{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:37:42Z","timestamp":1790213862977,"version":"4.1.0"},"reference-count":138,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Autophagy is an evolutionarily conserved process that contributes to maintain cell homeostasis. Although it is strongly regulated by many extracellular factors, induction of autophagy is mainly produced by starvation of nutrients. In mammalian cells, the regulation of autophagy by amino acids, and also by the hormone insulin, has been extensively investigated, but knowledge about the effects of other autophagy regulators, including another nutrient, glucose, is more limited. Here we will focus on the signalling pathways by which environmental glucose directly, i.e., independently of insulin and glucagon, regulates autophagy in mammalian cells, but we will also briefly mention some data in yeast. Although glucose deprivation mainly induces autophagy via AMPK activation and the subsequent inhibition of mTORC1, we will also comment other signalling pathways, as well as evidences indicating that, under certain conditions, autophagy can be activated by glucose. A better understanding on how glucose regulates autophagy not only will expand our basic knowledge of this important cell process, but it will be also relevant to understand common human disorders, such as cancer and diabetes, in which glucose levels play an important role.<\/jats:p>","DOI":"10.3390\/cells1030372","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T03:13:59Z","timestamp":1343445239000},"page":"372-395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Regulation of Autophagy by Glucose in Mammalian Cells"],"prefix":"10.3390","volume":"1","author":[{"given":"F\u00e9lix","family":"Moruno","sequence":"first","affiliation":[{"name":"Principe Felipe Research Centre, C\/Eduardo Primo Y\u00fafera 3, Valencia 46012, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"P\u00e9rez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Principe Felipe Research Centre, C\/Eduardo Primo Y\u00fafera 3, Valencia 46012, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Knecht","sequence":"additional","affiliation":[{"name":"Principe Felipe Research Centre, C\/Eduardo Primo Y\u00fafera 3, Valencia 46012, Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBERER), Valencia 46012, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1007\/s00018-009-0030-6","article-title":"Intracellular protein degradation in mammalian cells: Recent developments","volume":"66","author":"Knecht","year":"2009","journal-title":"Cell Mol. Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1152\/physrev.00030.2009","article-title":"Regulation of mammalian autophagy in physiology and pathophysiology","volume":"90","author":"Ravikumar","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","article-title":"mTOR regulation of autophagy","volume":"584","author":"Jung","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1016\/j.febslet.2007.06.043","article-title":"Regulation of various proteolytic pathways by insulin and amino acids in human fibroblasts","volume":"581","author":"Esteban","year":"2007","journal-title":"FEBS Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0021-9258(18)71356-2","article-title":"The release of labeled amino acids from the proteins of rat liver slices","volume":"201","author":"Simpson","year":"1953","journal-title":"J. Biol. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1432-1033.1987.tb11011.x","article-title":"Energy dependence of autophagic protein degradation in isolated rat hepatocytes","volume":"164","author":"Plomp","year":"1987","journal-title":"Eur. J. Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: Process and function","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes Dev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.semcdb.2010.03.009","article-title":"Regulation of macroautophagy in Saccharomyces cerevisiae","volume":"21","author":"Inoue","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1083\/jcb.124.6.903","article-title":"Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization","volume":"124","author":"Baba","year":"1994","journal-title":"J. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.ceb.2009.04.015","article-title":"Turnover of organelles by autophagy in yeast","volume":"21","author":"Farre","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nrm2708","article-title":"Dynamics and diversity in autophagy mechanisms: lessons from yeast","volume":"10","author":"Nakatogawa","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-cellbio-092910-154005","article-title":"The role of Atg proteins in autophagosome formation","volume":"27","author":"Mizushima","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4161\/cib.7711","article-title":"A selective autophagy pathway that degrades gluconeogenic enzymes during catabolite inactivation","volume":"2","author":"Brown","year":"2009","journal-title":"Commun. Integr. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9934","DOI":"10.1074\/jbc.271.17.9934","article-title":"Selective uptake of cytosolic, peroxisomal, and plasma membrane proteins into the yeast lysosome for degradation","volume":"271","author":"Chiang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1242\/jcs.108.1.25","article-title":"Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris","volume":"108","author":"Tuttle","year":"1995","journal-title":"J. Cell Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0076-6879(08)03214-X","article-title":"Pexophagy in Hansenula polymorpha","volume":"451","author":"Kiel","year":"2008","journal-title":"Methods Enzymol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4161\/auto.3164","article-title":"Early and late molecular events of glucose-induced pexophagy in Pichia pastoris require Vac8","volume":"2","author":"Fry","year":"2006","journal-title":"Autophagy"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"42875","DOI":"10.1074\/jbc.M205437200","article-title":"Removal of Pex3p is an important initial stage in selective peroxisome degradation in Hansenula polymorpha","volume":"277","author":"Bellu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.devcel.2007.12.011","article-title":"PpAtg30 tags peroxisomes for turnover by selective autophagy","volume":"14","author":"Farre","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1093\/emboj\/17.23.6942","article-title":"Efficient transition to growth on fermentable carbon sources in Saccharomyces cerevisiae requires signaling through the Ras pathway","volume":"17","author":"Jiang","year":"1998","journal-title":"EMBO J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.cellbi.2007.11.001","article-title":"G-protein-coupled receptor Gpr1 and G-protein Gpa2 of cAMP-dependent signaling pathway are involved in glucose-induced pexophagy in the yeast Saccharomyces cerevisiae","volume":"32","author":"Nazarko","year":"2008","journal-title":"Cell Biol. Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.1128\/MCB.21.17.5742-5752.2001","article-title":"Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p","volume":"21","author":"Wang","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13933","DOI":"10.1073\/pnas.0501046102","article-title":"An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase","volume":"102","author":"Budovskaya","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17049","DOI":"10.1073\/pnas.0903316106","article-title":"The Tor and PKA signaling pathways independently target the Atg1\/Atg13 protein kinase complex to control autophagy","volume":"106","author":"Stephan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1271\/bbb.110125","article-title":"Complex formation, phosphorylation, and localization of protein kinase A of Schizosaccharomyces pombe upon glucose starvation","volume":"75","author":"Gupta","year":"2011","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1091\/mbc.e07-05-0485","article-title":"Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae","volume":"18","author":"Yorimitsu","year":"2007","journal-title":"Mol. Biol. Cell."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4161\/auto.6.2.11129","article-title":"The Tor and cAMP-dependent protein kinase signaling pathways coordinately control autophagy in Saccharomyces cerevisiae","volume":"6","author":"Stephan","year":"2010","journal-title":"Autophagy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1128\/MMBR.70.1.177-191.2006","article-title":"The where, when, and how of organelle acidification by the yeast vacuolar H+-ATPas","volume":"70","author":"Kane","year":"2006","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"17025","DOI":"10.1016\/S0021-9258(17)46944-4","article-title":"Disassembly and reassembly of the yeast vacuolar H(+)-ATPase in vivo","volume":"270","author":"Kane","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1242\/jeb.203.1.81","article-title":"Assembly and regulation of the yeast vacuolar H(+)-ATPase","volume":"203","author":"Kane","year":"2000","journal-title":"J. Exp. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"20309","DOI":"10.1074\/jbc.M710470200","article-title":"Vacuolar and plasma membrane proton pumps collaborate to achieve cytosolic pH homeostasis in yeast","volume":"283","author":"Kane","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"36513","DOI":"10.1074\/jbc.M805232200","article-title":"The Ras\/cAMP\/protein kinase A pathway regulates glucose-dependent assembly of the vacuolar (H+)-ATPase in yeast","volume":"283","author":"Bond","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/MCB.25.2.575-589.2005","article-title":"Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells","volume":"25","author":"Sautin","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/hmg\/ddg109","article-title":"Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy","volume":"12","author":"Ravikumar","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1074\/jbc.M609532200","article-title":"Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein","volume":"282","author":"Sarkar","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.neuint.2011.01.008","article-title":"The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells","volume":"58","author":"Casarejos","year":"2011","journal-title":"Neurochem. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"H1599","DOI":"10.1152\/ajpheart.91449.2007","article-title":"Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes","volume":"295","author":"Maruyama","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.4161\/auto.5.8.10090","article-title":"Basal autophagy induction without AMP-activated protein kinase under low glucose conditions","volume":"5","author":"Williams","year":"2009","journal-title":"Autophagy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCRESAHA.110.227371","article-title":"Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes","volume":"107","author":"Hariharan","year":"2010","journal-title":"Circ. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"577","DOI":"10.4161\/auto.18980","article-title":"Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury","volume":"8","author":"Kobayashi","year":"2012","journal-title":"Autophagy"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.cmet.2011.04.004","article-title":"Autophagy in the cellular energetic balance","volume":"13","author":"Singh","year":"2011","journal-title":"Cell Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00280-010-1391-0","article-title":"2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion","volume":"67","author":"Xi","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Marambio, P., Toro, B., Sanhueza, C., Troncoso, R., Parra, V., Verdejo, H., Garcia, L., Quiroga, C., Munafo, D., and Diaz-Elizondo, J. (1802). Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes. Biochim. Biophys. Acta, 509\u2013518.","DOI":"10.1016\/j.bbadis.2010.02.002"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/BJ20090976","article-title":"MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP","volume":"426","author":"Younce","year":"2010","journal-title":"Biochem. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e17234","DOI":"10.1371\/journal.pone.0017234","article-title":"2-Deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1101\/gad.17420111","article-title":"AMP-activated protein kinase: An energy sensor that regulates all aspects of cell function","volume":"25","author":"Hardie","year":"2011","journal-title":"Genes Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy","volume":"100","author":"Matsui","year":"2007","journal-title":"Circ. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e19532","DOI":"10.1371\/journal.pone.0019532","article-title":"IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM\/AMPK\/p53 pathway","volume":"6","author":"Duan","year":"2011","journal-title":"PLoS One"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ncb1537","article-title":"The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis","volume":"9","author":"Liang","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: A nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1172\/JCI19874","article-title":"CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations","volume":"113","author":"Scott","year":"2004","journal-title":"J. Clin. Invest."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"Kahn","year":"2005","journal-title":"Cell Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1475-4924-2-28","article-title":"Complexes between the LKB1 tumor suppressor, STRAD alpha\/beta and MO25 alpha\/beta are upstream kinases in the AMP-activated protein kinase cascade","volume":"2","author":"Hawley","year":"2003","journal-title":"J. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4161\/auto.3710","article-title":"AMP-activated protein kinase and autophagy","volume":"3","author":"Meijer","year":"2007","journal-title":"Autophagy"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.bbrc.2008.02.126","article-title":"Role of AMP-activated protein kinase in autophagy and proteasome function","volume":"369","author":"Viana","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4161\/auto.7.1.13883","article-title":"Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt\/mTOR pathway","volume":"7","author":"Vucicevic","year":"2011","journal-title":"Autophagy"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1042\/BJ20090429","article-title":"Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose","volume":"425","author":"Han","year":"2010","journal-title":"Biochem. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"34870","DOI":"10.1074\/jbc.M605488200","article-title":"AMP-activated protein kinase and the regulation of autophagic proteolysis","volume":"281","author":"Meley","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ccr.2004.06.007","article-title":"The LKB1 tumor suppressor negatively regulates mTOR signaling","volume":"6","author":"Shaw","year":"2004","journal-title":"Cancer Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.molcel.2010.05.007","article-title":"Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply","volume":"38","author":"Choo","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.molcel.2011.08.030","article-title":"mTOR drives its own activation via SCF(betaTrCP)-dependent degradation of the mTOR inhibitor DEPTOR","volume":"44","author":"Gao","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.molcel.2011.08.029","article-title":"DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy","volume":"44","author":"Zhao","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_65","first-page":"1691","article-title":"MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation","volume":"34","author":"Yin","year":"2009","journal-title":"Int. J. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.molcel.2005.03.027","article-title":"AMP-activated protein kinase induces a p53-dependent metabolic checkpoint","volume":"18","author":"Jones","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1073\/pnas.0502857102","article-title":"The coordinate regulation of the p53 and mTOR pathways in cells","volume":"102","author":"Feng","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1158\/0008-5472.CAN-06-4149","article-title":"The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways","volume":"67","author":"Feng","year":"2007","journal-title":"Cancer Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)80416-X","article-title":"DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2","volume":"91","author":"Shieh","year":"1997","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/cdd.2009.5","article-title":"A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress","volume":"16","author":"Lee","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.cell.2008.06.028","article-title":"p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling","volume":"134","author":"Budanov","year":"2008","journal-title":"Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/embor.2008.246","article-title":"DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy","volume":"10","author":"Zalckvar","year":"2009","journal-title":"EMBO Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ceb.2009.12.001","article-title":"Autophagy regulation by p53","volume":"22","author":"Maiuri","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1089\/ars.2010.3478","article-title":"Oncosuppressive functions of autophagy","volume":"14","author":"Morselli","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0014-4827(02)00019-8","article-title":"Regulation of tumor suppressors by nuclear-cytoplasmic shuttling","volume":"282","author":"Fabbro","year":"2003","journal-title":"Exp. Cell Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ncb1730","article-title":"Regulation of autophagy by cytoplasmic p53","volume":"10","author":"Tasdemir","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1158\/0008-5472.CAN-07-5756","article-title":"AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27","volume":"68","author":"Short","year":"2008","journal-title":"Cancer Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1475-2867-11-31","article-title":"Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: Differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine","volume":"11","author":"Eto","year":"2011","journal-title":"Cancer Cell Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.4161\/cc.10.15.16912","article-title":"Siah1\/SIP regulates p27(kip1) stability and cell migration under metabolic stress","volume":"10","author":"Nagano","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.devcel.2008.01.013","article-title":"CDK inhibitors: Cell cycle regulators and beyond","volume":"14","author":"Besson","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gad.1185504","article-title":"p27Kip1 modulates cell migration through the regulation of RhoA activation","volume":"18","author":"Besson","year":"2004","journal-title":"Genes Dev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"27315","DOI":"10.1074\/jbc.M109.041400","article-title":"A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion","volume":"284","author":"Hoshino","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1074\/jbc.M109.046789","article-title":"Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells","volume":"285","author":"Yoo","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1582-4934.2003.tb00202.x","article-title":"Glucose deprivation induces mitochondrial dysfunction and oxidative stress in PC12 cell line","volume":"7","author":"Liu","year":"2003","journal-title":"J. Cell Mol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.yjmcc.2004.03.008","article-title":"Transient glucose deprivation causes upregulation of heme oxygenase-1 and cyclooxygenase-2 expression in cardiac fibroblasts","volume":"36","author":"Takeda","year":"2004","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1073\/pnas.0511154103","article-title":"Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology","volume":"103","author":"Yu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"F1348","DOI":"10.1152\/ajprenal.00028.2010","article-title":"Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: Implications in type 2 diabetic nephropathy","volume":"299","author":"Sedeek","year":"2010","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/cdd.2009.49","article-title":"Superoxide is the major reactive oxygen species regulating autophagy","volume":"16","author":"Chen","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","article-title":"Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4","volume":"26","author":"Shvets","year":"2007","journal-title":"EMBO J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3892\/mmr.2012.746","article-title":"Mitochondria-targeted antioxidant attenuates high glucose-induced P38 MAPK pathway activation in human neuroblastoma cells","volume":"5","author":"Cao","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.canlet.2008.09.042","article-title":"Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway","volume":"275","author":"Liu","year":"2009","journal-title":"Cancer Lett."