{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:08:47Z","timestamp":1790341727918,"version":"4.1.0"},"reference-count":174,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Diabetes mellitus (DM), one of the metabolic diseases which is characterized by sustained hyperglycemia, is a life-threatening disease. The global prevalence of DM is on the rise, mainly in low- and middle-income countries. Diabetes is a major cause of blindness, heart attacks, kidney failure, stroke, and lower limb amputation. Type 2 diabetes mellitus (T2DM) is a form of diabetes that is characterized by high blood sugar and insulin resistance. T2DM can be prevented or delayed by a healthy diet, regular physical activity, maintaining normal body weight, and avoiding alcohol and tobacco use. Ethanol and its metabolites can cause differentiation defects in stem cells and promote inflammatory injury and carcinogenesis in several tissues. Recent studies have suggested that diabetes can be treated, and its consequences can be avoided or delayed with proper management. DM has a greater risk for several cancers, such as breast, colorectal, endometrial, pancreatic, gallbladder, renal, and liver cancer. The incidence of cancer is significantly higher in patients with DM than in those without DM. In addition to DM, alcohol abuse is also a risk factor for many cancers. We present a review of the recent studies investigating the association of both DM and alcohol abuse with cancer incidence.<\/jats:p>","DOI":"10.3390\/cells10113077","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T08:05:16Z","timestamp":1636358716000},"page":"3077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance"],"prefix":"10.3390","volume":"10","author":[{"given":"Bao Q.","family":"Lam","sequence":"first","affiliation":[{"name":"Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Morvant","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ochsner Health System, 120 Ochsner Boulevard, Gretna, LA 70056, USA"},{"name":"A.B. Freeman School of Business, Tulane University, New Orleans, LA 70118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Shankar","sequence":"additional","affiliation":[{"name":"Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"John W. Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA"},{"name":"Southeast Louisiana Veterans Health Care System, New Orleans, LA 70119, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"A.B. Freeman School of Business, Tulane University, New Orleans, LA 70118, USA"},{"name":"Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7872","DOI":"10.1038\/s41598-017-08447-3","article-title":"Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer","volume":"7","author":"McGinn","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1007\/s11095-017-2238-8","article-title":"Novel Gemcitabine Conjugated Albumin Nanoparticles: A Potential Strategy to Enhance Drug Efficacy in Pancreatic Cancer Treatment","volume":"34","author":"Kushwah","year":"2017","journal-title":"Pharm. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1136\/gutjnl-2016-313458","article-title":"Development of autoimmune pancreatitis is independent of CDKN1A\/p21-mediated pancreatic inflammation","volume":"67","author":"Seleznik","year":"2017","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/em.21824","article-title":"Acetaldehyde and the genome: Beyond nuclear DNA adducts and carcinogenesis","volume":"55","author":"Brooks","year":"2014","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.crfs.2019.09.001","article-title":"Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities","volume":"1","author":"Srinivasan","year":"2019","journal-title":"Curr. Res. Food Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1080\/15563650.2019.1708091","article-title":"Fomepizole to treat disulfiram-ethanol reaction: A case series","volume":"58","author":"Schicchi","year":"2019","journal-title":"Clin. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/glycob\/cwr159","article-title":"Elucidation of the sugar recognition ability of the lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 by using unnatural glycopeptide substrates","volume":"22","author":"Yoshimura","year":"2012","journal-title":"Glycobiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s13318-010-0022-9","article-title":"Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors","volume":"35","author":"Hao","year":"2011","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1021\/np100358a","article-title":"Isolation, structure elucidation, and cytotoxic evaluation of furanonaphthoquinones from in vitro plantlets and cultures of Streptocarpus dunnii","volume":"74","author":"Sheridan","year":"2011","journal-title":"J. Nat. Prod."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"940","DOI":"10.2174\/138161208784139765","article-title":"AGE-RAGE System and Carcinogenesis","volume":"14","author":"Abe","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1373\/clinchem.2017.277376","article-title":"Obesity and Cancer: Evidence, Impact, and Future Directions","volume":"64","author":"Colditz","year":"2018","journal-title":"Clin. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/00498254.2019.1704097","article-title":"A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes","volume":"50","author":"Matsumoto","year":"2019","journal-title":"Xenobiotica"},{"key":"ref_13","first-page":"576","article-title":"Relationship between Blood Acetaldehyde Concentration and Psychomotor Function of Individuals with Different ALDH2 Genotypes after Alcohol Consumption","volume":"35","author":"Ye","year":"2019","journal-title":"Fa Yi Xue Za Zhi"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.omtm.2019.08.004","article-title":"Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency","volume":"15","author":"Matsumura","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/acer.14146","article-title":"Different Effects of Knockouts in ALDH 2 and ACSS 2 on Embryonic Stem Cell Differentiation","volume":"43","author":"Serio","year":"2019","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.alcohol.2019.03.004","article-title":"The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea","volume":"79","author":"Lee","year":"2019","journal-title":"Alcohol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1104\/pp.19.01162","article-title":"Failure to Maintain Acetate Homeostasis by Acetate-Activating Enzymes Impacts Plant Development","volume":"182","author":"Fu","year":"2020","journal-title":"Plant Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1055\/s-0030-1249934","article-title":"Pterosins from Pteris multifida","volume":"76","author":"Ouyang","year":"2010","journal-title":"Planta Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1476-4598-9-73","article-title":"Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway","volume":"9","author":"Li","year":"2010","journal-title":"Mol. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1021\/tx900301r","article-title":"Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells","volume":"23","author":"Viswesh","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14740\/wjon1166","article-title":"Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors","volume":"10","author":"Rawla","year":"2019","journal-title":"World J. Oncol."},{"key":"ref_22","first-page":"141","article-title":"Epidemiology and risk factors of pancreatic cancer","volume":"89","author":"Capasso","year":"2018","journal-title":"Acta BioMed Atenei Parm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejca.2018.09.007","article-title":"Strong excess risk of pancreatic cancer for low frequency and duration of cigarette smoking: A comprehensive review and meta-analysis","volume":"104","author":"Lugo","year":"2018","journal-title":"Eur. J. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.diabres.2018.05.024","article-title":"Metabolic syndrome and cancer: \u201cThe common soil hypothesis\u201d","volume":"143","author":"Bellastella","year":"2018","journal-title":"Diabetes Res. Clin. Pr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/CEJ.0000000000000428","article-title":"Worldwide incidence of hepatocellular carcinoma cases attributable to major risk factors","volume":"27","author":"Baecker","year":"2018","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jhep.2019.09.007","article-title":"Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis","volume":"72","author":"Clements","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s15010-019-01345-y","article-title":"Epidemiological and etiological variations in hepatocellular carcinoma","volume":"48","author":"Sagnelli","year":"2020","journal-title":"Infection"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.metabol.2018.10.013","article-title":"Burden of cancer attributable to obesity, type 2 diabetes and associated risk factors","volume":"92","year":"2019","journal-title":"Metabolism"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-4939-6996-8_3","article-title":"Isolation of Lipid Raft Proteins from CD133+ Cancer Stem Cells","volume":"1609","author":"Gupta","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1002\/mp.12432","article-title":"CyberKnife with integrated CT-on-rails: System description and first clinical application for pancreas SBRT","volume":"44","author":"Papalazarou","year":"2017","journal-title":"Med. Phys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jhep.2012.08.018","article-title":"CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease","volume":"58","author":"Leung","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/nure.12027","article-title":"Ethanol metabolism and its effects on the intestinal epithelial barrier","volume":"71","author":"Elamin","year":"2013","journal-title":"Nutr. Rev."},{"key":"ref_34","first-page":"155","article-title":"Alcohol and cancer","volume":"39","author":"Poschl","year":"2004","journal-title":"Lancet Alcohol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1080\/00365520212500","article-title":"Ethanol-derived microbial production of carcinogenic acetaldehyde in achlorhydric atrophic gastritis","volume":"37","author":"Mentula","year":"2002","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1158\/1078-0432.CCR-13-1664","article-title":"Combined targeting of STAT3\/NF-\u03baB\/COX-2\/EP4 for effective management of pancreatic cancer","volume":"20","author":"Gong","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jhep.2019.06.018","article-title":"ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles","volume":"71","author":"Seo","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1111\/jcmm.13666","article-title":"Chronic ethanol exposure of human pancreatic normal ductal epithelial cells induces cancer stem cell phenotype through SATB2","volume":"22","author":"Yu","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"108919","DOI":"10.1016\/j.cbi.2019.108919","article-title":"Modification of stem cell states by alcohol and acetaldehyde","volume":"316","author":"Serio","year":"2020","journal-title":"Chem. Interact."