{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:29:57Z","timestamp":1793042997689,"version":"4.5.0"},"reference-count":171,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council","doi-asserted-by":"publisher","award":["6793"],"award-info":[{"award-number":["6793"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>MicroRNAs are small non-coding RNA (18\u201324 nt long) that fine-tune gene expression at the post-transcriptional level. With the advent of \u201cmulti-omics\u201d analysis and sequencing approaches, they have now been implicated in every facet of basic molecular networks, including metabolism, homeostasis, and cell survival to aid cellular machinery in adapting to changing environmental cues. Many animals must endure harsh environmental conditions in nature, including cold\/freezing temperatures, oxygen limitation (anoxia\/hypoxia), and food or water scarcity, often requiring them to revamp their metabolic organization, frequently on a seasonal or life stage basis. MicroRNAs are important regulatory molecules in such processes, just as they are now well-known to be involved in many human responses to stress or disease. The present review outlines the role of miRNAs in natural animal models of environmental stress and adaptation including torpor\/hibernation, anoxia\/hypoxia tolerance, and freeze tolerance. We also discuss putative medical applications of advances in miRNA biology including organ preservation for transplant, inflammation, ageing, metabolic disorders (e.g., obesity), mitochondrial dysfunction (mitoMirs) as well as specialized miRNA subgroups respective to low temperature (CryomiRs) and low oxygen (OxymiRs). The review also covers differential regulation of conserved and novel miRNAs involved at cell, tissue, and stress specific levels across multiple species and their roles in survival. Ultimately, the species-specific comparison and conserved miRNA responses seen in evolutionarily disparate animal species can help us to understand the complex miRNA network involved in regulating and reorganizing metabolism to achieve diverse outcomes, not just in nature, but in human health and disease.<\/jats:p>","DOI":"10.3390\/cells10123374","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T20:29:27Z","timestamp":1638304167000},"page":"3374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["MicroRNA Cues from Nature: A Roadmap to Decipher and Combat Challenges in Human Health and Disease?"],"prefix":"10.3390","volume":"10","author":[{"given":"Gurjit","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7363-1853","authenticated-orcid":false,"given":"Kenneth B.","family":"Storey","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Allmer, J., and Yousef, M. (2022). Role of MicroRNAs in extreme animal survival strategies. miRNomics, Humana.","DOI":"10.1007\/978-1-0716-1170-8"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"13356","DOI":"10.1038\/s41598-017-13470-5","article-title":"Dynamic and modularized MicroRNA regulation and its implication in human cancers","volume":"7","author":"Shu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12986-018-0305-8","article-title":"MicroRNAs from plants to animals, do they define a new messenger for communication?","volume":"15","author":"Li","year":"2018","journal-title":"Nutr. Metab. (Lond.)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4161\/rna.3.3.3499","article-title":"MicroRNA-mediated silencing inside P bodies","volume":"3","author":"Chan","year":"2006","journal-title":"RNA Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4110\/in.2011.11.3.135","article-title":"MicroRNAs in human diseases: From cancer to cardiovascular disease","volume":"11","author":"Ha","year":"2011","journal-title":"Immune Netw."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrm3313","article-title":"MicroRNAs in metabolism and metabolic disorders","volume":"13","author":"Rottiers","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13287-017-0551-0","article-title":"MicroRNAs: Important regulators of stem cells","volume":"8","author":"Li","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/sj.bjc.6603023","article-title":"MicroRNAs in cell proliferation, cell death, and tumorigenesis","volume":"94","author":"Hwang","year":"2006","journal-title":"Br. J. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"English, S.G., Hadj-Moussa, H., and Storey, K.B. (2018). MicroRNAs regulate survival in oxygen-deprived environments. J. Exp. Biol.","DOI":"10.1242\/jeb.190579"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1387\/ijdb.082643pm","article-title":"Mammalian hibernation: Differential gene expression and novel application of epigenetic controls","volume":"53","author":"Morin","year":"2009","journal-title":"Int. J. Dev. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.ygeno.2021.01.017","article-title":"MicroRNA expression patterns in the brown fat of hibernating 13-lined ground squirrels","volume":"113","author":"Logan","year":"2021","journal-title":"Genomics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1800092","DOI":"10.1002\/bies.201800092","article-title":"Solving donor organ shortage with insights from freeze tolerance in nature","volume":"40","author":"Luu","year":"2018","journal-title":"BioEssays"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1152\/physrev.00016.2016","article-title":"Molecular physiology of freeze tolerance in vertebrates","volume":"97","author":"Storey","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2006.03.043","article-title":"Molecular basis for the recognition of primary MicroRNAs by the Drosha-DGCR8 complex","volume":"125","author":"Han","year":"2006","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microrna biogenesis, function and decay","volume":"11","author":"Krol","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.gpb.2012.06.004","article-title":"Biogenesis of mammalian micrornas: A global view","volume":"10","author":"Graves","year":"2012","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s13105-010-0050-6","article-title":"Biological functions of micrornas: A review","volume":"67","author":"Huang","year":"2011","journal-title":"J. Physiol. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.arr.2016.06.005","article-title":"A synopsis on aging\u2014Theories, mechanisms and future prospects","volume":"29","author":"Vitorino","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1196\/annals.1354.010","article-title":"Aging in mouse and human systems: A comparative study","volume":"1067","author":"Demetrius","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1242\/jcs.099200","article-title":"MicroRNAs and their roles in aging","volume":"125","author":"Slack","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.gpb.2012.09.001","article-title":"Differential expression of mature MicroRNAs involved in muscle maintenance of hibernating little brown bats, Myotis lucifugus: A model of muscle atrophy resistance","volume":"10","author":"Kornfeld","year":"2012","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1128\/MCB.00384-06","article-title":"Smad7 promotes and enhances skeletal muscle differentiation","volume":"26","author":"Kollias","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00360-004-0414-8","article-title":"Energetics and torpor of a South American  \u201cliving fossil\u201d, the microbiotheriid Dromiciops gliroides","volume":"174","author":"Bozinovic","year":"2004","journal-title":"J. Comp. Physiol. B Biochem. Syst. Environ. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"24627","DOI":"10.1038\/srep24627","article-title":"The hibernating south american marsupial, Dromiciops gliroides, displays torpor-sensitive MicroRNA expression patterns","volume":"6","author":"Moggridge","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ng1725","article-title":"The role of MicroRNA-1 and MicroRNA-133 in skeletal muscle proliferation and differentiation","volume":"38","author":"Chen","year":"2006","journal-title":"Nat. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1095-6433(99)00081-1","article-title":"Arousal from torpor in the Chilean mouse-opposum (Thylamys elegans): Does non-shivering thermogenesis play a role?","volume":"123","author":"Opazo","year":"1999","journal-title":"Comp. Biochem. Physiol. Part A Mol. Integr. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1086\/316709","article-title":"Nonshivering thermogenesis in a marsupial (the Tasmanian Bettong Bettongia gaimardi ) is not attributable to brown adipose tissue","volume":"72","author":"Rose","year":"1999","journal-title":"Physiol. Biochem. Zool."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.1002\/jcp.29294","article-title":"MicroRNAs facilitate skeletal muscle maintenance and metabolic suppression in hibernating brown bears","volume":"235","author":"Luu","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: A concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bpobgyn.2010.10.016","article-title":"Oxidative stress","volume":"25","author":"Burton","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e13031","DOI":"10.1111\/acel.13031","article-title":"Oxidative stress in the aging substantia nigra and the etiology of Parkinson\u2019s disease","volume":"18","author":"Trist","year":"2019","journal-title":"Aging Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"16839","DOI":"10.1038\/s41598-017-16829-w","article-title":"Age-dependent increase of oxidative stress regulates MicroRNA-29 family preserving cardiac health","volume":"7","author":"Heid","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fnagi.2019.00137","article-title":"Involvement of MicroRNA-34a in age-related susceptibility to oxidative stress in ARPE-19 cells by targeting the silent mating type information regulation 2 Homolog 1\/P66shc pathway: Implications for age-related macular degeneration","volume":"11","author":"Tong","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11977","DOI":"10.1038\/s41598-021-90583-y","article-title":"Identification of Nrf2-responsive MicroRNA networks as putative mediators of myocardial reductive stress","volume":"11","author":"Quiles","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jtherbio.2018.05.008","article-title":"Investigating Nrf2-associated non-coding RNAs in the hibernating ground squirrel, Ictidomys tridecemlineatus","volume":"75","author":"Frigault","year":"2018","journal-title":"J. Therm. