{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:15:57Z","timestamp":1790745357732,"version":"4.1.0"},"reference-count":203,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["DFG-Project number 374031971\u2013TRR240"],"award-info":[{"award-number":["DFG-Project number 374031971\u2013TRR240"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005970","name":"Deutsche Stiftung f\u00fcr Herzforschung","doi-asserted-by":"publisher","award":["DSHF-F\/22\/17"],"award-info":[{"award-number":["DSHF-F\/22\/17"]}],"id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12\/SDF-1\u03b1 are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3\/CXCR7. Platelets express CXCR4, ACKR3\/CXCR7, and are a vital source of CXCL12\/SDF-1\u03b1 themselves. In recent years, a regulatory impact of the CXCL12-CXCR4-CXCR7 axis on platelet biogenesis, i.e., megakaryopoiesis, thrombotic and thrombo-inflammatory actions have been revealed through experimental and clinical studies. Platelet surface expression of ACKR3\/CXCR7 is significantly enhanced following myocardial infarction (MI) in acute coronary syndrome (ACS) patients, and is also associated with improved functional recovery and prognosis. The therapeutic implications of ACKR3\/CXCR7 in myocardial regeneration and improved recovery following an ischemic episode, are well documented. Cardiomyocytes, cardiac-fibroblasts, endothelial lining of the blood vessels perfusing the heart, besides infiltrating platelets and monocytes, all express ACKR3\/CXCR7. This review recapitulates ligand induced differential trafficking of platelet CXCR4-ACKR3\/CXCR7 affecting their surface availability, and in regulating thrombo-inflammatory platelet functions and survival through CXCR4 or ACKR3\/CXCR7. It emphasizes the pro-thrombotic influence of CXCL12\/SDF-1\u03b1 exerted through CXCR4, as opposed to the anti-thrombotic impact of ACKR3\/CXCR7. Offering an innovative translational perspective, this review also discusses the advantages and challenges of utilizing ACKR3\/CXCR7 as a potential anti-thrombotic strategy in platelet-associated cardiovascular disorders, particularly in coronary artery disease (CAD) patients post-MI.<\/jats:p>","DOI":"10.3390\/cells11020213","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T20:29:26Z","timestamp":1641760166000},"page":"213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Atypical Roles of the Chemokine Receptor ACKR3\/CXCR7 in Platelet Pathophysiology"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3428-4107","authenticated-orcid":false,"given":"Madhumita","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrcardio.2017.206","article-title":"Current and future antiplatelet therapies: Emphasis on preserving haemostasis","volume":"15","author":"McFadyen","year":"2018","journal-title":"Nat. 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