{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:44:47Z","timestamp":1791855887109,"version":"4.3.4"},"reference-count":181,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00991 (Fondo Europeo de Desarrollo Regional: FEDER)"],"award-info":[{"award-number":["PI20\/00991 (Fondo Europeo de Desarrollo Regional: FEDER)"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CARIBE project","award":["4729\/031"],"award-info":[{"award-number":["4729\/031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Nowadays, new advances in society and health have brought an increased life expectancy. However, at the same time, aging comes with complications that impact the development of autoimmunity, neurodegenerative diseases and cancer. These complications affect the quality of life and impact the public health system. Specifically, with aging, a low-grade chronic sterile systemic inflammation with self-reactivity in the absence of acute infection occurs termed inflammaging. Inflammaging is related to an imbalanced immune response that can be either naturally acquired with aging or accelerated due to external triggers. Different molecules, metabolites and inflammatory forms of cell death are highly involved in these processes. Importantly, adoptive cellular immunotherapy is a modality of treatment for cancer patients that administers ex vivo expanded immune cells in the patient. The manipulation of these cells confers them enhanced proinflammatory properties. A general consequence of proinflammatory events is the development of autoimmune diseases and cancer. Herein, we review subsets of immune cells with a pertinent role in inflammaging, relevant proteins involved in these inflammatory events and external triggers that enhance and accelerate these processes. Moreover, we mention relevant preclinical studies that demonstrate associations of chronic inflammation with cancer development.<\/jats:p>","DOI":"10.3390\/cells10102562","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T23:08:31Z","timestamp":1632784111000},"page":"2562","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Inflammaging, an Imbalanced Immune Response That Needs to Be Restored for Cancer Prevention and Treatment in the Elderly"],"prefix":"10.3390","volume":"10","author":[{"given":"Juana","family":"Serrano-L\u00f3pez","sequence":"first","affiliation":[{"name":"Departmentof Experimental Hematology, Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jim\u00e9nez Diaz, IIS-FJD, Autonomous University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-2693","authenticated-orcid":false,"given":"Beatriz","family":"Mart\u00edn-Antonio","sequence":"additional","affiliation":[{"name":"Departmentof Experimental Hematology, Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jim\u00e9nez Diaz, IIS-FJD, Autonomous University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"ref_1","unstructured":"(2021, September 23). Ageing Europe. Available online: https:\/\/ec.europa.eu\/eurostat\/web\/products-statistical-books\/-\/ks-02-19-681."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: Linking Aging to Chronic Disease","volume":"159","author":"Kennedy","year":"2014","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"a025163","DOI":"10.1101\/cshperspect.a025163","article-title":"The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span","volume":"6","author":"Sierra","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The Hallmarks of Aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-Aging. An Evolutionary Perspective on Immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12979-020-0173-8","article-title":"Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging","volume":"17","author":"Thomas","year":"2020","journal-title":"Immun. Ageing"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/RTI.0000000000000349","article-title":"Age-Stratified Patterns of Thymic Involution on Multidetector CT","volume":"33","author":"Drabkin","year":"2018","journal-title":"J. Thorac. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.14336\/AD.2016.1230","article-title":"Cancer and Aging\u2014The Inflammatory Connection","volume":"8","author":"Zinger","year":"2017","journal-title":"Aging Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.4049\/jimmunol.1500082","article-title":"Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation","volume":"194","author":"Coder","year":"2015","journal-title":"J. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"705410","DOI":"10.3389\/fcell.2021.705410","article-title":"The Hematopoietic Bone Marrow Niche Ecosystem","volume":"9","author":"Landspersky","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cytogfr.2021.01.006","article-title":"Hallmarks of Aging and Immunosenescence: Connecting the Dots","volume":"59","author":"Rodrigues","year":"2021","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.coi.2010.06.007","article-title":"Stem Cells and the Aging Hematopoietic System","volume":"22","author":"Beerman","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111313","DOI":"10.1016\/j.exger.2021.111313","article-title":"The Elevated Level of IL-1\u03b1 in the Bone Marrow of Aged Mice Leads to MSC Senescence Partly by down-Regulating Bmi-1","volume":"148","author":"Zheng","year":"2021","journal-title":"Exp. Gerontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151718","DOI":"10.1016\/j.acthis.2021.151718","article-title":"IL-6 Regulates the Bone Metabolism and Inflammatory Microenvironment in Aging Mice by Inhibiting Setd7","volume":"123","author":"Wang","year":"2021","journal-title":"Acta Histochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1365-2249.2008.03658.x","article-title":"Ageing Is Associated with Diminished Apoptotic Cell Clearance in Vivo","volume":"152","author":"Aprahamian","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e20200770","DOI":"10.1590\/1678-7757-2020-0770","article-title":"Fc\u03b3 Receptors on Aging Neutrophils","volume":"29","author":"Gasparoto","year":"2021","journal-title":"J. Appl. Oral. