{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:21:43Z","timestamp":1790738503464,"version":"4.1.0"},"reference-count":146,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003006","name":"ETH Zurich","doi-asserted-by":"publisher","award":["ETH-18 14-2"],"award-info":[{"award-number":["ETH-18 14-2"]}],"id":[{"id":"10.13039\/501100003006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Preeclampsia is one of the most frequent and severe complications of pregnancy. Symptoms of preeclampsia usually occur after 20 weeks of pregnancy and include hypertension and kidney dysfunction with proteinuria. Up to now, delivery of the infant has been the most effective and life-saving treatment to alleviate symptoms of preeclampsia because a causative treatment does not exist, which could prolong a pregnancy complicated with preeclampsia. Preeclampsia is a complex medical condition, which is attributed to a variety of different risk factors and causes. Risk factors account for insufficient placentation and impaired vasculogenesis and finally culminate in this life-threatening condition of pregnancy. Despite progress, many pathomechanisms and causes of preeclampsia are still incompletely understood. In recent years, it was found that excessive protein complex formation between G-protein-coupled receptors is a common sign of preeclampsia. Specifically, the aberrant heteromerization of two vasoactive G-protein-coupled receptors (GPCRs), the angiotensin II AT1 receptor and the bradykinin B2 receptor, is a causative factor of preeclampsia symptoms. Based on this knowledge, inhibition of abnormal GPCR protein complex formation is an experimental treatment approach of preeclampsia. This review summarizes the impact of pathological GPCR protein aggregation on symptoms of preeclampsia and delineates potential new therapeutic targets.<\/jats:p>","DOI":"10.3390\/cells10102609","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T10:55:40Z","timestamp":1633085740000},"page":"2609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pathological AT1R-B2R Protein Aggregation and Preeclampsia"],"prefix":"10.3390","volume":"10","author":[{"given":"Ursula","family":"Quitterer","sequence":"first","affiliation":[{"name":"Molecular Pharmacology, Department of Chemistry and Applied Biosciences, ETH Zurich, Winterthurerstrasse 190, CH-8057 Z\u00fcrich, Switzerland"},{"name":"Department of Medicine, Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"AbdAlla","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology, Department of Chemistry and Applied Biosciences, ETH Zurich, Winterthurerstrasse 190, CH-8057 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","article-title":"Global and regional estimates of preeclampsia and eclampsia: A systematic review","volume":"170","author":"Abalos","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists (2020). Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222. Obstet. Gynecol., 135, e237\u2013e260.","DOI":"10.1097\/AOG.0000000000003891"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1001\/jama.2017.3439","article-title":"Screening for preeclampsia: US Preventive Services Task Force recommendation statement","volume":"317","author":"Grossman","year":"2017","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","article-title":"Pre-eclampsia","volume":"398","author":"Chappell","year":"2021","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/AOG.0b013e3182255999","article-title":"Timing of indicated late-preterm and early-term birth","volume":"118","author":"Spong","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Fox, R., Kitt, J., Leeson, P., Aye, C.Y.L., and Lewandowski, A.J. (2019). Preeclampsia: Risk factors, diagnosis, management, and the cardiovascular impact on the offspring. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101625"},{"key":"ref_7","first-page":"403","article-title":"Preeclampsia: Long-term consequences for vascular health","volume":"11","author":"Amaral","year":"2015","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00404-015-3671-8","article-title":"Diagnostic accuracy of the soluble Fms-like tyrosine kinase-1\/placental growth factor ratio for preeclampsia: A meta-analysis based on 20 studies","volume":"292","author":"Liu","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/87904","article-title":"Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions","volume":"7","author":"Carmeliet","year":"2001","journal-title":"Nat. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nm0901-1003","article-title":"Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness","volume":"7","author":"AbdAlla","year":"2001","journal-title":"Nat. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.semnephrol.2003.11.007","article-title":"AT1 receptor heterodimers and angiotensin II responsiveness in preeclampsia","volume":"24","author":"Quitterer","year":"2004","journal-title":"Semin. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cell.2018.10.050","article-title":"Beta-arrestin1 prevents preeclampsia by downregulation of mechanosensitive AT1-B2 receptor heteromers","volume":"176","author":"Quitterer","year":"2019","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1073\/pnas.92.8.3521","article-title":"Regulation of blood pressure by the type 1A angiotensin II receptor gene","volume":"92","author":"Ito","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.HYP.29.1.483","article-title":"Effect of high salt intake in mutant mice lacking bradykinin-B2 receptors","volume":"29","author":"Alfie","year":"1997","journal-title":"Hypertension"},{"key":"ref_17","unstructured":"(2021, September 29). Hypertension in Pregnancy: Diagnosis and Management. Available online: https:\/\/www.nice.org.uk\/guidance\/ng133."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"i1753","DOI":"10.1136\/bmj.i1753","article-title":"Clinical risk factors for pre-eclampsia determined in early pregnancy: Systematic review and meta-analysis of large cohort studies","volume":"353","author":"Bartsch","year":"2016","journal-title":"BMJ"},{"key":"ref_20","first-page":"283","article-title":"Racial\/ethnic differences in pregnancy-related hypertensive disease in nulliparous women","volume":"24","author":"Ghosh","year":"2014","journal-title":"Ethn. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2014.03.044","article-title":"The \u2018immunologic theory\u2019 of preeclampsia revisited: A lesson from donor oocyte gestations","volume":"211","author":"Levron","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s10815-016-0701-9","article-title":"Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis","volume":"33","author":"Blazquez","year":"2016","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1600-0412.2011.01111.x","article-title":"How accurate are maternal symptoms in predicting impending complications in women with preeclampsia? A systematic review and meta-analysis","volume":"90","author":"Thangaratinam","year":"2011","journal-title":"Acta Obstet Gynecol. Scand."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1515\/JPM.2005.037","article-title":"Cerebral edema on MRI in severe preeclamptic women developing eclampsia","volume":"33","author":"Matsuda","year":"2005","journal-title":"J. Perinat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/AOG.0000000000003290","article-title":"Systolic hypertension, preeclampsia-related mortality, and stroke in California","volume":"133","author":"Judy","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/0002-9378(95)91495-1","article-title":"Blindness associated with preeclampsia and eclampsia","volume":"172","author":"Cunningham","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1056\/NEJM197609092951102","article-title":"Hepatic fibrinogen deposits in preeclampsia. Immunofluorescent evidence","volume":"295","author":"Arias","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S245","DOI":"10.1007\/BF02389238","article-title":"Leberpathologie im Rahmen des HELLP-Syndroms","volume":"255","author":"Schneider","year":"1994","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1042\/CS20200894","article-title":"Maternal microvascular dysfunction during preeclamptic pregnancy","volume":"135","author":"Stanhewicz","year":"2021","journal-title":"Clin. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11906-020-01099-1","article-title":"Preeclampsia and kidney disease: Deciphering cause and effect","volume":"22","author":"Kattah","year":"2020","journal-title":"Curr. Hypertens. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4103\/0971-4065.202406","article-title":"Acute kidney injury in pregnancy-specific disorders","volume":"27","author":"Prakash","year":"2017","journal-title":"Indian J. Nephrol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1440-1681.2009.05334.x","article-title":"Role of proteinuria in defining pre-eclampsia: Clinical outcomes for women and babies","volume":"37","author":"Thornton","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12958-021-00751-y","article-title":"Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: A retrospective study","volume":"19","author":"Lei","year":"2021","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/hepr.13540","article-title":"Liver disease in pregnancy","volume":"50","author":"Sasamori","year":"2020","journal-title":"Hepatol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Han, C., Huang, P., Lyu, M., and Dong, J. (2020). Oxidative stress and preeclampsia-associated prothrombotic state. Antioxidants., 9.","DOI":"10.3390\/antiox9111139"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1182\/blood.2020005221","article-title":"Management of thrombotic microangiopathy in pregnancy and postpartum: Report from an international working group","volume":"136","author":"Fakhouri","year":"2020","journal-title":"Blood"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejogrb.2012.09.026","article-title":"Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): A review","volume":"166","author":"Abildgaard","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_38","unstructured":"Chew, L.C., and Verma, R.P. (2021). Fetal Growth Restriction, StatPearls Publishing."