{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:20:26Z","timestamp":1792718426633,"version":"4.5.0"},"reference-count":168,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Stroke remains the number one cause of morbidity in the United States. Within weeks to months after an ischemic event, there is a resolution of inflammation and evidence of neurogenesis; however, years following a stroke, there is evidence of chronic inflammation in the central nervous system, possibly by the persistence of an autoimmune response to brain antigens as a result of ischemia. The mechanisms underlying the involvement of macrophage and microglial activation after stroke are widely acknowledged as having a role in ischemic stroke pathology; thus, modulating inflammation and neurological recovery is a hopeful strategy for treating the long-term outcomes after ischemic injury. Current treatments fail to provide neuroprotective or neurorestorative benefits after stroke; therefore, to ameliorate brain injury-induced deficits, therapies must alter both the initial response to injury and the subsequent inflammatory process. This review will address differences in macrophage and microglia nomenclature and summarize recent work in elucidating the mechanisms of macrophage and microglial participation in antigen presentation, neuroprotection, angiogenesis, neurogenesis, synaptic remodeling, and immune modulating strategies for treating the long-term outcomes after ischemic injury.<\/jats:p>","DOI":"10.3390\/cells10123555","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T11:27:36Z","timestamp":1639654056000},"page":"3555","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Microglia and Macrophages in Neuroprotection, Neurogenesis, and Emerging Therapies for Stroke"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-4248","authenticated-orcid":false,"given":"Susanna R.","family":"Var","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA"},{"name":"Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN 55108, USA"},{"name":"Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1185-3183","authenticated-orcid":false,"given":"Anala V.","family":"Shetty","sequence":"additional","affiliation":[{"name":"Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA"},{"name":"Department of Biological Sciences, University of Minnesota Medical School, Minneapolis, MN 55108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-7969","authenticated-orcid":false,"given":"Andrew W.","family":"Grande","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA"},{"name":"Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter C.","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA"},{"name":"Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-4746","authenticated-orcid":false,"given":"Maxim C.","family":"Cheeran","sequence":"additional","affiliation":[{"name":"Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN 55108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics\u20142020 Update: A Report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1600-065X.2012.01127.x","article-title":"Inflammatory cell trafficking across the blood-brain barrier: Chemokine regulation and in vitro models","volume":"248","author":"Takeshita","year":"2012","journal-title":"Immunol. 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