{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:32:16Z","timestamp":1760236336400,"version":"build-2065373602"},"reference-count":81,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council","doi-asserted-by":"publisher","award":["(6362-2017: M.P.; RGPIN- 2020-05739: J.-F.B.)"],"award-info":[{"award-number":["(6362-2017: M.P.; RGPIN- 2020-05739: J.-F.B.)"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["(163014-2019: M.P. and J.-F.B., PJT-156029: J.-F.B.)"],"award-info":[{"award-number":["(163014-2019: M.P. and J.-F.B., PJT-156029: J.-F.B.)"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The endocannabinoid (eCB) system has been found in all visual parts of the central ner-vous system and plays a role in the processing of visual information in many species, including monkeys and humans. Using anatomical methods, cannabinoid receptors are present in the monkey retina, particularly in the vertical glutamatergic pathway, and also in the horizontal GABAergic pathway. Modulating the eCB system regulates normal retinal function as demonstrated by electrophysiological recordings. The characterization of the expression patterns of all types of cannabinoid receptors in the retina is progressing, and further research is needed to elucidate their exact role in processing visual information. Typical cannabinoid receptors include G-protein coupled receptor CB1R and CB2R, and atypical cannabinoid receptors include the G-protein coupled receptor 55 (GPR55) and the ion channel transient receptor potential vanilloid 1 (TRPV1). This review focuses on the expression and localization studies carried out in monkeys, but some data on other animal species and humans will also be reported. Furthermore, the role of the endogenous cannabinoid receptors in retinal function will also be presented using intraocular injections of known modulators (agonists and antagonists) on electroretinographic patterns in monkeys. The effects of the natural bioactive lipid lysophosphatidylglucoside and synthetic FAAH inhibitor URB597 on retinal function, will also be described. Finally, the potential of typical and atypical cannabinoid receptor acti-vity regulation in retinal diseases, such as age-related macular degeneration, diabetic retinopathy, glaucoma, and retinitis pigmentosa will be briefly explored.<\/jats:p>","DOI":"10.3390\/cells10113160","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T20:48:36Z","timestamp":1636922916000},"page":"3160","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Vertical and Horizontal Pathways in the Monkey Retina Are Modulated by Typical and Atypical Cannabinoid Receptors"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-4051","authenticated-orcid":false,"given":"Joseph","family":"Bouskila","sequence":"first","affiliation":[{"name":"School of Optometry, University of Montreal, Montreal, QC H3Y 1P1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5117-9368","authenticated-orcid":false,"given":"Maxime","family":"Bleau","sequence":"additional","affiliation":[{"name":"School of Optometry, University of Montreal, Montreal, QC H3Y 1P1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-4304","authenticated-orcid":false,"given":"Catarina","family":"Micaelo-Fernandes","sequence":"additional","affiliation":[{"name":"School of Optometry, University of Montreal, Montreal, QC H3Y 1P1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-6239","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Bouchard","sequence":"additional","affiliation":[{"name":"School of Optometry, University of Montreal, Montreal, QC H3Y 1P1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Ptito","sequence":"additional","affiliation":[{"name":"School of Optometry, University of Montreal, Montreal, QC H3Y 1P1, Canada"},{"name":"Behavioral Science Foundations, Eastern Caribbean, Estridge KN0101, Saint Kitts and Nevis"},{"name":"Department of Neuroscience, Copenhagen University, 2200 Copenhagen, Denmark"},{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1016\/j.bmcl.2008.06.091","article-title":"Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling","volume":"18","author":"Hoover","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/138955706776073466","article-title":"New insights into endocannabinoid degradation and its therapeutic potential","volume":"6","author":"Bari","year":"2006","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/sj.bjp.0705666","article-title":"The endocannabinoid system: A general view and latest additions","volume":"141","author":"Cascio","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/npp.2017.130","article-title":"Circulating endocannabinoids: From whence do