{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:58:55Z","timestamp":1784912335371,"version":"3.55.0"},"reference-count":41,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T00:00:00Z","timestamp":1633824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["2020-4.1.1-TKP2020"],"award-info":[{"award-number":["2020-4.1.1-TKP2020"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["NKFIH K119529"],"award-info":[{"award-number":["NKFIH K119529"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["New National Excellence Program \u00daNKP-20-5"],"award-info":[{"award-number":["New National Excellence Program \u00daNKP-20-5"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009615","name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, P\u00e9csi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","award":["KA-2021-20"],"award-info":[{"award-number":["KA-2021-20"]}],"id":[{"id":"10.13039\/501100009615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["Janos Bolyai Research Scholarship - Matyas Meggyes"],"award-info":[{"award-number":["Janos Bolyai Research Scholarship - Matyas Meggyes"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>We investigated peripartum maternal red blood cell (RBC) properties in early-onset preeclampsia (PE). Repeated blood samples were taken prospectively for hemorheological measurements at PE diagnosis (n = 13) or during 26\u201334 weeks of gestation in healthy pregnancies (n = 24), then at delivery, and 72 h postpartum. RBC aggregation was characterized by M index (infrared light transmission between the aggregated RBCs in stasis) and aggregation index (AI\u2014laser backscattering from the RBC aggregates). We observed significantly elevated RBC aggregation (M index = 9.8 vs. 8.5; AI = 72.9% vs. 67.5%; p &lt; 0.001) and reduced RBC deformability in PE (p &lt; 0.05). A positive linear relationship was observed between AI and gestational age at birth in PE by regression analysis (R2 = 0.554; p = 0.006). ROC analysis of AI showed an AUC of 0.84 (0.68\u20130.99) (p = 0.001) for PE and indicated a cutoff of 69.4% (sensitivity = 83.3%; specificity = 62.5%), while M values showed an AUC of 0.75 (0.58\u20130.92) (p = 0.019) and indicated a cutoff of 8.39 (sensitivity = 90.9% and specificity = 50%). The predicted probabilities from the combination of AI and M variables showed increased AUC = 0.90 (0.79\u20131.00) (p &lt; 0.001). Our results established impaired microcirculation in early-onset PE manifesting as deteriorated maternal RBC properties. The longer the pathologic pregnancy persists, the more pronounced the maternal erythrocyte aggregation. AI and M index could help in the prognostication of early-onset PE, but further investigations are warranted to confirm the prognostic role before the onset of symptoms.<\/jats:p>","DOI":"10.3390\/cells10102714","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T21:19:32Z","timestamp":1633900772000},"page":"2714","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Peripartum Investigation of Red Blood Cell Properties in Women Diagnosed with Early-Onset Preeclampsia"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5537-9738","authenticated-orcid":false,"given":"Beata","family":"Csiszar","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Galos","sequence":"additional","affiliation":[{"name":"Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"1st Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Funke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora Kinga","family":"Kevey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-2024","authenticated-orcid":false,"given":"Matyas","family":"Meggyes","sequence":"additional","affiliation":[{"name":"Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Department of Medical Microbiology and Immunology, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1208-2969","authenticated-orcid":false,"given":"Laszlo","family":"Szereday","sequence":"additional","affiliation":[{"name":"Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Department of Medical Microbiology and Immunology, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kenyeres","sequence":"additional","affiliation":[{"name":"Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"1st Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0114-5231","authenticated-orcid":false,"given":"Kalman","family":"Toth","sequence":"additional","affiliation":[{"name":"Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"1st Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-4227","authenticated-orcid":false,"given":"Barbara","family":"Sandor","sequence":"additional","affiliation":[{"name":"Szent\u00e1gothai Research Centre, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"1st Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ajog.2005.10.813","article-title":"Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions?","volume":"194","author":"Villar","year":"2006","journal-title":"Am. 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