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.it.2018.12.007","article-title":"Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?","volume":"40","author":"Mastroberardino","year":"2019","journal-title":"Trends Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.coi.2014.04.002","article-title":"Shaping of NK Cell Subsets by Aging","volume":"29","author":"Solana","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular Senescence: From Physiology to Pathology","volume":"15","author":"Serrano","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mad.2006.11.008","article-title":"Accumulation of Senescent Cells in Mitotic Tissue of Aging Primates","volume":"128","author":"Jeyapalan","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1038\/s41467-018-07825-3","article-title":"Impaired Immune Surveillance Accelerates Accumulation of Senescent Cells and Aging","volume":"9","author":"Ovadya","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature05529","article-title":"Senescence and Tumour Clearance Is Triggered by P53 Restoration in Murine Liver Carcinomas","volume":"445","author":"Xue","year":"2007","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/onc.2012.206","article-title":"Granule Exocytosis Mediates Immune Surveillance of Senescent Cells","volume":"32","author":"Sagiv","year":"2013","journal-title":"Oncogene"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Battram, A.M., Bachiller, M., and Mart\u00edn-Antonio, B. (2020). Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124346"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00262-003-0395-6","article-title":"Rapid Turnover of the CD8(+)CD28(-) T-Cell Subset of Effector Cells in the Circulation of Patients with Head and Neck Cancer","volume":"52","author":"Tsukishiro","year":"2003","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A Complex Secretory Program Orchestrated by the Inflammasome Controls Paracrine Senescence","volume":"15","author":"Acosta","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/ncb2811","article-title":"Transmitting Senescence to the Cell Neighbourhood","volume":"15","author":"Hoare","year":"2013","journal-title":"Nat. Cell Biol"},{"key":"ref_29","first-page":"1481","article-title":"Chemotherapy-Induced Changes and Immunosenescence of CD8+ T-Cells in Patients with Breast Cancer","volume":"35","author":"Onyema","year":"2015","journal-title":"Anticancer Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s40425-019-0825-4","article-title":"Chemotherapy Accelerates Immune-Senescence and Functional Impairments of V\u03b42pos T Cells in Elderly Patients Affected by Liver Metastatic Colorectal Cancer","volume":"7","author":"Bruni","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1586\/ehm.10.40","article-title":"Genomic Polymorphisms of the Innate Immune System and Allogeneic Stem Cell Transplantation","volume":"3","author":"Granell","year":"2010","journal-title":"Expert Rev. Hematol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Basisty, N., Kale, A., Jeon, O.H., Kuehnemann, C., Payne, T., Rao, C., Holtz, A., Shah, S., Sharma, V., and Ferrucci, L. (2020). A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000599"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2016.07.007","article-title":"The Blood-Brain Barrier in Alzheimer\u2019s Disease","volume":"107","author":"Zenaro","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2017.10.003","article-title":"Inflammageing and Metaflammation: The Yin and Yang of Type 2 Diabetes","volume":"41","author":"Prattichizzo","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, Inflammation, and Cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"628","DOI":"10.14336\/AD.2017.0103","article-title":"The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks","volume":"8","author":"Aunan","year":"2017","journal-title":"Aging Dis."},{"key":"ref_37","first-page":"71","article-title":"Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of Cancer: The Next Generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-Related Inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the Pathogenesis and Treatment of Inflammatory Diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/gerona\/glu127","article-title":"Aging and the Burden of Multimorbidity: Associations with Inflammatory and Anabolic Hormonal Biomarkers","volume":"70","author":"Fabbri","year":"2015","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ni.1935","article-title":"Activation of the NLRP3 Inflammasome by Islet Amyloid Polypeptide Provides a Mechanism for Enhanced IL-1\u03b2 in Type 2 Diabetes","volume":"11","author":"Masters","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2010.11.011","article-title":"The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity","volume":"12","author":"Stienstra","year":"2010","journal-title":"Cell Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1093\/eurheartj\/ehz587","article-title":"On behalf of the UCC-SMART study group The Relation between