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Izzo, C., Vitillo, P., Di Pietro, P., Visco, V., Strianese, A., Virtuoso, N., Ciccarelli, M., Galasso, G., Carrizzo, A., and Vecchione, C. (2021). The role of oxidative stress in cardiovascular aging and cardiovascular diseases. Life, 11.","DOI":"10.3390\/life11010060"},{"key":"ref_40","unstructured":"Ahmad, S.I. (2017). Hibernation and aging molecular mechanisms of mammalian hypometabolism and its links to longevity. Aging: Exploring a Complex Phenomenon, CRC Press."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"110889","DOI":"10.1016\/j.exger.2020.110889","article-title":"Suspended in time: Molecular responses to hibernation also promote longevity","volume":"134","author":"Storey","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1098\/rspb.2011.0190","article-title":"Hibernation is associated with increased survival and the evolution of slow life histories among mammals","volume":"278","author":"Turbill","year":"2011","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.15252\/embj.201695810","article-title":"Brain Metabolism in Health, Aging, and Neurodegeneration","volume":"36","author":"Camandola","year":"2017","journal-title":"EMBO J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3233\/JAD-190656","article-title":"Extracellular vesicles isolated from familial alzheimer\u2019s disease neuronal cultures induce aberrant Tau phosphorylation in the wild-type mouse brain","volume":"72","author":"Aulston","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.4103\/1673-5374.282242","article-title":"Regrowth and neuronal protection are key for mammalian hibernation: Roles for metabolic suppression","volume":"15","author":"Logan","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jprot.2014.01.006","article-title":"Critical roles of mitochondria in brain activities of torpid myotis ricketti bats revealed by a proteomic approach","volume":"105","author":"Zhang","year":"2014","journal-title":"J. Proteom."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.gene.2014.04.048","article-title":"Identification and expression of microrna in the brain of hibernating bats, Myotis lucifugus","volume":"544","author":"Biggar","year":"2014","journal-title":"Gene"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Yuan, L., Geiser, F., Lin, B., Sun, H., Chen, J., and Zhang, S. (2015). Down but Not Out: The role of MicroRNAs in hibernating bats. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0135064"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs\u2014MicroRNAs with a role in cancer","volume":"6","author":"Slack","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"330","DOI":"10.6026\/97320630002330","article-title":"Oncomirs: The potential role of non-coding MicroRNAs in understanding cancer","volume":"2","author":"Manikandan","year":"2008","journal-title":"Bioinformation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1476-4598-6-60","article-title":"OncomiRs: The discovery and progress of MicroRNAs in cancers","volume":"6","author":"Cho","year":"2007","journal-title":"Mol. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/1476-4598-9-306","article-title":"Serum MicroRNAs as non-invasive biomarkers for cancer","volume":"9","author":"Brase","year":"2010","journal-title":"Mol. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"R762","DOI":"10.1016\/j.cub.2014.06.043","article-title":"Aberrant regulation and function of MicroRNAs in cancer","volume":"24","author":"Adams","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12967-019-1920-5","article-title":"Circulating MiRNAs as non-invasive biomarkers to predict aggressive prostate cancer after radical prostatectomy","volume":"17","author":"Hoey","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"117417","DOI":"10.1016\/j.lfs.2020.117417","article-title":"Cell-free MiRNAs as non-invasive biomarkers in breast cancer: Significance in early diagnosis and metastasis prediction","volume":"246","author":"Kashyap","year":"2020","journal-title":"Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/cdd.2011.190","article-title":"MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant P53 gain of function","volume":"19","author":"Donzelli","year":"2012","journal-title":"Cell Death Differ."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1002\/cncr.25488","article-title":"MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer","volume":"116","author":"Majid","year":"2010","journal-title":"Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13046-016-0319-x","article-title":"Dysregulation of MicroRNA biogenesis in cancer: The Impact of mutant P53 on Drosha complex activity","volume":"35","author":"Gurtner","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ccell.2015.01.002","article-title":"Mutations in the SIX1\/2 pathway and the DROSHA\/DGCR8 MiRNA microprocessor complex underlie high-risk blastemal type wilms tumors","volume":"27","author":"Wegert","year":"2015","journal-title":"Cancer Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/dc.24564","article-title":"Multiplatform molecular test performance in indeterminate thyroid nodules","volume":"48","author":"Lupo","year":"2020","journal-title":"Diagn. Cytopathol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Barr\u00e9-Sinoussi, F., and