{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:53:34Z","timestamp":1791665614772,"version":"4.3.4"},"reference-count":157,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Growth hormone (GH) exerts multiple effects on different organs including the kidneys, either directly or via its main mediator, insulin-like-growth factor-1 (IGF-1). The GH\/IGF1 system plays a key role in normal kidney development, glomerular hemodynamic regulation, as well as tubular water, sodium, phosphate, and calcium handling. Transgenic animal models demonstrated that GH excess (and not IGF1) may lead to hyperfiltration, albuminuria, and glomerulosclerosis. GH and IGF-1 play a significant role in the early development of diabetic nephropathy, as well as in compensatory kidney hypertrophy after unilateral nephrectomy. Chronic kidney disease (CKD) and its complications in children are associated with alterations in the GH\/IGF1 axis, including growth retardation, related to a GH-resistant state, attributed to impaired kidney postreceptor GH-signaling and chronic inflammation. This may explain the safety of prolonged rhGH-treatment of short stature in CKD.<\/jats:p>","DOI":"10.3390\/cells10123371","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T20:29:27Z","timestamp":1638304167000},"page":"3371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Growth Hormone and IGF1 Actions in Kidney Development and Function"],"prefix":"10.3390","volume":"10","author":[{"given":"Evgenia","family":"Gurevich","sequence":"first","affiliation":[{"name":"Department of Nephrology, Schneider Children\u2019s Medical Center of Israel, 14 Kaplan Street, Petach Tikva 4920235, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Segev","sequence":"additional","affiliation":[{"name":"Shraga Segal Department of Microbiology and Immunology, Ben Gurion University, Beer Sheva 8410501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-7891","authenticated-orcid":false,"given":"Daniel","family":"Landau","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Schneider Children\u2019s Medical Center of Israel, 14 Kaplan Street, Petach Tikva 4920235, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, P.O. 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Horm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(00)81167-8","article-title":"Jak2 is essential for signaling through a variety of cytokine receptors","volume":"93","author":"Parganas","year":"1998","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1210\/mend.13.11.0368","article-title":"Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins","volume":"13","author":"Hansen","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0014-5793(94)00602-4","article-title":"Free insulin-like growth factors (IGF-I and IGF-II) in human serum","volume":"348","author":"Frystyk","year":"1994","journal-title":"FEBS Lett."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrm1837","article-title":"Critical nodes in signalling pathways: Insights into insulin action","volume":"7","author":"Taniguchi","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/13813450902783106","article-title":"The insulin-like growth factor-I receptor as an oncogene","volume":"115","author":"Werner","year":"2009","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_9","first-page":"E967","article-title":"Insulin-like growth factor (IGF)-binding proteins: Interactions with IGFs and intrinsic bioactivities","volume":"278","author":"Baxter","year":"2000","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1677\/joe.0.1750019","article-title":"IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms","volume":"175","author":"Mohan","year":"2002","journal-title":"J. Endocrinol."},{"key":"ref_11","first-page":"825","article-title":"A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro","volume":"49","author":"Salmon","year":"1957","journal-title":"J. Lab. Clin. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1432-0436.1985.tb00316.x","article-title":"A dual effector theory of growth-hormone action","volume":"29","author":"Green","year":"1985","journal-title":"Differentiation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s004670000363","article-title":"The growth hormone\/insulin-like growth factor-I system: Implications for organ growth and development","volume":"14","author":"Yakar","year":"2000","journal-title":"Pediatr. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/edrv.22.1.0419","article-title":"The somatomedin hypothesis: 2001","volume":"22","author":"Bondy","year":"2001","journal-title":"Endocr. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1210\/mend-1-3-243","article-title":"Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: Differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues","volume":"1","author":"Roberts","year":"1987","journal-title":"Mol. Endocrinol."