{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:23:06Z","timestamp":1760235786959,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI17C1050"],"award-info":[{"award-number":["HI17C1050"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["18172MFDS182"],"award-info":[{"award-number":["18172MFDS182"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Phosphatase of regenerating liver-1 (PRL-1) controls various cellular processes and liver regeneration. However, the roles of PRL-1 in liver regeneration induced by chorionic-plate-derived mesenchymal stem cells (CP-MSCs) transplantation remain unknown. Here, we found that increased PRL-1 expression by CP-MSC transplantation enhanced liver regeneration in a bile duct ligation (BDL) rat model by promoting the migration and proliferation of hepatocytes. Engrafted CP-MSCs promoted liver function via enhanced hepatocyte proliferation through increased PRL-1 expression in vivo and in vitro. Moreover, higher increased expression of PRL-1 regulated CP-MSC migration into BDL-injured rat liver through enhancement of migration-related signals by increasing Rho family proteins. The dual effects of PRL-1 on proliferation of hepatocytes and migration of CP-MSCs were substantially reduced when PRL-1 was silenced with siRNA-PRL-1 treatment. These findings suggest that PRL-1 may serve as a multifunctional enhancer for therapeutic applications of CP-MSC transplantation.<\/jats:p>","DOI":"10.3390\/cells10102530","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T20:15:32Z","timestamp":1632514532000},"page":"2530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-8242","authenticated-orcid":false,"given":"Jong Ho","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University, Gangneung-si 25457, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam-si 13488, Korea"},{"name":"Research Institute of Placental Science, CHA University, Seongnam-si 13488, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8149-5361","authenticated-orcid":false,"given":"Gi Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Kyungnam University, Changwon-si 51767, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam-si 13488, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-8128","authenticated-orcid":false,"given":"Ji Hye","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam-si 13488, Korea"},{"name":"Research Institute of Placental Science, CHA University, Seongnam-si 13488, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si Hyun","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Catholic University Medical College, Seoul 03312, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Koo","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-3651","authenticated-orcid":false,"given":"Seong-Gyu","family":"Hwang","sequence":"additional","affiliation":[{"name":"CHA Bundang Medical Center, Department of Internal Medicine, Division of Gastroenterology, CHA University School of Medicine, Seongnam-si 13496, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2320-7157","authenticated-orcid":false,"given":"Gi Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam-si 13488, Korea"},{"name":"Research Institute of Placental Science, CHA University, Seongnam-si 13488, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167sr1","DOI":"10.1126\/scitranslmed.3004700","article-title":"Therapy for fibrotic diseases: Nearing the starting line","volume":"5","author":"Friedman","year":"2013","journal-title":"Sci. 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