Systemic Inflammation and Incident Cancer in Patients with Stable Cardiovascular Disease: A Cohort Study","volume":"40","author":"Ridker","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10552-008-9212-z","article-title":"Associations of Circulating C-Reactive Protein and Interleukin-6 with Cancer Risk: Findings from Two Prospective Cohorts and a Meta-Analysis","volume":"20","author":"Harris","year":"2009","journal-title":"Cancer Causes Control"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000431091","article-title":"Immunology of Osteoporosis: A Mini-Review","volume":"62","author":"Pietschmann","year":"2016","journal-title":"Gerontology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00281-009-0161-8","article-title":"Colitis-Associated Cancer: The Role of T Cells in Tumor Development","volume":"31","author":"Waldner","year":"2009","journal-title":"Semin. Immunopathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1056\/NEJMoa1709866","article-title":"Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia","volume":"378","author":"Maude","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wang, S., Sun, J., Chen, K., Ma, P., Lei, Q., Xing, S., Cao, Z., Sun, S., Yu, Z., and Liu, Y. (2021). Perspectives of Tumor-Infiltrating Lymphocyte Treatment in Solid Tumors. BMC Med., 19.","DOI":"10.1186\/s12916-021-02006-4"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Shah, N., Martin-Antonio, B., Yang, H., Ku, S., Lee, D.A., Cooper, L.J.N., Decker, W.K., Li, S., Robinson, S.N., and Sekine, T. (2013). Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity. PLoS One, 8.","DOI":"10.1371\/journal.pone.0076781"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Bachiller, M., Battram, A.M., Perez-Amill, L., and Mart\u00edn-Antonio, B. (2020). Natural Killer Cells in Immunotherapy: Are We Nearly There?. Cancers, 12.","DOI":"10.3390\/cancers12113139"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s40425-019-0739-1","article-title":"Extracellular NK Histones Promote Immune Cell Anti-Tumor Activity by Inducing Cell Clusters through Binding to CD138 Receptor","volume":"7","author":"Najjar","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Liu, Y., Fang, Y., Chen, X., Wang, Z., Liang, X., Zhang, T., Liu, M., Zhou, N., Lv, J., and Tang, K. (2020). Gasdermin E-Mediated Target Cell Pyroptosis by CAR T Cells Triggers Cytokine Release Syndrome. Sci. Immunol., 5.","DOI":"10.1126\/sciimmunol.aax7969"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"702527","DOI":"10.3389\/fimmu.2021.702527","article-title":"Updating the NLRC4 Inflammasome: From Bacterial Infections to Autoimmunity and Cancer","volume":"12","author":"Wen","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"eaaz7548","DOI":"10.1126\/science.aaz7548","article-title":"Granzyme A from Cytotoxic Lymphocytes Cleaves GSDMB to Trigger Pyroptosis in Target Cells","volume":"368","author":"Zhou","year":"2020","journal-title":"Science"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mart\u00edn-Antonio, B., Su\u00f1e, G., Perez-Amill, L., Castella, M., and Urbano-Ispizua, A. (2017). Natural Killer Cells: Angels and Devils for Immunotherapy. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091868"},{"key":"ref_57","first-page":"217","article-title":"CAR-T Cell Therapy: A Door Is Open to Find Innumerable Possibilities of Treatments for Cancer Patients","volume":"35","author":"Marzal","year":"2018","journal-title":"Turk. J. Haematol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1056\/NEJMoa1910607","article-title":"Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors","volume":"382","author":"Liu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mad.2006.11.016","article-title":"Inflammaging and Anti-Inflammaging: A Systemic Perspective on Aging and Longevity Emerged from Studies in Humans","volume":"128","author":"Franceschi","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.exger.2014.01.023","article-title":"Immune Parameters Identify Italian Centenarians with a Longer Five-Year Survival Independent of Their Health and Functional Status","volume":"54","author":"Bucci","year":"2014","journal-title":"Exp. Gerontol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.18632\/aging.102826","article-title":"Successful Aging: Insights from Proteome Analyses of Healthy Centenarians","volume":"12","author":"Valenzuela","year":"2020","journal-title":"Aging"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-016-0345-3","article-title":"T Cells in Multiple Myeloma Display Features of Exhaustion and Senescence at the Tumor Site","volume":"9","author":"Thangavadivel","year":"2016","journal-title":"J. Hematol. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Lee, G.R. (2018). The Balance of Th17 versus Treg Cells in Autoimmunity. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030730"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.cmet.2020.04.016","article-title":"CD4+ T Cells at the Center of Inflammaging","volume":"32","author":"Kroemer","year":"2020","journal-title":"Cell Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/imm.13333","article-title":"Thymic Atrophy Creates Holes in Treg-Mediated Immuno-Regulation via Impairment of an Antigen-Specific Clone","volume":"163","author":"Thomas","year":"2021","journal-title":"Immunology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41423-018-0004-4","article-title":"When Worlds Collide: Th17 and Treg Cells in Cancer and Autoimmunity","volume":"15","author":"Knochelmann","year":"2018","journal-title":"Cell Mol. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Sun, L., Fu, J., and Zhou, Y. (2017). Metabolism Controls the Balance of Th17\/T-Regulatory Cells. Front. Immunol.","DOI":"10.3389\/fimmu.2017.01632"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni.1760","article-title":"Foxp3 + Regulatory T Cells: Differentiation, Specification, Subphenotypes","volume":"10","author":"Feuerer","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000355303","article-title":"Regulatory T Cells and the Immune Aging Process: A Mini-Review","volume":"60","author":"Jagger","year":"2014","journal-title":"Gerontology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4049\/jimmunol.181.3.1835","article-title":"Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation","volume":"181","author":"Lages","year":"2008","journal-title":"J. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-2249.2005.02798.x","article-title":"The Number of Human Peripheral Blood CD4+ CD25high Regulatory T Cells Increases with Age","volume":"140","author":"Gregg","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.4049\/jimmunol.170.4.1675","article-title":"CD4+CD25- T Cells in Aged Mice Are Hyporesponsive and Exhibit Suppressive Activity","volume":"170","author":"Shimizu","year":"2003","journal-title":"J. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/0192623311430693","article-title":"Regulatory T-Cells: Diverse Phenotypes Integral to Immune Homeostasis and Suppression","volume":"40","author":"Peterson","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8348","DOI":"10.4049\/jimmunol.177.12.8348","article-title":"High Accumulation of T Regulatory Cells Prevents the Activation of Immune Responses in Aged Animals","volume":"177","author":"Sharma","year":"2006","journal-title":"J. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1189\/jlb.0907627","article-title":"The Frequency of Regulatory CD3+CD8+CD28- CD25+ T Lymphocytes in Human Peripheral Blood Increases with Age","volume":"84","author":"Simone","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41571-019-0175-7","article-title":"Regulatory T Cells in Cancer Immunosuppression \u2014 Implications for Anticancer Therapy","volume":"16","author":"Togashi","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"609762","DOI":"10.3389\/fimmu.2021.609762","article-title":"Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies","volume":"12","author":"Dong","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41590-019-0589-5","article-title":"CD36-Mediated Metabolic Adaptation Supports Regulatory T Cell Survival and Function in Tumors","volume":"21","author":"Wang","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Raja, K.R.M., Rihova, L., Zahradova, L., Klincova, M., Penka, M., and Hajek, R. (2012). Increased T Regulatory Cells Are Associated with Adverse Clinical Features and Predict Progression in Multiple Myeloma. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047077"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1159\/000478012","article-title":"Autoimmunity in the Elderly: Insights from Basic Science and Clinics - A Mini-Review","volume":"63","author":"Watad","year":"2017","journal-title":"Gerontology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1073\/pnas.1621280114","article-title":"CCR8+FOXp3+ Treg Cells as Master Drivers of Immune Regulation","volume":"114","author":"Barsheshet","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1474-9726.2012.00812.x","article-title":"Aged Regulatory T Cells Protect from Autoimmune Inflammation despite Reduced STAT3 Activation and Decreased Constraint of IL-17 Producing T Cells","volume":"11","author":"Sun","year":"2012","journal-title":"Aging Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.7314\/APJCP.2015.16.7.2845","article-title":"IL-35 over-Expression Is Associated with Genesis of Gastric Cancer","volume":"16","author":"Fan","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/jgh.13342","article-title":"Treg Subsets in Inflammatory Bowel Disease and Colorectal Carcinoma: Characteristics, Role, and Therapeutic Targets","volume":"31","author":"Velde","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1182\/blood-2016-08-686659","article-title":"Mechanistic Approaches for the Prevention and Treatment of Chronic GVHD","volume":"129","author":"Cutler","year":"2017","journal-title":"Blood"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/17474086.2020.1709436","article-title":"The Role of Regulatory T Cells in Graft-versus-Host Disease Management","volume":"13","author":"Whangbo","year":"2020","journal-title":"Expert Rev. Hematol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bbmt.2017.11.004","article-title":"Influence of Age on Acute and Chronic GVHD in Children Undergoing HLA-Identical Sibling Bone Marrow Transplantation for Acute Leukemia: Implications for Prophylaxis","volume":"24","author":"Qayed","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/s41409-020-0848-y","article-title":"Machine Learning Applied to Gene Expression Analysis of T-Lymphocytes in Patients with CGVHD","volume":"55","author":"Lumbreras","year":"2020","journal-title":"Bone Marrow Transplant."