},{"key":"ref_16","first-page":"155","article-title":"Serum somatomedin activity measured as sulphation factor in peripheral, hepatic and renal veins in normal mongrel dogs: Early effects of intravenous injection of growth hormone","volume":"93","author":"Schimpff","year":"1980","journal-title":"Acta Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1073\/pnas.85.13.4889","article-title":"Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats","volume":"85","author":"Guler","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1073\/pnas.86.8.2868","article-title":"Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects","volume":"86","author":"Guler","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/dbio.2000.9975","article-title":"Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth","volume":"229","author":"Lupu","year":"2001","journal-title":"Dev. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1210\/er.2010-0009","article-title":"Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR\u2212\/\u2212) mouse","volume":"32","author":"List","year":"2011","journal-title":"Endocr. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0092-8674(00)81168-X","article-title":"Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis","volume":"93","author":"Neubauer","year":"1998","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa022926","article-title":"Growth hormone insensitivity associated with a STAT5b mutation","volume":"349","author":"Kofoed","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Landau, D., London, L., Bandach, I., and Segev, Y. (2018). The hypoxia inducible factor\/erythropoietin (EPO)\/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0196684"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1128\/MCB.24.18.8037-8047.2004","article-title":"Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation","volume":"24","author":"Cui","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_25","first-page":"344","article-title":"Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre\/loxP system","volume":"223","author":"Liu","year":"2000","journal-title":"Proc. Soc. Exp. Boil. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/(SICI)1520-6408(1999)24:3\/4<293::AID-DVG12>3.0.CO;2-S","article-title":"Insulin-like growth factor I regulates renal development in rodents","volume":"24","author":"Rogers","year":"1999","journal-title":"Dev. Genet."},{"key":"ref_27","first-page":"59","article-title":"Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)","volume":"75","author":"Liu","year":"1993","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/dbio.1997.8666","article-title":"Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development","volume":"189","author":"Louvi","year":"1997","journal-title":"Dev. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature01298","article-title":"IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice","volume":"421","author":"Holzenberger","year":"2003","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1007\/s00467-019-04437-x","article-title":"Genetic renal disease classification by hormonal axes","volume":"35","author":"Landau","year":"2020","journal-title":"Pediatr. Nephrol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1210\/er.2013-1071","article-title":"Growth hormone, insulin-like growth factor-1, and the kidney: Pathophysiological and clinical implications","volume":"35","author":"Mazziotti","year":"2014","journal-title":"Endocr. Rev."},{"key":"ref_32","first-page":"91","article-title":"Transgenic mice in renal research","volume":"20","author":"Striker","year":"1991","journal-title":"Adv. Nephrol. Necker Hosp."},{"key":"ref_33","first-page":"601","article-title":"Glomerulosclerosis at both early and late stages is associated with increased cell turnover in mice transgenic for growth hormone","volume":"65","author":"Pesce","year":"1991","journal-title":"Lab. Investig."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1210\/endo-123-6-2827","article-title":"Growth enhancement of transgenic mice expressing human insulin-like growth factor I","volume":"123","author":"Mathews","year":"1988","journal-title":"Endocrinology"},{"key":"ref_35","first-page":"398","article-title":"Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulin like growth factor-1","volume":"131","author":"Doi","year":"1988","journal-title":"Am. J. Pathol."},{"key":"ref_36","first-page":"541","article-title":"Glomerular lesions in mice transgenic for growth hormone and insulin like growth factor-I. I. Relationship between increased glomerular size and mesangial sclerosis","volume":"137","author":"Doi","year":"1990","journal-title":"Am. J. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e12709","DOI":"10.14814\/phy2.12709","article-title":"Growth hormone (GH)-transgenic insulin-like growth factor 1 (IGF1)-deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth","volume":"4","author":"Blutke","year":"2016","journal-title":"Physiol. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1210\/endo.136.9.7544274","article-title":"Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice","volume":"136","author":"Rajkumar","year":"1995","journal-title":"Endocrinology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1046\/j.1523-1755.2000.00090.x","article-title":"Glomerulosclerosis in mice transgenic for human insulin-like growth factor-binding protein-1","volume":"57","author":"Doublier","year":"2000","journal-title":"Kidney Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1203\/00006450-200105000-00009","article-title":"Overexpression of human insulin-like growth factor binding protein-1 in the mouse leads to nephron deficit","volume":"49","author":"Doublier","year":"2001","journal-title":"Pediatr. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1096\/fasebj.14.5.629","article-title":"Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins","volume":"14","author":"Schneider","year":"2000","journal-title":"FASEB J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1210\/endo.140.12.7169","article-title":"Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain","volume":"140","author":"Hoeflich","year":"1999","journal-title":"Endocrinology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1677\/jme.0.0150293","article-title":"Expression of human insulin-like growth factor-binding protein-3 in transgenic mice","volume":"15","author":"Murphy","year":"1995","journal-title":"J. Mol. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1210\/endo.142.5.8165","article-title":"Phenotypic manifestations of insulin-like growth factor-binding protein-3 overexpression in transgenic mice","volume":"142","author":"Modric","year":"2001","journal-title":"Endocrinology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1210\/en.2004-0905","article-title":"Overexpression of gly56\/gly80\/gly81-mutant insulin-like growth factor-binding protein-3 in transgenic mice","volume":"146","author":"Silha","year":"2005","journal-title":"Endocrinology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1210\/me.2005-0196","article-title":"Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5","volume":"20","author":"Ning","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1210\/mend.14.9.0517","article-title":"Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene","volume":"14","author":"Wood","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1128\/MCB.23.4.1251-1259.2003","article-title":"Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C\/EBP beta and mitogen-activated protein kinase\/extracellular signal-regulated kinase regulation","volume":"23","author":"Leu","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1210\/en.2007-1068","article-title":"Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice","volume":"149","author":"DeMambro","year":"2008","journal-title":"Endocrinology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1530\/JOE-11-0240","article-title":"Global Igfbp1 deletion does not affect prostate cancer development in a c-Myc transgenic mouse model","volume":"211","author":"Gray","year":"2011","journal-title":"J. Endocrinol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1159\/000508224","article-title":"SOCS2 Silencing Improves Somatic Growth without Worsening Kidney Function in CKD","volume":"51","author":"Landau","year":"2020","journal-title":"Am. J. Nephrol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"19378","DOI":"10.1073\/pnas.0809223105","article-title":"The hormonal action of IGF1 in postnatal mouse growth","volume":"105","author":"Stratikopoulos","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1073\/pnas.96.12.7088","article-title":"Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice","volume":"96","author":"Liu","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1681\/ASN.2017080887","article-title":"Conserved and divergent features of human and mouse kidney organogenesis","volume":"29","author":"McMahon","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1210\/endo.131.6.1446640","article-title":"Renal growth hormone receptor gene expression: Relationship to renal insulin-like growth factor system","volume":"131","author":"Chin","year":"1992","journal-title":"Endocrinology"},{"key":"ref_56","first-page":"3097","article-title":"Ontogeny of growth hormone receptors in human tissues: An immunohistochemical study","volume":"81","author":"Simard","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1083\/jcb.113.6.1447","article-title":"Insulin-like growth factors I and II are produced in the metanephros and are required for growth and development in vitro","volume":"113","author":"Rogers","year":"1991","journal-title":"J. Cell Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0303-7207(97)00123-8","article-title":"Gene expression of the insulin-like growth factor system during mouse kidney development","volume":"132","author":"Rosato","year":"1997","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1210\/mend-4-9-1386","article-title":"Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: Comparison with IGF-II gene expression","volume":"4","author":"Bondy","year":"1990","journal-title":"Mol. Endocrinol."