{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:24:18Z","timestamp":1775539458380,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Psoriasis is a chronic inflammatory skin disease that is mediated by complex crosstalk between immune cells and keratinocytes (KCs). Emerging studies have showed a specific psoriatic microRNAs signature, in which miR-21 is one of the most upregulated and dynamic miRNAs. In this study, we focused our investigations on the passenger miR-21-3p strand, which is poorly studied in skin and in psoriasis pathogenesis. Here, we showed the upregulation of miR-21-3p in an IMQ-induced psoriasiform mouse model. This upregulation was correlated with IL-22 expression and functionality, both in vitro and in vivo, and it occurred via STAT3 and NF-\u03baB signaling. We identified a network of differentially expressed genes involved in abnormal proliferation control and immune regulatory genes implicated in the molecular pathogenesis of psoriasis in response to miR-21-3p overexpression in KCs. These results were confirmed by functional assays that validated the proliferative potential of miR-21-3p. All these findings highlight the importance of miR-21-3p, an underestimated miRNA, in psoriasis and provide novel molecular targets for therapeutic purposes.<\/jats:p>","DOI":"10.3390\/cells10102547","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T01:59:47Z","timestamp":1632707987000},"page":"2547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["miR-21-3p\/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response"],"prefix":"10.3390","volume":"10","author":[{"given":"Florence","family":"Abdallah","sequence":"first","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire, CNRS-UPR4301, 45071 Orl\u00e9ans, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Henriet","sequence":"additional","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire, CNRS-UPR4301, 45071 Orl\u00e9ans, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Suet","sequence":"additional","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire, CNRS-UPR4301, 45071 Orl\u00e9ans, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Arar","sequence":"additional","affiliation":[{"name":"Centre Hospitalier d\u2019Orl\u00e9ans, 45071 Orl\u00e9ans, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudy","family":"Clemen\u00e7on","sequence":"additional","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire, CNRS-UPR4301, 45071 Orl\u00e9ans, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Malinge","sequence":"additional","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire, CNRS-UPR4301, 45071 Orl\u00e9ans, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-6311","authenticated-orcid":false,"given":"Ga\u00ebl","family":"Lecellier","sequence":"additional","affiliation":[{"name":"ENTROPIE, UMR250\/9220, CEDEX, 98800 Noumea, New Caledonia, France"},{"name":"Laboratoire D\u2019excellence \u201cCORAIL\u201d, USR 3278 CNRS-EPHE, Centre de Recherches Insulaires et Observatoire de l\u2019Environnement, Papetoai, Moorea, Polyn\u00e9sie Fran\u00e7aise, Universit\u00e9 de Paris-Saclay UVSQ, 55 Avenue de Paris, 78000 Versailles, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Baril","sequence":"additional","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire, CNRS-UPR4301, 45071 Orl\u00e9ans, France"},{"name":"Facult\u00e9 des Sciences, Universit\u00e9 d\u2019Orl\u00e9ans, Coll\u00e9guim Sciences et Techniques, 45071 Orl\u00e9ans, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-3937","authenticated-orcid":false,"given":"Chantal","family":"Pichon","sequence":"additional","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire, CNRS-UPR4301, 45071 Orl\u00e9ans, France"},{"name":"Facult\u00e9 des Sciences, Universit\u00e9 d\u2019Orl\u00e9ans, Coll\u00e9guim Sciences et Techniques, 45071 Orl\u00e9ans, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/bjd.15021","article-title":"Incidence, prevalence and mortality of patients with psoriasis: A U.K. population-based cohort study","volume":"176","author":"Springate","year":"2017","journal-title":"Br. 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