{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T06:46:45Z","timestamp":1794466005304,"version":"4.9.1"},"reference-count":246,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["EpoS"],"award-info":[{"award-number":["EpoS"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["LITMUS"],"award-info":[{"award-number":["LITMUS"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004434","name":"Universit\u00e0 degli Studi di Firenze","doi-asserted-by":"publisher","award":["Fondi Dipartimento"],"award-info":[{"award-number":["Fondi Dipartimento"]}],"id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation process consisting in altered deposition of extracellular matrix. Progression of fibrosis can lead to impaired liver architecture and function, resulting in cirrhosis and organ failure. Although fibrosis was previous thought to be an irreversible process, recent evidence convincingly demonstrated resolution of fibrosis in different organs when the cause of injury is removed. In the liver, due to its high regenerative ability, the extent of fibrosis regression and reversion to normal architecture is higher than in other tissues, even in advanced disease. The mechanisms of liver fibrosis resolution can be recapitulated in the following main points: removal of injurious factors causing chronic hepatic damage, elimination, or inactivation of myofibroblasts (through various cell fates, including apoptosis, senescence, and reprogramming), inactivation of inflammatory response and induction of anti-inflammatory\/restorative pathways, and degradation of extracellular matrix. In this review, we will discuss the major cellular and molecular mechanisms underlying the regression of fibrosis\/cirrhosis and the potential therapeutic approaches aimed at reversing the fibrogenic process.<\/jats:p>","DOI":"10.3390\/cells10102759","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T13:35:47Z","timestamp":1634304947000},"page":"2759","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":264,"title":["Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression"],"prefix":"10.3390","volume":"10","author":[{"given":"Alessandra","family":"Caligiuri","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50137 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7692-390X","authenticated-orcid":false,"given":"Alessandra","family":"Gentilini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50137 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Pastore","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50137 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-6508","authenticated-orcid":false,"given":"Stefano","family":"Gitto","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50137 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-0878","authenticated-orcid":false,"given":"Fabio","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50137 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.jhep.2004.12.008","article-title":"Fibrosis in chronic liver diseases: Diagnosis and management","volume":"42","author":"Pinzani","year":"2005","journal-title":"J. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"728","DOI":"10.21037\/atm-20-2948","article-title":"It\u2019s all about the spaces between cells: Role of extracellular matrix in liver fibrosis","volume":"9","author":"Khurana","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bpg.2017.04.005","article-title":"Reversal of liver fibrosis: From fiction to reality","volume":"31","author":"Zoubek","year":"2017","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2015.03.039","article-title":"Mechanisms of liver fibrosis resolution","volume":"63","author":"Tacke","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2018.06.003","article-title":"Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications","volume":"65","author":"Weiskirchen","year":"2019","journal-title":"Mol. Asp. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1172\/JCI93562","article-title":"The balancing act of the liver: Tissue regeneration versus fibrosis","volume":"128","author":"Huch","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1172\/JCI93563","article-title":"Resolution of organ fibrosis","volume":"128","author":"Jun","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/hep.29544","article-title":"Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis","volume":"67","author":"Krenkel","year":"2018","journal-title":"Hepatology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri.2017.90","article-title":"Type 2 immunity in tissue repair and fibrosis","volume":"18","author":"Gieseck","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.addr.2017.07.014","article-title":"The good and the bad collagens of fibrosis\u2014Their role in signaling and organ function","volume":"121","author":"Karsdal","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0140-6736(12)61425-1","article-title":"Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: A 5-year open-label follow-up study","volume":"381","author":"Marcellin","year":"2013","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/hep.25606","article-title":"A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis","volume":"56","author":"Aghemo","year":"2012","journal-title":"Hepatology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jhep.2017.11.012","article-title":"Determinants of fibrosis progression and regression in NASH","volume":"68","author":"Schuppan","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.1073\/pnas.1201840109","article-title":"Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis","volume":"109","author":"Kisseleva","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2012.06.036","article-title":"Deactivation of hepatic stellate cells during liver fibrosis resolution in mice","volume":"143","author":"Troeger","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"713754","DOI":"10.1155\/2014\/713754","article-title":"Genetic diseases that predispose to early liver cirrhosis","volume":"2014","author":"Scorza","year":"2014","journal-title":"Int. J. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"671640","DOI":"10.3389\/fphar.2021.671640","article-title":"Cellular mechanisms of liver fibrosis","volume":"12","author":"Acharya","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4254\/wjh.v7.i3.392","article-title":"Cirrhosis in children and adolescents: An overview","volume":"7","author":"Pinto","year":"2015","journal-title":"World J. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jhep.2020.04.003","article-title":"Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort","volume":"73","author":"Anstee","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3389\/fmed.2019.00304","article-title":"PNPLA3\u2014A potential therapeutic target for personalized treatment of chronic liver disease","volume":"6","author":"Dong","year":"2019","journal-title":"Front. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"37085","DOI":"10.1074\/jbc.M111.290114","article-title":"Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease","volume":"286","author":"Huang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Caligiuri, A., Gentilini, A., and Marra, F. (2016). Molecular pathogenesis of NASH. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17091575"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2174\/1566524016666161021163252","article-title":"Novel aspects in the pathogenesis of nonalcoholic steatohepatitis","volume":"16","author":"Gentilini","year":"2016","journal-title":"Curr. Mol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/hep.23812","article-title":"Patatin-like phospholipase domain-containing 3\/adiponutrin deficiency in mice is not associated with fatty liver disease","volume":"52","author":"Chen","year":"2010","journal-title":"Hepatology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1074\/jbc.M109.064501","article-title":"A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis","volume":"285","author":"He","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1002\/hep.30583","article-title":"PNPLA3, CGI-58, and inhibition of hepatic triglyceride hydrolysis in mice","volume":"69","author":"Wang","year":"2019","journal-title":"Hepatology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Murugesan, S., Goldberg, E.B., Dou, E., and Brown, W.J. (2013). Identification of diverse lipid droplet targeting motifs in the PNPLA family of triglyceride lipases. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064950"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/boc.201200036","article-title":"PNPLA3\/adiponutrin functions in lipid droplet formation","volume":"105","author":"Chamoun","year":"2013","journal-title":"Biol. Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/hep.29273","article-title":"The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation","volume":"66","author":"BasuRay","year":"2017","journal-title":"Hepatology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.1073\/pnas.1901974116","article-title":"Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis","volume":"116","author":"BasuRay","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/jcb.27378","article-title":"PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes","volume":"120","author":"Negoita","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/gut.45.1.134","article-title":"All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially","volume":"45","author":"Hellemans","year":"1999","journal-title":"Gut"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0003-9861(02)00058-9","article-title":"Regulation of the murine alpha(2)(I) collagen promoter by retinoic acid and retinoid X receptors","volume":"401","author":"Wang","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1002\/hep.29041","article-title":"The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells","volume":"65","author":"Bruschi","year":"2017","journal-title":"Hepatology"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"G\u00f6tze, S., Schumacher, E.C., Kordes, C., and H\u00e4ussinger, D. (2015). Epigenetic changes during hepatic stellate cell activation. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128745"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jhep.2006.03.016","article-title":"Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation","volume":"45","author":"Jiang","year":"2006","journal-title":"J. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2012.06.022","article-title":"DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats","volume":"264","author":"Bian","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"26729","DOI":"10.18632\/oncotarget.4925","article-title":"Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells","volume":"6","author":"Reiner","year":"2015","journal-title":"Oncotarget"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jhep.2015.11.024","article-title":"Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape","volume":"64","author":"Page","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nm.2893","article-title":"Multigenerational epigenetic adaptation of the hepatic wound-healing response","volume":"18","author":"Zeybel","year":"2012","journal-title":"Nat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/liv.12034","article-title":"A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-\u03b2 and vascular endothelial growth factor signalling","volume":"33","author":"Liu","year":"2013","journal-title":"Liver Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1111\/bph.12590","article-title":"A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells","volume":"171","author":"Park","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.bbamcr.2013.02.033","article-title":"Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases","volume":"1833","author":"Shaker","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"F996","DOI":"10.1152\/ajprenal.00282.2009","article-title":"Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy","volume":"297","author":"Pang","year":"2009","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1165\/rcmb.2011-0040OC","article-title":"Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis","volume":"46","author":"Davies","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1111\/acer.12172","article-title":"Binge ethanol-induced HDAC3 down-regulates Cpt1\u03b1 expression leading to hepatic steatosis and injury","volume":"37","author":"Kirpich","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_47","first-page":"919","article-title":"Sodium valproate blocks the transforming growth factor (TGF)-\u03b21 autocrine loop and attenuates the TGF-\u03b21-induced collagen synthesis in a human hepatic stellate cell line","volume":"28","author":"Watanabe","year":"2011","journal-title":"Int. J. Mol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1038\/s41598-018-22662-6","article-title":"Trichostatin A inhibits the activation of Hepatic stellate cells by Increasing C\/EBP-\u03b1 Acetylation in vivo and in vitro","volume":"8","author":"Ding","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1440-1746.2011.07002.x","article-title":"What\u2019s new in liver fibrosis? The origin of myofibroblasts in liver fibrosis","volume":"27","author":"Iwaisako","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"E3297","DOI":"10.1073\/pnas.1400062111","article-title":"Origin of myofibroblasts in the fibrotic liver in mice","volume":"111","author":"Iwaisako","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/hep.26053","article-title":"A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice","volume":"57","author":"Puche","year":"2013","journal-title":"Hepatology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","article-title":"Senescence