{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:12:46Z","timestamp":1792843966713,"version":"4.5.0"},"reference-count":93,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014261","name":"National Institute for Health Care Management Foundation","doi-asserted-by":"publisher","award":["U01HD086838-01A1"],"award-info":[{"award-number":["U01HD086838-01A1"]}],"id":[{"id":"10.13039\/100014261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>In mammals, the neuroendocrine system, which includes the communication between the hypothalamus and the pituitary, plays a major role in controlling body growth and cellular metabolism. GH produced from the pituitary somatotroph is considered the master regulator of somatic development and involved, directly and indirectly, in carbohydrate and lipid metabolism via complex, yet well-defined, signaling pathways. GH production from the pituitary gland is primarily regulated by the counter-regulatory effects of the hypothalamic GHRH and SST hormones. The role of IGF-1 feedback regulation in GH production has been demonstrated by pharmacologic interventions and in genetically modified mouse models. In the present review, we discuss the role of IGF-1 in the regulation of the GH-axis as it controls somatic growth and metabolic homeostasis. We present genetically modified mouse models that maintain the integrity of the GH\/GHRH-axis with the single exception of IGF-1 receptor (IGF-1R) deficiency in the hypothalamic GHRH neurons and somatotroph that reveals a novel mechanism controlling adipose tissues physiology and energy expenditure.<\/jats:p>","DOI":"10.3390\/cells10102664","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T09:24:04Z","timestamp":1633598644000},"page":"2664","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":153,"title":["The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-1748","authenticated-orcid":false,"given":"Sarmed","family":"Al-Samerria","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Rutgers\u2014Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Radovick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Rutgers\u2014Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00441-018-2859-1","article-title":"Development of neuroendocrine neurons in the mammalian hypothalamus","volume":"375","year":"2019","journal-title":"Cell Tissue Res."},{"key":"ref_2","unstructured":"Fink, G., Pfaff, D.W., and Levine, J.E. (2012). Chapter 1-An Introduction to Neuroendocrine Systems. Handbook of Neuroendocrinology, Academic Press."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1210\/me.2009-0393","article-title":"Targeted Deletion of Somatotroph Insulin-Like Growth Factor-I Signaling in a Cell-Specific Knockout Mouse Model","volume":"24","author":"Romero","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"ref_4","first-page":"39","article-title":"Genetic Mutations in the GH\/IGF Axis","volume":"16","year":"2018","journal-title":"Pediatr Endocrinol Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"T69","DOI":"10.1530\/JME-17-0311","article-title":"IGF1 receptor signaling pathways","volume":"61","author":"Hakuno","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Vitale, G., Pellegrino, G., Vollery, M., and Hofland, L.J. (2019). ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians\u2019 Perspective. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00027"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nrendo.2013.67","article-title":"The GH\/IGF-1 axis in ageing and longevity","volume":"9","author":"Junnila","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Takahashi, Y. (2017). The Role of Growth Hormone and Insulin-Like Growth Factor-I in the Liver. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071447"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.18679\/CN11-6030_R.2017.035","article-title":"Review of Insulin-Like Growth Factor 1 Signaling Pathway and Its Role in Protection against Brain Diseases","volume":"3","author":"Wei","year":"2017","journal-title":"Transl. Neurosci. Clin."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wrigley, S., Arafa, D., and Tropea, D. (2017). Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging. Front. Cell. Neurosci., 11.","DOI":"10.3389\/fncel.2017.00014"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Maglio, L.E., Noriega-Prieto, J.A., Maroto, I.B., Martin-Cortecero, J., Mu\u00f1oz-Callejas, A., Callejo-M\u00f3stoles, M., and Fern\u00e1ndez de Sevilla, D. (2021). IGF-1 facilitates extinction of conditioned fear. Elife, 10.","DOI":"10.7554\/eLife.67267"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1210\/en.2013-1261","article-title":"Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms","volume":"154","author":"Gahete","year":"2013","journal-title":"Endocrinology"},{"key":"ref_13","unstructured":"Fink, G., Pfaff, D.W., and Levine, J. (2011). Handbook of Neuroendocrinology, Elsevier Science & Technology."},{"key":"ref_14","unstructured":"Feingold, K.R., Anawalt, B., Boyce, A., Chrousos, G., de Herder, W.W., Dungan, K., Grossman, A., Hershman, J.M., Hofland, J., and Kaltsas, G. (2000). Functional Anatomy of the Hypothalamus and Pituitary. Endotext, MDText.com, Inc."},{"key":"ref_15","unstructured":"Lechan RM, T.R. (2021, June 12). Functional Anatomy of the Hypothalamus and Pituitary, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279126\/."},{"key":"ref_16","unstructured":"El Sayed, S.A., Fahmy, M.W., and Schwartz, J. (2020). Pituitary Gland Physiology. StatPearls, StatPearls Publishing, StatPearls Publishing LLC."