{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:42:30Z","timestamp":1792510950417,"version":"4.5.0"},"reference-count":308,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Claude Bernard\u2019s milieu int\u00e9rieur (internal environment) and the associated concept of homeostasis are fundamental to the understanding of the physiological responses to exercise and environmental stress. Maintenance of cellular homeostasis is thought to happen during exercise through the precise matching of cellular energetic demand and supply, and the production and clearance of metabolic by-products. The mind-boggling number of molecular and cellular pathways and the host of tissues and organ systems involved in the processes sustaining locomotion, however, necessitate an integrative examination of the body\u2019s physiological systems. This integrative approach can be used to identify whether function and cellular homeostasis are maintained or compromised during exercise. In this review, we discuss the responses of the human brain, the lungs, the heart, and the skeletal muscles to the varying physiological demands of exercise and environmental stress. Multiple alterations in physiological function and differential homeostatic adjustments occur when people undertake strenuous exercise with and without thermal stress. These adjustments can include: hyperthermia; hyperventilation; cardiovascular strain with restrictions in brain, muscle, skin and visceral organs blood flow; greater reliance on muscle glycogen and cellular metabolism; alterations in neural activity; and, in some conditions, compromised muscle metabolism and aerobic capacity. Oxygen supply to the human brain is also blunted during intense exercise, but global cerebral metabolism and central neural drive are preserved or enhanced. In contrast to the strain seen during severe exercise and environmental stress, a steady state is maintained when humans exercise at intensities and in environmental conditions that require a small fraction of the functional capacity. The impact of exercise and environmental stress upon whole-body functions and homeostasis therefore depends on the functional needs and differs across organ systems.<\/jats:p>","DOI":"10.3390\/cells11030383","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:44:33Z","timestamp":1643143473000},"page":"383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Physiological Function during Exercise and Environmental Stress in Humans\u2014An Integrative View of Body Systems and Homeostasis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-6520","authenticated-orcid":false,"given":"Gavin","family":"Travers","sequence":"first","affiliation":[{"name":"The European Astronaut Centre, The European Space Agency, Linder H\u00f6he, 51147 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-0248","authenticated-orcid":false,"given":"Pascale","family":"Kippelen","sequence":"additional","affiliation":[{"name":"Centre for Human Performance, Exercise and Rehabilitation, Brunel University London, Uxbridge UB8 3PH, UK"},{"name":"Division of Sport, Health and Exercise Sciences, Department of Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-4328","authenticated-orcid":false,"given":"Steven J.","family":"Trangmar","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, University of Roehampton, London SW15 4JD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-3311","authenticated-orcid":false,"given":"Jos\u00e9","family":"Gonz\u00e1lez-Alonso","sequence":"additional","affiliation":[{"name":"Centre for Human Performance, Exercise and Rehabilitation, Brunel University London, Uxbridge UB8 3PH, UK"},{"name":"Division of Sport, Health and Exercise Sciences, Department of Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bernard, C. (1879). Le\u00e7ons sur les Ph\u00e9nom\u00e8nes de la vie Communs aux Animaux et aux V\u00e9g\u00e9taus\/Par Claude Bernard., JB Bailli\u00e8re.","DOI":"10.5962\/bhl.title.1817"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1152\/physrev.1929.9.3.399","article-title":"Organization for physiological homeostasis","volume":"9","author":"Cannon","year":"1929","journal-title":"Physiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rowell, L.B. (1993). Human Cardiovascular Control, Oxford University Press.","DOI":"10.1093\/oso\/9780195073621.001.0001"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1152\/physrev.00035.2013","article-title":"Regulation of Increased blood flow (hyperemia) to muscles during exercise: A hierarchy of competing physiological needs","volume":"95","author":"Joyner","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-201X.1998.0293e.x","article-title":"Skeletal muscle blood flow in humans and its regulation during exercise","volume":"162","author":"Saltin","year":"1998","journal-title":"Acta Physiol. Scand."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1469-7793.1998.895ba.x","article-title":"Muscle blood flow is reduced with dehydration during prolonged exercise in humans","volume":"513","author":"Calbet","year":"1998","journal-title":"J. Physiol."},{"key":"ref_7","first-page":"103","article-title":"Maximal oxygen uptake as a parametric measure of cardiorespiratory capacity","volume":"39","author":"Hawkins","year":"2007","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1152\/jappl.1992.73.3.1067","article-title":"Effects of training on muscle O2 transport at VO2max","volume":"73","author":"Roca","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1152\/jappl.1989.67.1.291","article-title":"Evidence for tissue diffusion limitation of VO2max in normal humans","volume":"67","author":"Roca","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1161\/circ.104.12.1350","article-title":"A 30-year follow-up of the Dallas Bedrest and Training Study: I. Effect of age on the cardiovascular response to exercise","volume":"104","author":"McGuire","year":"2001","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1113\/jphysiol.2005.086025","article-title":"Limitations to systemic and locomotor limb muscle oxygen delivery and uptake during maximal exercise in humans","volume":"566","author":"Mortensen","year":"2005","journal-title":"J. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/01.RES.24.5.711","article-title":"Human cardiovascular adjustments to rapid changes in skin temperature during exercise","volume":"24","author":"Rowell","year":"1969","journal-title":"Circ. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1113\/jphysiol.1985.sp015794","article-title":"Maximal perfusion of skeletal muscle in man","volume":"366","author":"Andersen","year":"1985","journal-title":"J. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1152\/jappl.1972.33.2.175","article-title":"Response to exercise after blood loss and reinfusion","volume":"33","author":"Ekblom","year":"1972","journal-title":"J. Appl. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/japplphysiol.00444.2020","article-title":"Is the healthy respiratory system built just right, overbuilt, or underbuilt to meet the demands imposed by exercise?","volume":"129","author":"Dempsey","year":"2020","journal-title":"J. Appl. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI103636","article-title":"The physiological meaning of the maximal oxygen intake test","volume":"37","author":"Mitchell","year":"1958","journal-title":"J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1152\/jappl.1967.23.3.353","article-title":"Maximal oxygen uptake in athletes","volume":"23","author":"Saltin","year":"1967","journal-title":"J. Appl. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1152\/jappl.1988.64.4.1309","article-title":"Operation Everest II: Oxygen transport during exercise at extreme simulated altitude","volume":"64","author":"Sutton","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1113\/jphysiol.2012.241646","article-title":"A novel role for the red blood cell in the regulation of tissue O2 supply","volume":"590","year":"2012","journal-title":"J. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1152\/physrev.1956.36.3.307","article-title":"Human physical fitness with special reference to sex and age","volume":"36","year":"1956","journal-title":"Physiol. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1161\/CIRCULATIONAHA.107.734764","article-title":"Exercise capacity and mortality in black and white men","volume":"117","author":"Kokkinos","year":"2008","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2165\/00007256-199010040-00004","article-title":"Developmental aspects of physiological function relating to aerobic exercise in children","volume":"10","author":"Rowland","year":"1990","journal-title":"Sports Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1378\/chest.12-1458","article-title":"Reference values for cardiorespiratory response and fitness on the treadmill in a 20- to 85-year-old population","volume":"144","author":"Edvardsen","year":"2013","journal-title":"Chest"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/jappl.1993.74.1.245","article-title":"Middle cerebral artery blood velocity and cerebral blood flow and O2 uptake during dynamic exercise","volume":"74","author":"Madsen","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"ref_25","unstructured":"Siegel, G.J., Arganoff, B.W., Albers, R.W., Fisher, S.K., and Uhler, M.D. (1999). Regulation of Cerebral Metabolic Rate. Basic Neurochemistry: Molecular, Cellular and Medical Aspects, Lippincott-Raven."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1469-7793.2001.t01-1-00849.x","article-title":"Exercise increases blood flow to locomotor, vestibular, cardiorespiratory and visual regions of the brain in miniature swine","volume":"533","author":"Delp","year":"2001","journal-title":"J. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuroscience.2011.02.006","article-title":"Primary motor cortex activity is elevated with incremental exercise intensity","volume":"181","author":"Schneider","year":"2011","journal-title":"Neuroscience"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s002210000493","article-title":"Cerebral activation during bicycle movements in man","volume":"135","author":"Christensen","year":"2000","journal-title":"Exp. Brain Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/jcbfm.1985.48","article-title":"Normal Average Value of Cerebral Blood Flow in Younger Adults is 50 mL\/100 g\/min","volume":"5","author":"Lassen","year":"1985","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/brain\/94.4.635","article-title":"Contralateral focal increase of cerebral blood flow in man during arm work","volume":"94","author":"Olesen","year":"1971","journal-title":"Brain"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1152\/jappl.1992.72.3.1123","article-title":"Middle cerebral artery flow velocity and blood flow during exercise and muscle ischemia in humans","volume":"72","author":"Perko","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1152\/jappl.1996.81.1.413","article-title":"Carotid artery blood flow and middle cerebral artery blood flow velocity during physical exercise","volume":"81","author":"Hellstrom","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1113\/jphysiol.2012.244905","article-title":"Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals","volume":"591","author":"Fisher","year":"2013","journal-title":"J. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1113\/jphysiol.2010.204461","article-title":"The distribution of blood flow in the carotid and vertebral arteries during dynamic exercise in humans","volume":"589","author":"Sato","year":"2011","journal-title":"J. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e13108","DOI":"10.14814\/phy2.13108","article-title":"Whole body hyperthermia, but not skin hyperthermia, accelerates brain and locomotor limb circulatory strain and impairs exercise capacity in humans","volume":"5","author":"Trangmar","year":"2017","journal-title":"Physiol. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1113\/jphysiol.2014.272104","article-title":"Dehydration affects cerebral blood flow but not its metabolic rate for oxygen during maximal exercise in trained humans","volume":"592","author":"Trangmar","year":"2014","journal-title":"J. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1113\/jphysiol.2014.281212","article-title":"Influence of high altitude on cerebral blood flow and fuel utilization during exercise and recovery","volume":"592","author":"Smith","year":"2014","journal-title":"J. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1469-7793.2001.t01-1-00279.x","article-title":"Middle cerebral artery blood velocity is reduced with hyperthermia during prolonged exercise in humans","volume":"534","author":"Nybo","year":"2001","journal-title":"J. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/sms.12379","article-title":"Heat stress exacerbates the reduction in middle cerebral artery blood velocity during prolonged self-paced exercise","volume":"25","author":"Racinais","year":"2015","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1152\/japplphysiol.00049.2002","article-title":"Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans","volume":"93","author":"Nybo","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"H750","DOI":"10.1152\/ajpheart.00138.2015","article-title":"Heat training increases exercise capacity in hot but not in temperate conditions: A mechanistic counter-balanced cross-over study","volume":"309","author":"Keiser","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.2004.060574","article-title":"Brain and central haemodynamics and oxygenation during maximal exercise in humans","volume":"557","author":"Dalsgaard","year":"2004","journal-title":"J. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"H1598","DOI":"10.1152\/ajpheart.00525.2015","article-title":"Dehydration accelerates reductions in cerebral blood flow during prolonged exercise in the heat without compromising brain metabolism","volume":"309","author":"Trangmar","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e14433","DOI":"10.14814\/phy2.14433","article-title":"Dehydration reduces stroke volume and cardiac output during exercise because of impaired cardiac filling and venous return, not left ventricular function","volume":"8","author":"Watanabe","year":"2020","journal-title":"Physiol. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature09613","article-title":"Glial and neuronal control of brain blood flow","volume":"468","author":"Attwell","year":"2010","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"AN20120021","DOI":"10.1042\/AN20120021","article-title":"Fueling and Imaging Brain Activation","volume":"4","author":"Dienel","year":"2012","journal-title":"ASN Neuro"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1113\/JP280162","article-title":"Nitric oxide is fundamental to neurovascular coupling in humans","volume":"598","author":"Hoiland","year":"2020","journal-title":"J. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The neurovascular unit coming of age: A journey through neurovascular coupling in health and disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/jcbfm.1995.60","article-title":"Persistent resetting of the cerebral oxygen\/glucose uptake ratio by brain activation: Evidence obtained with the Kety\u2014Schmidt technique","volume":"15","author":"Madsen","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1126\/science.3260686","article-title":"Nonoxidative glucose consumption during focal physiologic neural activity","volume":"241","author":"Fox","year":"1988","journal-title":"Science"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jneumeth.2011.03.017","article-title":"Neurovascular coupling and distribution of cerebral blood flow during exercise","volume":"198","author":"Willie","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00421-007-0595-4","article-title":"Prefrontal cortex oxygenation and neuromuscular responses to exhaustive exercise","volume":"102","author":"Rupp","year":"2007","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"H164","DOI":"10.1152\/ajpheart.01104.2007","article-title":"Cerebrovascular responses to incremental exercise during hypobaric hypoxia: Effect of oxygenation on maximal performance","volume":"294","author":"Subudhi","year":"2008","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1113\/jphysiol.2011.210880","article-title":"Frontal cerebral cortex blood flow, oxygen delivery and oxygenation during normoxic and hypoxic exercise in athletes","volume":"589","author":"Vogiatzis","year":"2011","journal-title":"J. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1113\/jphysiol.2013.268953","article-title":"Integrative regulation of human brain blood flow","volume":"592","author":"Willie","year":"2014","journal-title":"J. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1113\/EP086249","article-title":"Regulation of cerebral blood flow and metabolism during exercise","volume":"102","author":"Smith","year":"2017","journal-title":"Exp. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1152\/jappl.1992.73.5.1825","article-title":"Regional cerebral artery mean flow velocity and blood flow during dynamic exercise in humans","volume":"73","author":"Jorgensen","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1113\/JP278827","article-title":"Evidence for temperature-mediated regional increases in cerebral blood flow during exercise","volume":"598","author":"Caldwell","year":"2020","journal-title":"J. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1113\/jphysiol.2011.212118","article-title":"Reductions in cerebral blood flow during passive heat stress in humans: Partitioning the mechanisms","volume":"589","author":"Nelson","year":"2011","journal-title":"J. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/japplphysiol.00394.2013","article-title":"Regional changes in brain blood flow during severe passive hyperthermia: Effects of PaCO2 and extracranial blood flow","volume":"115","author":"Bain","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1038\/jcbfm.2013.149","article-title":"Blood flow distribution during heat stress: Cerebral and systemic blood flow","volume":"33","author":"Ogoh","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1748-1716.2010.02084.x","article-title":"Cerebral oxygenation is reduced during hyperthermic exercise in humans","volume":"199","author":"Rasmussen","year":"2010","journal-title":"Acta Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/sj.jcbfm.9600416","article-title":"Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans","volume":"27","author":"Rasmussen","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1113\/jphysiol.2007.149401","article-title":"Restrictions in systemic and locomotor skeletal muscle perfusion, oxygen supply and VO2 during high-intensity whole-body exercise in humans","volume":"586","author":"Mortensen","year":"2008","journal-title":"J. Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1113\/jphysiol.2008.152058","article-title":"Haemodynamic responses to exercise, ATP infusion and thigh compression in humans: Insight into the role of muscle mechanisms on cardiovascular function","volume":"586","author":"Mortensen","year":"2008","journal-title":"J. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1152\/jappl.1999.86.3.1032","article-title":"Influence of body temperature on the development of fatigue during prolonged exercise in the heat","volume":"86","author":"Teller","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1152\/jappl.2001.90.3.1057","article-title":"Effects of marked hyperthermia with and without dehydration on VO2 kinetics during intense exercise","volume":"90","author":"Nybo","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/sms.12444","article-title":"Critical core temperature: A hypothesis too simplistic to explain hyperthermia-induced fatigue","volume":"25","author":"Nybo","year":"2015","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1113\/jphysiol.2002.030023","article-title":"Inadequate heat release from the human brain during prolonged exercise with hyperthermia","volume":"545","author":"Nybo","year":"2002","journal-title":"J. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"7603","DOI":"10.1073\/pnas.97.13.7603","article-title":"Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation","volume":"97","author":"Yablonskiy","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s004240100515","article-title":"Brain activity and fatigue during prolonged exercise in the heat","volume":"442","author":"Nielsen","year":"2001","journal-title":"Pfl\u00fcgers Arch."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jtherbio.2004.08.047","article-title":"Heat induced fatigue and changes of the EEG is not related to reduced perfusion of the brain during prolonged exercise in humans","volume":"29","author":"Rasmussen","year":"2004","journal-title":"J. Therm. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e12916","DOI":"10.1111\/apha.12916","article-title":"Cerebrocortical activity during self-paced exercise in temperate, hot and hypoxic conditions","volume":"222","author":"Zanow","year":"2018","journal-title":"Acta Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1113\/expphysiol.2013.074583","article-title":"Voluntary muscle and motor cortical activation during progressive exercise and passively induced hyperthermia","volume":"99","author":"Christian","year":"2014","journal-title":"Exp. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1152\/japplphysiol.00633.2013","article-title":"Brain mapping after prolonged cycling and during recovery in the heat","volume":"115","author":"Roelands","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1113\/jphysiol.2008.157420","article-title":"Hyperthermia impairs short-term memory and peripheral motor drive transmission","volume":"586","author":"Racinais","year":"2008","journal-title":"J. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1113\/jphysiol.2012.228890","article-title":"Supraspinal fatigue after normoxic and hypoxic exercise in humans","volume":"590","author":"Goodall","year":"2012","journal-title":"J. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/sms.12370","article-title":"Augmented supraspinal fatigue following constant-load cycling in the heat","volume":"25","author":"Goodall","year":"2015","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fphys.2014.00142","article-title":"Breakpoints in ventilation, cerebral and muscle oxygenation, and muscle activity during an incremental cycling exercise","volume":"5","author":"Racinais","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s00424-002-0841-x","article-title":"The effects of heat stress on neuromuscular activity during endurance exercise","volume":"444","author":"Hunter","year":"2002","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/jappl.1986.60.2.653","article-title":"Temporal pattern of arterial CO2 partial pressure during exercise in humans","volume":"60","author":"Forster","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1152\/jappl.1967.22.1.71","article-title":"Interaction of physiological mechanisms during exercise","volume":"22","author":"Wasserman","year":"1967","journal-title":"J. Appl. Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1113\/jphysiol.1984.sp015412","article-title":"Exercise-induced arterial hypoxaemia in healthy human subjects at sea level","volume":"355","author":"Dempsey","year":"1984","journal-title":"J. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1046\/j.1365-201X.1998.00405.x","article-title":"The influence of PaO2, pH and SaO2 on maximal oxygen uptake","volume":"164","author":"Nielsen","year":"1998","journal-title":"Acta Physiol. Scand."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1113\/jphysiol.2013.252767","article-title":"Exercise-induced arterial hypoxaemia and the mechanics of breathing in healthy young women","volume":"591","author":"Dominelli","year":"2013","journal-title":"J. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1097\/00005768-200005000-00008","article-title":"Evidence for an inadequate hyperventilation inducing arterial hypoxemia at submaximal exercise in all highly trained endurance athletes","volume":"32","author":"Durand","year":"2000","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1152\/jappl.1994.77.2.912","article-title":"Pulmonary gas exchange during exercise in athletes. I. Ventilation-perfusion mismatch and diffusion limitation","volume":"77","author":"Hopkins","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1152\/jappl.1986.61.1.260","article-title":"Pulmonary gas exchange in humans exercising at sea level and simulated altitude","volume":"61","author":"Wagner","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1152\/japplphysiol.00311.2020","article-title":"Systemic but not local rehydration restores dehydration-induced changes in pulmonary function in healthy adults","volume":"130","author":"Marshall","year":"2021","journal-title":"J. Appl. Physiol."},{"key":"ref_90","first-page":"842","article-title":"The effect of dehydration on the ventilatory capacity in normal subjects","volume":"105","author":"Govindaraj","year":"1972","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e000210","DOI":"10.1136\/bmjsem-2016-000210","article-title":"Changes in lung function during exercise are independently mediated by increases in deep body temperature","volume":"3","author":"Tipton","year":"2017","journal-title":"BMJ Open Sport Exerc. Med."},{"key":"ref_92","first-page":"494","article-title":"The influence of high air temperatures No","volume":"5","author":"Haldane","year":"1905","journal-title":"I. J. Hyg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00511235","article-title":"Core temperature thresholds for hyperpnea during passive hyperthermia in humans","volume":"71","author":"Cabanac","year":"1995","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1152\/japplphysiol.00146.2007","article-title":"Comparison of hyperthermic hyperpnea elicited during rest and submaximal, moderate-intensity exercise","volume":"104","author":"Fujii","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1152\/japplphysiol.00335.2012","article-title":"Comparison of hyperthermic hyperventilation during passive heating and prolonged light and moderate exercise in the heat","volume":"113","author":"Tsuji","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1113\/JP280970","article-title":"Influence of the mode of heating on cerebral blood flow, non-invasive intracranial pressure and thermal tolerance in humans","volume":"599","author":"Gibbons","year":"2021","journal-title":"J. Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1113\/jphysiol.1955.sp005377","article-title":"The role of body temperature in controlling ventilation during exercise in one normal subject breathing oxygen","volume":"129","author":"Cotes","year":"1955","journal-title":"J. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1152\/ajpregu.00932.2005","article-title":"The effects of hyperthermia and hypoxia on ventilation during low-intensity steady-state exercise","volume":"292","author":"Chu","year":"2007","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1152\/jappl.1996.81.3.1249","article-title":"Exercise hyperpnea and hyperthermia in humans","volume":"81","author":"White","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Semple, S.J.G., Adams, L., and Brian, B.J. (1995). Core temperature thresholds for ventilation during exercise. Modeling and Control of Ventilation, Plenum Press.","DOI":"10.1007\/978-1-4615-1933-1"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1152\/jappl.1968.25.6.742","article-title":"Heat-induced hyperventilation","volume":"25","author":"Gaudio","year":"1968","journal-title":"J. Appl. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1152\/japplphysiol.00541.2005","article-title":"Relationship between ventilatory response and body temperature during prolonged submaximal exercise","volume":"100","author":"Hayashi","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/23328940.2016.1143760","article-title":"Characteristics of hyperthermia-induced hyperventilation in humans","volume":"3","author":"Tsuji","year":"2016","journal-title":"Temperature"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1152\/japplphysiol.00210.2006","article-title":"Components and mechanisms of thermal hyperpnea","volume":"101","author":"White","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1152\/jappl.1974.37.1.103","article-title":"Respiratory heat loss at increased core temperature","volume":"37","author":"Hanson","year":"1974","journal-title":"J. Appl. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1152\/jappl.1991.71.2.590","article-title":"Heat loss from the human head during exercise","volume":"71","author":"Rasch","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1152\/japplphysiol.00992.2010","article-title":"Point: Humans do demonstrate selective brain cooling during hyperthermia","volume":"110","author":"White","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/japplphysiol.00992.2010a","article-title":"Counterpoint: Humans do not demonstrate selective brain cooling during hyperthermia","volume":"110","author":"Nybo","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1172\/JCI101997","article-title":"The blood flow and oxygen consumption of the human brain in diabetic acidosis and coma","volume":"27","author":"Kety","year":"1948","journal-title":"J. Clin. Investig."