of activated stellate cells limits liver fibrosis","volume":"134","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","article-title":"Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors","volume":"102","author":"Iredale","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.biopha.2012.10.002","article-title":"Clearance of activated stellate cells for hepatic fibrosis regression: Molecular basis and translational potential","volume":"67","author":"Kong","year":"2013","journal-title":"Biomed. Pharmacother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.yexcr.2017.02.038","article-title":"Modulation of hepatic stellate cells and reversibility of hepatic fibrosis","volume":"352","author":"Huang","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.jhep.2011.05.018","article-title":"The liver X receptor in hepatic stellate cells: A novel antifibrogenic target?","volume":"55","author":"Mallat","year":"2011","journal-title":"J. Hepatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s11658-019-0179-4","article-title":"Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2","volume":"24","author":"Ban","year":"2019","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.phytochem.2006.12.001","article-title":"Isozymes of plant hexokinase: Occurrence, properties and functions","volume":"68","author":"Claeyssen","year":"2007","journal-title":"Phytochemistry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fcell.2018.00150","article-title":"Role of metabolism in hepatic stellate cell activation and fibrogenesis","volume":"6","author":"Hou","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Li, J., Ghazwani, M., Liu, K., Huang, Y., Chang, N., Fan, J., He, F., Li, L., Bu, S., and Xie, W. (2017). Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182679"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1053\/j.gastro.2017.12.022","article-title":"Hedgehog-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells","volume":"154","author":"Du","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1535370219898141","article-title":"Mechanisms of liver fibrosis and its role in liver cancer","volume":"245","author":"Dhar","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1136\/gut.48.4.548","article-title":"Apoptosis of hepatic stellate cells: Involvement in resolution of biliary fibrosis and regulation by soluble growth factors","volume":"48","author":"Issa","year":"2001","journal-title":"Gut"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.28432","article-title":"Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells","volume":"64","author":"Oh","year":"2016","journal-title":"Hepatology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.cellsig.2009.05.008","article-title":"Down-regulation of FoxO-dependent c-FLIP expression mediates TRAIL-induced apoptosis in activated hepatic stellate cells","volume":"21","author":"Park","year":"2009","journal-title":"Cell. Signal."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3389\/fphar.2017.00980","article-title":"MicroRNA-145 increases the apoptosis of activated hepatic stellate cells induced by TRAIL through NF-\u03baB signaling pathway","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.bbrc.2016.01.083","article-title":"Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells","volume":"470","author":"Siegmund","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0199-6","article-title":"The role of the apoptosis-related protein BCL-B in the regulation of mitophagy in hepatic stellate cells during the regression of liver fibrosis","volume":"51","author":"Ding","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10238-016-0438-x","article-title":"Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: A putative synergy between retinoic acid and PPAR-gamma signalings","volume":"17","author":"Panebianco","year":"2017","journal-title":"Clin. Exp. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: When bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1101\/gad.1971610","article-title":"The essence of senescence","volume":"24","author":"Kuilman","year":"2010","journal-title":"Genes Dev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.201009094","article-title":"Four faces of cellular senescence","volume":"192","author":"Rodier","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1128\/MCB.00049-13","article-title":"Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts","volume":"33","author":"Kim","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"ref_75","first-page":"5700","article-title":"Interleukin-10 promotes primary rat hepatic stellate cell senescence by upregulating the expression levels of p53 and p21","volume":"17","author":"Huang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_76","first-page":"5449","article-title":"IL-22 inactivates hepatic stellate cells via downregulation of the TGF-\u03b21\/Notch signaling pathway","volume":"17","author":"Chen","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.3892\/mmr.2014.3048","article-title":"Celecoxib derivative OSU-03012 inhibits the proliferation and activation of hepatic stellate cells by inducing cell senescence","volume":"11","author":"Zhang","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejphar.2014.10.055","article-title":"Curcumin regulates peroxisome proliferator-activated receptor-\u03b3 coactivator-1\u03b1 expression by AMPK pathway in hepatic stellate cells in vitro","volume":"746","author":"Zhai","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1111\/j.1440-1746.2006.04584.x","article-title":"Hepatic stellate cells and the reversal of fibrosis","volume":"21","author":"Kisseleva","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1189\/JLB.0309135","article-title":"Liver natural killer and natural killer T cells: Immunobiology and emerging roles in liver diseases","volume":"86","author":"Gao","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3181\/0707-MR-190","article-title":"Mechanisms of fibrogenesis","volume":"233","author":"Kisseleva","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1002\/hep.27392","article-title":"IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice","volume":"60","author":"Mitra","year":"2014","journal-title":"Hepatology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1053\/j.gastro.2005.10.055","article-title":"Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners","volume":"130","author":"Radaeva","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/JLB.2A0118-031RR","article-title":"Activated NK cells kill hepatic stellate cells via p38\/PI3K signaling in a TRAIL-involved degranulation manner","volume":"105","author":"Li","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/labinvest.2012.54","article-title":"NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner","volume":"92","author":"Eisenhardt","year":"2012","journal-title":"Lab. Investig."