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Larocque, K., Ovadje, P., Djurdjevic, S., Mehdi, M., Green, J., and Pandey, S. (2014). Novel Analogue of Colchicine Induces Selective Pro-Death Autophagy and Necrosis in Human Cancer Cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087064"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/mt.2013.277","article-title":"In Vivo Proof of Concept of Adoptive Immunotherapy for Hepatocellular Carcinoma Using Allogeneic Suicide Gene-modified Killer Cells","volume":"22","author":"Leboeuf","year":"2014","journal-title":"Mol. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0025-7125(16)31248-2","article-title":"Alcohol, Alcoholism, and Cancer","volume":"68","author":"Breeden","year":"1984","journal-title":"Med. Clin. North Am."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3748\/wjg.v19.i5.638","article-title":"Alcohol consumption on pancreatic diseases","volume":"19","author":"Hijona","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_44","first-page":"0409","article-title":"Pancreatic cancer","volume":"2010","author":"Kocher","year":"2010","journal-title":"BMJ Clin. Evid."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"323s","DOI":"10.1111\/j.1530-0277.1998.tb04386.x","article-title":"Alcohol and Risk of Cancer","volume":"22","author":"Ringborg","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_46","first-page":"200","article-title":"Alcohol consumption and the gastrointestinal tract","volume":"4","author":"Stermer","year":"2002","journal-title":"Isr. Med. Assoc. J. IMAJ"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"332","DOI":"10.4254\/wjh.v12.i7.332","article-title":"Oxidative stress in alcohol-related liver disease","volume":"12","author":"Tan","year":"2020","journal-title":"World J. Hepatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"921","DOI":"10.7150\/ijbs.42300","article-title":"Aldehyde Dehydrogenase, Liver Disease and Cancer","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1079\/PNS2003323","article-title":"Alcohol and cancer: Genetic and nutritional aspects","volume":"63","author":"Stickel","year":"2004","journal-title":"Proc. Nutr. Soc."},{"key":"ref_50","first-page":"5","article-title":"Relationship between prolactin, breast cancer risk, and antipsychotics in patients with schizophrenia: A critical review","volume":"133","author":"Peuskens","year":"2015","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.amjmed.2014.10.014","article-title":"The Mediterranean Diet, its Components, and Cardiovascular Disease","volume":"128","author":"Widmer","year":"2015","journal-title":"Am. J. Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"De Lorgeril, M., and Salen, P. (2014). Do statins increase and Mediterranean diet decrease the risk of breast cancer?. BMC Med., 12.","DOI":"10.1186\/1741-7015-12-94"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1158\/1055-9965.EPI-16-0789","article-title":"Type II Diabetes, Obesity, and Breast Cancer Risk: The Multiethnic Cohort","volume":"26","author":"Maskarinec","year":"2017","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.2337\/diacare.26.6.1752","article-title":"Type 2 Diabetes and Subsequent Incidence of Breast Cancer in the Nurses\u2019 Health Study","volume":"26","author":"Michels","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2174\/0929867324666171005111911","article-title":"Biomarkers of Alcohol Consumption in Body Fluids\u2014Possibilities and Limitations of Application in Toxicological Analysis","volume":"26","author":"Wiergowski","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Chen, J., Qin, C., Zhou, Y., Chen, Y., Mao, M., and Yang, J. (2021). Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer. FEBS Open Bio.","DOI":"10.1002\/2211-5463.13314"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ol.2021.12876","article-title":"Metformin suppresses breast cancer growth via inhibition of cyclooxygenase-2","volume":"22","author":"Shi","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3906\/sag-1908-112","article-title":"Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism","volume":"51","author":"Emre","year":"2021","journal-title":"Turk. J. Med. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"i2314","DOI":"10.1136\/bmj.i2314","article-title":"Five year change in alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal women: Prospective cohort study","volume":"353","author":"Dam","year":"2016","journal-title":"BMJ"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/bcr3574","article-title":"Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells","volume":"15","author":"Leung","year":"2013","journal-title":"Breast Cancer Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3109\/0284186X.2014.998774","article-title":"Influence of metabolic indicators, smoking, alcohol and socioeconomic position on mortality after breast cancer","volume":"54","author":"Larsen","year":"2015","journal-title":"Acta Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1053\/j.seminoncol.2010.05.010","article-title":"The Use of Animal Models for Cancer Chemoprevention Drug Development","volume":"37","author":"Steele","year":"2010","journal-title":"Semin. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.1016\/j.bmc.2010.07.038","article-title":"Modulators of the hedgehog signaling pathway","volume":"18","author":"Heretsch","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1871520617666170918143911","article-title":"4-aryl\/heteroaryl-4H-fused Pyrans as Anti-proliferative Agents: Design, Synthesis and Biological Evaluation","volume":"18","author":"Kumar","year":"2018","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.colsurfb.2017.09.010","article-title":"PEGylated thermosensitive lipid-coated hollow gold nanoshells for effective combinational chemo-photothermal therapy of pancreatic cancer","volume":"160","author":"Poudel","year":"2017","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/RCT.0000000000000666","article-title":"Computed Tomography Image Quality Evaluation of a New Iterative Reconstruction Algorithm in the Abdomen (Adaptive Statistical Iterative Reconstruction\u2013V) a Comparison With Model-Based Iterative Reconstruction, Adaptive Statistical Iterative Reconstruction, and Filtered Back Projection Reconstructions","volume":"42","author":"Goodenberger","year":"2018","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jso.24623","article-title":"Current and future therapies for advanced pancreatic cancer","volume":"116","author":"Gupta","year":"2017","journal-title":"J. Surg. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-017-2469-7","article-title":"Incidence of and factors associated with catheter-related bloodstream infection in patients with advanced solid tumors on home parenteral nutrition managed using a standardized catheter care protocol","volume":"17","author":"Vashi","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ejmech.2017.04.062","article-title":"Synthesis of novel benzylidene analogues of betulinic acid as potent cytotoxic agents","volume":"135","author":"Gupta","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-01696-2","article-title":"Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer","volume":"7","author":"Dauer","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.steroids.2017.04.002","article-title":"A convergent synthesis of novel alkyne\u2013azide cycloaddition congeners of betulinic acid as potent cytotoxic agent","volume":"123","author":"Dangroo","year":"2017","journal-title":"Steroids"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/biof.1309","article-title":"Mangiferin modulation of metabolism and metabolic syndrome","volume":"42","author":"Fomenko","year":"2016","journal-title":"BioFactors"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1007\/s11999-016-4976-z","article-title":"The Biologic Response to Polyetheretherketone (PEEK) Wear Particles in Total Joint Replacement: A Systematic Review","volume":"474","author":"Pasko","year":"2016","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/acer.13078","article-title":"A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury","volume":"40","author":"Wang","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"30197","DOI":"10.2807\/1560-7917.ES.2016.21.15.30197","article-title":"Vibrio cholerae non-O1 bacteraemia: Description of three cases in the Netherlands and a literature review","volume":"21","author":"Engel","year":"2016","journal-title":"Eurosurveillance"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2169\/internalmedicine.55.3272","article-title":"Meningococcemia in Adults: A Review of the Literature","volume":"55","author":"Takada","year":"2016","journal-title":"Intern. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1097\/CCM.0000000000001652","article-title":"Pharmacological Therapy for the Prevention and Treatment of Weakness After Critical Illness","volume":"44","author":"Shepherd","year":"2016","journal-title":"Crit. Care Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/JTN.0000000000000194","article-title":"Impact of Alcohol on Outcomes in Hospitalized Major Trauma Patients","volume":"23","author":"Leonard","year":"2016","journal-title":"J. Trauma Nurs."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1517\/13543776.2016.1157165","article-title":"Sphingosine 1-phosphate receptor 1 agonists: A patent review (2013-2015)","volume":"26","author":"Guerrero","year":"2016","journal-title":"Expert Opin. Ther. Patents"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1007\/s00253-016-7731-1","article-title":"Inhibition of poly(adenosine diphosphate-ribose) polymerase using quinazolinone nucleus","volume":"100","author":"Hemalatha","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_81","first-page":"247","article-title":"Prevention of Non-Enzymatic Glycosylation (Glycation): Implication in the Treatment of Diabetic Complication","volume":"10","author":"Younus","year":"2016","journal-title":"Int. J. Health Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.fitote.2016.02.001","article-title":"Research progress on berberine with a special focus on its oral bioavailability","volume":"109","author":"Liu","year":"2016","journal-title":"Fitoterapia"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jep.2016.01.032","article-title":"Ethnobotany, phytochemistry, and pharmacology of the genus Litsea: An update","volume":"181","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.orcp.2015.12.004","article-title":"A review on possible therapeutic targets to contain obesity: The role of phytochemicals","volume":"10","author":"Balaji","year":"2016","journal-title":"Obes. Res. Clin. Pr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1517\/14728222.2016.1111873","article-title":"The multiple faces of RAGE\u2014opportunities for therapeutic intervention in aging and chronic disease","volume":"20","author":"Ramasamy","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/1573406411666151030110530","article-title":"Antioxidant, Antimicrobial Activity and Medicinal Properties of Grewia asiatica L.","volume":"12","author":"Shukla","year":"2016","journal-title":"Med. Chem."