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41590-019-0316-2","article-title":"C-Maf-Dependent Treg Cell Control of Intestinal TH17 Cells and IgA Establishes Host-Microbiota Homeostasis","volume":"20","author":"Neumann","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"20088","DOI":"10.1073\/pnas.2006895117","article-title":"Regulatory T Cells Suppress Th17 Cell Ca2+ Signaling in the Spinal Cord during Murine Autoimmune Neuroinflammation","volume":"117","author":"Othy","year":"2020","journal-title":"PNAS"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/cei.13094","article-title":"Th17, Synchronically Increased with Tregs and Bregs, Promoted by Tumour Cells via Cell-Contact in Primary Hepatic Carcinoma","volume":"192","author":"Wang","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.exger.2013.09.003","article-title":"The Th17\/Treg Balance Is Disturbed during Aging","volume":"48","author":"Schmitt","year":"2013","journal-title":"Exp. Gerontol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cmet.2020.04.015","article-title":"Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation","volume":"32","author":"Bharath","year":"2020","journal-title":"Cell Metab."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s13402-012-0093-5","article-title":"Skewed Immunological Balance between Th17 (CD4(+)IL17A (+)) and Treg (CD4 (+)CD25 (+)FOXP3 (+)) Cells in Human Oral Squamous Cell Carcinoma","volume":"35","author":"Gaur","year":"2012","journal-title":"Cell Oncol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1158\/0008-5472.CAN-10-2907","article-title":"Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer","volume":"71","author":"Tosolini","year":"2011","journal-title":"Cancer Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.exger.2013.10.006","article-title":"Increased Th17 Differentiation in Aged Mice Is Significantly Associated with High IL-1\u03b2 Level and Low IL-2 Expression","volume":"49","author":"Lim","year":"2014","journal-title":"Exp. Gerontol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1182\/blood-2009-10-246660","article-title":"Elevated IL-17 Produced by TH17 Cells Promotes Myeloma Cell Growth and Inhibits Immune Function in Multiple Myeloma","volume":"115","author":"Prabhala","year":"2010","journal-title":"Blood"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1182\/blood-2008-03-143222","article-title":"Dendritic Cells Mediate the Induction of Polyfunctional Human IL17-Producing Cells (Th17-1 Cells) Enriched in the Bone Marrow of Patients with Myeloma","volume":"112","author":"Dhodapkar","year":"2008","journal-title":"Blood"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Harmer, D., Falank, C., and Reagan, M.R. (2019). Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma. Front. Endocrinol.","DOI":"10.3389\/fendo.2018.00788"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41375-020-0947-1","article-title":"MiR-21 Antagonism Abrogates Th17 Tumor Promoting Functions in Multiple Myeloma","volume":"35","author":"Rossi","year":"2021","journal-title":"Leukemia"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"107781","DOI":"10.1016\/j.intimp.2021.107781","article-title":"Interleukin-17 Induces Pyroptosis in Osteoblasts through the NLRP3 Inflammasome Pathway in Vitro","volume":"96","author":"Lei","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.clml.2019.12.009","article-title":"A Unique Role of T Helper 17 Cells in Different Treatment Stages of Multiple Myeloma","volume":"20","author":"Ma","year":"2020","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1038\/s41467-018-07305-8","article-title":"Microbiota-Driven Interleukin-17-Producing Cells and Eosinophils Synergize to Accelerate Multiple Myeloma Progression","volume":"9","author":"Calcinotto","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1182\/blood-2005-08-3101","article-title":"Dysfunctional T Regulatory Cells in Multiple Myeloma","volume":"107","author":"Prabhala","year":"2006","journal-title":"Blood"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1182\/blood-2010-05-283895","article-title":"A Novel Role of IL-17\u2013Producing Lymphocytes in Mediating Lytic Bone Disease in Multiple Myeloma","volume":"116","author":"Noonan","year":"2010","journal-title":"Blood"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fendo.2020.00406","article-title":"Immunological Drivers in Graves\u2019 Disease: NK Cells as a Master Switcher","volume":"11","author":"Gallo","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.autrev.2017.11.018","article-title":"NK Cells in Autoimmune Diseases: Linking Innate and Adaptive Immune Responses","volume":"17","author":"Gianchecchi","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jaut.2016.04.003","article-title":"Dysregulation of Regulatory CD56(Bright) NK Cells\/T Cells Interactions in Multiple Sclerosis","volume":"72","author":"Laroni","year":"2016","journal-title":"J. Autoimmun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature10624","article-title":"Natural Killer Cells Act as Rheostats Modulating Antiviral T Cells","volume":"481","author":"Waggoner","year":"2011","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2249.2007.03555.x","article-title":"Finnish Multiple Sclerosis and Pregnancy Study Group Immunoregulatory Factors in Multiple Sclerosis Patients during and after Pregnancy: Relevance of Natural Killer Cells","volume":"151","author":"Airas","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"663660","DOI":"10.3389\/fimmu.2021.663660","article-title":"Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"965","DOI":"10.4049\/jimmunol.1500591","article-title":"CD56brightCD16- NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+ T Cell Proliferation","volume":"195","author":"Morandi","year":"2015","journal-title":"J. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1210\/en.2012-1247","article-title":"Immunoregulatory Natural Killer Cells Suppress Autoimmunity by Down-Regulating Antigen-Specific CD8+ T Cells in Mice","volume":"153","author":"Ehlers","year":"2012","journal-title":"Endocrinology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00262-015-1720-6","article-title":"Natural Killer Cell Immunosenescence in Acute Myeloid Leukaemia Patients: New Targets for Immunotherapeutic Strategies?","volume":"65","author":"Campos","year":"2016","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_115","first-page":"1","article-title":"NK Cells of the Oldest Seniors Represent Constant and Resistant to Stimulation High Expression of Cellular Protective Proteins SIRT1 and HSP70","volume":"15","author":"Kaszubowska","year":"2018","journal-title":"Immun. Ageing"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1182\/bloodadvances.2019000953","article-title":"Myeloma Cells Induce the Accumulation of Activated CD94low NK Cells by Cell-to-Cell Contacts Involving CD56 Molecules","volume":"4","author":"Barberi","year":"2020","journal-title":"Blood Adv."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/caac.20073","article-title":"Cancer Statistics, 2010","volume":"60","author":"Jemal","year":"2010","journal-title":"CA Cancer J. Clin."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3389\/fimmu.2017.00573","article-title":"Natural Killer Defective Maturation Is Associated with Adverse Clinical Outcome in Patients with Acute Myeloid Leukemia","volume":"8","author":"Chretien","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1182\/blood-2005-08-027979","article-title":"Deficient Expression of NCR in NK Cells from Acute Myeloid Leukemia: Evolution during Leukemia Treatment and Impact of Leukemia Cells in NCRdull Phenotype Induction","volume":"109","author":"Fauriat","year":"2007","journal-title":"Blood"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"836","DOI":"10.3324\/haematol.2013.087536","article-title":"Leukemia-Induced Phenotypic and Functional Defects in Natural Killer Cells Predict Failure to Achieve Remission in Acute Myeloid Leukemia","volume":"99","author":"Stringaris","year":"2014","journal-title":"Haematologica"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s41423-020-00574-8","article-title":"Single-Cell Profiling Reveals the Trajectories of Natural Killer Cell Differentiation in Bone Marrow and a Stress Signature Induced by Acute Myeloid Leukemia","volume":"18","author":"Crinier","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e2020459118","DOI":"10.1073\/pnas.2020459118","article-title":"High-Dimensional Mass Cytometry Analysis of NK Cell Alterations in AML Identifies a Subgroup with Adverse Clinical Outcome","volume":"118","author":"Chretien","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"36492","DOI":"10.18632\/oncotarget.26362","article-title":"Intratumoral CD56bright Natural Killer Cells Are Associated with Improved Survival in Bladder Cancer","volume":"9","author":"Mukherjee","year":"2018","journal-title":"Oncotarget"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1038\/s41598-019-40933-8","article-title":"Circulating CD56 Bright NK Cells Inversely Correlate with Survival of Melanoma Patients","volume":"9","author":"Ebering","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Jabrane-Ferrat, N. (2019). Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01397"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.immuni.2017.11.018","article-title":"Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors","volume":"47","author":"Fu","year":"2017","journal-title":"Immunity"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1452","article-title":"Decidual NK Cells Regulate Key Developmental Processes at the Human Fetal-Maternal Interface","volume":"12","author":"Hanna","year":"2006","journal-title":"Nat. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.14336\/AD.2020.0603","article-title":"Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience","volume":"11","author":"Moskalev","year":"2020","journal-title":"Aging Dis."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Meyers, A.K., and Zhu, X. (2020). The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging. Cells, 9.","DOI":"10.3390\/cells9081808"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1002\/jcp.29268","article-title":"Emerging Insights into Molecular Mechanisms Underlying Pyroptosis and Functions of Inflammasomes in Diseases","volume":"235","author":"Lu","year":"2020","journal-title":"J. Cell Physiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cytogfr.2020.08.003","article-title":"Mechanisms of NLRP3 Priming in Inflammaging and Age Related Diseases","volume":"55","author":"Gritsenko","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by Inflammatory Caspases Determines Pyroptotic Cell Death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 Inflammasomes Are Required for Atherogenesis and Activated by Cholesterol Crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"507208","DOI":"10.1155\/2014\/507208","article-title":"Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice","volume":"2014","author":"Zheng","year":"2014","journal-title":"Mediators Inflamm."