{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:13:13Z","timestamp":1790399593437,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["320030_182690"],"award-info":[{"award-number":["320030_182690"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Mesothelioma is an aggressive cancer associated with asbestos exposure. RNA-binding motif protein 8a (RBM8A) mRNA editing increases in mouse tissues upon asbestos exposure. The aim of this study was to further characterize the role of RBM8A in mesothelioma and the consequences of its mRNA editing. RBM8A protein expression was higher in mesothelioma compared to mesothelial cells. Silencing RBM8A changed splicing patterns in mesothelial and mesothelioma cells but drastically reduced viability only in mesothelioma cells. In the tissues of asbestos-exposed mice, editing of Rbm8a mRNA was associated with increased protein immunoreactivity, with no change in mRNA levels. Increased adenosine deaminase acting on dsRNA (ADAR)-dependent editing of Alu elements in the RBM8A 3\u2032UTR was observed in mesothelioma cells compared to mesothelial cells. Editing stabilized protein expression. The unedited RBM8A 3\u2032UTR had a stronger interaction with Musashi (MSI) compared to the edited form. The silencing of MSI2 in mesothelioma or overexpression of Adar2 in mesothelial cells resulted in increased RBM8A protein levels. Therefore, ADAR-dependent editing contributes to maintaining elevated RBM8A protein levels in mesothelioma by counteracting MSI2-driven downregulation. A wider implication of this mechanism for the translational control of protein expression is suggested by the editing of similarly structured Alu elements in several other transcripts.<\/jats:p>","DOI":"10.3390\/cells10123543","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T09:02:19Z","timestamp":1639558939000},"page":"3543","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Double-Stranded RNA Structural Elements Holding the Key to Translational Regulation in Cancer: The Case of Editing in RNA-Binding Motif Protein 8A"],"prefix":"10.3390","volume":"10","author":[{"given":"Asra","family":"Abukar","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wipplinger","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Hariharan","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3622-3172","authenticated-orcid":false,"given":"Suna","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ronner","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Sculco","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Okonska","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Kresoja-Rakic","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"},{"name":"Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7612-9394","authenticated-orcid":false,"given":"Hubert","family":"Rehrauer","sequence":"additional","affiliation":[{"name":"Functional Genomics Center Z\u00fcrich, Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich, University of Z\u00fcrich, 8057 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Qi","sequence":"additional","affiliation":[{"name":"Functional Genomics Center Z\u00fcrich, Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich, University of Z\u00fcrich, 8057 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor W.","family":"Beusechem","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-0294","authenticated-orcid":false,"given":"Emanuela","family":"Felley-Bosco","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1021\/acs.chemrestox.8b00146","article-title":"Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials","volume":"31","author":"MacFarlane","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3322\/caac.21572","article-title":"Mesothelioma: Scientific clues for prevention, diagnosis, and therapy","volume":"69","author":"Carbone","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1158\/1535-7163.MCT-19-0356","article-title":"Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition","volume":"19","author":"Okonska","year":"2020","journal-title":"Mol. Cancer Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/geno.1999.6064","article-title":"MAGOH interacts with a novel RNA-binding protein","volume":"63","author":"Zhao","year":"2000","journal-title":"Genomics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"a034728","DOI":"10.1101\/cshperspect.a034728","article-title":"What Are 3\u2032UTRs Doing?","volume":"11","author":"Mayr","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrm.2016.116","article-title":"Alternative polyadenylation of mRNA precursors","volume":"18","author":"Tian","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e1411","DOI":"10.1002\/wrna.1411","article-title":"The exon junction complex: A lifelong guardian of mRNA fate","volume":"8","author":"Woodward","year":"2017","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.molcel.2018.08.030","article-title":"Exon Junction Complexes Suppress Spurious Splice Sites to Safeguard Transcriptome Integrity","volume":"72","author":"Boehm","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng.3520","article-title":"Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations","volume":"48","author":"Bueno","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ygeno.2010.02.002","article-title":"Knockdown of COPA, identified by loss-of-function screen, induces apoptosis and suppresses tumor growth in mesothelioma mouse model","volume":"95","author":"Sudo","year":"2010","journal-title":"Genomics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a Cancer Dependency Map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/ng.3984","article-title":"Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells","volume":"49","author":"Meyers","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.canlet.2021.03.004","article-title":"Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development","volume":"507","author":"Sun","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1038\/s41388-018-0153-z","article-title":"How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations","volume":"37","author":"Rehrauer","year":"2018","journal-title":"Oncogene"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"200112","DOI":"10.1098\/rsob.200112","article-title":"RNA editing in mesothelioma: A look forward","volume":"10","author":"Hariharan","year":"2020","journal-title":"Open Biol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Athanasiadis, A., Rich, A., and Maas, S. (2004). Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol., 2.","DOI":"10.1371\/journal.pbio.0020391"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s10555-020-09884-9","article-title":"RNA-biology ruling cancer progression? Focus on 3\u2032UTRs and splicing","volume":"39","year":"2020","journal-title":"Cancer Metastasis Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e1757","DOI":"10.1038\/cddis.2015.124","article-title":"Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K\/mTOR inhibitors","volume":"6","author":"Echeverry","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kresoja-Rakic, J., and Felley-Bosco, E. (2018). Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells. J. Vis. Exp., e57516.","DOI":"10.3791\/57516"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1093\/carcin\/bgr127","article-title":"Pleural mesothelioma side populations have a precursor phenotype","volume":"32","author":"Frei","year":"2011","journal-title":"Carcinogenesis"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1186\/s13059-014-0551-7","article-title":"Transcriptome-wide modulation of splicing by the exon junction complex","volume":"15","author":"Wang","year":"2014","journal-title":"Genome Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5849","DOI":"10.1093\/nar\/gkaa305","article-title":"The cell line A-to-I RNA editing catalogue","volume":"48","author":"Schaffer","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"D109","DOI":"10.1093\/nar\/gkt996","article-title":"RADAR: A rigorously annotated database of A-to-I RNA editing","volume":"42","author":"Ramaswami","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"D258","DOI":"10.1093\/nar\/gks961","article-title":"Darned in 2013: Inclusion of model organisms and linking with Wikipedia","volume":"41","author":"Kiran","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"14941","DOI":"10.1038\/srep14941","article-title":"Profiling RNA editing in human tissues: Towards the inosinome Atlas","volume":"5","author":"Picardi","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1038\/emboj.2012.292","article-title":"Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay","volume":"31","author":"Liu","year":"2012","journal-title":"EMBO J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-1-4939-1369-5_8","article-title":"RNA pulldown protocol for in vitro detection and identification of RNA-associated proteins","volume":"1206","author":"Huarte","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1073\/pnas.91.6.2230","article-title":"Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3","volume":"91","author":"Wang","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1261\/rna.965408","article-title":"miRDB: A microRNA target prediction and functional annotation database with a wiki interface","volume":"14","author":"Wang","year":"2008","journal-title":"RNA"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Oehl, K., Vrugt, B., Wagner, U., Kirschner, M.B., Meerang, M., Weder, W., Felley-Bosco, E., Wollscheid, B., Bankov, K., and Demes, M.C. (2021). Alterations in BAP1 Are Associated with Cisplatin Resistance through Inhibition of Apoptosis in Malignant Pleural Mesothelioma. Clin. Cancer Res., 2277\u20132291.","DOI":"10.1158\/1078-0432.CCR-20-4037"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.21037\/tlcr.2017.04.12","article-title":"In vitro experimental models of mesothelioma revisited","volume":"6","author":"Singh","year":"2017","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Shankavaram, U.T., Varma, S., Kane, D., Sunshine, M., Chary, K.K., Reinhold, W.C., Pommier, Y., and Weinstein, J.N. (2009). CellMiner: A relational database and query tool for the NCI-60 cancer cell lines. BMC Genom., 10.","DOI":"10.1186\/1471-2164-10-277"},{"key":"ref_34","first-page":"D682","article-title":"Ensembl 2020","volume":"48","author":"Yates","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/geno.2000.6315","article-title":"Identification and structural analysis of human RBM8A and RBM8B: Two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor","volume":"69","author":"Salicioni","year":"2000","journal-title":"Genomics"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1038\/s41467-021-25173-7","article-title":"The pathogenesis of mesothelioma is driven by a dysregulated translatome","volume":"12","author":"Grosso","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.molcel.2021.01.040","article-title":"Alternative RNA structures formed during transcription depend on elongation rate and modify RNA processing","volume":"81","author":"Saldi","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"W70","DOI":"10.1093\/nar\/gkn188","article-title":"The Vienna RNA websuite","volume":"36","author":"Gruber","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nsmb.3203","article-title":"Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity","volume":"23","author":"Matthews","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1017\/S135583820101007X","article-title":"Substrate recognition by ADAR1 and ADAR2","volume":"7","author":"Wong","year":"2001","journal-title":"RNA"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Fukao, A., Tomohiro, T., and Fujiwara, T. (2021). Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors. Cells, 10.","DOI":"10.3390\/cells10071711"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1038\/s41467-020-15814-8","article-title":"HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells","volume":"11","author":"Nguyen","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mcn.2005.09.003","article-title":"The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1","volume":"31","author":"Battelli","year":"2006","journal-title":"Mol. Cell Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1128\/MCB.21.12.3888-3900.2001","article-title":"The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA","volume":"21","author":"Imai","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1083\/jcb.200708004","article-title":"Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP","volume":"181","author":"Kawahara","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jhep.2020.07.021","article-title":"RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis","volume":"74","author":"Song","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.gde.2017.11.006","article-title":"Expanding horizons: New roles for non-canonical RNA-binding proteins in cancer","volume":"48","author":"Moore","year":"2018","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1038\/s41388-019-0711-z","article-title":"High-throughput RNAi screening reveals cancer-selective lethal targets in the RNA spliceosome","volume":"38","author":"Blijlevens","year":"2019","journal-title":"Oncogene"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"24799","DOI":"10.1038\/srep24799","article-title":"Cross-tissue Analysis of Gene and Protein Expression in Normal and Cancer Tissues","volume":"6","author":"Kosti","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.isci.2019.10.059","article-title":"Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines","volume":"21","author":"Guo","year":"2019","journal-title":"iScience"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ccell.2019.02.005","article-title":"The Proteogenomic Landscape of Curable Prostate Cancer","volume":"35","author":"Sinha","year":"2019","journal-title":"Cancer Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature18003","article-title":"Proteogenomics connects somatic mutations to signalling in breast cancer","volume":"534","author":"Mertins","year":"2016","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature13438","article-title":"Proteogenomic characterization of human colon and rectal cancer","volume":"513","author":"Zhang","year":"2014","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1158\/2159-8290.CD-18-0804","article-title":"Integrative Molecular Characterization of Malignant Pleural Mesothelioma","volume":"8","author":"Hmeljak","year":"2018","journal-title":"Cancer Discov."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/s10637-014-0076-7","article-title":"Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells","volume":"32","author":"Chen","year":"2014","journal-title":"Investig. New Drugs"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Grosso, S., Pesce, E., Brina, D., Beugnet, A., Loreni, F., and Biffo, S. (2011). Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0029136"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"14443","DOI":"10.1038\/ncomms14443","article-title":"Pervasive translational regulation of the cell signalling circuitry underlies mammalian development","volume":"8","author":"Fujii","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1038\/ncomms6274","article-title":"Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3\u2032-UTR landscape across seven tumour types","volume":"5","author":"Xia","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"31993","DOI":"10.18632\/oncotarget.16669","article-title":"miR-29a regulates the proliferation and differentiation of retinal progenitors by targeting Rbm8a","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1165\/rcmb.2009-0060OC","article-title":"MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications","volume":"42","author":"Busacca","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13059-014-0575-z","article-title":"Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma","volume":"16","author":"Tomaselli","year":"2015","journal-title":"Genome Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-cellbio-100814-125446","article-title":"Musashi signaling in stem cells and cancer","volume":"31","author":"Fox","year":"2015","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1093\/nar\/gkw207","article-title":"Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration","volume":"44","author":"Bennett","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrm.2017.130","article-title":"A brave new world of RNA-binding proteins","volume":"19","author":"Hentze","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/12\/3543\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:48:43Z","timestamp":1760168923000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/10\/12\/3543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":64,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["cells10123543"],"URL":"https:\/\/doi.org\/10.3390\/cells10123543","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,15]]}}}