they come and where are they going?","volume":"43","author":"Hillard","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuropharm.2004.07.030","article-title":"Cannabinoid physiology and pharmacology: 30 years of progress","volume":"47","author":"Howlett","year":"2004","journal-title":"Neuropharmacology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1054\/plef.2001.0340","article-title":"Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression","volume":"66","author":"Mechoulam","year":"2002","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","article-title":"The molecular logic of endocannabinoid signalling","volume":"4","author":"Piomelli","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/346561a0","article-title":"Structure of a cannabinoid receptor and functional expression of the cloned cDNA","volume":"346","author":"Matsuda","year":"1990","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/365061a0","article-title":"Molecular characterization of a peripheral receptor for cannabinoids","volume":"365","author":"Munro","year":"1993","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1073\/pnas.92.8.3376","article-title":"Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide","volume":"92","author":"Facci","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/cercor\/bhj136","article-title":"Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate neocortex: A regional and laminar analysis","volume":"17","author":"Eggan","year":"2007","journal-title":"Cereb. Cortex"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1523\/JNEUROSCI.4134-09.2011","article-title":"Concerted action of CB1 cannabinoid receptor and deleted in colorectal cancer in axon guidance","volume":"31","author":"Argaw","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9247057","DOI":"10.1155\/2016\/9247057","article-title":"Expression and Function of the Endocannabinoid System in the Retina and the Visual Brain","volume":"2016","author":"Bouchard","year":"2016","journal-title":"Neural Plast."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Duff, G., Argaw, A., C\u00e9cyre, B., Cherif, H., Tea, N., Zabouri, N., Casanova, C., Ptito, M., and Bouchard, J.F. (2013). Cannabinoid receptor CB2 modulates axon guidance. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070849"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tips.2006.12.004","article-title":"The emerging functions of endocannabinoid signaling during CNS development","volume":"28","author":"Harkany","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuroscience.2011.11.041","article-title":"Expression and localization of the cannabinoid receptor type 1 and the enzyme fatty acid amide hydrolase in the retina of vervet monkeys","volume":"202","author":"Bouskila","year":"2012","journal-title":"Neuroscience"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2916732","DOI":"10.1155\/2016\/2916732","article-title":"The endocannabinoid system in the retina: From physiology to practical and therapeutic applications","volume":"2016","author":"Schwitzer","year":"2016","journal-title":"Neural Plast."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.preteyeres.2008.07.002","article-title":"Endocannabinoids in the retina: From marijuana to neuroprotection","volume":"27","author":"Yazulla","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Di Marzo, V. (2014). Cannabinoids, Wiley.","DOI":"10.1002\/9781118451281"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Bouskila, J., Harrar, V., Javadi, P., Beierschmitt, A., Palmour, R., Casanova, C., Bouchard, J.-F., and Ptito, M. (2016). Cannabinoid receptors CB1 and CB2 modulate the Electroretinographic waves in Vervet monkeys. Neural Plast., 2016.","DOI":"10.1155\/2016\/1253245"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"14565","DOI":"10.1073\/pnas.96.25.14565","article-title":"Cannabinoid CB1 receptors and ligands in vertebrate retina: Localization and function of an endogenous signaling system","volume":"96","author":"Straiker","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8079","DOI":"10.1167\/iovs.13-12514","article-title":"Roles of cannabinoid receptors type 1 and 2 on the retinal function of adult mice","volume":"54","author":"Zabouri","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Cherif, H., Argaw, A., C\u00e9cyre, B., Bouchard, A., Gagnon, J., Javadi, P., Desgent, S., Mackie, K., and Bouchard, J.