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1113\/jphysiol.2009.172023","article-title":"The effects of reduced end-tidal carbon dioxide tension on cerebral blood flow during heat stress","volume":"587","author":"Brothers","year":"2009","journal-title":"J. Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1113\/expphysiol.2008.042143","article-title":"Effects of chemoreflexes on hyperthermic hyperventilation and cerebral blood velocity in resting heated humans","volume":"93","author":"Fujii","year":"2008","journal-title":"Exp. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1113\/jphysiol.1993.sp019477","article-title":"Exercise-induced diaphragmatic fatigue in healthy humans","volume":"460","author":"Johnson","year":"1993","journal-title":"J. Physiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1152\/japplphysiol.01389.2005","article-title":"Exercise-induced abdominal muscle fatigue in healthy humans","volume":"100","author":"Taylor","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.resp.2005.12.015","article-title":"Consequences of exercise-induced respiratory muscle work","volume":"151","author":"Dempsey","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1113\/jphysiol.2007.150060","article-title":"Modulation of the control of muscle sympathetic nerve activity during incremental leg cycling","volume":"586","author":"Ichinose","year":"2008","journal-title":"J. Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1113\/jphysiol.2004.063107","article-title":"Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle","volume":"558","author":"Rosenmeier","year":"2004","journal-title":"J. Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1152\/japplphysiol.01281.2006","article-title":"Cardiac output and leg and arm blood flow during incremental exercise to exhaustion on the cycle ergometer","volume":"103","author":"Calbet","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1152\/jappl.1997.82.5.1573","article-title":"Respiratory muscle work compromises leg blood flow during maximal exercise","volume":"82","author":"Harms","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/jappl.2000.89.1.131","article-title":"Effects of respiratory muscle work on exercise performance","volume":"89","author":"Harms","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1113\/EP086566","article-title":"Effects of respiratory muscle work on respiratory and locomotor blood flow during exercise","volume":"102","author":"Dominelli","year":"2017","journal-title":"Exp. Physiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/jappl.1998.85.2.609","article-title":"Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise","volume":"85","author":"Harms","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1152\/jappl.1992.72.5.1810","article-title":"Oxygen cost of exercise hyperpnea: Measurement","volume":"72","author":"Aaron","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1113\/jphysiol.2014.285965","article-title":"Oxygen cost of exercise hyperpnoea is greater in women compared with men","volume":"593","author":"Dominelli","year":"2015","journal-title":"J. Physiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1113\/jphysiol.2009.171694","article-title":"Intercostal muscle blood flow limitation in athletes during maximal exercise","volume":"587","author":"Vogiatzis","year":"2009","journal-title":"J. Physiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1113\/jphysiol.2013.262246","article-title":"Maximal heart rate does not limit cardiovascular capacity in healthy humans: Insight from right atrial pacing during maximal exercise","volume":"592","author":"Munch","year":"2014","journal-title":"J. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1113\/EP086561","article-title":"Reappraisal of systemic venous chemoreceptors: Might they explain the matching of breathing to metabolic rate in humans?","volume":"102","author":"Parkes","year":"2017","journal-title":"Exp. Physiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"893506","DOI":"10.1155\/2013\/893506","article-title":"Evaluating the importance of the carotid chemoreceptors in controlling breathing during exercise in man","volume":"2013","author":"Parkes","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/cphy.c100045","article-title":"Control of breathing during exercise","volume":"2","author":"Forster","year":"2012","journal-title":"Compr. Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1113\/jphysiol.2013.261586","article-title":"Defining the neurocircuitry of exercise hyperpnoea","volume":"592","author":"Paterson","year":"2014","journal-title":"J. Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1152\/japplphysiol.00462.2010","article-title":"Group III and IV muscle afferents contribute to ventilatory and cardiovascular response to rhythmic exercise in humans","volume":"109","author":"Amann","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1113\/EP087649","article-title":"Control of exercise hyperpnoea: Contributions from thin-fibre skeletal muscle afferents","volume":"104","author":"Bruce","year":"2019","journal-title":"Exp. Physiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1152\/japplphysiol.00562.2018","article-title":"Carotid chemoreceptors have a limited role in mediating the hyperthermia-induced hyperventilation in exercising humans","volume":"126","author":"Fujii","year":"2019","journal-title":"J. Appl. Physiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"R669","DOI":"10.1152\/ajpregu.00419.2014","article-title":"Voluntary suppression of hyperthermia-induced hyperventilation mitigates the reduction in cerebral blood flow velocity during exercise in the heat","volume":"308","author":"Tsuji","year":"2015","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1152\/jn.00743.2002","article-title":"Response of the respiratory network of mice to hyperthermia","volume":"89","author":"Tryba","year":"2003","journal-title":"J. Neurophysiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1748-1716.1965.tb04073.x","article-title":"On the nervous factors controlling respiration and circulation during exercise experiments with curarization","volume":"63","author":"Asmussen","year":"1965","journal-title":"Acta Physiol. Scand."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1113\/jphysiol.1977.sp012088","article-title":"Thin-fibre receptors responding to mechanical, chemical, and thermal stimulation in the skeletal muscle of the dog","volume":"273","author":"Kumazawa","year":"1977","journal-title":"J. Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0006-8993(76)90020-2","article-title":"Responses of group IV and group III muscle afferents to thermal stimuli","volume":"113","author":"Hertel","year":"1976","journal-title":"Brain Res."},{"key":"ref_138","unstructured":"Rowell, L.B. (1986). Human Circulation: Regulation During Physical Stress, Oxford University Press."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1152\/jappl.1964.19.2.268","article-title":"Cardiac output during submaximal and maximal work","volume":"19","author":"Cuddy","year":"1964","journal-title":"J. Appl. Physiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1152\/jappl.1966.21.4.1150","article-title":"Cardiac output during submaximal and maximal exercise in active middle-aged athletes","volume":"21","author":"Grimby","year":"1966","journal-title":"J. Appl. Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1172\/JCI118237","article-title":"Myoglobin O2 desaturation during exercise. Evidence of limited O2 transports","volume":"96","author":"Richardson","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_142","first-page":"155","article-title":"Muscular exercise, lactic acid and the supply and utilisation of oxygen.\u2014Parts VII\u2013VIII","volume":"97","author":"Hill","year":"1924","journal-title":"Proc. R. Soc. London. Ser. B Contain. Pap. Biol. Character"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1152\/jappl.1961.16.6.977","article-title":"Maximal oxygen uptake and heart rate in various types of muscular activity","volume":"16","author":"Saltin","year":"1961","journal-title":"J. Appl. Physiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1152\/japplphysiol.00224.2006","article-title":"Relationship between cardiac output and oxygen consumption during upright cycle exercise in healthy humans","volume":"101","author":"Beck","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"H478","DOI":"10.1152\/ajpheart.00314.2011","article-title":"Left ventricular mechanical limitations to stroke volume in healthy humans during incremental exercise","volume":"301","author":"Shave","year":"2011","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_146","first-page":"1","article-title":"Circulatory changes during muscular work in man; with special reference to arterial and central venous pressures in the systemic circulation","volume":"8","author":"Holmgren","year":"1956","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1152\/jappl.1992.73.3.1114","article-title":"Relationship between body and leg VO2 during maximal cycle ergometry","volume":"73","author":"Knight","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1097\/00005768-200010000-00009","article-title":"Change in left atrial and ventricular dimensions during and immediately after exercise","volume":"32","author":"Pokan","year":"2000","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/00005768-199708000-00009","article-title":"Left ventricular function in response to the transition from aerobic to anaerobic metabolism","volume":"29","author":"Pokan","year":"1997","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1161\/01.CIR.0000049746.29175.3F","article-title":"Reductions in systemic and skeletal muscle blood flow and oxygen delivery limit maximal aerobic capacity in humans","volume":"107","author":"Calbet","year":"2003","journal-title":"Circulation"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1172\/JCI105484","article-title":"Reductions in cardiac output, central blood volume, and stroke volume with thermal stress in normal men during exercise","volume":"45","author":"Rowell","year":"1966","journal-title":"J. Clin. Investig."