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As such, they regulate a wide range of both cellular and physiological processes. In this review, we will summarize recent work on the role of Rho GTPase-regulated pathways in skeletal muscle development, regeneration, tissue mass homeostatic balance, and metabolism. In addition, we will present current evidence that links the dysregulation of these GTPases with diseases caused by skeletal muscle dysfunction. Overall, this information underscores the critical role of a number of members of the Rho GTPase subfamily in muscle development and the overall metabolic balance of mammalian species.<\/jats:p>","DOI":"10.3390\/cells10112984","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T12:39:42Z","timestamp":1635856782000},"page":"2984","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Rho GTPases in Skeletal Muscle Development and Homeostasis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-2969","authenticated-orcid":false,"given":"Sonia","family":"Rodr\u00edguez-Fdez","sequence":"first","affiliation":[{"name":"Molecular Mechanisms of Cancer Program, Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-University of Salamanca, 37007 Salamanca, Spain"},{"name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-University of Salamanca, 37007 Salamanca, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), CSIC-University of Salamanca, 37007 Salamanca, Spain"},{"name":"Wellcome-MRC Institute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge CB2 0QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9398-6072","authenticated-orcid":false,"given":"Xos\u00e9 R.","family":"Bustelo","sequence":"additional","affiliation":[{"name":"Molecular Mechanisms of Cancer Program, Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-University of Salamanca, 37007 Salamanca, Spain"},{"name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-University of Salamanca, 37007 Salamanca, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), CSIC-University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI88880","article-title":"Skeletal muscle inflammation and insulin resistance in obesity","volume":"127","author":"Wu","year":"2017","journal-title":"J. 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