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/10253890.2018.1470238","article-title":"Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility","volume":"21","author":"Gjerstad","year":"2018","journal-title":"Stress"},{"key":"ref_18","first-page":"153","article-title":"The endocrine system: An overview","volume":"22","author":"Bartke","year":"1998","journal-title":"Alcohol Health Res. World"},{"key":"ref_19","unstructured":"Sadiq, N.M., and Tadi, P. (2020). Physiology, Pituitary Hormones. StatPearls, StatPearls Publishing LLC."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0014-5793(78)80237-3","article-title":"Primary structure of human insulin-like growth factor II","volume":"89","author":"Rinderknecht","year":"1978","journal-title":"Febs Lett."},{"key":"ref_21","first-page":"56","article-title":"The role of IGF-1 in obesity, cardiovascular disease, and cancer","volume":"33","author":"AsghariHanjani","year":"2019","journal-title":"Med. J. Islam Repub Iran."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00592-010-0227-z","article-title":"The IGF system","volume":"48","author":"Annunziata","year":"2011","journal-title":"Acta Diabetol."},{"key":"ref_23","first-page":"59","article-title":"Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)","volume":"75","author":"Liu","year":"1993","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1128\/MCB.17.3.1595","article-title":"Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt","volume":"17","author":"Kulik","year":"1997","journal-title":"Mol. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1210\/endo.141.4.7475","article-title":"Insulin-like growth factor I receptor signaling--overlapping or redundant pathways?","volume":"141","author":"LeRoith","year":"2000","journal-title":"Endocrinology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"11843","DOI":"10.1016\/S0021-9258(18)80143-0","article-title":"High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum","volume":"264","author":"Baxter","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"T11","DOI":"10.1530\/JME-17-0254","article-title":"IGF-binding proteins","volume":"61","author":"Bach","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nrd2359","article-title":"Modifying IGF1 activity: An approach to treat endocrine disorders, atherosclerosis and cancer","volume":"6","author":"Clemmons","year":"2007","journal-title":"Nat. Reviews. Drug Discov."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1530\/acta.0.1210753","article-title":"Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates","volume":"121","author":"Guler","year":"1989","journal-title":"Acta Endocrinol."},{"key":"ref_30","first-page":"801","article-title":"Insulin-like growth factor-binding proteins in serum and other biological fluids: Regulation and functions","volume":"18","author":"Rajaram","year":"1997","journal-title":"Endocr. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1210\/er.2001-0033","article-title":"Cellular Actions of the Insulin-Like Growth Factor Binding Proteins","volume":"23","author":"Firth","year":"2002","journal-title":"Endocr. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1210\/en.2008-0981","article-title":"Early postnatal nutrition determines somatotropic function in mice","volume":"150","author":"Kappeler","year":"2009","journal-title":"Endocrinology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e0170083","DOI":"10.1371\/journal.pone.0170083","article-title":"IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice","volume":"12","author":"Decourtye","year":"2017","journal-title":"Plos One"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1056\/NEJM199702273360907","article-title":"Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors","volume":"336","year":"1997","journal-title":"New Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.ATV.0000105902.89459.09","article-title":"Expression, Regulation, and Function of IGF-1, IGF-1R, and IGF-1 Binding Proteins in Blood Vessels","volume":"24","author":"Delafontaine","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1178626419842176","DOI":"10.1177\/1178626419842176","article-title":"The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Nervous System","volume":"12","author":"Lewitt","year":"2019","journal-title":"Biochem. Insights"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"T187","DOI":"10.1530\/JME-18-0076","article-title":"40 YEARS of IGF1: Understanding the tissue-specific roles of IGF1\/IGF1R in regulating metabolism using the Cre\/loxP system","volume":"61","author":"Kineman","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"ref_38","first-page":"3","article-title":"Insulin-like growth factors and their binding proteins: Biological actions","volume":"16","author":"Jones","year":"1995","journal-title":"Endocr. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ding, H., and Wu, T. (2018). Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00499"},{"key":"ref_40","first-page":"1","article-title":"Structure, expression, and regulation of the IGF-I gene","volume":"343","author":"Adamo","year":"1993","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4248\/BR201303003","article-title":"Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development","volume":"1","author":"Wang","year":"2013","journal-title":"Bone Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/0306-4522(92)90193-6","article-title":"Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II","volume":"46","author":"Bondy","year":"1992","journal-title":"Neuroscience"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1460-9568.2006.05248.x","article-title":"Insulin-like growth factor I (IGF-I) and its receptor (IGF-1R) in the rat anterior pituitary","volume":"25","author":"Eppler","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"145","DOI":"10.6065\/apem.2017.22.3.145","article-title":"Effects of growth hormone on glucose metabolism and insulin resistance in human","volume":"22","author":"Kim","year":"2017","journal-title":"Ann. Pediatr Endocrinol Metab"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.tem.2020.04.005","article-title":"Insulin and Growth Hormone Balance: Implications for Obesity","volume":"31","author":"Huang","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2169\/internalmedicine.41.7","article-title":"Regulation of human growth hormone secretion and its disorders","volume":"41","author":"Kato","year":"2002","journal-title":"Intern. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-019-0036-y","article-title":"Targeting growth hormone function: Strategies and therapeutic applications","volume":"4","author":"Lu","year":"2019","journal-title":"Signal. Transduct Target."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Poudel, S.B., Dixit, M., Neginskaya, M., Nagaraj, K., Pavlov, E., Werner, H., and Yakar, S. (2020). Effects of GH\/IGF on the Aging Mitochondria. Cells, 9.","DOI":"10.3390\/cells9061384"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.beem.2010.08.010","article-title":"Acid-labile subunit (ALS) deficiency","volume":"25","author":"Hwa","year":"2011","journal-title":"Best Pr. Res. Clin. Endocrinol Metab"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molmet.2018.10.008","article-title":"The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes","volume":"19","author":"Haywood","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.metabol.2015.11.009","article-title":"Altered somatotroph feedback regulation improves metabolic efficiency and limits adipose deposition in male mice","volume":"65","author":"Romero","year":"2016","journal-title":"Metabolism"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"A52","DOI":"10.1210\/jendso\/bvab048.103","article-title":"Interrupted IGF-1 Feedback in GHRH Neurons and Somatotrophs Results in Impaired Weight Gain and Increased Energy Expenditure","volume":"5","author":"Aloqaily","year":"2021","journal-title":"J. Endocr. Soc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1210\/en.2019-00167","article-title":"GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity","volume":"160","author":"List","year":"2019","journal-title":"Endocrinology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"13215","DOI":"10.1073\/pnas.94.24.13215","article-title":"A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor\/binding protein gene (the Laron mouse)","volume":"94","author":"Zhou","year":"1997","journal-title":"Proc. Natl. Acad. Sci. United States Am."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1056\/NEJM200006013422203","article-title":"A preliminary study of growth hormone therapy for Crohn\u2019s disease","volume":"342","author":"Slonim","year":"2000","journal-title":"New Engl. J. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/mgme.2001.3164","article-title":"Growth hormone receptor\/binding protein (GHR\/BP) knockout mice: A 3-year update","volume":"73","author":"List","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1210\/er.2010-0009","article-title":"Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-\/-) mouse","volume":"32","author":"List","year":"2011","journal-title":"Endocr. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"E405","DOI":"10.1152\/ajpendo.00423.2003","article-title":"Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice","volume":"287","author":"Liu","year":"2004","journal-title":"Am. J. Physiology. Endocrinol. Metab."},{"key":"ref_59","first-page":"1","article-title":"Money for old mice. Competition seeks world\u2019s longest-lasting mouse","volume":"22","author":"Pilcher","year":"2003","journal-title":"Nat. News"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/235107a0","article-title":"Somatomedin: Proposed designation for sulphation factor","volume":"235","author":"Daughaday","year":"1972","journal-title":"Nature"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1073\/pnas.96.13.7324","article-title":"Normal growth and development in the absence of hepatic insulin-like growth factor I","volume":"96","author":"Yakar","year":"1999","journal-title":"Proc. Natl. Acad. Sci. United States Am."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ecl.2012.04.008","article-title":"Insulin-like growth factor 1 physiology: Lessons from mouse models","volume":"41","author":"Yakar","year":"2012","journal-title":"Endocrinol Metab Clin. North. Am."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.2337\/diabetes.50.5.1110","article-title":"Liver-Specific igf-1 Gene Deletion Leads to Muscle Insulin Insensitivity","volume":"50","author":"Yakar","year":"2001","journal-title":"Diabetes"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0531-5565(00)00172-8","article-title":"The network and the remodeling theories of aging: Historical background and new perspectives","volume":"35","author":"Franceschi","year":"2000","journal-title":"Exp. Gerontol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/366461a0","article-title":"A C. elegans mutant that lives twice as long as wild type","volume":"366","author":"Kenyon","year":"1993","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1126\/science.277.5328.942","article-title":"daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans","volume":"277","author":"Kimura","year":"1997","journal-title":"Science"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Kappeler, L., De Magalhaes Filho, C., Dupont, J., Leneuve, P., Cervera, P., P\u00e9rin, L., Loudes, C., Blaise, A., Klein, R., and Epelbaum, J. (2008). Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. Plos Biol, 6.","DOI":"10.1371\/journal.pbio.0060254"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ecl.2012.04.017","article-title":"Metabolic actions of insulin-like growth factor-I in normal physiology and diabetes","volume":"41","author":"Clemmons","year":"2012","journal-title":"Endocrinol Metab Clin. North. Am."