},{"key":"ref_60","first-page":"962","article-title":"Insulin-like growth factor system gene expression in the human kidney","volume":"75","author":"Chin","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/edrv-10-1-68","article-title":"Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations","volume":"10","author":"Daughaday","year":"1989","journal-title":"Endocr. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1210\/endo.135.5.7525257","article-title":"Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: Endocrine changes and effects on body and organ growth","volume":"135","author":"Wolf","year":"1994","journal-title":"Endocrinology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2265.1994.tb03937.x","article-title":"Cardiovascular and renal effects of growth hormone","volume":"40","author":"Caidahl","year":"1994","journal-title":"Clin. Endocrinol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0140-6736(89)92328-3","article-title":"Beneficial effects of growth hormone treatment in GH-deficient adults","volume":"333","author":"Pedersen","year":"1989","journal-title":"Lancet"},{"key":"ref_65","first-page":"80","article-title":"Extracellular fluid volume and renal function in pituitary insufficiency and acromegaly","volume":"46","author":"Falkheden","year":"1964","journal-title":"Acta Endocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3109\/0886022X.2013.875834","article-title":"Kidney growth and renal functions under the growth hormone replacement therapy in children","volume":"36","author":"Ece","year":"2014","journal-title":"Ren. Fail."},{"key":"ref_67","first-page":"226","article-title":"Glomerular filtration rate and renal plasma flow in acromegaly","volume":"21","author":"Ikkos","year":"1956","journal-title":"Acta Endocrinol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ando.2011.08.001","article-title":"Impact of growth hormone hypersecretion on the adult human kidney","volume":"72","author":"Grunenwald","year":"2011","journal-title":"Ann. Endocrinol."},{"key":"ref_69","first-page":"151","article-title":"Effect of growth hormone and insulin-like growth factor I on urinary albumin excretion: Studies in acromegaly and growth hormone deficiency","volume":"129","author":"Hoogenberg","year":"1993","journal-title":"Acta Endocrinol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S0026-0495(00)80040-2","article-title":"Exercise-induced microalbuminuria in patients with active acromegaly: Acute effects of slow-release lanreotide, a long-acting somatostatin analog","volume":"49","author":"Manelli","year":"2000","journal-title":"Metabolism"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/BF00869089","article-title":"Renal function in Laron syndrome patients treated by insulin-like growth factor-I","volume":"8","author":"Klinger","year":"1994","journal-title":"Pediatr. Nephrol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1172\/JCI113878","article-title":"Evidence that insulin-like growth factor I increases renal plasma flow and glomerular filtration rate in fasted rats","volume":"83","author":"Hirschberg","year":"1989","journal-title":"J. Clin. Investig."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1172\/JCI115119","article-title":"Effects of recombinant human insulin-like growth factor I on glomerular dynamics in the rat","volume":"87","author":"Hirschberg","year":"1991","journal-title":"J. Clin. Investig."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0272-6386(12)81085-7","article-title":"Growth hormone-induced glomerular hyperfiltration is dependent on vasodilating prostanoids","volume":"21","author":"Nowack","year":"1993","journal-title":"Am. J. Kidney Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/path.4165","article-title":"Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse","volume":"230","author":"Hale","year":"2013","journal-title":"J. Pathol."},{"key":"ref_76","first-page":"423","article-title":"Growth hormone, the insulin-like growth factor system, and the kidney","volume":"17","author":"Feld","year":"1996","journal-title":"Endocr. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1210\/edrv-16-1-63","article-title":"Clinical aspects of growth hormone deficiency in adults","volume":"16","author":"Blok","year":"1995","journal-title":"Endocr. Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1210\/edrv-12-3-189","article-title":"Human growth hormone replacement therapy: Pharmacological and clinical aspects","volume":"12","year":"1991","journal-title":"Endocr. Rev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11154-020-09604-2","article-title":"Growth hormone deficiency and replacement in children","volume":"22","author":"Boguszewski","year":"2021","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1172\/JCI102977","article-title":"Body water and sodium in patients with acromegaly","volume":"33","author":"Ikkos","year":"1954","journal-title":"J. Clin. Investig."