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1161\/ATVBAHA.117.309575","article-title":"NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report","volume":"37","author":"Kritikou","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41419-021-03562-6","article-title":"Protectin DX Restores Treg\/Th17 Cell Balance in Rheumatoid Arthritis by Inhibiting NLRP3 Inflammasome via MiR-20a","volume":"12","author":"Jin","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/1753425919886643","article-title":"Leptin Facilitates the Differentiation of Th17 Cells from MRL\/Mp-Fas Lpr Lupus Mice by Activating NLRP3 Inflammasome","volume":"26","author":"Yu","year":"2020","journal-title":"Innate Immun."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"17951","DOI":"10.1074\/jbc.RA119.010545","article-title":"NLRP3 Negatively Regulates Treg Differentiation through Kpna2-Mediated Nuclear Translocation","volume":"294","author":"Park","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev-nutr-071816-064836","article-title":"Fatty Acids and NLRP3 Inflammasome-Mediated Inflammation in Metabolic Tissues","volume":"37","author":"Ralston","year":"2017","journal-title":"Annu. Rev. Nutr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.celrep.2011.11.005","article-title":"The Nlrp3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence","volume":"1","author":"Youm","year":"2012","journal-title":"Cell Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1182\/blood-2009-03-213595","article-title":"Obesity Accelerates Thymic Aging","volume":"114","author":"Yang","year":"2009","journal-title":"Blood"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.cmet.2019.10.006","article-title":"Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis","volume":"30","author":"Camell","year":"2019","journal-title":"Cell Metab."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/cdd.2014.120","article-title":"Transmissible Cytotoxicity of Multiple Myeloma Cells by Cord Blood-Derived NK Cells Is Mediated by Vesicle Trafficking","volume":"22","author":"Najjar","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"15402","DOI":"10.1038\/ncomms15402","article-title":"Antigen-Specific CD8+ T Cell Feedback Activates NLRP3 Inflammasome in Antigen-Presenting Cells through Perforin","volume":"8","author":"Yao","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3389\/fimmu.2020.00482","article-title":"Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-Automatic Bioreactor: Experience From an Academic Phase I Clinical Trial","volume":"11","author":"Castella","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_146","first-page":"173","article-title":"Preclinical Development of a Humanized Chimeric Antigen Receptor against B Cell Maturation Antigen for Multiple Myeloma","volume":"106","author":"Castella","year":"2021","journal-title":"Haematologica"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41591-018-0036-4","article-title":"Monocyte-Derived IL-1 and IL-6 Are Differentially Required for Cytokine-Release Syndrome and Neurotoxicity Due to CAR T Cells","volume":"24","author":"Norelli","year":"2018","journal-title":"Nat. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1182\/blood-2018-10-881722","article-title":"GM-CSF Inhibition Reduces Cytokine Release Syndrome and Neuroinflammation but Enhances CAR-T Cell Function in Xenografts","volume":"133","author":"Sterner","year":"2019","journal-title":"Blood"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"99-115.e12","DOI":"10.1016\/j.immuni.2020.11.005","article-title":"Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging","volume":"54","author":"Mogilenko","year":"2021","journal-title":"Immunity"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jid.2018.09.031","article-title":"Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling","volume":"139","author":"Turner","year":"2019","journal-title":"J. Invest. Dermatol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4049\/jimmunol.1700885","article-title":"Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging","volume":"200","author":"Campbell","year":"2018","journal-title":"J. Immunol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.7150\/thno.49288","article-title":"Granzyme A Inhibition Reduces Inflammation and Increases Survival during Abdominal Sepsis","volume":"11","author":"Comas","year":"2021","journal-title":"Theranostics"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"107847","DOI":"10.1016\/j.celrep.2020.107847","article-title":"Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation","volume":"32","author":"Santiago","year":"2020","journal-title":"Cell Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1093\/intimm\/dxh320","article-title":"Differential Expression of the Granzymes A, K and M and Perforin in Human Peripheral Blood Lymphocytes","volume":"17","author":"Bade","year":"2005","journal-title":"Int. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/cdd.2013.189","article-title":"Granzyme M: Behind Enemy Lines","volume":"21","author":"Bovenschen","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Heath, J.J., and Grant, M.D. (2020). The Immune Response Against Human Cytomegalovirus Links Cellular to Systemic Senescence. Cells, 9.","DOI":"10.3390\/cells9030766"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.4049\/jimmunol.1000430","article-title":"A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis","volume":"185","author":"Anthony","year":"2010","journal-title":"J. Immunol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.imbio.2016.02.006","article-title":"Granzyme M and K Release in Human Experimental Endotoxemia","volume":"221","author":"Wensink","year":"2016","journal-title":"Immunobiology"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e2302","DOI":"10.1038\/cddis.2016.215","article-title":"Granzyme M Has a Critical Role in Providing Innate Immune Protection in Ulcerative Colitis","volume":"7","author":"Krasnova","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"103177","DOI":"10.1016\/j.critrevonc.2020.103177","article-title":"Chronic Inflammation towards Cancer Incidence: A Systematic Review and Meta-Analysis of Epidemiological Studies","volume":"157","author":"Michels","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.semarthrit.2015.06.005","article-title":"Survival and Cancer Risk in an Unselected and Complete Norwegian Idiopathic Inflammatory Myopathy Cohort","volume":"45","author":"Dobloug","year":"2015","journal-title":"Semin. Arthritis. Rheum."