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1248\/bpb.33.545","article-title":"p38 Mitogen-activated protein kinase is involved in endoplasmic reticulum stress-induced cell death and autophagy in human gingival fibroblasts","volume":"33","author":"Kim","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/emboj.2009.321","article-title":"Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP","volume":"29","author":"Webber","year":"2010","journal-title":"EMBO J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"21353","DOI":"10.1074\/jbc.M511052200","article-title":"Bcl-2 Phosphorylation by p38 MAPK: Identification of target sites and biologic consequences","volume":"281","author":"Marcocci","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.molcel.2008.06.001","article-title":"JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy","volume":"30","author":"Wei","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/sj.cdd.4402076","article-title":"A novel cell type-specific role of p38alpha in the control of autophagy and cell death in colorectal cancer cells","volume":"14","author":"Comes","year":"2007","journal-title":"Cell Death Differ."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1080\/01635580903532390","article-title":"Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)","volume":"62","author":"Thyagarajan","year":"2010","journal-title":"Nutr. Cancer"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0016-5085(99)70076-4","article-title":"Involvement of p38MAPK in the regulation of proteolysis by liver cell hydration","volume":"116","author":"Haussinger","year":"1999","journal-title":"Gastroenterology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e23054","DOI":"10.1371\/journal.pone.0023054","article-title":"SB202190-Induced Cell Type-Specific Vacuole Formation and Defective Autophagy Do Not Depend on p38 MAP Kinase Inhibition","volume":"6","author":"Menon","year":"2011","journal-title":"PLoS One"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10495-011-0685-y","article-title":"Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK","volume":"17","author":"hang","year":"2012","journal-title":"Apoptosis"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jcp.22847","article-title":"NADPH oxidase-derived superoxide anion-induced apoptosis is mediated via the JNK-dependent activation of NF-kappaB in cardiomyocytes exposed to high glucose","volume":"227","author":"Tsai","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"26845","DOI":"10.1074\/jbc.M502318200","article-title":"Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators","volume":"280","author":"Song","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.4161\/auto.7.10.16643","article-title":"Involvement of mitophagy in oncogenic K-Ras-induced transformation: Overcoming a cellular energy deficit from glucose deficiency","volume":"7","author":"Kim","year":"2011","journal-title":"Autophagy"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jnutbio.2011.03.014","article-title":"Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (\u2212)-epigallocatechin-3-gallate","volume":"23","author":"Yan","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"21412","DOI":"10.1074\/jbc.M109.026013","article-title":"A non-canonical MEK\/ERK signaling pathway regulates autophagy via regulating Beclin 1","volume":"284","author":"Wang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1582-4934.2008.00282.x","article-title":"Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-alpha-induced cell death in MCF-7 cells","volume":"12","author":"Sivaprasad","year":"2008","journal-title":"J. Cell Mol. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1074\/jbc.270.1.13","article-title":"A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29","volume":"270","author":"Couvineau","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"39090","DOI":"10.1074\/jbc.M006198200","article-title":"Erk1\/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells","volume":"275","author":"Pattingre","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.1158\/0008-5472.CAN-05-3557","article-title":"Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase\/extracellular signal-regulated kinase activity","volume":"66","author":"Corcelle","year":"2006","journal-title":"Cancer Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e9996","DOI":"10.1371\/journal.pone.0009996","article-title":"Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation","volume":"5","author":"Wong","year":"2010","journal-title":"PLoS One"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.niox.2008.09.001","article-title":"p38MAPK and ERK promote nitric oxide production in cultured human retinal pigmented epithelial cells induced by high concentration glucose","volume":"20","author":"Yuan","year":"2009","journal-title":"Nitric Oxide"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"974","DOI":"10.2337\/diabetes.52.4.974","article-title":"Differential activation mechanisms of Erk-1\/2 and p70(S6K) by glucose in pancreatic beta-cells","volume":"52","author":"Briaud","year":"2003","journal-title":"Diabetes"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"E1836","DOI":"10.1152\/ajpendo.00115.2007","article-title":"Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling","volume":"293","author":"Wu","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.molcel.2012.01.010","article-title":"p85alpha SH2 Domain Phosphorylation by IKK Promotes Feedback Inhibition of PI3K and Akt in Response to Cellular