{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:49:17Z","timestamp":1760402957848,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>David Mason started his research career at a time when lymphoma diagnosis was based primarily on cellular morphology, clinical symptoms and special cytochemical stains using formalin fixed tissue sections. There were occasions, however, where the morphology was unhelpful, such as in the case of anaplastic or poorly differentiated tumours, where a distinction between lymphoma and a non-haematopoietic tumour was often problematical. Accurate diagnosis became even more important with the developments in the clinical staging of lymphoma and the availability of more effective treatments. One way forward to improve diagnosis was to use immunohistochemistry to study the antigens expressed by the tumor cells.<\/jats:p>","DOI":"10.3390\/cells11010174","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T20:42:16Z","timestamp":1641415336000},"page":"174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphoma versus Carcinoma and Other Collaborations"],"prefix":"10.3390","volume":"11","author":[{"given":"Karen","family":"Pulford","sequence":"first","affiliation":[{"name":"Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3181\/00379727-47-13084P","article-title":"Immunological properties of an antibody containing a fluorescent group","volume":"47","author":"Coons","year":"1941","journal-title":"Proc. Soc. Exp. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/16.9.557","article-title":"Simultaneous localization of multiple tissue antigens using the peroxidase-labeled antibody method: A study on pituitary glands of the rat","volume":"16","author":"Nakane","year":"1968","journal-title":"J. Histochem. Cytochem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0140-6736(74)91071-X","article-title":"The nature of Reed-Sternberg cells and other malignant \u201creticulum\u201d cells","volume":"2","author":"Taylor","year":"1974","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1136\/jcp.27.7.548","article-title":"Intracellular immunoglobulins. A comparative study on three standard tissue processing methods using horseradish peroxidase and fluorochrome conjugates","volume":"27","author":"Burns","year":"1974","journal-title":"J. Clin. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/jcp.27.1.14","article-title":"The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibody","volume":"27","author":"Taylor","year":"1974","journal-title":"J. Clin. Pathol."},{"key":"ref_6","first-page":"417","article-title":"The immunohistological detection of intracellular immunoglobulin in formalin-paraffin sections from multiple myeloma and related conditions using the immunoperoxidase technique","volume":"18","author":"Taylor","year":"1974","journal-title":"Clin. Exp. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/jcp.30.6.541","article-title":"Intracellular lysozyme and lactoferrin in myeloproliferative disorders","volume":"30","author":"Mason","year":"1977","journal-title":"J. Clin. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/jcp.31.5.454","article-title":"Alkaline phosphatase and peroxidase for double immunoenzymatic labelling of cellular constituents","volume":"31","author":"Mason","year":"1978","journal-title":"J. Clin. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/jcp.35.11.1253","article-title":"Use of monoclonal antibodies for the histopathological diagnosis of human malignancy","volume":"35","author":"Gatter","year":"1982","journal-title":"J. Clin. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1056\/NEJM198311243092102","article-title":"Diagnosis of human lymphoma with monoclonal antileukocyte antibodies","volume":"309","author":"Warnke","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/ajcp\/82.1.33","article-title":"The differential diagnosis of routinely processed anaplastic tumors using monoclonal antibodies","volume":"82","author":"Gatter","year":"1984","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0140-6736(85)92794-1","article-title":"Clinical importance of analysing malignant tumours of uncertain origin with immunohistological techniques","volume":"1","author":"Gatter","year":"1985","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"key":"ref_14","unstructured":"Jaffe, E.S., Harris, H.L., Stein, H., and Vardiman, J.W. (2001). WHO Classification of Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues, International Agency for Research on Cancer Press."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1182\/blood.V66.4.848.848","article-title":"The expression of the Hodgkin\u2019s disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells","volume":"66","author":"Stein","year":"1985","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2141.1990.tb02560.x","article-title":"CD30-positive large cell lymphomas (\u2018Ki-1 lymphoma\u2019) are associated with a chromosomal translocation involving 5q35","volume":"74","author":"Mason","year":"1990","journal-title":"Br. J. Haematol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.8122112","article-title":"Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin\u2019s lymphoma","volume":"263","author":"Morris","year":"1994","journal-title":"Science"},{"key":"ref_18","first-page":"1567","article-title":"Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3","volume":"9","author":"Shiota","year":"1994","journal-title":"Oncogene"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1182\/blood.V91.6.2076","article-title":"ALK-positive lymphoma: A single disease with a broad spectrum of morphology","volume":"91","author":"Benharroch","year":"1998","journal-title":"Blood"},{"key":"ref_20","unstructured":"Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E., Pileri, S., Stein, H., Thiele, J., and Vardiman, J.W. (2008). Tumours of Haematopoietic and Lymphoid Tissues, International Agency for Research on Cancer. [4th ed.]."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/1\/174\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:12:53Z","timestamp":1760364773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/1\/174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["cells11010174"],"URL":"https:\/\/doi.org\/10.3390\/cells11010174","relation":{},"ISSN":["2073-4409"],"issn-type":[{"type":"electronic","value":"2073-4409"}],"subject":[],"published":{"date-parts":[[2022,1,5]]}}}