},{"key":"ref_152","first-page":"790","article-title":"Altered control of skin blood flow during exercise at high internal temperatures","volume":"43","author":"Brengelmann","year":"1977","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"H562","DOI":"10.1152\/ajpheart.1993.265.2.H562","article-title":"Mechanisms of control of skin blood flow during prolonged exercise in humans","volume":"265","author":"Kellogg","year":"1993","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"H371","DOI":"10.1152\/ajpheart.1994.266.2.H371","article-title":"Effect of systemic yohimbine on the control of skin blood flow during local heating and dynamic exercise","volume":"266","author":"Kenney","year":"1994","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/jappl.1988.64.2.649","article-title":"Muscle blood flow is not reduced in humans during moderate exercise and heat stress","volume":"64","author":"Savard","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1152\/jappl.1990.69.3.1040","article-title":"Muscle blood flow and muscle metabolism during exercise and heat stress","volume":"69","author":"Nielsen","year":"1990","journal-title":"J. Appl. Physiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1152\/ajpheart.2000.278.2.H321","article-title":"Stroke volume during exercise: Interaction of environment and hydration","volume":"278","author":"Coyle","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"R663","DOI":"10.1152\/ajpregu.00662.2010","article-title":"Hemodynamic responses to heat stress in the resting and exercising human leg: Insight into the effect of temperature on skeletal muscle blood flow","volume":"300","author":"Pearson","year":"2011","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/ajplegacy.1944.142.2.253","article-title":"Work in the heat as affected by intake of water, salt and glucose","volume":"142","author":"Pitts","year":"1944","journal-title":"Am. J. Physiol. Content"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1113\/jphysiol.1955.sp005235","article-title":"The effects of water and salt intake upon the performance of men working in hot and humid environments","volume":"127","author":"Ladell","year":"1955","journal-title":"J. Physiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1152\/jappl.1991.71.3.871","article-title":"Fluid replacement and glucose infusion during exercise prevent cardiovascular drift","volume":"71","author":"Hamilton","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/jappl.1995.79.5.1487","article-title":"Dehydration reduces cardiac output and increases systemic and cutaneous vascular resistance during exercise","volume":"79","author":"Below","year":"1995","journal-title":"J. Appl. Physiol."},{"key":"ref_163","first-page":"6","article-title":"Separate and combined influences of dehydration and hyperthermia on cardiovascular responses to exercise","volume":"19","year":"1998","journal-title":"Int. J. Sports Med."},{"key":"ref_164","first-page":"177","article-title":"Thermal and circulatory responses to repeated bouts of prolonged running","volume":"11","author":"Sawka","year":"1979","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1152\/jappl.1985.59.5.1394","article-title":"Thermoregulatory and blood responses during exercise at graded hypohydration levels","volume":"59","author":"Sawka","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Arngrimsson, S., Petitt, D., Borrani, F., Skinner, K., and Cureton, K. (2004). Hyperthermia and maximal oxygen uptake in men and women. Eur. J. Appl. Physiol., 92.","DOI":"10.1007\/s00421-004-1053-1"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1152\/japplphysiol.00528.2011","article-title":"Dehydration reduces left ventricular filling at rest and during exercise independent of twist mechanics","volume":"111","author":"Pearson","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00421-012-2579-2","article-title":"Haemodynamic responses to dehydration in the resting and exercising human leg","volume":"113","author":"Pearson","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00421-004-1079-4","article-title":"Hypohydration effects on thermoregulation during moderate exercise in the cold","volume":"92","author":"Kenefick","year":"2004","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1152\/jappl.1992.73.4.1340","article-title":"Influence of graded dehydration on hyperthermia and cardiovascular drift during exercise","volume":"73","author":"Montain","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1152\/jappl.1964.19.6.1114","article-title":"Aerobic and anaerobic work capacity after dehydration","volume":"19","author":"Saltin","year":"1964","journal-title":"J. Appl. Physiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/jappl.1958.12.2.189","article-title":"Work performance after dehydration: Effects of physical conditioning and heat acclimatization","volume":"12","author":"Buskirk","year":"1958","journal-title":"J. Appl. Physiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1113\/jphysiol.1914.sp001669","article-title":"On the mechanical factors which determine the output of the ventricles","volume":"48","author":"Patterson","year":"1914","journal-title":"J. Physiol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1172\/JCI105043","article-title":"Indocyanine green clearance and estimated hepatic blood Flow during mild to maximal exercise in upright man","volume":"43","author":"Rowell","year":"1964","journal-title":"J. Clin. Investig."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1152\/jappl.1965.20.3.384","article-title":"Hepatic clearance of indocyanine green in man under thermal and exercise stresses","volume":"20","author":"Rowell","year":"1965","journal-title":"J. Appl. Physiol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1152\/ajplegacy.1948.152.3.505","article-title":"Effects of exercise and some other influences on the renal circulation in man","volume":"152","author":"White","year":"1948","journal-title":"Am. J. Physiol. Content"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1172\/JCI102011","article-title":"The effect of exercise on renal plasma flow in normal male subjects","volume":"27","author":"Chapman","year":"1948","journal-title":"J. Clin. Investig."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1152\/jappl.1965.20.6.1294","article-title":"Renal clearances during prolonged supine exercise at different loads","volume":"20","author":"Grimby","year":"1965","journal-title":"J. Appl. Physiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/01.RES.44.6.739","article-title":"The cardiac and vascular factors that determine systemic blood flow","volume":"44","author":"Levy","year":"1979","journal-title":"Circ. Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1152\/ajplegacy.1955.180.3.463","article-title":"Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output","volume":"180","author":"Guyton","year":"1955","journal-title":"Am. J. Physiol. Content"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/ajplegacy.1957.189.3.609","article-title":"Venous return at various right atrial pressures and the normal venous return curve","volume":"189","author":"Guyton","year":"1957","journal-title":"Am. J. Physiol. Content"},{"key":"ref_182","unstructured":"Rowell, L.B., and Shepherd, J.T. (1996). Section 12: Exercise: Regulation and integration of multiple systems. Handbook of Physiology, Oxford University Press."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"H316","DOI":"10.1152\/ajpheart.1993.265.1.H316","article-title":"Dependence of cardiac filling pressure on cardiac output during rest and dynamic exercise in dogs","volume":"265","author":"Sheriff","year":"1993","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1139\/y96-058","article-title":"Central venous pressure during exercise: Role of muscle pump","volume":"74","author":"Notarius","year":"1996","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1172\/JCI105312","article-title":"Effects of exercise on myocardial force-velocity relations in intact unanesthetized man: Relative roles of changes in heart rate, sympathetic activity, and ventricular dimensions","volume":"44","author":"Sonnenblick","year":"1965","journal-title":"J. Clin. Investig."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/BF01906411","article-title":"Studies on the regulation of myocardial blood flow in man","volume":"71","author":"Heiss","year":"1976","journal-title":"Basic Res. Cardiol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1749-6632.1977.tb38200.x","article-title":"Myocardial blood flow and oxygen consumption during exercise","volume":"301","author":"Gobel","year":"1977","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_188","first-page":"245","article-title":"The effect of adrenergic \u03b2-receptor blockade on coronary circulation in man during work","volume":"191","author":"Malmberg","year":"1972","journal-title":"Acta Med. Scand."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/01.CIR.48.6.1173","article-title":"Effect of propranolol on myocardial oxygen consumption and its hemodynamic correlates during upright exercise","volume":"48","author":"Jorgensen","year":"1973","journal-title":"Circulation"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.0954-6820.1971.tb07462.x","article-title":"Coronary circulation during heavy exercise in control subjects and patients with coronary heart disease","volume":"190","author":"Holmberg","year":"1971","journal-title":"Acta Med. Scand."