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1093\/rheumatology\/keab166","article-title":"A Systematic Review and Meta-Analysis to Inform Cancer Screening Guidelines in Idiopathic Inflammatory Myopathies","volume":"60","author":"Oldroyd","year":"2021","journal-title":"Rheumatology"},{"key":"ref_163","first-page":"990","article-title":"Strong Correlation between Cancer Progression and Anti-Transcription Intermediary Factor 1\u03b3 Antibodies in Dermatomyositis Patients","volume":"36","author":"Muro","year":"2018","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/07315724.2015.1080101","article-title":"Diet and Inflammation: Possible Effects on Immunity, Chronic Diseases, and Life Span","volume":"34","author":"Ricordi","year":"2015","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41430-018-0196-9","article-title":"Meta-Analysis of the Association between the Dietary Inflammatory Index (DII) and Breast Cancer Risk","volume":"73","author":"Wang","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Lu, D.-L., Ren, Z.-J., Zhang, Q., Ren, P.-W., Yang, B., Liu, L.-R., and Dong, Q. (2018). Meta-Analysis of the Association between the Inflammatory Potential of Diet and Urologic Cancer Risk. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204845"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1200\/JCO.2016.67.4283","article-title":"Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation","volume":"34","author":"Iyengar","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1289\/ehp.8360","article-title":"Correlation of in Vitro Cytokine Responses with the Chemical Composition of Soil-Derived Particulate Matter","volume":"114","author":"Veranth","year":"2006","journal-title":"Environ. Health Perspect"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Kim, H.-B., Shim, J.-Y., Park, B., and Lee, Y.-J. (2018). Long-Term Exposure to Air Pollutants and Cancer Mortality: A Meta-Analysis of Cohort Studies. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15112608"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e388","DOI":"10.3324\/haematol.2018.214155","article-title":"Myelodysplastic Syndrome-Associated Spliceosome Gene Mutations Enhance Innate Immune Signaling","volume":"104","author":"Pollyea","year":"2019","journal-title":"Haematologica"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ccell.2018.07.003","article-title":"Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations","volume":"34","author":"Lee","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1182\/blood-2016-07-730556","article-title":"The NLRP3 Inflammasome Functions as a Driver of the Myelodysplastic Syndrome Phenotype","volume":"128","author":"Basiorka","year":"2016","journal-title":"Blood"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ccr.2013.03.022","article-title":"Mutant P53 Prolongs NF-\u039aB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer","volume":"23","author":"Cooks","year":"2013","journal-title":"Cancer Cell"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2014.04.036","article-title":"Animal Models of Gastrointestinal Inflammation and Cancer","volume":"108","author":"Lu","year":"2014","journal-title":"Life Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ccr.2009.12.008","article-title":"Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKbeta- and JNK1-Dependent Inflammation","volume":"17","author":"Takahashi","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/01902140490495020","article-title":"Role of Inflammation in Mouse Lung Tumorigenesis: A Review","volume":"31","author":"Malkinson","year":"2005","journal-title":"Exp. Lung Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.20021258","article-title":"Deficiencies of GM-CSF and Interferon Gamma Link Inflammation and Cancer","volume":"197","author":"Enzler","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1172\/JCI44796","article-title":"A Dual Role for the Immune Response in a Mouse Model of Inflammation-Associated Lung Cancer","volume":"121","author":"Dougan","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/carcin\/bgg094","article-title":"Cigarette Smoke Exposure Increases Ulcerative Colitis-Associated Colonic Adenoma Formation in Mice","volume":"24","author":"Liu","year":"2003","journal-title":"Carcinogenesis"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1073\/pnas.0812347106","article-title":"Nitric Oxide and TNF-Alpha Trigger Colonic Inflammation and Carcinogenesis in Helicobacter Hepaticus-Infected, Rag2-Deficient Mice","volume":"106","author":"Erdman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1172\/JCI81203","article-title":"STK4 Regulates TLR Pathways and Protects against Chronic Inflammation-Related Hepatocellular Carcinoma","volume":"125","author":"Li","year":"2015","journal-title":"J. Clin. 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