Montagutelli, X. (2015). Animal models are essential to biological research: Issues and perspectives. Futur. Sci. OA, 1.","DOI":"10.4155\/fso.15.63"},{"key":"ref_63","first-page":"708","article-title":"Mammalian models of chemically induced primary malignancies exploitable for imaging-based preclinical theragnostic research","volume":"5","author":"Liu","year":"2015","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/d41586-018-05890-8","article-title":"The mice with human tumours: Growing pains for a popular cancer model","volume":"560","author":"Willyard","year":"2018","journal-title":"Nature"},{"key":"ref_65","unstructured":"Buffenstein, R., Amoroso, V., Andziak, B., Avdieiev, S., Azpurua, J., Barker, A.J., Bennett, N.C., Brie\u00f1o-Enr\u00edquez, M.A., Bronner, G.N., and Coen, C. (2021). The naked truth: A comprehensive clarification and classification of current \u2018myths\u2019 in naked mole-rat biology. Biol. Rev., brv.12791."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12943-019-1089-9","article-title":"Role of hypoxia in cancer therapy by regulating the tumor microenvironment","volume":"18","author":"Jing","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Logan, S.M., Szereszewski, K.E., Bennett, N.C., Hart, D.W., van Jaarsveld, B., Pamenter, M.E., and Storey, K.B. (2020). The brains of six african mole-rat species show divergent responses to hypoxia. J. Exp. Biol., 223.","DOI":"10.1242\/jeb.215905"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Liu, F.J., Kaur, P., Karolina, D.S., Sepramaniam, S., Armugam, A., Wong, P.T.H., and Jeyaseelan, K. (2015). MiR-335 regulates Hif-1\u03b1 to reduce cell death in both mouse cell line and rat ischemic models. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128432"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1002\/jcp.30216","article-title":"Hypoxic naked mole\u2013rat brains use MicroRNA to coordinate hypometabolic fuels and neuroprotective defenses","volume":"236","author":"Pamenter","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nri.2016.40","article-title":"MicroRNAs as regulatory elements in immune system logic","volume":"16","author":"Mehta","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.gene.2018.08.014","article-title":"Identification of novel and conserved MicroRNA and their expression in the gray mouse lemur, Microcebus murinus, a primate capable of daily torpor","volume":"677","author":"Biggar","year":"2018","journal-title":"Gene"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Zhang, S., Yu, J., Sun, B.F., Hou, G.Z., Yu, Z.J., and Luo, H. (2020). Microrna-92a targets Sertad3 and regulates the growth, invasion, and migration of prostate cancer cells via the P53 pathway. OncoTargets Ther.","DOI":"10.2147\/OTT.S249168"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fnmol.2017.00160","article-title":"Downregulation of MicroRNA-193b-3p promotes autophagy and cell survival by targeting TSC1\/MTOR signaling in NSC-34 cells","volume":"10","author":"Li","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41380-019-0421-5","article-title":"MiR-218: A molecular switch and potential biomarker of susceptibility to stress","volume":"25","author":"Nouel","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Fhu, C.W., and Ali, A. (2020). Fatty acid synthase: An emerging target in cancer. Molecules, 25.","DOI":"10.3390\/molecules25173935"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/hep.31000","article-title":"Fatty acid synthase inhibitor TVB-2640 reduces hepatic de novo lipogenesis in males with metabolic abnormalities","volume":"72","author":"Parks","year":"2020","journal-title":"Hepatology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11010-014-2105-4","article-title":"Differential expression of MiRNAs with metabolic implications in hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus","volume":"394","author":"Morin","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Hadj-Moussa, H., and Storey, K.B. (2020). The OxymiR response to oxygen limitation: A comparative MicroRNA perspective. J. Exp. Biol., 223.","DOI":"10.1242\/jeb.204594"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.pocean.2010.04.004","article-title":"Metabolic physiology of the humboldt squid, Dosidicus gigas: Implications for vertical migration in a pronounced oxygen minimum zone","volume":"86","author":"Rosa","year":"2010","journal-title":"Prog. Oceanogr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.bbagrm.2018.04.007","article-title":"Potential role for MicroRNA in regulating hypoxia-induced metabolic suppression in jumbo squids","volume":"1861","author":"Logan","year":"2018","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Teixeira, A.F., ten Dijke, P., and Zhu, H.-J. (2020). On-target anti-TGF-\u03b2 therapies are not succeeding in clinical cancer treatments: What are remaining challenges?. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00605"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2174\/138945013804806424","article-title":"MicroRNAs: Innovative targets for cerebral ischemia and stroke","volume":"14","author":"Ouyang","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/CIRCRESAHA.109.212183","article-title":"The role of MicroRNA-133 in cardiac hypertrophy uncovered","volume":"106","author":"Abdellatif","year":"2010","journal-title":"Circ. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cbpa.2006.03.019","article-title":"Anoxia tolerance in turtles: Metabolic regulation and gene expression","volume":"147","author":"Storey","year":"2007","journal-title":"Comp. Biochem. Physiol. Part A Mol. Integr. Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1242\/jeb.01124","article-title":"Lactate accumulation, glycogen depletion, and shell composition of hatchling turtles during simulated aquatic hibernation","volume":"207","author":"Reese","year":"2004","journal-title":"J. Exp. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fnut.2014.00027","article-title":"Lactate and cancer: Revisiting the Warburg Effect in an era of lactate shuttling","volume":"1","author":"Goodwin","year":"2015","journal-title":"Front. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.gene.2012.10.049","article-title":"Regulation of P53 by reversible post-transcriptional and post-translational mechanisms in liver and skeletal muscle of an anoxia tolerant turtle, Trachemys scripta elegans","volume":"513","author":"Zhang","year":"2013","journal-title":"Gene"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.4161\/cc.19790","article-title":"Evidence for cell cycle suppression and MicroRNA regulation of Cyclin D1 during anoxia exposure in turtles","volume":"11","author":"Biggar","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Lee, Y., Johnson, K.R., and Hallenbeck, J.M. (2012). Global protein conjugation by Ubiquitin-like-modifiers during ischemic stress is regulated by MicroRNAs and confers robust tolerance to ischemia. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047787"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Wei, W., and Lin, H.-K. (2012). The key role of Ubiquitination and Sumoylation in signaling and cancer: A research topic. Front. Oncol., 2.","DOI":"10.3389\/fonc.2012.00187"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/sj.jcbfm.9600395","article-title":"Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells","volume":"27","author":"Lee","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.18632\/oncotarget.3052","article-title":"The MicroRNA-200 family: Small molecules with novel roles in cancer development, progression and therapy","volume":"6","author":"Humphries","year":"2015","journal-title":"Oncotarget"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12943-016-0563-x","article-title":"MiR-182 promotes cancer invasion by linking RET oncogene activated NF-\u039aB to loss of the HES1\/Notch1 regulatory circuit","volume":"16","author":"Spitschak","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1743-7075-2-30","article-title":"Targeting energy metabolism in brain cancer: Review and hypothesis","volume":"2","author":"Seyfried","year":"2005","journal-title":"Nutr. Metab. (Lond.)"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Symonds, M. (2017). The Physiological Significance of Brown Adipose Tissue and the Beiging of White Adipose Tissue in People. Adipose Tissue Biology, Springer International Publishing.","DOI":"10.1007\/978-3-319-52031-5"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev-physiol-021113-170252","article-title":"A new era in brown adipose tissue biology: Molecular control of brown fat development and energy homeostasis","volume":"76","author":"Kajimura","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fendo.2020.00156","article-title":"Inflammatory signaling and brown fat activity","volume":"11","author":"Omran","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Ballinger, M.A., and Andrews, M.T. (2018). Nature\u2019s fat-burning machine: Brown adipose tissue in a hibernating mammal. J. Exp. Biol., 221.","DOI":"10.1242\/jeb.162586"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature21025","article-title":"An Argonaute phosphorylation cycle promotes MicroRNA-mediated silencing","volume":"542","author":"Golden","year":"2017","journal-title":"Nature"},{"key":"ref_100","first-page":"E1085","article-title":"A stringent validation of mouse adipose tissue identity markers","volume":"308","author":"Larsson","year":"2015","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1002\/jcb.29539","article-title":"MiR-92a regulates brown adipocytes differentiation, mitochondrial oxidative respiration, and heat generation by targeting SMAD7","volume":"121","author":"Zhang","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.gpb.2014.08.003","article-title":"Expression profiling and structural characterization of MicroRNAs in adipose tissues of hibernating ground squirrels","volume":"12","author":"Wu","year":"2014","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.pcad.2018.07.002","article-title":"Role of human brown fat in obesity, metabolism and cardiovascular disease: Strategies to turn up the heat","volume":"61","author":"Ruiz","year":"2018","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Javadov, S., Kozlov, A.V., and Camara, A.K.S. (2020). Mitochondria in health and diseases. Cells, 9.","DOI":"10.3390\/cells9051177"},{"key":"ref_105","first-page":"269","article-title":"Characterization of MiRNAs modulated by torpor in the hibernating ground squirrel, Ictidomys tridecemlineatus liver by next-generation sequencing","volume":"38","author":"Morin","year":"2017","journal-title":"Cryo Lett."