Starvation","volume":"45","author":"Comb","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.2337\/diabetes.53.11.2910","article-title":"Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase","volume":"53","author":"Ramana","year":"2004","journal-title":"Diabetes"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"F147","DOI":"10.1152\/ajprenal.00361.2010","article-title":"High glucose promotes nascent nephron apoptosis via NF-kappaB and p53 pathways","volume":"300","author":"Chen","year":"2011","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1128\/MCB.01396-08","article-title":"p65\/RelA modulates BECN1 transcription and autophagy","volume":"29","author":"Copetti","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/onc.2010.553","article-title":"IKK-dependent, NF-kappaB-independent control of autophagic gene expression","volume":"30","author":"Comb","year":"2011","journal-title":"Oncogene"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/emboj.2009.364","article-title":"The IKK complex contributes to the induction of autophagy","volume":"29","author":"Criollo","year":"2010","journal-title":"EMBO J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1038\/emboj.2011.413","article-title":"Inhibition of autophagy by TAB2 and TAB3","volume":"30","author":"Criollo","year":"2011","journal-title":"EMBO J."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1073\/pnas.0712145105","article-title":"A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy","volume":"105","author":"Lee","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"28319","DOI":"10.1074\/jbc.M109.024406","article-title":"FoxO transcription factors promote autophagy in cardiomyocytes","volume":"284","author":"Sengupta","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4331\/wjbc.v2.i10.232","article-title":"Mechanisms of autophagy and apoptosis: Recent developments in breast cancer cells","volume":"2","author":"Esteve","year":"2011","journal-title":"World J. Biol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1074\/jbc.M411860200","article-title":"Involvement of endoplasmic reticulum stress in insulin resistance and diabetes","volume":"280","author":"Nakatani","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"930","DOI":"10.2337\/db06-1160","article-title":"Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy","volume":"56","author":"Kaniuk","year":"2007","journal-title":"Diabetes"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cmet.2008.08.013","article-title":"Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia","volume":"8","author":"Jung","year":"2008","journal-title":"Cell Metab."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4161\/auto.7.1.13044","article-title":"The emerging role of autophagy in the pathophysiology of diabetes mellitus","volume":"7","author":"Gonzalez","year":"2011","journal-title":"Autophagy"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","article-title":"A central role for JNK in obesity and insulin resistance","volume":"420","author":"Hirosumi","year":"2002","journal-title":"Nature"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.tibs.2010.04.004","article-title":"cJun NH2-terminal kinase 1 (JNK1): Roles in metabolic regulation of insulin resistance","volume":"35","author":"Sabio","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nm1111","article-title":"Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide","volume":"10","author":"Kaneto","year":"2004","journal-title":"Nat. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"16809","DOI":"10.1073\/pnas.0805677105","article-title":"Identification of a new JNK inhibitor targeting the JNK-JIP interaction site","volume":"105","author":"Stebbins","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1474-4422(12)70005-4","article-title":"Diabetes, hyperglycaemia, and acute ischaemic stroke","volume":"11","author":"Luitse","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/CIRCULATIONAHA.111.078212","article-title":"Rheb is a critical regulator of autophagy during myocardial ischemia: Pathophysiological implications in obesity and metabolic syndrome","volume":"125","author":"Sciarretta","year":"2012","journal-title":"Circulation"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"29776","DOI":"10.1074\/jbc.M603783200","article-title":"Enhancing macroautophagy protects against ischemia\/reperfusion injury in cardiac myocytes","volume":"281","author":"Brady","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.jacc.2009.08.031","article-title":"Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction","volume":"54","author":"Buss","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1161\/CIRCULATIONAHA.111.041814","article-title":"Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia-Reperfusion Injury","volume":"125","author":"Ma","year":"2012","journal-title":"Circulation"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/1\/3\/372\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:51:30Z","timestamp":1760219490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/1\/3\/372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,27]]},"references-count":138,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,9]]}},"alternative-id":["cells1030372"],"URL":"https:\/\/doi.org\/10.3390\/cells1030372","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,27]]}}}