},{"key":"ref_69","first-page":"77","article-title":"Role of insulin-like growth factor iin maintaining normal glucose homeostasis","volume":"62 Suppl 1","author":"Clemmons","year":"2004","journal-title":"Horm Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.2337\/db21-0028","article-title":"Modulation of Glucose Production by Central Insulin Requires IGF-1 Receptors in AgRP Neurons","volume":"70","author":"Quipildor","year":"2021","journal-title":"Diabetes"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1210\/endo.136.4.7895674","article-title":"A functional assessment of insulin\/insulin-like growth factor-I hybrid receptors","volume":"136","author":"Seely","year":"1995","journal-title":"Endocrinology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"13620","DOI":"10.1074\/jbc.M107771200","article-title":"Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture","volume":"277","author":"Sakai","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1042\/bj2850269","article-title":"Effects of insulin-like growth factor I on the rates of glucose transport and utilization in rat skeletal muscle in vitro","volume":"285","author":"Dimitriadis","year":"1992","journal-title":"Biochem. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.908001","article-title":"Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes","volume":"15","author":"Kim","year":"2001","journal-title":"Genes Dev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41387-017-0002-0","article-title":"Central IGF1 improves glucose tolerance and insulin sensitivity in mice","volume":"7","author":"Hong","year":"2017","journal-title":"Nutr. Diabetes"},{"key":"ref_76","unstructured":"Mahmood, T.A., Arulkumaran, S., and Chervenak, F.A. (2020). Chapter 1\u2014Worldwide epidemic of obesity. Obesity and Obstetrics, Elsevier. [2nd ed.]."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.3390\/ijms15046184","article-title":"Obesity and its metabolic complications: The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease","volume":"15","author":"Jung","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1091\/mbc.e15-10-0749","article-title":"Cell biology of fat storage","volume":"27","author":"Cohen","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/(SICI)1097-4644(1999)75:32+<59::AID-JCB8>3.0.CO;2-1","article-title":"Insights into the transcriptional control of adipocyte differentiation","volume":"75","author":"Morrison","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1210\/jc.2003-031682","article-title":"Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes","volume":"89","author":"Scavo","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0014-5793(86)80856-0","article-title":"Specific binding of human growth hormone but not insulin-like growth factors by human adipocytes","volume":"205","author":"DiGirolamo","year":"1986","journal-title":"Febs Lett."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2337\/db07-1538","article-title":"Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth","volume":"57","author":"Koch","year":"2008","journal-title":"Diabetes"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.2337\/db16-0212","article-title":"Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function","volume":"65","author":"Boucher","year":"2016","journal-title":"Diabetes"},{"key":"ref_84","first-page":"139","article-title":"Old age as a privilege of the \u201cselfish ones\u201d","volume":"1","author":"Davidovic","year":"2010","journal-title":"Aging Dis."},{"key":"ref_85","first-page":"72","article-title":"Modern Biological Theories of Aging","volume":"1","author":"Jin","year":"2010","journal-title":"Aging Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.beem.2017.02.005","article-title":"GH and ageing: Pitfalls and new insights","volume":"31","author":"Bartke","year":"2017","journal-title":"Best Pr. Res. Clin. Endocrinol Metab"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12979-016-0072-1","article-title":"The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila","volume":"13","author":"McCormack","year":"2016","journal-title":"Immun. Ageing"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1073\/pnas.15.9.733","article-title":"DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE","volume":"15","author":"Snell","year":"1929","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ghir.2008.05.005","article-title":"Role of the GH\/IGF-1 axis in lifespan and healthspan: Lessons from animal models","volume":"18","author":"Berryman","year":"2008","journal-title":"Growth Horm. Igf Res."},{"key":"ref_90","first-page":"147","article-title":"Insulin, IGF-1 and longevity","volume":"1","year":"2010","journal-title":"Aging Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrm2234","article-title":"Endocrine regulation of ageing","volume":"8","author":"Russell","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/35106646","article-title":"Extending the lifespan of long-lived mice","volume":"414","author":"Bartke","year":"2001","journal-title":"Nature"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1038\/s41467-018-04805-5","article-title":"Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice","volume":"9","author":"Mao","year":"2018","journal-title":"Nat. Commun."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/10\/2664\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:09:38Z","timestamp":1760166578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/10\/2664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":93,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["cells10102664"],"URL":"https:\/\/doi.org\/10.3390\/cells10102664","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,5]]}}}