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1161\/01.CIR.50.6.1179","article-title":"Hemodynamic predictors of myocardial oxygen consumption during static and dynamic exercise","volume":"50","author":"Nelson","year":"1974","journal-title":"Circulation"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1161\/01.CIR.62.3.528","article-title":"Left ventricular performance in normal subjects: A comparison of the responses to exercise in the upright and supine positions","volume":"62","author":"Poliner","year":"1980","journal-title":"Circulation"},{"key":"ref_193","first-page":"146","article-title":"Bicycle exercise stress in PET for assessment of coronary flow reserve: Repeatability and comparison with adenosine stress","volume":"44","author":"Wyss","year":"2003","journal-title":"J. Nucl. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1748-1716.1991.tb09181.x","article-title":"Myocardial blood flow and lactate metabolism at rest and during exercise with reduced arterial oxygen content","volume":"142","author":"Berglund","year":"1991","journal-title":"Acta Physiol. Scand."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/01.CIR.0000087432.63671.2E","article-title":"Influence of altitude exposure on coronary flow reserve","volume":"108","author":"Wyss","year":"2003","journal-title":"Circulation"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/occmed\/kqv015","article-title":"Effect of exercise, heat stress and dehydration on myocardial performance","volume":"65","author":"Fehling","year":"2015","journal-title":"Occup. Med. (Chic. Ill.)"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"H965","DOI":"10.1152\/ajpheart.00466.2020","article-title":"Exercise heat acclimation has minimal effects on left ventricular volumes, function and systemic hemodynamics in euhydrated and dehydrated trained humans","volume":"319","author":"Travers","year":"2020","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_198","first-page":"1342","article-title":"Arterial-ventricular coupling with aging and disease","volume":"105","author":"Chantler","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1152\/japplphysiol.90600.2008","article-title":"Arterial-ventricular coupling: Mechanistic insights into cardiovascular performance at rest and during exercise","volume":"105","author":"Chantler","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"740121","DOI":"10.3389\/fphys.2021.740121","article-title":"Exercise heat acclimation with dehydration does not affect vascular and cardiac volumes or systemic hemodynamics during endurance exercise","volume":"12","author":"Travers","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1152\/jappl.1971.30.1.64","article-title":"Venomotor responses to rapid changes in skin temperature in exercising man","volume":"30","author":"Rowell","year":"1971","journal-title":"J. Appl. Physiol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S1440-2440(00)80080-8","article-title":"Effects of heat stress on physiological responses and exercise performance in elite cyclists","volume":"3","author":"Tatterson","year":"2000","journal-title":"J. Sci. Med. Sport"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1152\/jappl.1992.73.3.903","article-title":"Fluid ingestion during exercise increases skin blood flow independent of increases in blood volume","volume":"73","author":"Montain","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1152\/japplphysiol.00377.2010","article-title":"Interaction of hyperthermia and heart rate on stroke volume during prolonged exercise","volume":"109","author":"Trinity","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1152\/japplphysiol.00965.2017","article-title":"Cardiovascular responses to exercise when increasing skin temperature with narrowing of the core-to-skin temperature gradient","volume":"125","author":"Chou","year":"2018","journal-title":"J. Appl. Physiol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1249\/MSS.0000000000002029","article-title":"Low stroke volume during exercise with hot skin is due to elevated heart rate","volume":"51","author":"Chou","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1249\/MSS.0000000000000539","article-title":"Warm skin alters cardiovascular responses to cycling after preheating and precooling","volume":"47","author":"Lee","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0002-8703(70)90254-1","article-title":"The effects of exercise and changes in body temperature on the intrinsic heart rate in man","volume":"79","author":"Jose","year":"1970","journal-title":"Am. Heart J."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/jappl.1999.86.3.799","article-title":"Stroke volume decline during prolonged exercise is influenced by the increase in heart rate","volume":"86","author":"Fritzsche","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1152\/jappl.1997.82.4.1229","article-title":"Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise","volume":"82","author":"Below","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"ref_211","first-page":"E380","article-title":"Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration","volume":"265","author":"Romijn","year":"1993","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1152\/jappl.1993.75.4.1654","article-title":"Anaerobic energy release in working muscle during 30 s to 3 min of exhausting bicycling","volume":"75","author":"Tabata","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1365-201X.1998.0298f.x","article-title":"Energy supply and muscle fatigue in humans","volume":"162","author":"Sahlin","year":"1998","journal-title":"Acta Physiol. Scand."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s42255-020-0251-4","article-title":"Skeletal muscle energy metabolism during exercise","volume":"2","author":"Hargreaves","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_215","first-page":"E956","article-title":"ATP production and efficiency of human skeletal muscle during intense exercise: Effect of previous exercise","volume":"280","author":"Bangsbo","year":"2001","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1469-7793.2001.00295.x","article-title":"The effects of increasing exercise intensity on muscle fuel utilisation in humans","volume":"536","author":"Loon","year":"2001","journal-title":"J. Physiol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1152\/jappl.1993.75.4.1911","article-title":"High muscle blood flow in man: Is maximal O2 extraction compromised?","volume":"75","author":"Richardson","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1152\/jappl.1997.83.4.1383","article-title":"Ultrasound Doppler estimates of femoral artery blood flow during dynamic knee extensor exercise in humans","volume":"83","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1113\/jphysiol.2007.136309","article-title":"Exercise hyperaemia: Magnitude and aspects on regulation in humans","volume":"583","author":"Saltin","year":"2007","journal-title":"J. Physiol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1152\/jappl.1985.59.4.1322","article-title":"Rat muscle blood flows during high-speed locomotion","volume":"59","author":"Armstrong","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1152\/jappl.1987.62.4.1724","article-title":"Training effects on regional blood flow response to maximal exercise in foxhounds","volume":"62","author":"Musch","year":"1987","journal-title":"J. Appl. Physiol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/cphy.c100048","article-title":"Peripheral Circulation","volume":"2","author":"Laughlin","year":"2012","journal-title":"Compr. Physiol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1152\/japplphysiol.01220.2003","article-title":"Ideas about control of skeletal and cardiac muscle blood flow (1876\u20132003): Cycles of revision and new vision","volume":"97","author":"Rowell","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1113\/JP279223","article-title":"August Krogh\u2019s theory of muscle microvascular control and oxygen delivery: A paradigm shift based on new data","volume":"598","author":"Poole","year":"2020","journal-title":"J. Physiol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1113\/EP085383","article-title":"Blood temperature and perfusion to exercising and non-exercising human limbs","volume":"100","author":"Calbet","year":"2015","journal-title":"Exp. Physiol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/cphy.c130015","article-title":"Cutaneous Vasodilator and Vasoconstrictor Mechanisms in Temperature Regulation","volume":"4","author":"Johnson","year":"2014","journal-title":"Comp Physiol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/cphy.c140015","article-title":"Human Cardiovascular Responses to Passive Heat Stress","volume":"5","author":"Crandall","year":"2014","journal-title":"Comp Physiol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1152\/jappl.1998.85.2.627","article-title":"Lactate efflux from exercising human skeletal muscle: Role of intracellular PO2","volume":"85","author":"Richardson","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1469-7793.2000.00603.x","article-title":"Heat production in human skeletal muscle at the onset of intense dynamic exercise","volume":"524","author":"Quistorff","year":"2000","journal-title":"J. Physiol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1152\/japplphysiol.00013.2019","article-title":"Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: Gateway to function and dysfunction","volume":"127","author":"Poole","year":"2019","journal-title":"J. Appl. Physiol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1113\/jphysiol.2002.034496","article-title":"Arm blood flow and oxygenation on the transition from arm to combined arm and leg exercise in humans","volume":"547","author":"Volianitis","year":"2003","journal-title":"J. Physiol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"H1736","DOI":"10.1152\/ajpheart.01001.2003","article-title":"Effect of fitness on arm vascular and metabolic responses to upper body exercise","volume":"286","author":"Volianitis","year":"2004","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1748-1716.1992.tb09261.x","article-title":"Effect of arm-cranking on leg blood flow and noradrenaline spillover during leg exercise in man","volume":"144","author":"Richter","year":"1992","journal-title":"Acta Physiol. Scand."