},{"key":"ref_106","first-page":"15677","article-title":"MiR-15b mediates liver cancer cells proliferation through targeting BCL-2","volume":"8","author":"Zhang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.3892\/ijo.2016.3751","article-title":"Knockdown of MiR-25 increases the sensitivity of liver cancer stem cells to TRAIL-induced apoptosis via PTEN\/PI3K\/Akt\/Bad signaling pathway","volume":"49","author":"Feng","year":"2016","journal-title":"Int. J. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1006\/bbrc.2001.4765","article-title":"Mechanisms of neuroprotection by a novel rescue factor humanin from swedish mutant amyloid precursor protein","volume":"283","author":"Hashimoto","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/cbf.3422","article-title":"Identification of a prosurvival neuroprotective mitochondrial peptide in a mammalian hibernator","volume":"37","author":"Szereszewski","year":"2019","journal-title":"Cell Biochem. Funct."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10930-020-09944-7","article-title":"Oxidative Damage? not a problem! the characterization of Humanin-like mitochondrial peptide in anoxia tolerant freshwater turtles","volume":"40","author":"Wijenayake","year":"2021","journal-title":"Protein J."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"14212","DOI":"10.1038\/s41598-018-32616-7","article-title":"Humanin prevents age-related cognitive decline in mice and is associated with improved cognitive age in humans","volume":"8","author":"Yen","year":"2018","journal-title":"Sci. Rep.,"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"dju006","DOI":"10.1093\/jnci\/dju006","article-title":"New role for the mitochondrial peptide Humanin: Protective agent against chemotherapy-induced side effects","volume":"106","author":"Cohen","year":"2014","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1167\/iovs.15-17053","article-title":"The mitochondrial-derived peptide Humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction","volume":"57","author":"Sreekumar","year":"2016","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nature01627","article-title":"Humanin peptide suppresses apoptosis by interfering with bax activation","volume":"423","author":"Guo","year":"2003","journal-title":"Nature"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"8542","DOI":"10.1038\/s41598-020-65381-7","article-title":"Humanin promotes tumor progression in experimental triple negative breast cancer","volume":"10","author":"Gottardo","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.2147\/DMSO.S306026","article-title":"[Gly14]-Humanin ameliorates high glucose-induced apoptosis by inhibiting the expression of MicroRNA-155 in endothelial microparticles","volume":"14","author":"Shen","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1385\/MN:30:3:327","article-title":"Humanin: After the discovery","volume":"30","author":"Niikura","year":"2004","journal-title":"Mol. Neurobiol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Borralho, P.M., Rodrigues, C.M.P., and Steer, C.J. (2015). MicroRNAs in mitochondria: An unexplored niche. Advances in Experimental Medicine and Biology, Springer.","DOI":"10.1007\/978-3-319-22380-3_3"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"206382","DOI":"10.1155\/2015\/206382","article-title":"A complex genome-MicroRNA interplay in human mitochondria","volume":"2015","author":"Shinde","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1161\/CIRCRESAHA.112.267732","article-title":"Nuclear MiRNA regulates the mitochondrial genome in the heart","volume":"110","author":"Das","year":"2012","journal-title":"Circ. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"865638","DOI":"10.1155\/2013\/865638","article-title":"Mediators of inflammation and immune responses in the human gastrointestinal tract","volume":"2013","author":"Arranz","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_122","first-page":"4042509","article-title":"Mitochondria associated MicroRNA expression profiling of heart failure","volume":"2017","author":"Wang","year":"2017","journal-title":"BioMed Res. Int."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1007\/s00018-019-03375-z","article-title":"MiR-378a: A new emerging microrna in metabolism","volume":"77","author":"Machado","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.exger.2014.03.002","article-title":"MitomiRs in human inflamm-aging: A hypothesis involving MiR-181a, MiR-34a and MiR-146a","volume":"56","author":"Rippo","year":"2014","journal-title":"Exp. Gerontol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Olivieri, F., Rippo, M.R., Procopio, A.D., and Fazioli, F. (2013). Circulating Inflamma-MiRs in aging and age-related diseases. Front. Genet., 4.","DOI":"10.3389\/fgene.2013.00121"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1167\/iovs.09-4874","article-title":"Modulation of inflammatory markers by MiR-146a during replicative senescence in trabecular meshwork