},{"key":"ref_87","first-page":"471","article-title":"Epidemiology of Pancreatic Cancer","volume":"59","author":"Michaud","year":"2016","journal-title":"Pathol. Epidemiol. Cancer"},{"key":"ref_88","first-page":"7","article-title":"Cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA: A Cancer J. Clin."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4239\/wjd.v4.i6.234","article-title":"Betatrophin: A liver-derived hormone for the pancreatic \u03b2-cell proliferation","volume":"4","author":"Raghow","year":"2013","journal-title":"World J. Diabetes"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.diabres.2013.10.021","article-title":"Prevalence of insulin resistance and cardiometabolic risk in Korean children and adolescents: A population-based study","volume":"103","author":"Yi","year":"2014","journal-title":"Diabetes Res. Clin. Pr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ejmech.2017.03.033","article-title":"Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive\u2014Based, natural product lead optimization approach","volume":"133","author":"Manivannan","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.phrs.2017.03.003","article-title":"Identification of sennoside A as a novel inhibitor of the slingshot (SSH) family proteins related to cancer metastasis","volume":"119","author":"Lee","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3892\/ijmm.2017.2894","article-title":"MicroRNA-7 functions as a tumor-suppressor gene by regulating ILF2 in pancreatic carcinoma","volume":"39","author":"Bi","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1074\/jbc.M116.750299","article-title":"Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine","volume":"292","author":"Harshbarger","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.biopha.2016.07.029","article-title":"The apoptotic and autophagic properties of two natural occurring prodrugs, hyperoside and hypoxoside, against pancreatic cancer cell lines","volume":"83","author":"Boukes","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.phymed.2016.07.004","article-title":"Isolation and characterization of bioactive metabolites from Xylaria psidii, an endophytic fungus of the medicinal plant Aegle marmelos and their role in mitochondrial dependent apoptosis against pancreatic cancer cells","volume":"23","author":"Arora","year":"2016","journal-title":"Phytomedicine"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e2421","DOI":"10.1038\/cddis.2016.305","article-title":"RETRACTED ARTICLE: Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition","volume":"7","author":"Zhang","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7783","DOI":"10.1021\/acs.jmedchem.6b00041","article-title":"Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic \u03b2-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress","volume":"59","author":"Duan","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1002\/ijc.30253","article-title":"Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity","volume":"139","author":"Xu","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3892\/or.2016.4867","article-title":"Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells","volume":"36","author":"Kasukabe","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1016\/j.bmcl.2016.06.046","article-title":"A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties","volume":"26","author":"Kumar","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11357-016-9922-1","article-title":"Cristacarpin promotes ER stress-mediated ROS generation leading to premature senescence by activation of p21waf-1","volume":"38","author":"Chakraborty","year":"2016","journal-title":"AGE"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1158\/1535-7163.MCT-15-0648","article-title":"Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61","volume":"15","author":"Huang","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bbrc.2016.03.052","article-title":"Identification of baicalein as a ferroptosis inhibitor by natural product library screening","volume":"473","author":"Xie","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1055\/s-0035-1558308","article-title":"Secondary Metabolites from Endophytic Fungus Penicillium pinophilum Induce ROS-Mediated Apoptosis through Mitochondrial Pathway in Pancreatic Cancer Cells","volume":"82","author":"Koul","year":"2016","journal-title":"Planta Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.bmcl.2016.01.054","article-title":"Evaluation of synthetic coumarins for antiausterity cytotoxicity against pancreatic cancers","volume":"26","author":"Farley","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.oraloncology.2006.02.005","article-title":"Acetaldehyde production from ethanol by oral streptococci","volume":"43","author":"Kurkivuori","year":"2007","journal-title":"Oral Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/00004836-199010000-00018","article-title":"Insulinoma after