{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:44:38Z","timestamp":1790750678928,"version":"4.1.0"},"reference-count":132,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Cerebral stroke, traumatic brain injury, and hypoxic ischemic encephalopathy are among the most frequently occurring brain injuries. A complex pathogenesis, characterized by a synergistic interaction between alterations of the cerebrovascular system, cell death, and inflammation, is at the basis of the brain damage that leads to behavioral and neurodevelopmental disabilities in affected subjects. Sildenafil is a selective inhibitor of the enzyme phosphodiesterase 5 (PDE5) that is able to cross the blood\u2013brain barrier. Preclinical data suggest that sildenafil may be a good candidate for the prevention or repair of brain injury in both adults and neonates. The aim of this review is to summarize the evidence supporting the neuroprotective action of sildenafil and discuss the possible benefits of the association of sildenafil with current therapeutic strategies.<\/jats:p>","DOI":"10.3390\/cells10102766","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T13:35:47Z","timestamp":1634304947000},"page":"2766","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Sildenafil-Mediated Neuroprotection from Adult to Neonatal Brain Injury: Evidence, Mechanisms, and Future Translation"],"prefix":"10.3390","volume":"10","author":[{"given":"Manuela","family":"Zinni","sequence":"first","affiliation":[{"name":"Inserm UMR1141 NeuroDiderot, Universit\u00e9 de Paris, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Pansiot","sequence":"additional","affiliation":[{"name":"Inserm UMR1141 NeuroDiderot, Universit\u00e9 de Paris, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Louis","family":"L\u00e9ger","sequence":"additional","affiliation":[{"name":"Pediatric and Neonatal Intensive Care Unit, Armand-Trousseau University Hospital, Assistance Publique-H\u00f4pitaux de Paris, Sorbonne University, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"El Kamouh","sequence":"additional","affiliation":[{"name":"Inserm UMR1141 NeuroDiderot, Universit\u00e9 de Paris, 75019 Paris, France"},{"name":"Laboratoire de Physiologie et G\u00e9nomique des Poissons-INRAE, 35700 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Baud","sequence":"additional","affiliation":[{"name":"Laboratory of Child Growth and Development, University of Geneva, 1211 Geneva, Switzerland"},{"name":"Division of Neonatology and Pediatric Intensive Care, Children\u2019s University Hospital of Geneva, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1474-4422(18)30415-0","article-title":"Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"James","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/pch\/pxy194","article-title":"Epidemiology of neonatal stroke: A population-based study","volume":"25","author":"Clive","year":"2019","journal-title":"Paediatr. 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