and lessens cell death without affecting iron, ferritin, transferrin, or inflammation after intracerebral hemorrhage in rats","volume":"28","author":"Caliaperumal","year":"2014","journal-title":"Neurorehabil. Neural. Repair."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbr.2013.11.034","article-title":"Motor skills training promotes motor functional recovery and induces synaptogenesis in the motor cortex and striatum after intracerebral hemorrhage in rats","volume":"260","author":"Tamakoshi","year":"2014","journal-title":"Behav. Brain Res."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.brainres.2010.07.070","article-title":"Treadmill running improves motor function and alters dendritic morphology in the striatum after collagenase-induced intracerebral hemorrhage in rats","volume":"1355","author":"Takamatsu","year":"2010","journal-title":"Brain Res."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1161\/STROKEAHA.114.006654","article-title":"Vagus nerve stimulation during rehabilitative training improves functional recovery after intracerebral hemorrhage","volume":"45","author":"Hays","year":"2014","journal-title":"Stroke"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1056\/NEJMoa0911341","article-title":"Robot-assisted therapy for long-term upper-limb impairment after stroke","volume":"362","author":"Lo","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jama.2019.2413","article-title":"Cerebral Intraparenchymal Hemorrhage: A Review","volume":"321","author":"Gross","year":"2019","journal-title":"JAMA"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nrneurol.2018.17","article-title":"Nontraumatic intracerebral haemorrhage in young adults","volume":"14","author":"Tatlisumak","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1055\/s-0038-1649503","article-title":"Global Burden of Stroke","volume":"38","author":"Katan","year":"2018","journal-title":"Semin. Neurol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/10\/2513\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:03:42Z","timestamp":1760166222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/10\/2513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,23]]},"references-count":241,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["cells10102513"],"URL":"https:\/\/doi.org\/10.3390\/cells10102513","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,23]]}}}