streptozotocin therapy for metastatic gastrinoma: Natural history or iatrogenic complication?","volume":"12","author":"Bar","year":"1990","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1021\/bi00267a002","article-title":"Sequence analysis of a growth hormone releasing factor from a human pancreatic islet tumor","volume":"21","author":"Spiess","year":"1982","journal-title":"Biochemistry"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nut.2016.09.005","article-title":"Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy","volume":"34","author":"Gounder","year":"2017","journal-title":"Nutrition"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/jphp.12676","article-title":"Proposed mechanisms of Terminalia catappa in hyperglycaemia and associated diabetic complications","volume":"69","author":"Behl","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_112","first-page":"228","article-title":"Supplementing Conventional Treatment with Pycnogenol\u00ae May Improve Hepatitis C Virus\u2013Associated Type 2 Diabetes: A Mini Review","volume":"4","author":"Ezzikouri","year":"2016","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.2337\/db05-0470","article-title":"Foxa1-Deficient Mice Exhibit Impaired Insulin Secretion due to Uncoupled Oxidative Phosphorylation","volume":"55","author":"Vatamaniuk","year":"2006","journal-title":"Diabetes"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s10552-015-0615-3","article-title":"Alcohol consumption and liver cancer risk: A meta-analysis","volume":"26","author":"Chuang","year":"2015","journal-title":"Cancer Causes Control."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3350\/cmh.2020.0203","article-title":"Alcohol and hepatocarcinogenesis","volume":"26","author":"Taniai","year":"2020","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jgh3.12336","article-title":"Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma","volume":"4","author":"Thylur","year":"2020","journal-title":"JGH Open"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/1535370217744511","article-title":"Association of liver cirrhosis severity with type 2 diabetes mellitus in hepatocellular carcinoma","volume":"243","author":"Makol","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cld.2017.08.008","article-title":"Risk Factors for the Development of Nonalcoholic Fatty Liver Disease\/Nonalcoholic Steatohepatitis, Including Genetics","volume":"22","author":"Lim","year":"2018","journal-title":"Clin. Liver Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1002\/sim.4041","article-title":"Random-effects meta-regression models for studying nonlinear dose-response relationship, with an application to alcohol and esophageal squamous cell carcinoma","volume":"29","author":"Rota","year":"2010","journal-title":"Stat. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.oraloncology.2010.07.010","article-title":"A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 2: Results by subsites","volume":"46","author":"Turati","year":"2010","journal-title":"Oral Oncol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.oraloncology.2010.03.024","article-title":"A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 1: Overall results and dose-risk relation","volume":"46","author":"Tramacere","year":"2010","journal-title":"Oral Oncol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s10552-010-9556-z","article-title":"Alcohol and endometrial cancer risk: A case\u2013control study and a meta-analysis","volume":"21","author":"Turati","year":"2010","journal-title":"Cancer Causes Control."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/ijc.24936","article-title":"Alcohol drinking and pancreatic cancer risk: A meta-analysis of the dose-risk relation","volume":"126","author":"Tramacere","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1158\/1055-9965.EPI-08-0880","article-title":"Alcohol Intake and Pancreatic Cancer Risk: A Pooled Analysis of Fourteen Cohort Studies","volume":"18","author":"Genkinger","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.addbeh.2010.08.023","article-title":"First consumption ever of multiple substances: Applying an expert-based taxonomy to a Swiss national sample of adolescents","volume":"36","author":"Berchtold","year":"2011","journal-title":"Addict. Behav."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1017\/S1368980010000947","article-title":"Who eats healthily? A population-based study among young Swiss residents","volume":"13","author":"Meier","year":"2010","journal-title":"Public Health Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s10552-010-9548-z","article-title":"Alcohol intake and pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium (PanScan)","volume":"21","author":"Michaud","year":"2010","journal-title":"Cancer Causes Control."