cells","volume":"51","author":"Li","year":"2010","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.omtn.2019.06.013","article-title":"The different roles of MiRNA-92a-2-5p and Let-7b-5p in mitochondrial translation in Db\/Db mice","volume":"17","author":"Li","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s41419-019-1734-7","article-title":"Mitochondrial MiR-762 regulates apoptosis and myocardial infarction by impairing ND2","volume":"10","author":"Yan","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"256","DOI":"10.21037\/atm.2018.06.21","article-title":"Mitochondria and cardiovascular diseases\u2014from pathophysiology to treatment","volume":"6","author":"Siasos","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"162","DOI":"10.11622\/smedj.2019032","article-title":"Joseph Murray (1919\u20132012): First transplant surgeon","volume":"60","author":"Tan","year":"2019","journal-title":"Singapore Med. J."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Beyar, R. (2011). Challenges in organ transplantation. Rambam Maimonides Med. J., 2.","DOI":"10.5041\/RMMJ.10049"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nbt.3889","article-title":"The promise of organ and tissue preservation to transform medicine","volume":"35","author":"Giwa","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/febs.14683","article-title":"Bringing nature back: Using hibernation to reboot organ preservation","volume":"286","author":"Storey","year":"2019","journal-title":"FEBS J."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/aps.2017.182","article-title":"Organ preservation: From the past to the future","volume":"39","author":"Jing","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Storey, K.B., and Storey, J.M. (2010). Metabolic rate depression. Advances in Clinical Chemistry, Elsevier\/Academic Press.","DOI":"10.1016\/S0065-2423(10)52003-1"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gpb.2015.06.001","article-title":"The gray mouse lemur: A model for studies of primate metabolic rate depression","volume":"13","author":"Storey","year":"2015","journal-title":"Genom. Proteom Bioinform."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3389\/fphys.2020.623665","article-title":"The torpid state: Recent advances in metabolic adaptations and protective mechanisms","volume":"11","author":"Giroud","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1152\/physiolgenomics.00005.2016","article-title":"Analysis of MicroRNA expression during the torpor-arousal cycle of a mammalian hibernator, the 13-lined ground squirrel","volume":"48","author":"Wu","year":"2016","journal-title":"Physiol. Genomics"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1681\/ASN.2010040351","article-title":"The evolving role of MTOR inhibition in transplantation tolerance","volume":"22","author":"McMahon","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1242\/jeb.066225","article-title":"Regulation of the MTOR signaling network in hibernating thirteen-lined ground squirrels","volume":"215","author":"Wu","year":"2012","journal-title":"J. Exp. Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/jcp.26908","article-title":"MiR-874 alleviates renal injury and inflammatory response in diabetic nephropathy through targeting toll-like receptor-4","volume":"234","author":"Yao","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Chae, S., Choi, J., Lim, S., Choi, H.J., Park, J., Hong, S.H., Park, C.S., Choi, J.H., and Chae, M.S. (2020). Stress burden related to postreperfusion syndrome may aggravate hyperglycemia with insulin resistance during living donor liver transplantation: A propensity score-matching analysis. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0243873"},{"key":"ref_143","first-page":"2263","article-title":"Normothermic preservation poised to change organ transplants","volume":"319","author":"Abbasi","year":"2018","journal-title":"JAMA."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/01.sa.0000087691.31092.12","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest","volume":"47","author":"Nikolov","year":"2003","journal-title":"Surv. Anesthesiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1213\/00000539-195911000-00010","article-title":"The use of hypothermia after cardiac arrest","volume":"38","author":"Benson","year":"1959","journal-title":"Anesth. Analg."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Peberdy, M.A., Callaway, C.W., Neumar, R.W., Geocadin, R.G., Zimmerman, J.L., Donnino, M., Gabrielli, A., Silvers, S.M., Zaritsky, A.L., and Merchant, R. (2010). Part 9: Post-cardiac arrest care: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation, 122.","DOI":"10.1161\/CIRCULATIONAHA.110.971002"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0169-328X(01)00247-9","article-title":"Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia","volume":"95","author":"Zhang","year":"2001","journal-title":"Mol. Brain Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1089\/neu.1997.14.561","article-title":"The effect of brain temperature on acute inflammation after traumatic brain injury in rats","volume":"14","author":"Whalen","year":"1997","journal-title":"J. Neurotrauma"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s004010000290","article-title":"Immunomorphological sequelae of severe