-F. (2015). Role of GPR55 during Axon Growth and Target Innervation. Eneuro, 2.","DOI":"10.1523\/ENEURO.0011-15.2015"},{"key":"ref_24","first-page":"2442","article-title":"Localization of cannabinoid CB1 receptors in the human anterior eye and retina","volume":"40","author":"Straiker","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/cne.22534","article-title":"Cannabinoid receptor type 1 expression during postnatal development of the rat retina","volume":"519","author":"Zabouri","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/19336950.2015.1009272","article-title":"Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress","volume":"9","author":"Sappington","year":"2015","journal-title":"Channels"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"12116","DOI":"10.1038\/s41598-020-68937-9","article-title":"Transient receptor potential vanilloid type 1 is expressed in the horizontal pathway of the vervet monkey retina","volume":"10","author":"Bouskila","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Bouskila, J., Javadi, P., Casanova, C., Ptito, M., and Bouchard, J.-F. (2013). Rod photoreceptors express GPR55 in the adult vervet monkey retina. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081080"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/cne.23333","article-title":"M\u00fcller cells express the cannabinoid CB2 receptor in the vervet monkey retina","volume":"521","author":"Bouskila","year":"2013","journal-title":"J. Comp. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bouskila, J., Palmour, R., Bouchard, J.-F., and Ptito, M. (2018). The Endocannabinoid System in the Vervet Monkey Retina. Primates, 145\u2013162.","DOI":"10.5772\/intechopen.71830"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.2174\/092986708784567716","article-title":"Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists","volume":"15","author":"Ashton","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00210-013-0930-8","article-title":"Evaluation of the specificity of antibodies raised against cannabinoid receptor type 2 in the mouse retina","volume":"387","author":"Thomas","year":"2014","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1113\/JP274562","article-title":"Mouse retinal ganglion cell signalling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways","volume":"595","author":"Jo","year":"2017","journal-title":"J. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3127658","DOI":"10.1155\/2016\/3127658","article-title":"A Comparative Analysis of the Endocannabinoid System in the Retina of Mice, Tree Shrews, and Monkeys","volume":"2016","author":"Bouskila","year":"2016","journal-title":"Neural Plast."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1098\/rstb.2011.0394","article-title":"The evolution and comparative neurobiology of endocannabinoid signalling","volume":"367","author":"Elphick","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2174\/0929867023370707","article-title":"The palmitoylethanolamide family: A new class of anti-inflammatory agents?","volume":"9","author":"Lambert","year":"2002","journal-title":"Curr. Med. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/35102582","article-title":"An anorexic lipid mediator regulated by feeding","volume":"414","author":"Navarro","year":"2001","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/bj20020438","article-title":"Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells","volume":"366","author":"Maccarrone","year":"2002","journal-title":"Biochem. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/cne.21568","article-title":"Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules","volume":"506","author":"Simon","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"ref_40","first-page":"150","article-title":"Localization of diacylglycerol lipase alpha and monoacylglycerol lipase during postnatal development of the rat retina","volume":"8","author":"Monette","year":"2014","journal-title":"Front. Neuroanat."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S095252381600002X","article-title":"Scotopic vision in the monkey is modulated by the G protein-coupled receptor 55","volume":"33","author":"Bouskila","year":"2016","journal-title":"Vis. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.tips.2018.02.011","article-title":"Lysophosphatidylinositols, from cell membrane constituents to GPR55 ligands","volume":"39","author":"Alhouayek","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.aab3516","article-title":"Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord","volume":"349","author":"Guy","year":"2015","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0896-6273(04)00005-4","article-title":"Selective transmission of single photon responses by saturation at the rod-to-rod bipolar synapse","volume":"41","author":"Sampath","year":"2004","journal-title":"Neuron"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.2174\/0929867323666160425113836","article-title":"Advances