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.mito.2010.12.006","article-title":"Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans","volume":"11","author":"Boushel","year":"2011","journal-title":"Mitochondrion"},{"key":"ref_235","first-page":"137","article-title":"Fatigue of submaximal static contractions","volume":"556","author":"Cafarelli","year":"1986","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1152\/jappl.1994.76.6.2411","article-title":"Behavior of motor units in human biceps brachii during a submaximal fatiguing contraction","volume":"76","author":"Garland","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1152\/japplphysiol.01053.2007","article-title":"A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions","volume":"104","author":"Taylor","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s004210050140","article-title":"Myoelectric evidence of peripheral muscle fatigue during exercise in severe hypoxia: Some references to m. vastus lateralis myosin heavy chain composition","volume":"75","author":"Taylor","year":"1997","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1172\/JCI107645","article-title":"Substrate turnover during prolonged exercise in man","volume":"53","author":"Ahlborg","year":"1974","journal-title":"J. Clin. Investig."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s004240050361","article-title":"Acute and adaptive responses in humans to exercise in a warm, humid environment","volume":"434","author":"Nielsen","year":"1997","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1113\/jphysiol.1993.sp019482","article-title":"Human circulatory and thermoregulatory adaptations with heat acclimation and exercise in a hot, dry environment","volume":"460","author":"Nielsen","year":"1993","journal-title":"J. Physiol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1152\/jappl.1991.71.4.1245","article-title":"Contribution of excising legs to the slow component of oxygen uptake kinetics in humans","volume":"71","author":"Poole","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1152\/jappl.1992.73.5.1838","article-title":"Leg vasoconstriction during dynamic exercise with reduced cardiac output","volume":"73","author":"Pawelczyk","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1152\/jappl.1996.80.1.363","article-title":"Effect of fluid ingestion on muscle metabolism during prolonged exercise","volume":"80","author":"Hargreaves","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"H369","DOI":"10.1152\/ajpheart.00078.2015","article-title":"Local temperature-sensitive mechanisms are important mediators of limb tissue hyperemia in the heat-stressed human at rest and during small muscle mass exercise","volume":"309","author":"Chiesa","year":"2015","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_246","first-page":"e14953","article-title":"Regional thermal hyperemia in the human leg: Evidence of the importance of thermosensitive mechanisms in the control of the peripheral circulation","volume":"9","author":"Gibson","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/japplphysiol.00965.2015","article-title":"Temperature and blood flow distribution in the human leg during passive heat stress","volume":"120","author":"Chiesa","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1113\/jphysiol.2010.194506","article-title":"\u03b1-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg","volume":"588","author":"Keller","year":"2010","journal-title":"J. Physiol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"H89","DOI":"10.1152\/ajpheart.00519.2016","article-title":"Acute limb heating improves macro- and microvascular dilator function in the leg of aged humans","volume":"312","author":"Romero","year":"2017","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/japplphysiol.01490.2005","article-title":"Effect of temperature on skeletal muscle energy turnover during dynamic knee-extensor exercise in humans","volume":"101","author":"Ferguson","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"H1936","DOI":"10.1152\/ajpheart.00389.2010","article-title":"Erythrocyte-dependent regulation of human skeletal muscle blood flow: Role of varied oxyhemoglobin and exercise on nitrite, S -nitrosohemoglobin, and ATP","volume":"299","author":"Dufour","year":"2010","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0008-6363(97)00100-4","article-title":"Time course of brachial artery diameter responses to rhythmic handgrip exercise in humans","volume":"35","author":"Shoemaker","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1113\/jphysiol.2010.203034","article-title":"Local release of ATP into the arterial inflow and venous drainage of human skeletal muscle: Insight from ATP determination with the intravascular microdialysis technique","volume":"589","author":"Mortensen","year":"2011","journal-title":"J. Physiol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1113\/JP274532","article-title":"Sympatholytic effect of intravascular ATP is independent of nitric oxide, prostaglandins, Na+\/K+ -ATPase and K IR channels in humans","volume":"595","author":"Hearon","year":"2017","journal-title":"J. Physiol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1113\/jphysiol.2012.233106","article-title":"Regulation of blood flow distribution in skeletal muscle: Role of erythrocyte-released ATP","volume":"590","author":"Ellsworth","year":"2012","journal-title":"J. Physiol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/10739680590895028","article-title":"Regulation of blood flow in the microcirculation","volume":"12","author":"Segal","year":"2005","journal-title":"Microcirculation"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2165\/00007256-200535080-00001","article-title":"Haemorheology in exercise and training","volume":"35","author":"Ali","year":"2005","journal-title":"Sports Med."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3389\/fphys.2019.01329","article-title":"Blood Rheology: Key parameters, impact on blood flow, role in sickle cell disease and effects of exercise","volume":"10","author":"Nader","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1113\/expphysiol.2014.081620","article-title":"Regulation of the skeletal muscle blood flow in humans","volume":"99","author":"Mortensen","year":"2014","journal-title":"Exp. Physiol."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1113\/jphysiol.2007.136416","article-title":"The roles of adenosine and related substances in exercise hyperaemia","volume":"583","author":"Marshall","year":"2007","journal-title":"J. Physiol."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"H2155","DOI":"10.1152\/ajpheart.1995.269.6.H2155","article-title":"The erythrocyte as a regulator of vascular tone","volume":"269","author":"Ellsworth","year":"1995","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Sender, R., Fuchs, S., and Milo, R. (2016). Revised estimates for the number of human and bacteria cells in the body. PLoS Biol., 14.","DOI":"10.1101\/036103"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"H1726","DOI":"10.1152\/ajpheart.1998.275.5.H1726","article-title":"Deformation-induced ATP release from red blood cells requires CFTR activity","volume":"275","author":"Sprague","year":"1998","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1126\/science.276.5321.2034","article-title":"Blood flow regulation by S -Nitrosohemoglobin in the physiological oxygen gradient","volume":"276","author":"Stamler","year":"1997","journal-title":"Science"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1073\/pnas.97.21.11482","article-title":"Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans","volume":"97","author":"Gladwin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1469-7793.2001.0331l.x","article-title":"Exercising skeletal muscle blood flow in humans responds to reduction in arterial oxyhaemoglobin, but not to altered free oxygen","volume":"530","author":"Richardson","year":"2001","journal-title":"J. Physiol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/01.RES.0000044939.73286.E2","article-title":"Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery","volume":"91","author":"Olsen","year":"2002","journal-title":"Circ. Res."