{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:21:48Z","timestamp":1760235708693,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001456","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["19K09453"],"award-info":[{"award-number":["19K09453"]}],"id":[{"id":"10.13039\/100001456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Genetic analysis in glioma has been developed recently. Spinal cord glioma is less common than intracranial glioma. Thus, the clinical significance of genetic mutations in spinal cord gliomas remains unclear. Furthermore, because the spinal cord is an important communication channel between the brain and the rest of the body, increased attention should be paid to its functional prognosis. In this study, we investigated the functional prognosis and driver genetic mutations in eight patients with spinal cord gliomas (World Health Organization grade I, three cases; grade II, two cases; grade III\/IV, three cases). IDH mutations were detected in all grade II cases and H3F3A mutations were detected in all grade III\/IV cases. The functional status of grade I and II gliomas remained unchanged or improved 1 year after surgery, whereas grade III\/IV gliomas remained unchanged or deteriorated. Spinal glioma progenitor cells with H3F3A mutations were associated with accelerated tumor-associated spinal cord injury, which led to functional impairment. Conversely, the presence of IDH mutations, which are rarely reported in spinal gliomas, indicated a relatively favorable functional prognosis.<\/jats:p>","DOI":"10.3390\/cells10102525","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T20:15:32Z","timestamp":1632514532000},"page":"2525","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-1663","authenticated-orcid":false,"given":"Yoshitaka","family":"Nagashima","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiharu","family":"Ohka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Hospital Organization Nagoya Medical Center, Nagoya 460-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3274-5272","authenticated-orcid":false,"given":"Kosuke","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"},{"name":"Institutes of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Nishii","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Aichi Medical University, Nagakute 480-1195, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1344-2548","authenticated-orcid":false,"given":"Yotaro","family":"Kitano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"},{"name":"Department of Neurosurgery, Mie University, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirano","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"},{"name":"Division of Cancer Biology, Aichi Cancer Center, Nagoya 464-8681, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Natsume","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya 466-8550, Japan"},{"name":"Institutes of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan"},{"name":"Division of Neurosurgery, Kawamura Medical Society Hospital, Gifu 501-3144, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000075953","article-title":"Incidence of central nervous system tumors in Gironde, France","volume":"23","author":"Provost","year":"2004","journal-title":"Neuroepidemiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s11910-011-0190-2","article-title":"Adult primary intradural spinal cord tumors: A review","volume":"11","author":"Chamberlain","year":"2011","journal-title":"Curr. 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