},{"key":"ref_81","first-page":"206","article-title":"Cardiovascular complications of acromegaly","volume":"82","author":"Maione","year":"2020","journal-title":"Ann. Endocrinol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ki.1993.57","article-title":"Effects of insulin-like growth factor I on renal function in normal men","volume":"43","author":"Hirschberg","year":"1993","journal-title":"Kidney Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJM199105233242107","article-title":"Effects of the infusion of insulin-like growth factor I in a child with growth hormone insensitivity syndrome (Laron dwarfism)","volume":"324","author":"Walker","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1677\/JOE-07-0024","article-title":"Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression","volume":"193","author":"Svensson","year":"2007","journal-title":"J. Endocrinol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0026-0495(90)90065-K","article-title":"The antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system","volume":"39","author":"Ho","year":"1990","journal-title":"Metabolism"},{"key":"ref_86","first-page":"E803","article-title":"Blockade of the renin-angiotensin-aldosterone system prevents growth hormone-induced fluid retention in humans","volume":"272","author":"Frandsen","year":"1997","journal-title":"Am. J. Physiol. Content"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1210\/jcem-72-4-768","article-title":"Expansion of extracellular volume and suppression of atrial natriuretic peptide after growth hormone administration in normal man","volume":"72","author":"Hansen","year":"1991","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1210\/en.2008-0143","article-title":"Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly","volume":"149","author":"Kamenicky","year":"2008","journal-title":"Endocrinology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1210\/jc.2011-0078","article-title":"Body fluid expansion in acromegaly is related to enhanced epithelial sodium channel (ENaC) activity","volume":"96","author":"Kamenicky","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"18111","DOI":"10.1074\/jbc.C400080200","article-title":"Epithelial sodium channels are activated by furin-dependent proteolysis","volume":"279","author":"Hughey","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0026-0495(82)90055-5","article-title":"Sodium potassium dependent ATPase in hypophysectomized rats: Response to growth hormone, triiodothyronine, and cortisone","volume":"31","author":"Shimomura","year":"1982","journal-title":"Metabolism"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1210\/endo.132.1.8419119","article-title":"Insulin-like growth factor-I regulation of renal 25-hydroxyvitamin D-1-hydroxylase activity","volume":"132","author":"Nesbitt","year":"1993","journal-title":"Endocrinology"},{"key":"ref_93","first-page":"81","article-title":"Effects of short-term insulin-like growth factor-I (IGF-I) or growth hormone (GH) treatment on bone metabolism and on production of 1,25-dihydroxycholecalciferol in GH-deficient adults","volume":"83","author":"Bianda","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_94","first-page":"309","article-title":"Treatment of adults with growth hormone (GH) deficiency with recombinant human GH","volume":"76","author":"Bengtsson","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_95","first-page":"3352","article-title":"Effects of 12 months of growth hormone (GH) treatment on calciotropic hormones, calcium homeostasis, and bone metabolism in adults with acquired GH deficiency: A double blind, randomized, placebo-controlled study","volume":"81","author":"Hansen","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0022-3476(05)83484-5","article-title":"Effects of long-term treatment with growth hormone on bone and mineral metabolism in children with growth hormone deficiency","volume":"122","author":"Saggese","year":"1993","journal-title":"J. Pediatr."},{"key":"ref_97","first-page":"273","article-title":"Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency\/Laron syndrome","volume":"77","author":"Vaccarello","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.4158\/EP13228.CR","article-title":"Hypercalcemia and acromegaly-clarifying the connections. A case report and review of the literature","volume":"20","author":"Manroa","year":"2014","journal-title":"Endocr. Pract."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Adema, A.Y., de Roij van Zuijdewijn, C.L.M., Hoenderop, J.G., de Borst, M.H., Ter Wee, P.M., Heijboer, A.C., Vervloet, M.G., and NIGRAM Consortium (2018). Influence of exogenous growth hormone administration on circulating concentrations of \u03b1-klotho in healthy and chronic kidney disease subjects: A prospective, single-center open case-control pilot study. BMC Nephrol., 19.","DOI":"10.1186\/s12882-018-1114-z"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/cen.12756","article-title":"Effect of Growth hormone replacement therapy on soluble Klotho in patients with Growth hormone deficiency","volume":"83","author":"Locher","year":"2015","journal-title":"Clin. Endocrinol."