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1113\/jphysiol.2003.044024","article-title":"Human skeletal muscle sympathetic nerve activity, heart rate and limb haemodynamics with reduced blood oxygenation and exercise","volume":"551","author":"Hanada","year":"2003","journal-title":"J. Physiol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"H2833","DOI":"10.1152\/ajpheart.2001.280.6.H2833","article-title":"Role of erythrocyte in regulating local O2 delivery mediated by hemoglobin oxygenation","volume":"280","author":"Jagger","year":"2001","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"H438","DOI":"10.1152\/ajpheart.1999.276.2.H438","article-title":"Arterial O2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans","volume":"276","author":"Roach","year":"1999","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"H1787","DOI":"10.1152\/ajpheart.1997.273.4.H1787","article-title":"Cardiovascular responses to dynamic exercise with acute anemia in humans","volume":"273","author":"Koskolou","year":"1997","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1113\/jphysiol.2005.101121","article-title":"Erythrocytes and the regulation of human skeletal muscle blood flow and oxygen delivery: Role of erythrocyte count and oxygenation state of haemoglobin","volume":"572","author":"Mortensen","year":"2006","journal-title":"J. Physiol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1113\/jphysiol.2012.234963","article-title":"Contribution of intravascular versus interstitial purines and nitric oxide in the regulation of exercise hyperaemia in humans","volume":"590","author":"Hellsten","year":"2012","journal-title":"J. Physiol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"R1131","DOI":"10.1152\/ajpregu.00226.2002","article-title":"Effect of mild carboxy-hemoglobin on exercising skeletal muscle: Intravascular and intracellular evidence","volume":"283","author":"Richardson","year":"2002","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1152\/japplphysiol.00179.2004","article-title":"Vasodilatory mechanisms in contracting skeletal muscle","volume":"97","author":"Clifford","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1113\/EP085910","article-title":"Mechanisms for the control of local tissue blood flow during thermal interventions: Influence of temperature-dependent ATP release from human blood and endothelial cells","volume":"102","author":"Kalsi","year":"2017","journal-title":"Exp. Physiol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1152\/japplphysiol.00269.2011","article-title":"Local heating, but not indirect whole body heating, increases human skeletal muscle blood flow","volume":"111","author":"Heinonen","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_278","doi-asserted-by":"crossref","unstructured":"Nemkov, T., Skinner, S.C., Nader, E., Stefanoni, D., Robert, M., Cendali, F., Stauffer, E., Cibiel, A., Boisson, C., and Connes, P. (2021). Acute cycling exercise induces changes in red blood cell deformability and membrane lipid remodeling. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020896"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1152\/jappl.1981.50.6.1255","article-title":"Erythrocyte volume, plasma volume, and acid-base changes in exercise and heat dehydration","volume":"50","author":"Underkofler","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"34D","DOI":"10.1016\/0002-9149(85)91053-7","article-title":"Cardiovascular control during exercise: Central and reflex neural mechanisms","volume":"55","author":"Mitchell","year":"1985","journal-title":"Am. J. Cardiol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1113\/expphysiol.2012.071001","article-title":"Neural circulatory control during exercise: Early insights","volume":"98","author":"Mitchell","year":"2013","journal-title":"Exp. Physiol."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/cphy.c140022","article-title":"Autonomic adjustments to exercise in humans","volume":"5","author":"Fisher","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1113\/jphysiol.2003.059287","article-title":"Maximal muscular vascular conductances during whole body upright exercise in humans","volume":"558","author":"Calbet","year":"2004","journal-title":"J. Physiol."},{"key":"ref_284","doi-asserted-by":"crossref","unstructured":"Furst, B. (2020). The Heart and Circulation, Springer International Publishing. [2nd ed.].","DOI":"10.1007\/978-3-030-25062-1"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"jeb215335","DOI":"10.1242\/jeb.215335","article-title":"What determines systemic blood flow in vertebrates?","volume":"223","author":"Joyce","year":"2020","journal-title":"J. Exp. Biol."},{"key":"ref_286","unstructured":"Guyton, A.C. (1969). Cardiac output, venous return, and their regulation- an integrative analysis of the circulation. Textbook of Medical Physiology, W.B. Saunders Company."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1113\/jphysiol.2011.225334","article-title":"Peripheral vasodilatation determines cardiac output in exercising humans: Insight from atrial pacing","volume":"590","author":"Bada","year":"2012","journal-title":"J. Physiol."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/01.CIR.32.4.549","article-title":"Effects of changing heart rate in man by electrical stimulation of the right atrium. studies at rest, during exercise, and with isoproterenol","volume":"32","author":"Ross","year":"1965","journal-title":"Circulation"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1161\/01.CIR.33.6.925","article-title":"The relation of heart rate to cardiovascular dynamics","volume":"33","author":"Stein","year":"1966","journal-title":"Circulation"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"H1510","DOI":"10.1152\/ajpheart.00996.2010","article-title":"Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: A pet study with nitric oxide and cyclooxygenase inhibition","volume":"300","author":"Ilkka","year":"2011","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/01.RES.14.2.126","article-title":"Intrinsic regulation of skeletal muscle blood flow","volume":"14","author":"Jones","year":"1964","journal-title":"Circ. Res."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/01.RES.26.2.163","article-title":"Propagated vasodilation in the microcirculation of the hamster cheek pouch","volume":"26","author":"Duling","year":"1970","journal-title":"Circ. Res."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1113\/jphysiol.2008.155432","article-title":"Activation of ATP\/UTP-selective receptors increases blood flow and blunts sympathetic vasoconstriction in human skeletal muscle","volume":"586","author":"Rosenmeier","year":"2008","journal-title":"J. Physiol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"R447","DOI":"10.1152\/ajpregu.00746.2005","article-title":"Effects of ATP-induced leg vasodilation on VO2 peak and leg O2 extraction during maximal exercise in humans","volume":"291","author":"Calbet","year":"2006","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1113\/jphysiol.2006.127423","article-title":"Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg","volume":"581","author":"Mortensen","year":"2007","journal-title":"J. Physiol."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1113\/JP270408","article-title":"Limitations to oxygen transport and utilization during sprint exercise in humans: Evidence for a functional reserve in muscle O2 diffusing capacity","volume":"593","author":"Calbet","year":"2015","journal-title":"J. Physiol."},{"key":"ref_297","unstructured":"Steiner, R. (1999). Introducing Anthroposopical Medicine: Lecture of Mmarch 22 1920, Donarch, Switzerland, SteinerBooks."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/BF02119022","article-title":"Arbeitet das Herz wie eine Druckpumpe oder wie ein Sto\u00dfheber","volume":"1","author":"Havlicek","year":"1937","journal-title":"Arch. Kreislaufforsch."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1053\/j.jvca.2015.02.022","article-title":"The heart: Pressure-propulsion pump or organ of impedance?","volume":"29","author":"Furst","year":"2015","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/thx.15.1.47","article-title":"Energy sources of blood circulation and the mechanical action of the heart","volume":"15","year":"1960","journal-title":"Thorax"},{"key":"ref_301","first-page":"201","article-title":"On the possibility of blood circulation continuing after stopping the heart","volume":"7","author":"Michalowski","year":"1966","journal-title":"J. Cardiovasc. Surg. (Torino)"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1113\/JP281517","article-title":"Acid\u2013base balance and cerebrovascular regulation","volume":"599","author":"Caldwell","year":"2021","journal-title":"J. Physiol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.1190721","article-title":"Astrocytes control breathing through pH-ependent release of ATP","volume":"329","author":"Gourine","year":"2010","journal-title":"Science"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1126\/science.1683005","article-title":"Pre-B\u00f6tzinger complex: A brainstem region that may generate respiratory rhythm in mammals","volume":"254","author":"Smith","year":"1991","journal-title":"Science"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41467-017-02723-6","article-title":"Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity","volume":"9","author":"Sheikhbahaei","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_306","first-page":"1381","article-title":"Maximal oxygen uptake: \u201cclassical\u201d versus \u201ccontemporary\u201d viewpoints: A rebuttal","volume":"30","author":"Noakes","year":"1998","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1113\/jphysiol.2007.145110","article-title":"Arterial oxygenation, central motor output and exercise performance in humans","volume":"585","author":"Noakes","year":"2007","journal-title":"J. Physiol."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/00005768-199705000-00001","article-title":"Challenging beliefs: Ex Africa semper aliquid novi","volume":"29","author":"Noakes","year":"1997","journal-title":"Med. Sci. Sports Exerc."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/3\/383\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:06:25Z","timestamp":1760133985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/3\/383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,24]]},"references-count":308,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["cells11030383"],"URL":"https:\/\/doi.org\/10.3390\/cells11030383","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,24]]}}}