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/ijerph7010046","article-title":"Challenging the \u201cInoffensiveness\u201d of Regular Cannabis Use by Its Associations with Other Current Risky Substance Use\u2014A Census of 20-Year-Old Swiss Men","volume":"7","author":"Gmel","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1007\/s001250051442","article-title":"The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells","volume":"42","author":"Brock","year":"1999","journal-title":"Diabetologia"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/ajcn\/69.6.1135","article-title":"Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects","volume":"69","author":"Thomsen","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0026-0495(99)90005-7","article-title":"Differential effects of cis and trans fatty acids on insulin release from isolated mouse islets","volume":"48","author":"Kudahl","year":"1999","journal-title":"Metabolism"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1515\/BC.2006.047","article-title":"Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress","volume":"387","author":"Seitz","year":"2006","journal-title":"Biol. Chem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000367971","article-title":"Serum Adiponectin Is Associated with Worsened Overall Survival in a Prospective Cohort of Hepatocellular Carcinoma Patients","volume":"88","author":"Siegel","year":"2014","journal-title":"Oncology"},{"key":"ref_135","first-page":"59","article-title":"Helicobacter pylori Infection and Gastric Adenocarcinoma","volume":"7","author":"Correa","year":"2011","journal-title":"US Gastroenterol. Hepatol. Rev."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1055\/s-0031-1297969","article-title":"Diabetes Mellitus and Incidence and Mortality of Gastric Cancer: A Meta-Analysis","volume":"120","author":"Tian","year":"2012","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3748\/wjg.v19.i6.936","article-title":"Pre-existing diabetes mellitus increases the risk of gastric cancer: A meta-analysis","volume":"19","author":"Yoon","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/MEG.0b013e32834b8d73","article-title":"Diabetes mellitus and risk of gastric cancer","volume":"23","author":"Ge","year":"2011","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/1477-3163.90481","article-title":"Diabetes mellitus and gastric carcinoma: Is there an association?","volume":"10","author":"Jayaprakash","year":"2011","journal-title":"J. Carcinog."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.ejca.2014.05.020","article-title":"Diabetes mellitus increases the risk of early gastric cancer development","volume":"50","author":"Sekikawa","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2893.2009.01085.x","article-title":"Occult hepatitis B virus infection increases hepatocellular carcinogenesis by eight times in patients with non-B, non-C liver cirrhosis: A cohort study","volume":"16","author":"Ikeda","year":"2009","journal-title":"J. Viral Hepat."},{"key":"ref_142","first-page":"1301","article-title":"Omeprazole and regulation of cytokine profile in Helicobacter pylori-infected patients with duodenal ulcer disease","volume":"47","author":"Kountouras","year":"2000","journal-title":"Hepatogastroenterology"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0140-6736(96)90013-6","article-title":"Oxidative damage to DNA in diabetes mellitus","volume":"347","author":"Dandona","year":"1996","journal-title":"Lancet"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrendo.2009.219","article-title":"Diabetes therapy and cancer risk","volume":"5","author":"Vigneri","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.4161\/cc.9.8.11512","article-title":"Hyperinsulinemia and type 2 diabetes: Impact on cancer","volume":"9","author":"Novosyadlyy","year":"2010","journal-title":"Cell Cycle"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.coph.2008.07.004","article-title":"Targeting insulin and insulin-like growth factor signalling in oncology","volume":"8","author":"Pollak","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"238","DOI":"10.12659\/MSM.899423","article-title":"Alcohol Consumption and Gastric Cancer Risk: A Meta-Analysis","volume":"23","author":"Ma","year":"2017","journal-title":"Med Sci. Monit."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000443155","article-title":"Etiology and Prevention of Esophageal Cancer","volume":"3","author":"Yang","year":"2016","journal-title":"Gastrointest. Tumors"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1158\/1055-9965.EPI-15-0961","article-title":"Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B\u2013Related Hepatocellular Carcinoma","volume":"25","author":"Liu","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejphar.2010.04.007","article-title":"Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration","volume":"637","author":"Fouad","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Yacoub, R., Habib, H., Lahdo, A., Al Ali, R., Varjabedian, L., Atalla, G., Akl, N.K., Aldakheel, S., Alahdab, S., and Albitar, S. (2010). Association between smoking and chronic kidney disease: A case control study. BMC Public Health, 10.","DOI":"10.1186\/1471-2458-10-731"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"E199","DOI":"10.1111\/j.1530-0277.2012.01894.x","article-title":"Ethanol-Induced Mast Cell-Mediated Inflammation Leads to Increased Susceptibility of Intestinal Tumorigenesis in the APC\u0394468Min Mouse Model of Colon Cancer","volume":"37","author":"Wimberly","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ijc.24343","article-title":"The impact of dietary and lifestyle risk factors on risk of colorectal cancer: A quantitative overview of the epidemiological evidence","volume":"125","author":"Huxley","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4143\/crt.2004.36.2.93","article-title":"Molecular Epidemiology of Colon Cancer","volume":"36","author":"Kim","year":"2004","journal-title":"Cancer Res. Treat."