towards the discovery of GPR55 ligands","volume":"23","author":"Morales","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1134\/S0006297921140054","article-title":"TRPV1 Ion Channel: Structural Features, Activity Modulators, and Therapeutic Potential","volume":"86","author":"Gladkikh","year":"2021","journal-title":"Biochemistry (Moscow)"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/22761","article-title":"Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide","volume":"400","author":"Zygmunt","year":"1999","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3390\/cells3030914","article-title":"TRPV1 and endocannabinoids: Emerging molecular signals that modulate mammalian vision","volume":"3","author":"Ryskamp","year":"2014","journal-title":"Cells"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1023\/B:NEUR.0000046574.72380.e8","article-title":"Localization of vanilloid receptor 1 (TRPV1\/VR1)-like immunoreactivity in goldfish and zebrafish retinas: Restriction to photoreceptor synaptic ribbons","volume":"33","author":"Zimov","year":"2004","journal-title":"J. Neurocytol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1017\/S095252380707054X","article-title":"Vanilloid receptor 1 (TRPV1\/VR1) co-localizes with fatty acid amide hydrolase (FAAH) in retinal amacrine cells","volume":"24","author":"Zimov","year":"2007","journal-title":"Vis. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ijdevneu.2009.07.003","article-title":"Ontogenetic expression of the vanilloid receptors TRPV1 and TRPV2 in the rat retina","volume":"27","author":"Leonelli","year":"2009","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fncel.2018.00353","article-title":"Polymodal TRPV1 and TRPV4 sensors colocalize but do not functionally interact in a subpopulation of mouse retinal ganglion cells","volume":"12","author":"Lakk","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_53","first-page":"1507","article-title":"Differential expression and localization of transient receptor potential vanilloid 1 in rabbit and human eyes","volume":"28","author":"Gallego","year":"2013","journal-title":"Histol. Histopathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10571-012-9904-5","article-title":"Retinal cell death induced by TRPV1 activation involves NMDA signaling and upregulation of nitric oxide synthases","volume":"33","author":"Leonelli","year":"2013","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_55","unstructured":"O\u2019Leary, C. (2016). The Role of TRPV1 and TRPV4 Channels in Retinal Angiogenesis, Queen\u2019s University Belfast."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1167\/iovs.18-26344","article-title":"Involvement of TRPV1 and TRPV4 channels in retinal angiogenesis","volume":"60","author":"McGahon","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Gebhart, G.F., and Schmidt, R.F. (2013). Ocular Nociceptors. Encyclopedia of Pain, Springer.","DOI":"10.1007\/978-3-642-28753-4"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Choi, S., Guo, L., and Cordeiro, M.F. (2021). Retinal and Brain Microglia in Multiple Sclerosis and Neurodegeneration. Cells, 10.","DOI":"10.3390\/cells10061507"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Hamid, M.A., Moustafa, M.T., Nashine, S., Costa, R.D., Schneider, K., Atilano, S.R., Kuppermann, B.D., and Kenney, M.C. (2021). Anti-VEGF Drugs Influence Epigenetic Regulation and AMD-Specific Molecular Markers in ARPE-19 Cells. Cells, 10.","DOI":"10.3390\/cells10040878"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Othman, R., Cagnone, G., Joyal, J.-S., Vaucher, E., and Couture, R. (2021). Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies. Cells, 10.","DOI":"10.3390\/cells10081913"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Holan, V., Palacka, K., and Hermankova, B. (2021). Mesenchymal Stem Cell-Based Therapy for Retinal Degenerative Diseases: Experimental Models and Clinical Trials. Cells, 10.","DOI":"10.3390\/cells10030588"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Yoo, H.-S., Shanmugalingam, U., and Smith, P.D. (2021). Harnessing Astrocytes and M\u00fcller Glial Cells in the Retina for Survival and Regeneration of Retinal Ganglion Cells. Cells, 10.","DOI":"10.3390\/cells10061339"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/s41433-020-0770-y","article-title":"Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases","volume":"34","author":"Seah","year":"2020","journal-title":"Eye"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1007\/s10792-019-01140-6","article-title":"The value of nutritional supplements in treating Age-Related Macular Degeneration: A review of the literature","volume":"39","author":"Mukhtar","year":"2019","journal-title":"Int. Ophthalmol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Wallsh, J.O., and Gallemore, R.P. (2021). Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options. Cells, 10.","DOI":"10.3390\/cells10051049"},{"key":"ref_66","first-page":"456","article-title":"A comparative study of prostaglandin analogs and ocular beta-blockers on intraocular pressure reduction","volume":"14","author":"Johny","year":"2020","journal-title":"Drug Invent. Today"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2174\/1570159X15666170724104305","article-title":"Neuroprotection by (endo) cannabinoids in glaucoma and retinal neurodegenerative diseases","volume":"16","author":"Rapino","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Xu, H., and Azuara-Blanco, A. (2014). Phytocannabinoids in Degenerative and Inflammatory Retinal Diseases: Glaucoma, Age-Related Macular Degeneration, Diabetic Retinopathy and Uveoretinitis. Handbook of Cannabis, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780199662685.003.0033"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5617","DOI":"10.1158\/0008-5472.CAN-03-3927","article-title":"Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas","volume":"64","author":"Alvarez","year":"2004","journal-title":"Cancer Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5526","DOI":"10.1167\/iovs.08-2196","article-title":"Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor","volume":"49","author":"Liou","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4155\/fmc.09.93","article-title":"Cannabinoids as novel anti-inflammatory drugs","volume":"1","author":"Nagarkatti","year":"2009","journal-title":"Future Med. Chem."},{"key":"ref_73","first-page":"215","article-title":"Cannabidiol as a putative novel therapy for diabetic retinopathy: A postulated mechanism of action as an entry point for biomarker-guided clinical development","volume":"7","author":"Liou","year":"2009","journal-title":"Curr. Pharm. Pers. Med. (Former. Curr. Pharm.)"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Passani, A., Posarelli, C., Sframeli, A.T., Perciballi, L., Pellegrini, M., Guidi, G., and Figus, M. (2020). Cannabinoids in Glaucoma Patients: The Never-Ending Story. J. Clin. Med., 9.","DOI":"10.3390\/jcm9123978"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Vernazza, S., Oddone, F., Tirendi, S., and Bassi, A.M. (2021). Risk Factors for Retinal Ganglion Cell Distress in Glaucoma and Neuroprotective Potential Intervention. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22157994"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"101301","DOI":"10.1016\/j.isci.2020.101301","article-title":"Cannabinoids and cannabinoid receptors: The story so far","volume":"23","author":"Shahbazi","year":"2020","journal-title":"Iscience"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.exer.2015.05.007","article-title":"Synthetic and endogenous cannabinoids protect retinal neurons from AMPA excitotoxicity in vivo, via activation of CB1 receptors: Involvement of PI3K\/Akt and MEK\/ERK signaling pathways","volume":"136","author":"Kokona","year":"2015","journal-title":"Exp. Eye Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/glia.22942","article-title":"M\u00fcller glia as an important source of cytokines and inflammatory factors present in the gliotic retina during proliferative vitreoretinopathy","volume":"64","author":"Eastlake","year":"2016","journal-title":"Glia"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tips.2006.11.001","article-title":"Cannabinoid CB2 receptor: A new target for controlling neural cell survival?","volume":"28","author":"Romero","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9892","DOI":"10.1021\/ja0486317","article-title":"Porphyrins as photosensitizers to enhance night vision","volume":"126","author":"Washington","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kramer, R.H., and Davenport, C.M. (2015). Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter. PLoS Biol., 13.","DOI":"10.1371\/journal.pbio.1002322"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/11\/3160\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:29:49Z","timestamp":1760167789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/11\/3160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,13]]},"references-count":81,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["cells10113160"],"URL":"https:\/\/doi.org\/10.3390\/cells10113160","relation":{},"ISSN":["2073-4409"],"issn-type":[{"type":"electronic","value":"2073-4409"}],"subject":[],"published":{"date-parts":[[2021,11,13]]}}}