},{"key":"ref_101","first-page":"229","article-title":"FGF23 promotes renal calcium reabsorption through the TRPV5 channel","volume":"33","author":"Andrukhova","year":"2014","journal-title":"EMBO J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1210\/jc.2002-021787","article-title":"Effects of growth hormone replacement on parathyroid hormone sensitivity and bone mineral metabolism","volume":"88","author":"Ahmad","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1172\/JCI115312","article-title":"Effects of growth hormone and insulin-like growth factor I on rabbit proximal convoluted tubule transport","volume":"88","author":"Quigley","year":"1991","journal-title":"J. Clin. Investig."},{"key":"ref_104","first-page":"428","article-title":"Effects of insulin-like growth factor I on phosphate transport in cultured proximal tubule cells","volume":"126","author":"Hirschberg","year":"1995","journal-title":"J. Lab. Clin. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s004240050759","article-title":"IGF-I and vanadate stimulate Na\/Pi-cotransport in OK cells by increasing type II Na\/Pi-cotransporter protein stability","volume":"437","author":"Jehle","year":"1998","journal-title":"Pflugers Arch."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jocn.2019.11.012","article-title":"Serum phosphate: Does it more closely reflect the true state of acromegaly?","volume":"71","author":"Xie","year":"2020","journal-title":"J. Clin. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1007\/s00467-021-05097-6","article-title":"Renal effects of growth hormone in health and in kidney disease","volume":"36","author":"Haffner","year":"2021","journal-title":"Pediatr. Nephrol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/S0022-5347(01)66929-5","article-title":"Gene expression after uninephrectomy in the rat: Simultaneous expression of positive and negative growth control elements","volume":"154","author":"Moskowitz","year":"1995","journal-title":"J. Urol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1046\/j.1523-1755.1999.00776.x","article-title":"Compensatory renal growth in uninephrectomized adult mice is growth hormone dependent","volume":"56","author":"Flyvbjerg","year":"1999","journal-title":"Kidney Int."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1210\/endo.130.1.1309331","article-title":"Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats","volume":"130","author":"Mulroney","year":"1992","journal-title":"Endocrinology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3389\/fphys.2020.00725","article-title":"Physiology and pathophysiology of compensatory adaptations of a solitary functioning kidney","volume":"11","author":"McArdle","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/pr.2013.87","article-title":"European childhood obesity project. Does insulin-like growth factor-1 mediate protein-induced kidney growth in infants? A secondary analysis from a randomized controlled trial","volume":"74","author":"Luque","year":"2013","journal-title":"Pediatr. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"F628","DOI":"10.1152\/ajprenal.1994.266.4.F628","article-title":"Early increase in pulsatile growth hormone release after unilateral nephrectomy in adult rats","volume":"266","author":"Haramati","year":"1994","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1046\/j.1523-1755.1999.00647.x","article-title":"Gender differences in renal growth and function after uninephrectomy in adult rats","volume":"56","author":"Mulroney","year":"1999","journal-title":"Kidney Int."},{"key":"ref_115","first-page":"A1154","article-title":"Gender differences in renal Ang II AT1 receptor regulation after uninephrectomy: GH dependence in the male rat","volume":"12","author":"Mok","year":"1998","journal-title":"FASEB J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1210\/me.2011-0047","article-title":"Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH","volume":"25","author":"Nordstrom","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ghir.2011.07.008","article-title":"A marked deficiency in circulating and renal IGF-I peptide does not inhibit compensatory renal enlargement in uninephrectomized mice","volume":"21","author":"Landau","year":"2011","journal-title":"Growth Horm. IGF Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/ki.1995.139","article-title":"Cellular events in the evolution of experimental diabetic nephropathy","volume":"47","author":"Young","year":"1995","journal-title":"Kidney Int."