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.bbadis.2012.09.008","article-title":"Natural killer and natural killer T cells in liver fibrosis","volume":"1832","author":"Gao","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/hep.24190","article-title":"Suppression of innate immunity (natural killer cell\/interferon-\u03b3) in the advanced stages of liver fibrosis in mice","volume":"53","author":"Jeong","year":"2011","journal-title":"Hepatology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: Therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.25744","article-title":"Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3389\/fimmu.2019.00477","article-title":"\u03b3\u03b4T Cells suppress liver fibrosis via strong cytolysis and enhanced NK cell-mediated cytotoxicity against hepatic stellate cells","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1002\/hep.29636","article-title":"B lymphocytes limit senescence-driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury","volume":"67","author":"Faggioli","year":"2018","journal-title":"Hepatology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.stem.2016.01.010","article-title":"Direct reprogramming of hepatic myofibroblasts into hepatocytes in vivo attenuates liver fibrosis","volume":"18","author":"Song","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/hep.30965","article-title":"A deactivation factor of fibrogenic hepatic stellate cells induces regression of liver fibrosis in mice","volume":"71","author":"Nakano","year":"2020","journal-title":"Hepatology"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1074\/jbc.M410078200","article-title":"Adipogenic transcriptional regulation of hepatic stellate cells","volume":"280","author":"She","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13069-015-0031-z","article-title":"In vitro reversion of activated primary human hepatic stellate cells","volume":"8","author":"Najimi","year":"2015","journal-title":"Fibrogenesis Tissue Repair"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1039\/C6IB00027D","article-title":"Gradually softening hydrogels for modeling hepatic stellate cell behavior during fibrosis regression","volume":"8","author":"Caliari","year":"2016","journal-title":"Integr. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1053\/j.gastro.2018.02.015","article-title":"P300 Acetyltransferase mediates stiffness-induced activation of hepatic stellate cells into tumor-promoting myofibroblasts","volume":"154","author":"Dou","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.31151","article-title":"Taming the savage breast from within: Transcription factor 21, a regulator of stellate cell deactivation","volume":"71","author":"Wang","year":"2020","journal-title":"Hepatology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/01.LAB.0000069036.63405.5C","article-title":"Apoptotic body engulfment by a human stellate cell line is profibrogenic","volume":"83","author":"Canbay","year":"2003","journal-title":"Lab. Investig."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1053\/jhep.2003.50472","article-title":"Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression","volume":"38","author":"Canbay","year":"2003","journal-title":"Hepatology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/hep.21093","article-title":"Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo","volume":"43","author":"Zhan","year":"2006","journal-title":"Hepatology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1053\/j.gastro.2012.09.008","article-title":"Sterile inflammation in the liver","volume":"143","author":"Kubes","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2013.07.018","article-title":"Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis","volume":"39","author":"McHedlidze","year":"2013","journal-title":"Immunity"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat. Med."},{"key":"ref_106","first-page":"G269","article-title":"Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells","volume":"275","author":"Hellerbrand","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/j.gastro.2014.06.043","article-title":"Roles for chemokines in liver disease","volume":"147","author":"Marra","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_111","first-page":"187","article-title":"Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11357-007-9043-y","article-title":"Neutrophil depletion delays wound repair in aged mice","volume":"30","author":"Nishio","year":"2008","journal-title":"Age"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/annrheumdis-2015-207338","article-title":"Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome","volume":"75","author":"Cumpelik","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI122258","article-title":"Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223","volume":"129","author":"Calvente","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1053\/j.gastro.2014.01.018","article-title":"A histologic scoring system for prognosis of patients with alcoholic hepatitis","volume":"146","author":"Altamirano","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.celrep.2019.10.024","article-title":"Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis","volume":"29","author":"Dobie","year":"2019","journal-title":"Cell Rep."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/sji.12468","article-title":"Macrophage phenotype in liver injury and repair","volume":"85","author":"Sun","year":"2016","journal-title":"Scand. J. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yexcr.2015.10.017","article-title":"Differential gene expression in human, murine, and cell line-derived macrophages upon polarization","volume":"347","author":"Spiller","year":"2016","journal-title":"Exp. Cell. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Roohani, S., and Tacke, F. (2021). Liver injury and the macrophage issue: Molecular and mechanistic facts and their clinical relevance. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147249"},{"key":"ref_123","first-page":"935","article-title":"Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia\/reperfusion injury","volume":"41","author":"Song","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","author":"Ramachandran","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fphys.2012.00056","article-title":"Functional role of monocytes and macrophages for the inflammatory response in acute liver injury","volume":"3","author":"Zimmermann","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/gutjnl-2011-300304","article-title":"Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury","volume":"61","author":"Baeck","year":"2012","journal-title":"Gut"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1053\/j.gastro.2014.01.061","article-title":"Vascular endothelial growth factor promotes fibrosis resolution and repair in mice","volume":"146","author":"Yang","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ebiom.2018.01.028","article-title":"IL-4 receptor alpha signaling through macrophages differentially regulates liver fibrosis progression and reversal","volume":"29","author":"Weng","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-85148-y","article-title":"Patterns of dendritic cell and monocyte subsets are associated with disease severity and mortality in liver cirrhosis patients","volume":"11","author":"Cardoso","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/cyto.b.21530","article-title":"Monocytes and macrophages in flow cytometry","volume":"92","author":"Lambert","year":"2017","journal-title":"Cytom. Part B Clin. Cytom."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"661182","DOI":"10.3389\/fimmu.2021.661182","article-title":"Macrophages in chronic liver failure: Diversity, plasticity and therapeutic targeting","volume":"12","author":"Singanayagam","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.4049\/jimmunol.178.8.5288","article-title":"Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis","volume":"178","author":"Fallowfield","year":"2007","journal-title":"J. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1189\/jlb.3A0614-280R","article-title":"Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis","volume":"97","author":"Barnes","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.7150\/ijbs.25589","article-title":"Kupffer-derived matrix metalloproteinase-9 contributes to liver fibrosis resolution","volume":"14","author":"Feng","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1056\/NEJM200102083440604","article-title":"Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct","volume":"344","author":"Hammel","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jhep.2004.03.007","article-title":"Cirrhosis reversal: A duel between dogma and myth","volume":"40","author":"Desmet","year":"2004","journal-title":"J. Hepatol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1053\/gast.2003.50013","article-title":"Histological outcome during long-term lamivudine therapy","volume":"124","author":"Dienstag","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_139","first-page":"101","article-title":"Liver regeneration","volume":"93","author":"Michalopoulos","year":"2005","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: Biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/hep.25567","article-title":"Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis","volume":"55","author":"Pellicoro","year":"2012","journal-title":"Hepatology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.5858\/2000-124-1599-ROHC","article-title":"Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis","volume":"124","author":"Wanless","year":"2000","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1042\/CS20171370","article-title":"Extrahepatic angiogenesis hinders recovery of portal hypertension and collaterals in rats with cirrhosis resolution","volume":"132","author":"Hsu","year":"2018","journal-title":"Clin. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.jhep.2020.08.006","article-title":"Hepatic benefits of HCV cure","volume":"73","author":"Calvaruso","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/j.jhep.2016.07.039","article-title":"Reversion of disease manifestations after HCV eradication","volume":"65","author":"Berenguer","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/liv.13193","article-title":"Impact of viral eradication with sofosbuvir-based therapy on the outcome of post-transplant hepatitis C with severe fibrosis","volume":"37","author":"Martini","year":"2016","journal-title":"Liver Int."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1177\/2050640618786067","article-title":"Long-term changes in liver elasticity in hepatitis C virus-infected patients with sustained virologic response after treatment with direct-acting antivirals","volume":"6","author":"Pietsch","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_148","first-page":"737","article-title":"Reversibility of liver fibrosis","volume":"9","author":"Brenner","year":"2013","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/jvh.12578","article-title":"Regression of fibrosis and portal hypertension in HCV-associated cirrhosis and sustained virologic response after interferon-free antiviral therapy","volume":"23","author":"Knop","year":"2016","journal-title":"J. Viral Hepat."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jhep.2016.05.027","article-title":"Sustained virologic response to interferon-free therapies ameliorates HCV-induced portal hypertension","volume":"65","author":"Mandorfer","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1053\/gast.2002.35352","article-title":"Determinants of early mortality in patients with decompensated chronic hepatitis B treated with antiviral therapy","volume":"123","author":"Fontana","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"153","DOI":"10.7326\/0003-4819-150-3-200902030-00004","article-title":"Immediate listing for liver transplantation versus standard care for Child-Pugh stage B alcoholic cirrhosis: A randomized trial","volume":"150","author":"Vanlemmens","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/TP.0000000000001633","article-title":"Disease reversibility in patients with post-hepatitis C cirrhosis: Is the point of no return the same before and after liver transplantation? A review","volume":"101","author":"Vinaixa","year":"2017","journal-title":"Transplantation"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1053\/j.gastro.2004.09.014","article-title":"Hepatocellular carcinoma in cirrhosis: Incidence and risk factors","volume":"127","author":"Fattovich","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.3748\/wjg.v24.i39.4436","article-title":"Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer","volume":"24","author":"Sagar","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-pathol-052016-100322","article-title":"The role of cancer-associated fibroblasts and fibrosis in liver cancer","volume":"12","author":"Affo","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Baglieri, J., Brenner, D.A., and Kisseleva, T. (2019). The role of fibrosis and liver-associated fibroblasts in the pathogenesis of hepatocellular carcinoma. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071723"},{"key":"ref_158","first-page":"1","article-title":"No evidence for higher rates of hepatocellular carcinoma after direct-acting antiviral treatment: A meta-analysis","volume":"5","author":"Rutledge","year":"2019","journal-title":"Hepatoma Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/hep.31060","article-title":"G Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection","volume":"71","author":"Ghany","year":"2019","journal-title":"Hepatology"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/hep.29911","article-title":"Liver angiopoietin-2 is a key predictor of de novo or recurrent hepatocellular cancer after hepatitis C virus direct-acting antivirals","volume":"68","author":"Faillaci","year":"2018","journal-title":"Hepatology"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1053\/j.gastro.2018.07.015","article-title":"Incidence of hepatocellular carcinoma after direct antiviral therapy for HCV in patients with cirrhosis included in surveillance programs","volume":"155","author":"Nahon","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Villani, R., Facciorusso, A., Bellanti, F., Tamborra, R., Piscazzi, A., Landriscina, M., Vendemiale, G., and Serviddio, G. (2016). DAAs rapidly reduce inflammation but increase serum VEGF level: A rationale for tumor risk during anti-HCV treatment. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167934"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.dld.2018.09.016","article-title":"Immune inflammation indicators and ALBI score to predict liver cancer in HCV-patients treated with direct-acting antivirals","volume":"51","author":"Gardini","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1002\/hep.27635","article-title":"Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis","volume":"61","author":"Castells","year":"2015","journal-title":"Hepatology"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1053\/j.gastro.2011.12.017","article-title":"Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats","volume":"142","author":"Xie","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1053\/j.gastro.2010.11.053","article-title":"Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease","volume":"140","author":"Beaven","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/01.shk.0000191377.78144.d9","article-title":"Activation of the liver X receptor protects against hepatic injury in endotoxemia by suppressing Kupffer cell activation","volume":"25","author":"Wang","year":"2006","journal-title":"Shock"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"166235","DOI":"10.1016\/j.bbadis.2021.166235","article-title":"Nuclear receptors in liver fibrosis","volume":"1867","author":"Brusilovskaya","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"21309","DOI":"10.1038\/srep21309","article-title":"Liver X receptor \u03b1 is essential for the capillarization of liver sinusoidal endothelial cells in liver injury","volume":"6","author":"Xing","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0187-x","article-title":"Altered AKAP12 expression in portal fibroblasts and liver sinusoids mediates transition from hepatic fibrogenesis to fibrosis resolution","volume":"50","author":"Lee","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.cell.2019.07.021","article-title":"LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis","volume":"178","author":"Xu","year":"2019","journal-title":"Cell"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.antiviral.2014.03.012","article-title":"Reversal, maintenance or progression: What happens to the liver after a virologic cure of hepatitis C?","volume":"107","author":"Lee","year":"2014","journal-title":"Antivir. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3904\/kjim.2016.268","article-title":"Reversal of liver cirrhosis: Current evidence and expectations","volume":"32","author":"Jung","year":"2017","journal-title":"Korean J. Intern. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jhep.2018.12.003","article-title":"Fibrosis and alcohol-related liver disease","volume":"70","author":"Lackner","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/gutjnl-2016-312473","article-title":"Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal","volume":"66","author":"Ikenaga","year":"2017","journal-title":"Gut"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1053\/j.gastro.2018.07.006","article-title":"Simtuzumab is ineffective for patients with bridging fibrosis or compensated cirrhosis caused by nonalcoholic steatohepatitis","volume":"155","author":"Harrison","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/hep.30309","article-title":"Is this the last requiem for simtuzumab?","volume":"69","author":"Fickert","year":"2019","journal-title":"Hepatology"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nbt1396","article-title":"Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone","volume":"26","author":"Sato","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0223-5234(00)00179-3","article-title":"Phosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologies","volume":"35","author":"Piaz","year":"2000","journal-title":"Eur. J. Med. Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"L636","DOI":"10.1152\/ajplung.00158.2011","article-title":"Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts","volume":"301","author":"Stumm","year":"2011","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1476-5381.2012.01847.x","article-title":"cAMP and Epac in the regulation of tissue fibrosis","volume":"166","author":"Insel","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1182\/blood.V91.8.2645.2645_2645_2657","article-title":"Integrin signaling: The platelet paradigm","volume":"91","author":"Shattil","year":"1998","journal-title":"Blood"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1001\/archinte.159.17.2041","article-title":"A new pharmacological treatment for intermittent claudication: Results of a randomized, multicenter trial","volume":"159","author":"Beebe","year":"1999","journal-title":"Arch. Intern. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1517\/14656566.9.15.2683","article-title":"Cilostazol and peripheral arterial disease","volume":"9","author":"Pearce","year":"2008","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1055\/s-2004-833480","article-title":"Platelet cyclic adenosine monophosphate phosphodiesterases: Targets for regulating platelet-related thrombosis","volume":"30","author":"Colman","year":"2004","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1161\/01.ATV.18.12.1942","article-title":"Effect of the novel antiplatelet agent cilostazol on plasma lipoproteins in patients with intermittent claudication","volume":"18","author":"Elam","year":"1998","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Chancharoenthana, W., Leelahavanichkul, A., Taratummarat, S., Wongphom, J., Tiranathanagul, K., and Eiam-Ong, S. (2017). Cilostazol attenuates intimal hyperplasia in a mouse model of chronic kidney disease. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187872"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Kherallah, R.Y., Khawaja, M., Olson, M., Angiolillo, D., and Birnbaum, Y. (2021). Cilostazol: A review of basic mechanisms and clinical uses. Cardiovasc. Drugs Ther.","DOI":"10.1007\/s10557-021-07187-x"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1136\/gut.2007.144550","article-title":"Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease","volume":"57","author":"Fujita","year":"2008","journal-title":"Gut"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/hepr.12140","article-title":"Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride-induced liver fibrosis","volume":"44","author":"Saito","year":"2013","journal-title":"Hepatol. Res."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"El Awdan, S.A., Rahman, R.F.A., Ibrahim, H.M., Hegazy, R.R., El Marasy, S.A., Badawi, M., and Arbid, M.S. (2019). Regression of fibrosis by cilostazol in a rat model of thioacetamide-induced liver fibrosis: Up regulation of hepatic cAMP, and modulation of inflammatory, oxidative stress and apoptotic biomarkers. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0216301"},{"key":"ref_192","first-page":"2381","article-title":"Cilostazol protects rats against alcohol-induced hepatic fibrosis via suppression of TGF-\u03b21\/CTGF activation and the cAMP\/Epac1 pathway","volume":"17","author":"Han","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1056\/NEJM199111213252103","article-title":"Effect of oral milrinone on mortality in severe chronic heart failure","volume":"325","author":"Packer","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"e000068","DOI":"10.1136\/openhrt-2014-000068","article-title":"Efficacy of cilostazol on platelet reactivity and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: Insights from a meta-analysis of randomised trials","volume":"1","author":"Bangalore","year":"2014","journal-title":"Open Heart"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ijcard.2012.09.007","article-title":"Adverse effects of cilostazol on left ventricular function in a patient with a sigmoid shaped interventricular septum","volume":"165","author":"Umazume","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jhep.2016.04.018","article-title":"Sinusoidal communication in liver fibrosis and regeneration","volume":"65","author":"Marrone","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0168-8278(01)00146-5","article-title":"Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis","volume":"35","author":"Paizis","year":"2001","journal-title":"J. Hepatol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0016-5085(03)00695-4","article-title":"Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II","volume":"125","author":"Bataller","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1470320316628717","DOI":"10.1177\/1470320316628717","article-title":"Therapeutic effect of renin angiotensin system inhibitors on liver fibrosis","volume":"17","author":"Zhu","year":"2016","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jss.2009.10.033","article-title":"\u03b2-catenin regulates mesenchymal progenitor cell differentiation during hepatogenesis","volume":"164","author":"Berg","year":"2010","journal-title":"J. Surg. Res."},{"key":"ref_201","first-page":"G39","article-title":"Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis","volume":"294","author":"Cheng","year":"2008","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbrc.2007.12.085","article-title":"Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells","volume":"367","author":"Kordes","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41598-017-00282-w","article-title":"Selective inhibitor of Wnt\/\u03b2-catenin\/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model","volume":"7","author":"Tokunaga","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/hep4.1158","article-title":"Tumor necrosis factor-\u03b1-mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice","volume":"2","author":"Osawa","year":"2018","journal-title":"Hepatol. Commun."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.csbj.2021.04.029","article-title":"Farnesoid X receptor (FXR): Structures and ligands","volume":"19","author":"Jiang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1016\/j.febslet.2006.07.082","article-title":"Nuclear bile acid receptor FXR as pharmacological target: Are we there yet?","volume":"580","author":"Modica","year":"2006","journal-title":"FEBS Lett."},{"key":"ref_207","first-page":"39","article-title":"Liver fibrosis in the context of nonalcoholic steatohepatitis: The role of adipokines","volume":"64","author":"Pastore","year":"2018","journal-title":"Minerva Gastroenterol. Dietol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1053\/j.gastro.2004.08.001","article-title":"The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis","volume":"127","author":"Fiorucci","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"e005","DOI":"10.1621\/nrs.08005","article-title":"Deciphering the nuclear bile acid receptor FXR paradigm","volume":"8","author":"Modica","year":"2010","journal-title":"Nucl. Recept. Signal."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/hep.22519","article-title":"Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response","volume":"48","author":"Wang","year":"2008","journal-title":"Hepatology"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","article-title":"Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial","volume":"385","author":"Loomba","year":"2015","journal-title":"Lancet"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/S0140-6736(19)33041-7","article-title":"Obeticholic acid for the treatment of non-alcoholic steatohepatitis: Interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial","volume":"394","author":"Younossi","year":"2019","journal-title":"Lancet"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41575-018-0065-y","article-title":"Apoptosis and necroptosis in the liver: A matter of life and death","volume":"15","author":"Schwabe","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hep4.1360","article-title":"Emricasan ameliorates portal hypertension and liver fibrosis in cirrhotic rats through a hepatocyte-mediated paracrine mechanism","volume":"3","author":"Manicardi","year":"2019","journal-title":"Hepatol. Commun."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jhep.2019.11.024","article-title":"A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis","volume":"72","author":"Harrison","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jhep.2019.12.010","article-title":"Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension","volume":"72","author":"Bosch","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4062\/biomolther.2020.016","article-title":"Selonsertib inhibits liver fibrosis via downregulation of ASK1\/ MAPK pathway of hepatic stellate cells","volume":"28","author":"Yoon","year":"2020","journal-title":"Biomol. Ther."