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1007\/s43032-020-00393-2","article-title":"Fetal growth restriction: Does an integrated maternal hemodynamic-placental model fit better?","volume":"28","author":"Mecacci","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_40","unstructured":"Scott, G., Gillon, T.E., Pels, A., von Dadelszen, P., and Magee, L.A. (2020). Guidelines-similarities and dissimilarities: A systematic review of international clinical practice guidelines for pregnancy hypertension. Am. J. Obstet. Gynecol., S0002-9378(20)30846-2."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijgo.12802","article-title":"The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention","volume":"145","author":"Poon","year":"2019","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.emc.2019.01.008","article-title":"Hypertensive disorders of pregnancy","volume":"37","author":"Wilkerson","year":"2019","journal-title":"Emerg. Med. Clin. N. Am."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.0960-7692.2001.00572.x","article-title":"Multicenter screening for pre-eclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation","volume":"18","author":"Papageorghiou","year":"2001","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Nikuei, P., Rajaei, M., Roozbeh, N., Mohseni, F., Poordarvishi, F., Azad, M., and Haidari, S. (2020). Diagnostic accuracy of sFlt1\/PIGF ratio as a marker for preeclampsia. BMC Pregnancy Childbirth, 20.","DOI":"10.1186\/s12884-020-2744-2"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1111\/1471-0528.16425","article-title":"Placental growth factor in suspected preterm pre-eclampsia: A review of the evidence and practicalities of implementation","volume":"127","author":"Hurrell","year":"2020","journal-title":"BJOG"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(18)33212-4","article-title":"Placental growth factor testing to assess women with suspected pre-eclampsia: A multicentre, pragmatic, stepped-wedge cluster-randomized controlled trial","volume":"393","author":"Duhig","year":"2019","journal-title":"Lancet"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/AOG.0000000000003694","article-title":"Preeclampsia Triage by Rapid Assay Trial (PETRA) Investigators. Placental Growth Factor and the risk of adverse neonatal and maternal outcomes","volume":"135","author":"Parchem","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2019.09.003","article-title":"Placental growth factor predicts time to delivery in women with signs or symptoms of early preterm preeclampsia: A prospective multicenter study","volume":"222","author":"Barton","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"10","DOI":"10.12703\/b\/9-10","article-title":"Recent advances in the diagnosis and management of pre-eclampsia","volume":"9","author":"Hurrell","year":"2020","journal-title":"Fac. Rev."},{"key":"ref_50","unstructured":"(2021, September 29). PlGF-Based Testing to Help Diagnose Suspected Pre-Eclampsia (Triage PlGF Test, Elecsys Immunoassay sFlt-1\/PlGF Ratio, DELFIA Xpress PlGF 1-2-3 Test, and BRAHMS sFlt-1 Kryptor\/BRAHMS PlGF Plus Kryptor PE Ratio). Available online: https:\/\/www.nice.org.uk\/guidance\/dg23."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/HYPERTENSIONAHA.119.12739","article-title":"Randomized interventional study on prediction of preeclampsia\/eclampsia in women with suspected preeclampsia: INSPIRE","volume":"74","author":"Cerdeira","year":"2019","journal-title":"Hypertension"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.preghy.2018.03.007","article-title":"A clinical evaluation of placental growth factor in routine practice in high-risk women presenting with suspected pre-eclampsia and\/or fetal growth restriction","volume":"14","author":"Ormesher","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/GCO.0000000000000694","article-title":"Low-dose aspirin in pregnancy: Who? when? how much? and why?","volume":"33","author":"Mather","year":"2021","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2019.02.034","article-title":"Aspirin delays the development of preeclampsia","volume":"220","author":"Wright","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"ACOG Committee Opinion No. 743 (2018). Low-dose aspirin use during pregnancy. Obstet. Gynecol., 132, e44\u2013e52.","DOI":"10.1097\/AOG.0000000000002708"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Walsh, S.W., and Strauss, J.F. (2021). The road to low-dose aspirin therapy for the prevention of preeclampsia began with the placenta. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136985"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.HYP.38.3.718","article-title":"Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction","volume":"38","author":"Granger","year":"2001","journal-title":"Hypertension"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"H661","DOI":"10.1152\/ajpheart.00202.2020","article-title":"Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia","volume":"319","author":"Qu","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"Preeclampsia-pathophysiology and clinical presentations: JACC State-of-the-art review","volume":"76","author":"Ives","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2217\/bmm-2020-0545","article-title":"Clinical implications of placenta-derived angiogenic\/anti-angiogenic biomarkers in preeclampsia","volume":"15","author":"Hong","year":"2021","journal-title":"Biomark. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"H2011","DOI":"10.1152\/ajpheart.01005.2020","article-title":"Role of arterial impairment in preeclampsia: Should the paradigm shift?","volume":"320","author":"Pereira","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_62","unstructured":"Melchiorre, K., Giorgione, V., and Thilaganathan, B. (2021). The placenta and preeclampsia: Villain or victim?. Am. J. Obstet. Gynecol, S0002-9378(20)31198-4."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"107680","DOI":"10.1016\/j.exer.2019.05.020","article-title":"The renin-angiotensin-aldosterone system and its therapeutic targets","volume":"186","author":"Danser","year":"2019","journal-title":"Exp Eye Res."},{"key":"ref_64","first-page":"9","article-title":"The renin-angiotensin aldosterone system: Pathophysiological role and pharmacologic inhibition","volume":"13","author":"Atlas","year":"2007","journal-title":"J. Manag. Care Pharm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"104230","DOI":"10.1016\/j.phrs.2019.04.014","article-title":"Improvements of symptoms of Alzheimer\u2018s disease by inhibition of the angiotensin system","volume":"154","author":"Quitterer","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s11906-006-0011-1","article-title":"The role of RAS in the pathogenesis of preeclampsia","volume":"8","author":"Shah","year":"2006","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1172\/JCI107462","article-title":"A study of angiotensin II pressor response throughout primigravid pregnancy","volume":"52","author":"Gant","year":"1973","journal-title":"J. Clin. Investig."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/ajh\/2.4.238","article-title":"Increased intracellular free calcium and sensitivity to angiotensin II in platelets of preeclamptic women","volume":"2","author":"Haller","year":"1989","journal-title":"Am. J. Hypertens."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1172\/JCI83918","article-title":"Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia","volume":"126","author":"Burke","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1161\/HYPERTENSIONAHA.117.09386","article-title":"Increased angiotensin II sensitivity contributes to microvascular dysfunction in women who have had preeclampsia","volume":"70","author":"Stanhewicz","year":"2017","journal-title":"Hypertension"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.semnephrol.2010.10.005","article-title":"Renin angiotensin signaling in normal pregnancy and preeclampsia","volume":"31","author":"Irani","year":"2011","journal-title":"Semin. Nephrol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI4106","article-title":"Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor","volume":"103","author":"Wallukat","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1161\/01.HYP.0000154785.50570.63","article-title":"Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia","volume":"45","author":"Dechend","year":"2005","journal-title":"Hypertension"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1161\/CIRCRESAHA.113.300752","article-title":"Angiotensin receptor agonistic autoantibodies and hypertension: Preeclampsia and beyond","volume":"113","author":"Xia","year":"2013","journal-title":"Circ. Res."},{"key":"ref_75","first-page":"90","article-title":"Detection of serum autoantibodies against AT1A-receptor during the development of the four types of hypertensive rat models","volume":"58","author":"Chen","year":"2006","journal-title":"Sheng Li Xue Bao"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"7724","DOI":"10.1073\/pnas.88.17.7724","article-title":"Expression cloning of a rat B2 bradykinin receptor","volume":"88","author":"McEachern","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"13706","DOI":"10.1074\/jbc.270.23.13706","article-title":"Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons","volume":"270","author":"Borkowski","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Girolami, J.P., Bouby, N., Richer-Giudicelli, C., and Alhenc-Gelas, F. (2021). Kinins and kinin receptors in cardiovascular and renal diseases. Pharmaceuticals, 14.","DOI":"10.3390\/ph14030240"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1056\/NEJM199810293391804","article-title":"Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects","volume":"339","author":"Gainer","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"101861","DOI":"10.1016\/j.redox.2021.101861","article-title":"Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia","volume":"40","author":"Guerby","year":"2021","journal-title":"Redox. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/01.ATV.0000125114.88079.96","article-title":"Dysfunction of endothelial nitric oxide synthase and atherosclerosis","volume":"24","author":"Kawashima","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fmed.2019.00032","article-title":"Increased reactive oxygen species generation contributes to the atherogenic activity of the B2 bradykinin receptor","volume":"6","author":"Perhal","year":"2019","journal-title":"Front. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1471-0528.1997.tb10939.x","article-title":"Loss of endothelium-dependent relaxation in myometrial resistance arteries in pre-eclampsia","volume":"104","author":"Ashworth","year":"1997","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1067\/mob.2002.127378","article-title":"Endothelial dysfunction in uterine circulation in preeclampsia: Can estrogens improve it","volume":"187","author":"Svedas","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_85","first-page":"208","article-title":"Urinary kallikrein excretion in normal and hypertensive pregnancy at term","volume":"18","author":"Jalkanen","year":"1986","journal-title":"Ann. Clin. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1471-0528.1996.tb09767.x","article-title":"Early prediction of pre-eclampsia by measurement of kallikrein and creatinine on a random urine sample","volume":"103","author":"Millar","year":"1996","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1471-0528.1996.tb09547.x","article-title":"A comparison of the inactive urinary kallikrein:creatinine ratio and the angiotensin sensitivity test for the prediction of pre-eclampsia","volume":"103","author":"Kyle","year":"1996","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1385\/ENDO:29:3:491","article-title":"Expression of kallikrein, bradykinin b2 receptor, and endothelial nitric oxide synthase in placenta in normal gestation, preeclampsia, and placenta accreta","volume":"29","author":"Corthorn","year":"2006","journal-title":"Endocrine"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/35024095","article-title":"AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration","volume":"407","author":"AbdAlla","year":"2000","journal-title":"Nature"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fmed.2019.00009","article-title":"Discovery of pathologic GPCR aggregation","volume":"6","author":"Quitterer","year":"2019","journal-title":"Front. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/ncb1137","article-title":"Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II","volume":"6","author":"Zou","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1016\/S0021-9258(18)61153-6","article-title":"Angiotensin II-stimulated Na+\/H+ exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and independent pathways","volume":"262","author":"Berk","year":"1987","journal-title":"J. Biol. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.tips.2005.01.004","article-title":"Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation","volume":"26","author":"Bulenger","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"39721","DOI":"10.1074\/jbc.M105253200","article-title":"The angiotensin II AT2 receptor is an AT1 receptor antagonist","volume":"276","author":"AbdAlla","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1161\/01.CIR.0000160867.23556.7D","article-title":"G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor","volume":"111","author":"Kostenis","year":"2005","journal-title":"Circulation"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1161\/01.HYP.0000228997.88162.a8","article-title":"Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization","volume":"48","author":"Abadir","year":"2006","journal-title":"Hypertension"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/bbrc.1996.1076","article-title":"Salt-sensitive hypertension in bradykinin B2 receptor knockout mice","volume":"224","author":"Alfie","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1385\/JMN:26:2-3:185","article-title":"Mesangial AT1\/B2 receptor heterodimers contribute to angiotensin II hyperresponsiveness in experimental hypertension","volume":"26","author":"AbdAlla","year":"2005","journal-title":"J. Mol. Neurosci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/1753944715624853","article-title":"The emerging role of endothelin-1 in the pathogenesis of pre-eclampsia","volume":"10","author":"Saleh","year":"2016","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1152\/physrev.00023.2003","article-title":"Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase","volume":"83","author":"Somlyo","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nm1666","article-title":"G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension","volume":"14","author":"Wirth","year":"2008","journal-title":"Nat. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1080\/10641955.2017.1385795","article-title":"FN1, FOS, and ITGA5 induce preeclampsia: Abnormal expression and methylation","volume":"36","author":"Zhao","year":"2017","journal-title":"Hypertens. Pregnancy"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e12310","DOI":"10.14814\/phy2.12310","article-title":"Regulation of soluble fms-like tyrosine kinase-1 production in response to placental ischemia\/hypoxia: Role of angiotensin II","volume":"3","author":"Murphy","year":"2015","journal-title":"Physiol. Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/01.RES.0000254703.11154.18","article-title":"Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy","volume":"100","author":"Zhou","year":"2007","journal-title":"Circ. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.3390\/ijms16034600","article-title":"Nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia","volume":"16","author":"Matsubara","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"290ra88","DOI":"10.1126\/scitranslmed.aaa5038","article-title":"Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia","volume":"7","author":"Holobotovskyy","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/j.1471-0528.1981.tb01198.x","article-title":"A prospective study of plasma angiotensin-converting enzyme in normotensive primigravidae and their infants","volume":"88","author":"Oats","year":"1981","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.placenta.2009.02.009","article-title":"Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"428.e1","DOI":"10.1016\/j.ajog.2007.10.783","article-title":"Twin pregnancy and the risk of preeclampsia: Bigger placenta or relative ischemia","volume":"198","author":"Bdolah","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1111\/bph.14685","article-title":"Bradykinin increases BP in endotoxemic rat: Functional and biochemical evidence of angiotensin II AT1\/bradykinin B2 receptor heterodimerization","volume":"176","author":"Anton","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.siny.2006.04.001","article-title":"Inflammation and pre-eclampsia","volume":"11","author":"Borzychowski","year":"2006","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1111\/bph.14466","article-title":"Inflammatory mediators: A causal link to hypertension during preeclampsia","volume":"176","author":"Cornelius","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"18872","DOI":"10.1074\/jbc.M113.472381","article-title":"The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers","volume":"288","author":"Wilson","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1074\/jbc.M706892200","article-title":"Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription","volume":"283","author":"Lee","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"31051","DOI":"10.1074\/jbc.272.49.31051","article-title":"Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation\/dephosphorylation of beta-arrestin1","volume":"272","author":"Lin","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1681\/ASN.2006101127","article-title":"The Bradykinin B2 receptor gene is a target of angiotensin II type 1 receptor signaling","volume":"18","author":"Shen","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1136\/bmj.39366.416817.BE","article-title":"Prepregnancy cardiovascular risk factors as predictors of pre-eclampsia: Population based cohort study","volume":"335","author":"Magnussen","year":"2007","journal-title":"BMJ"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0140-6736(85)92207-X","article-title":"Prevention of pre-eclampsia by early antiplatelet therapy","volume":"1","author":"Beaufils","year":"1985","journal-title":"Lancet"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s40265-017-0823-0","article-title":"Aspirin for prevention of preeclampsia","volume":"77","author":"Atallah","year":"2017","journal-title":"Drugs"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Van Doorn, R., Mukhtarova, N., Flyke, I.P., Lasarev, M., Kim, K., Hennekens, C.H., and Hoppe, K.K. (2021). Dose of aspirin to prevent preterm preeclampsia in women with moderate or high-risk factors: A systematic review and meta-analysis. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0247782"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1055\/s-0038-1660105","article-title":"Potentiation of adrenaline-induced platelet aggregation by angiotensin II","volume":"54","author":"Ding","year":"1985","journal-title":"Thromb. Haemost."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0038-1645692","article-title":"Effect of angiotensin II on collagen-induced platelet activation in normotensive subjects","volume":"63","author":"Swartz","year":"1990","journal-title":"Thromb. Haemost."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1161\/01.HYP.0000034745.98129.EC","article-title":"Angiotensin II AT1 receptor antagonists inhibit platelet adhesion and aggregation by nitric oxide release","volume":"40","author":"Kalinowski","year":"2002","journal-title":"Hypertension"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.earlhumdev.2005.11.001","article-title":"Fetopathy associated with exposure to angiotensin converting enzyme inhibitors and angiotensin receptor antagonists","volume":"82","author":"Quan","year":"2006","journal-title":"Early Hum. Dev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/hr.2015.12","article-title":"Outomes of 83 fetuses exposed to angiotensin receptor blockers during the second or third trimesters: A literature review","volume":"38","author":"Shimada","year":"2015","journal-title":"Hypertens. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1074\/jbc.275.4.2893","article-title":"Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state","volume":"275","author":"Thomas","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.pharmtox.010909.105800","article-title":"Molecular mechanism of beta-arrestin-biased agonism at seven-transmembrane receptors","volume":"522","author":"Reiter","year":"2012","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1210\/me.2013-1314","article-title":"Minireview: More than just a hammer: Ligand \u201cbias\u201d and pharmaceutical discovery","volume":"28","author":"Luttrell","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1536\/ihj.15-256","article-title":"Biased agonism of the angiotensin II type I receptor","volume":"56","author":"Ikeda","year":"2015","journal-title":"Int. Heart J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.phrs.2017.06.013","article-title":"Current topics in angiotensin II type 1 receptor research: Focus on inverse agonism, receptor dimerization and biased agonism","volume":"123","author":"Takezako","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1042\/CS20180222","article-title":"Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats","volume":"132","author":"Ogunlade","year":"2018","journal-title":"Clin. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1161\/HYPERTENSIONAHA.120.15793","article-title":"Beta-arrestin-biased agonist targeting the brain AT1R (angiotensin II type 1 receptor) increases aversion to saline and lowers blood pressure in deoxycorticosterone acetate-salt hypertension","volume":"77","author":"Zanaty","year":"2021","journal-title":"Hypertension"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00392-017-1168-0","article-title":"Relationship between baseline systolic blood pressure and long-term outcomes in acute heart failure patients treated with TRV027: An exploratory subgroup analysis of BLAST-AHF","volume":"107","author":"Cotter","year":"2018","journal-title":"Clin. Res. Cardiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"79","DOI":"10.12891\/ceog1853.2015","article-title":"The effect of calcium channel blockers on prevention of preeclampsia in pregnant women with chronic hypertension","volume":"42","author":"Jiang","year":"2015","journal-title":"Clin, Exp. Obstet. Gynecol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/bph.14875","article-title":"A bivalent antihypertensive vaccine targeting L-type calcium channels and angiotensin AT1 receptors","volume":"177","author":"Wu","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e2019126118","DOI":"10.1073\/pnas.2019126118","article-title":"Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers","volume":"118","author":"Singh","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1753944708094227","article-title":"Preeclampsia and future cardiovascular risk: Formal risk factor or failed stress test?","volume":"2","author":"Craici","year":"2008","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1042\/CS20150567","article-title":"Long-term renal and cardiovascular risk after preeclampsia: Towards screening and prevention","volume":"130","author":"Paauw","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/clc.22887","article-title":"Adverse pregnancy outcomes and future maternal cardiovascular disease","volume":"41","author":"Hauspurg","year":"2018","journal-title":"Clin. Cardiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"625726","DOI":"10.3389\/fped.2021.625726","article-title":"The immediate and long-term impact of preeclampsia on offspring vascular and cardiac physiology in the preterm infant","volume":"9","author":"Frost","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_141","first-page":"194","article-title":"Preeclampsia emerging as a novel risk factor for cardiovascular disease in the offspring","volume":"16","author":"Karatza","year":"2020","journal-title":"Curr. Pediatr. Rev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e1920964","DOI":"10.1001\/jamanetworkopen.2019.20964","article-title":"Adverse pregnancy outcomes and long-term maternal kidney disease: A systematic review and meta-analysis","volume":"3","author":"Barrett","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Khashan, A.S., Evans, M., Kublickas, M., McCarthy, F.P., Kenny, L.C., Stenvinkel, P., Fitzgerald, T., and Kublickiene, K. (2019). Preeclampsia and risk of end stage kidney disease: A Swedish nationwide cohort study. PLoS Med., 16.","DOI":"10.1371\/journal.pmed.1002977"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"l1516","DOI":"10.1136\/bmj.l1516","article-title":"Pre-eclampsia and risk of later kidney disease: Nationwide cohort study","volume":"365","author":"Kristensen","year":"2019","journal-title":"BMJ"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2013.09.027","article-title":"End-stage renal disease after hypertensive disorders in pregnancy","volume":"210","author":"Wu","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1056\/NEJMoa0706790","article-title":"Preeclampsia and the risk of end-stage renal disease","volume":"359","author":"Vikse","year":"2008","journal-title":"N. Engl. J. Med."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/10\/2609\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:08:20Z","timestamp":1760166500000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/10\/2609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":146,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["cells10102609"],"URL":"https:\/\/doi.org\/10.3390\/cells10102609","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,1]]}}}