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s001250051515","article-title":"Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease","volume":"43","author":"Flyvbjerg","year":"2000","journal-title":"Diabetologia"},{"key":"ref_120","first-page":"9","article-title":"Changes in the growth hormone-IGF-I axis in non-obese diabetic mice","volume":"1","author":"Landau","year":"2000","journal-title":"Int. J. Exp. Diabetes Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"605","DOI":"10.2337\/diab.41.5.605","article-title":"Low plasma growth hormone binding protein in IDDM","volume":"41","author":"Mercado","year":"1992","journal-title":"Diabetes"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/ndt\/gfg142","article-title":"The effect of growth hormone on the development of diabetic kidney disease in rats","volume":"18","author":"Landau","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_123","first-page":"1395","article-title":"Experimental diabetic renal growth: Role of growth hormone and insulin-like growth factor-I","volume":"9","author":"Besbas","year":"1994","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1681\/ASN.V10112374","article-title":"Growth hormone receptor antagonism prevents early renal changes in nonobese diabetic mice","volume":"10","author":"Segev","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jama.1991.03460070070045","article-title":"Somatostatin analogue, octreotide, reduces increased glomerular filtration rate and kidney size in insulin-dependent diabetes","volume":"265","author":"Serri","year":"1991","journal-title":"JAMA"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/ndt\/gfh528","article-title":"Comparison between somatostatin analogues and ACE inhibitor in the NOD mouse model of diabetic kidney disease","volume":"19","author":"Segev","year":"2004","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1681\/ASN.V83436","article-title":"Renal hypertrophy in hyperglycemic non-obese diabetic mice is associated with persistent renal accumulation of insulin-like growth factor I","volume":"8","author":"Segev","year":"1997","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0272-6386(98)70075-7","article-title":"Preferential expression of insulin-like growth factor binding proteins-1, -3, and -5 during early diabetic renal hypertrophy in rats","volume":"32","author":"Park","year":"1998","journal-title":"Am. J. Kidney Dis."},{"key":"ref_129","first-page":"188","article-title":"Increased kidney and liver insulin-like growth factor II\/mannose-6-phosphate receptor concentration in experimental diabetes in rats","volume":"4","author":"Flyvbjerg","year":"1994","journal-title":"Growth Regul."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/sj.ki.5002531","article-title":"Apoptosis in the kidneys of patients with type II diabetic nephropathy","volume":"72","author":"Verzola","year":"2007","journal-title":"Kidney Int."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1210\/en.2006-1285","article-title":"Identification of the glomerular podocyte as a target for growth hormone action","volume":"148","author":"Reddy","year":"2007","journal-title":"Endocrinology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.diabres.2006.09.012","article-title":"Novel roles of the IGF-IGFBP axis in etiopathophysiology of diabetic nephropathy","volume":"76","author":"Vasylyeva","year":"2007","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1210\/en.2006-0066","article-title":"Low insulin-like growth factor binding protein-2 expression is responsible for increased insulin receptor substrate-1 phosphorylation in mesangial cells from mice susceptible to glomerulosclerosis","volume":"147","author":"Fornoni","year":"2006","journal-title":"Endocrinology"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ghir.2005.02.008","article-title":"Insulin-like growth factor binding protein-3 mediates cytokine-induced mesangial cell apoptosis","volume":"15","author":"Vasylyeva","year":"2005","journal-title":"Growth Horm. IGF Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/jcb.25150","article-title":"Growth Hormone Induces Transforming Growth Factor-Beta-Induced Protein in Podocytes: Implications for Podocyte Depletion and Proteinuria","volume":"116","author":"Chitra","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"16109","DOI":"10.1074\/jbc.RA119.008966","article-title":"Growth hormone induces Notch1 signaling in podocytes and contributes to proteinuria in diabetic nephropathy","volume":"294","author":"Nishad","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/dmrr.1172","article-title":"The emerging role of NO and IGF-1 in early renal hypertrophy in STZ-induced diabetic rats","volume":"27","author":"Iaina","year":"2011","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/ndt\/15.3.347","article-title":"Aminoguanidine ameliorates changes in the IGF system in experimental diabetic nephropathy","volume":"15","author":"Bach","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/ki.2008.403","article-title":"Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells","volume":"74","author":"Isshiki","year":"2008","journal-title":"Kidney Int."