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/hep.29514","article-title":"The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial","volume":"67","author":"Loomba","year":"2018","journal-title":"Hepatology"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jhep.2020.02.027","article-title":"Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials","volume":"73","author":"Harrison","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.3389\/fimmu.2019.02852","article-title":"Therapeutic targeting of hepatic macrophages for the treatment of liver diseases","volume":"10","author":"Weiskirchen","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"304","DOI":"10.14218\/JCTH.2020.00023","article-title":"Antihepatic fibrosis drugs in clinical trials","volume":"8","author":"Guo","year":"2020","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Traber, P.G., Chou, H., Zomer, E., Hong, F., Klyosov, A., Fiel, M.I., and Friedman, S.L. (2013). Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075361"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/apt.13816","article-title":"Randomised clinical study: GR-MD-02, a galectin-3 inhibitor, vs. placebo in patients having non-alcoholic steatohepatitis with advanced fibrosis","volume":"44","author":"Harrison","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1053\/j.gastro.2019.11.296","article-title":"Effects of belapectin, an inhibitor of galectin-3, in patients with nonalcoholic steatohepatitis with cirrhosis and portal hypertension","volume":"158","author":"Chalasani","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.3389\/fimmu.2018.02948","article-title":"The role of monocytes and macrophages in acute and acute-on-chronic liver failure","volume":"9","author":"Triantafyllou","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fimmu.2020.00218","article-title":"Targeting of hepatic macrophages by therapeutic nanoparticles","volume":"11","author":"Colino","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/hep4.1290","article-title":"Combatting fibrosis: Exosome-based therapies in the regression of liver fibrosis","volume":"3","author":"Chen","year":"2018","journal-title":"Hepatol. Commun."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1681\/ASN.2012101031","article-title":"TGF-\u03b21-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis","volume":"24","author":"Borges","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/jcmm.12730","article-title":"Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2","volume":"20","author":"Gremmels","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.surg.2014.04.014","article-title":"Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver","volume":"156","author":"Charrier","year":"2014","journal-title":"Surgery"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3389\/fphar.2017.00748","article-title":"The human amnion epithelial cell secretome decreases hepatic fibrosis in mice with chronic liver fibrosis","volume":"8","author":"Alhomrani","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"14135","DOI":"10.1038\/srep14135","article-title":"MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells","volume":"5","author":"Hyun","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jhep.2012.11.011","article-title":"miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression","volume":"58","author":"Li","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"e346","DOI":"10.1038\/emm.2017.63","article-title":"Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases","volume":"49","author":"Lou","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1111\/jcmm.14115","article-title":"Strategies to improve the efficiency of mesenchymal stem cell transplantation for reversal of liver fibrosis","volume":"23","author":"Hu","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"8616","DOI":"10.1038\/srep08616","article-title":"Tonsil-derived mesenchymal stem cells ameliorate CCl4-induced liver fibrosis in mice via autophagy activation","volume":"5","author":"Park","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.3748\/wjg.v23.i46.8152","article-title":"In vivo hepatic differentiation potential of human umbilical cord-derived mesenchymal stem cells: Therapeutic effect on liver fibrosis\/cirrhosis","volume":"23","author":"Zhang","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Pinheiro, D., Dias, I., Ribeiro Silva, K., Stumbo, A.C., Thole, A., Cortez, E., De Carvalho, L., Weiskirchen, R., and Carvalho, S. (2019). Mechanisms underlying cell therapy in liver fibrosis: An overview. Cells, 8.","DOI":"10.3390\/cells8111339"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1111\/jgh.12653","article-title":"Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: Regulation of Treg\/Th17 cells","volume":"29","author":"Xu","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1440-1746.2011.07024.x","article-title":"Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients","volume":"27","author":"Zhang","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/jgh.14081","article-title":"A study about immunomodulatory effect and efficacy and prognosis of human umbilical cord mesenchymal stem cells in patients with chronic hepatitis B-induced decompensated liver cirrhosis","volume":"33","author":"Fang","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1002\/hep.28693","article-title":"Transplantation with autologous bone marrow-derived mesenchymal stem cells for alcoholic cirrhosis: Phase 2 trial","volume":"64","author":"Suk","year":"2016","journal-title":"Hepatology"},{"key":"ref_243","first-page":"G949","article-title":"Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration","volume":"285","author":"Schwabe","year":"2003","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"ref_244","first-page":"1858","article-title":"CCR1 and CCR5 promote hepatic fibrosis in mice","volume":"119","author":"Seki","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Lefebvre, E., Moyle, G., Reshef, R., Richman, L.P., Thompson, M., Hong, F., Chou, H.L., Hashiguchi, T., Plato, C., and Poulin, D. (2016). Antifibrotic effects of the dual CCR2\/CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158156"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/hep.29477","article-title":"A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis","volume":"67","author":"Friedman","year":"2018","journal-title":"Hepatology"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/10\/2759\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:15:06Z","timestamp":1760166906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/10\/2759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":246,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["cells10102759"],"URL":"https:\/\/doi.org\/10.3390\/cells10102759","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,15]]}}}