},{"key":"ref_155","first-page":"4787","article-title":"Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer","volume":"57","author":"Wilkens","year":"1997","journal-title":"Cancer Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1592\/phco.30.11.1159","article-title":"Diabetes Mellitus and Increased Risk of Cancer: Focus on Metformin and the Insulin Analogs","volume":"30","author":"McFarland","year":"2010","journal-title":"Pharmacother. J. Hum. Pharmacol. Drug Ther."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/SMJ.0b013e3181c35776","article-title":"The Continuation of Oral Medications with the Initiation of Insulin Therapy in Type 2 Diabetes: A Review of the Evidence","volume":"103","author":"McFarland","year":"2010","journal-title":"South. Med. J."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1345\/aph.1M411","article-title":"Gemfibrozil-Induced Myositis in a Patient with Normal Renal Function","volume":"44","author":"Hahn","year":"2010","journal-title":"Ann. Pharmacother."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Sudha, T., El-Far, A.H., Mousa, D.S., and Mousa, S.A. (2020). Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models. Molecules, 25.","DOI":"10.3390\/molecules25061412"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/sj.bjc.6601568","article-title":"Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4\u2032-tetramethoxystilbene","volume":"90","author":"Sale","year":"2004","journal-title":"Br. J. Cancer"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"e00090","DOI":"10.14309\/ctg.0000000000000090","article-title":"Colorectal Cancer Risks According to Sex Differences in Patients With Type II Diabetes Mellitus","volume":"10","author":"Lee","year":"2019","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Zhu, Z., Zhang, X., Shen, Z., Zhong, S., Wang, X., Lu, Y., and Xu, C. (2013). Diabetes Mellitus and Risk of Bladder Cancer: A Meta-Analysis of Cohort Studies. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0056662"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1002\/ijc.27878","article-title":"Type 2 diabetes mellitus, insulin-use and risk of bladder cancer in a large cohort study","volume":"132","author":"Newton","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e8588","DOI":"10.1097\/MD.0000000000008588","article-title":"Diabetes mellitus and the risk of bladder cancer","volume":"96","author":"Xu","year":"2017","journal-title":"Medicine"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.bbrc.2007.01.047","article-title":"Insulin induces a transcriptional activation of epiregulin, HB-EGF and amphiregulin, by a PI3K-dependent mechanism: Identification of a specific insulin-responsive promoter element","volume":"354","author":"Ornskov","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1111\/j.1742-4658.2006.05539.x","article-title":"Insulin-induced proliferation of bladder cancer cells is mediated through activation of the epidermal growth factor system","volume":"273","author":"Ornskov","year":"2006","journal-title":"FEBS J."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gtc.2004.12.009","article-title":"Metabolic Implications of Obesity: Before and After Gastric Bypass","volume":"34","author":"Richardson","year":"2005","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"10290","DOI":"10.1074\/jbc.M408985200","article-title":"Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle","volume":"280","author":"Richardson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s00345-019-02825-4","article-title":"Impact of alcohol consumption on the risk of developing bladder cancer: A systematic review and meta-analysis","volume":"37","author":"Vartolomei","year":"2019","journal-title":"World J. Urol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1620\/tjem.239.9","article-title":"Risk of Alcohol Consumption in Bladder Cancer: Case-Control Study from a Nationwide Inpatient Database in Japan","volume":"239","author":"Zaitsu","year":"2016","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/aje\/153.1.38","article-title":"Alcohol Consumption and Bladder Cancer Risk: Results from the Netherlands Cohort Study","volume":"153","author":"Zeegers","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/carcin\/bgw033","article-title":"Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: Gene\u2013environment interaction","volume":"37","author":"Masaoka","year":"2016","journal-title":"Carcinogenesis"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0741-8329(98)00042-1","article-title":"Blood and Urinary Levels of Ethanol, Acetaldehyde, and C4 Compounds Such as Diacetyl, Acetoin, and 2,3-Butanediol in Normal Male Students After Ethanol Ingestion","volume":"17","author":"Otsuka","year":"1999","journal-title":"Alcohol"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/mutage\/gew016","article-title":"Increased levels of the acetaldehyde-derived DNA adductN2-ethyldeoxyguanosine in oral mucosa DNA from Rhesus monkeys exposed to alcohol","volume":"31","author":"Balbo","year":"2016","journal-title":"Mutagenesis"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/11\/3077\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:27:30Z","timestamp":1760167650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/11\/3077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,8]]},"references-count":174,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["cells10113077"],"URL":"https:\/\/doi.org\/10.3390\/cells10113077","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,8]]}}}