brain injury induced by fluid-percussion in juvenile pigs\u2014Effects of mild hypothermia","volume":"101","author":"Brodhun","year":"2001","journal-title":"Acta Neuropathol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1038\/jcbfm.2011.33","article-title":"Therapeutic hypothermia alters microrna responses to traumatic brain injury in rats","volume":"31","author":"Truettner","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"15432","DOI":"10.1038\/s41598-020-71931-w","article-title":"Body temperature-dependent MicroRNA expression analysis in rats: Rno-MiR-374-5p regulates apoptosis in skeletal muscle cells via Mex3B under hypothermia","volume":"10","author":"Umehara","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/jeb.104828","article-title":"Insight into post-transcriptional gene regulation: Stress-responsive MicroRNAs and their role in the environmental stress survival of tolerant animals","volume":"218","author":"Biggar","year":"2015","journal-title":"J. Exp. Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/jmcb\/mjx053","article-title":"Functional impact of MicroRNA regulation in models of extreme stress adaptation","volume":"10","author":"Biggar","year":"2018","journal-title":"J. Mol. Cell Biol."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Storey, K.B., and Storey, J.M. (2013). Molecular biology of freezing tolerance. Comprehensive Physiology, John Wiley & Sons, Inc.","DOI":"10.1002\/cphy.c130007"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"R1771","DOI":"10.1152\/ajpregu.1994.266.6.R1771","article-title":"1H magnetic resonance imaging of freezing and thawing in freeze-tolerant frogs","volume":"266","author":"Rubinsky","year":"1994","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-020-03820-9","article-title":"MondoA:MLX complex regulates glucose-dependent gene expression and links to circadian rhythm in liver and brain of the freeze-tolerant wood frog, Rana sylvatica","volume":"473","author":"Singh","year":"2020","journal-title":"Mol. Cell. Biochem.,"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cryobiol.2009.08.009","article-title":"MicroRNA regulation below zero: Differential expression of MiRNA-21 and MiRNA-16 during freezing in wood frogs","volume":"59","author":"Biggar","year":"2009","journal-title":"Cryobiology"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1007\/s00018-018-2821-0","article-title":"Micromanaging freeze tolerance: The biogenesis and regulation of neuroprotective MicroRNAs in frozen brains","volume":"75","author":"Storey","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1038\/jcbfm.2013.157","article-title":"Inhibition of MicroRNA-181 reduces forebrain ischemia-induced neuronal loss","volume":"33","author":"Moon","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2014.11.007","article-title":"Post-Stroke treatment with MiR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia","volume":"264","author":"Xu","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00360-015-0951-3","article-title":"MicroRNA regulation in heart and skeletal muscle over the freeze\u2013thaw cycle in the freeze tolerant wood frog","volume":"186","author":"Bansal","year":"2016","journal-title":"J. Comp. Physiol. B"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jtherbio.2016.09.008","article-title":"Exploration of low temperature MicroRNA function in an anoxia tolerant vertebrate ectotherm, the red eared slider turtle (Trachemys scripta elegans)","volume":"68","author":"Biggar","year":"2017","journal-title":"J. Therm. Biol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1582-4934.2008.00556.x","article-title":"MiR-21: A small multi-faceted rna","volume":"13","author":"Krichevsky","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","article-title":"MiRBase: Annotating high confidence MicroRNAs using deep sequencing data","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"MiRBase: From MicroRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA Therapeutics: Towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s10637-016-0407-y","article-title":"Phase I study of MRX34, a liposomal MiR-34a mimic, administered twice weekly in patients with advanced solid tumors","volume":"35","author":"Beg","year":"2017","journal-title":"Investig. New Drugs"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nature06783","article-title":"LNA-mediated MicroRNA silencing in non-human primates","volume":"452","author":"Lindow","year":"2008","journal-title":"Nature"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2006.01.005","article-title":"MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting","volume":"3","author":"Esau","year":"2006","journal-title":"Cell Metab."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/jmcb\/mjq045","article-title":"The emerging roles of micrornas in the molecular responses of metabolic rate depression","volume":"3","author":"Biggar","year":"2011","journal-title":"J. Mol. Cell Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/17460441.2020.1765770","article-title":"Challenges identifying efficacious MiRNA therapeutics for cancer","volume":"15","author":"Segal","year":"2020","journal-title":"Expert Opin. 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