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00467-007-0527-x","article-title":"Growth hormone axis in chronic kidney disease","volume":"23","author":"Mahesh","year":"2008","journal-title":"Pediatr. Nephrol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1046\/j.1523-1755.2000.00141.x","article-title":"Growth hormone receptor abundance in tibial growth plates of uremic rats: GH\/IGF-I treatment","volume":"58","author":"Edmondson","year":"2000","journal-title":"Kidney Int."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1210\/jcem.82.4.3893","article-title":"Reduced concentration of serum growth hormone (GH)-binding protein in children with chronic renal failure: Correlation with GH insensitivity. The European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. The German Study Group for Growth Hormone Treatment in Chronic Renal Failure","volume":"82","author":"Cronin","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00467-004-1713-8","article-title":"Growth hormone resistance in uremia, a role for impaired JAK\/STAT signaling","volume":"20","author":"Rabkin","year":"2005","journal-title":"Pediatr. Nephrol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1172\/JCI11895","article-title":"Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia","volume":"108","author":"Schaefer","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/ki.2013.196","article-title":"Epiphyseal growth plate growth hormone receptor signaling is decreased in chronic kidney disease-related growth retardation","volume":"84","author":"Troib","year":"2013","journal-title":"Kidney Int."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1097\/01.ASN.0000139492.36400.6C","article-title":"Chronic uremia attenuates growth hormone-induced signal transduction in skeletal muscle","volume":"15","author":"Sun","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/ndt\/gfu003","article-title":"Impaired renal growth hormone JAK\/STAT5 signaling in chronic kidney disease","volume":"29","author":"Wiezel","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1053\/j.ajkd.2014.05.024","article-title":"Insulin-like growth factors and kidney disease","volume":"65","author":"Bach","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"ref_149","first-page":"1654","article-title":"The insulin-like growth factor axis and growth in children with chronic renal failure: A report of the Southwest Pediatric Nephrology Study Group","volume":"83","author":"Powell","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1172\/JCI118499","article-title":"Impaired actions of insulin-like growth factor 1 on protein Synthesis and degradation in skeletal muscle of rats with chronic renal failure. Evidence for a postreceptor defect","volume":"97","author":"Ding","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00467-005-1821-0","article-title":"Growth hormone\/insulin-like growth factor system in children with chronic renal failure","volume":"20","author":"Kiepe","year":"2005","journal-title":"Pediatr. Nephrol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/ki.1993.372","article-title":"Effect of metabolic acidosis on the expression of insulin-like growth factor and growth hormone receptor","volume":"44","author":"Challa","year":"1993","journal-title":"Kidney Int."},{"key":"ref_153","first-page":"33","article-title":"Mechanisms of steroid impairment of growth","volume":"58","author":"Hochberg","year":"2002","journal-title":"Horm. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s004670050277","article-title":"Somatic and renal effects of growth hormone in rats with chronic renal failure","volume":"11","author":"Kawaguchi","year":"1997","journal-title":"Pediatr. Nephrol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"F747","DOI":"10.1152\/ajprenal.1990.259.5.F747","article-title":"Effects of growth hormone and IGF-I on renal function in rats with normal and reduced renal mass","volume":"259","author":"Miller","year":"1990","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/BF01453681","article-title":"How safe is the treatment of uraemic children with recombinant human growth hormone?","volume":"5","author":"Heinrich","year":"1991","journal-title":"Pediatr. Nephrol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/BF00866727","article-title":"Differential effects of recombinant human growth hormone on glomerular filtration rate and renal plasma flow in chronic renal failure","volume":"9","author":"Maxwell","year":"1995","journal-title":"Pediatr. Nephrol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/12\/3371\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:38:00Z","timestamp":1760168280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/12\/3371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,30]]},"references-count":157,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["cells10123371"],"URL":"https:\/\/doi.org\/10.3390\/cells10123371","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,30]]}}}