{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:13:36Z","timestamp":1792113216282,"version":"4.4.0"},"reference-count":193,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:00:00Z","timestamp":1634428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF\/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment\u2019s role in MF\/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF\/SS pathogenesis and progression, opening up new therapeutic avenues.<\/jats:p>","DOI":"10.3390\/cells10102780","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T23:13:32Z","timestamp":1634512412000},"page":"2780","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Microenvironment\u2019s Role in Mycosis Fungoides and S\u00e9zary Syndrome: From Progression to Therapeutic Implications"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-7171","authenticated-orcid":false,"given":"Alessandro","family":"Pileri","sequence":"first","affiliation":[{"name":"Dermatology, IRCCS, S. Orsola-Malpighi Polyclinic, 40100 Bologna, Italy"},{"name":"Department of Specialistic, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, University of Bologna, 40100 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Guglielmo","sequence":"additional","affiliation":[{"name":"Dermatology, IRCCS, S. Orsola-Malpighi Polyclinic, 40100 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vieri","family":"Grandi","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences, University of Florence, 20019 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-1035","authenticated-orcid":false,"given":"Silvia Alberti","family":"Violetti","sequence":"additional","affiliation":[{"name":"UOC Dermatologia, Fondazione Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Fanoni","sequence":"additional","affiliation":[{"name":"UOC Dermatologia, Fondazione Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Fava","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic, University of Turin Medical School, 10092 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Agostinelli","sequence":"additional","affiliation":[{"name":"Department of Specialistic, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, University of Bologna, 40100 Bologna, Italy"},{"name":"Hematopathology, IRCCS, S. Orsola-Malpighi Polyclinic, 40100 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Berti","sequence":"additional","affiliation":[{"name":"UOC Dermatologia, Fondazione Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Quaglino","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic, University of Turin Medical School, 10092 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Pimpinelli","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences, University of Florence, 20019 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1182\/blood-2008-10-184168","article-title":"Cutaneous Lymphoma Incidence Patterns in the United States: A Population-Based Study of 3884 Cases","volume":"113","author":"Bradford","year":"2009","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/2013.jamadermatol.541","article-title":"Topical Chemotherapy in Cutaneous T-Cell Lymphoma: Positive Results of a Randomized, Controlled, Multi-Center Trial Testing the Efficacy and Safety of a Novel 0.02% Mechlorethamine Gel in Mycosis Fungoides","volume":"149","author":"Lessin","year":"2013","journal-title":"JAMA Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1093\/annonc\/mdx352","article-title":"Global Patterns of Care in Advanced Stage Mycosis Fungoides\/Sezary Syndrome: A Multicenter Retrospective Follow-up Study from the Cutaneous Lymphoma International Consortium","volume":"28","author":"Quaglino","year":"2017","journal-title":"Ann. 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