{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:30:51Z","timestamp":1790062251150,"version":"4.0.1"},"reference-count":179,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Spondyloarthritis (SpA) is a family of chronic inflammatory diseases, being the most prevalent ankylosing spondylitis (AS) and psoriatic arthritis (PsA). These diseases share genetic, clinical and immunological features, such as the implication of human leukocyte antigen (HLA) class I molecule 27 (HLA-B27), the inflammation of peripheral, spine and sacroiliac joints and the presence of extra-articular manifestations (psoriasis, anterior uveitis, enthesitis and inflammatory bowel disease). Monocytes and macrophages are essential cells of the innate immune system and are the first line of defence against external agents. In rheumatic diseases including SpA, the frequency and phenotypic and functional characteristics of both cell types are deregulated and are involved in the pathogenesis of these diseases. In fact, monocytes and macrophages play key roles in the inflammatory processes characteristics of SpA. The aim of this review is analysing the characteristics and functional roles of monocytes and macrophages in these diseases, as well as the impact of different current therapies on these cell types.<\/jats:p>","DOI":"10.3390\/cells11030515","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T05:42:33Z","timestamp":1643866953000},"page":"515","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of Current Therapies"],"prefix":"10.3390","volume":"11","author":[{"given":"Sara","family":"Mart\u00ednez-Ramos","sequence":"first","affiliation":[{"name":"Rheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain"},{"name":"Rheumatology Department, University Hospital Complex of Vigo, 36214 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4451-9248","authenticated-orcid":false,"given":"Carlos","family":"Rafael-Vidal","sequence":"additional","affiliation":[{"name":"Rheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain"},{"name":"Rheumatology Department, University Hospital Complex of Vigo, 36214 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3461-3537","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Pego-Reigosa","sequence":"additional","affiliation":[{"name":"Rheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain"},{"name":"Rheumatology Department, University Hospital Complex of Vigo, 36214 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5902-2699","authenticated-orcid":false,"given":"Samuel","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Rheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain"},{"name":"Rheumatology Department, University Hospital Complex of Vigo, 36214 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/ard.61.5.453","article-title":"Prevalence of Rheumatic Diseases in a Rheumatological Outpatient Practice","volume":"61","author":"Vanhoof","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","article-title":"Ankylosing Spondylitis","volume":"369","author":"Braun","year":"2007","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.semarthrit.2021.04.007","article-title":"Peripheral Arthritis and Higher Disease Activity Lead to More Functional Impairment in Axial Spondyloarthritis: Longitudinal Analysis from ESPAXIA","volume":"51","author":"Capelusnik","year":"2021","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/rheumatology\/ket239","article-title":"Undifferentiated Spondyloarthritis vs Ankylosing Spondylitis and Psoriatic Arthritis: A Real-Life Prospective Cohort Study of Clinical Presentation and Response to Treatment","volume":"52","author":"Paramarta","year":"2013","journal-title":"Rheumatology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1136\/annrheumdis-2021-eular.218","article-title":"Age at Onset in Axial Spondyloarthritis around the World: Data from the International ASAS-PERSPA Study","volume":"80","author":"Boel","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrrheum.2014.181","article-title":"The Changing Clinical Picture and Epidemiology of Spondyloarthritis","volume":"11","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"A325","DOI":"10.1016\/j.autrev.2009.11.012","article-title":"Geoepidemiology: The Environment and Spondyloarthropathies","volume":"9","author":"Ehrenfeld","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.3748\/wjg.v25.i18.2162","article-title":"Inflammatory Bowel Diseases and Spondyloarthropathies: From Pathogenesis to Treatment","volume":"25","author":"Fragoulis","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nrrheum.2016.42","article-title":"New Evidence on the Management of Spondyloarthritis","volume":"12","author":"Sieper","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.berh.2018.12.001","article-title":"Advances in Understanding the Pathophysiology of Spondyloarthritis","volume":"32","author":"Lories","year":"2018","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/rheumatology\/ken506","article-title":"First Signs and Symptoms of Spondyloarthritis\u2014Data from an Inception Cohort with a Disease Course of Two Years or Less (REGISPONSER-Early)","volume":"48","author":"Escudero","year":"2009","journal-title":"Rheumatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jaad.2008.02.047","article-title":"Reiter\u2019s Syndrome: The Classic Triad and More","volume":"59","author":"Wu","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0889-857X(03)00043-7","article-title":"Enteropathic Arthritis","volume":"29","author":"Holden","year":"2003","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/art.39573","article-title":"Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 Treatment Recommendations for Psoriatic Arthritis","volume":"68","author":"Coates","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e001136","DOI":"10.1136\/rmdopen-2019-001136","article-title":"Peripheral Spondyloarthritis: A Neglected Entity\u2014State of the Art","volume":"6","author":"Carron","year":"2020","journal-title":"RMD Open"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jbspin.2010.05.001","article-title":"Spondyloarthropathies: An Independent Cardiovascular Risk Factor?","volume":"77","author":"Mathieu","year":"2010","journal-title":"Jt. Bone Spine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105261","DOI":"10.1016\/j.jbspin.2021.105261","article-title":"The Negative Impact of Depression in Women with Axial Spondyloarthropathy","volume":"89","author":"Maguire","year":"2022","journal-title":"Jt. Bone Spine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/acr2.11316","article-title":"The Annual Diagnostic Prevalence of Ankylosing Spondylitis and Axial Spondyloarthritis in the United States Using Medicare and MarketScan Databases","volume":"3","author":"Curtis","year":"2021","journal-title":"ACR Open Rheumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.jaad.2020.10.031","article-title":"Trends in Mortality and Cause-Specific Mortality among Patients with Psoriasis and Psoriatic Arthritis in Ontario, Canada","volume":"84","author":"Colaco","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.3389\/fimmu.2020.553742","article-title":"Innate Cells: The Alternative Source of IL-17 in Axial and Peripheral Spondyloarthritis?","volume":"11","author":"Rosine","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.3389\/fimmu.2021.708186","article-title":"Macrophages: The Good, the Bad, and the Gluttony","volume":"12","author":"Ross","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Roszkowski, L., and Ciechomska, M. (2021). Tuning Monocytes and Macrophages for Personalized Therapy and Diagnostic Challenge in Rheumatoid Arthritis. Cells, 10.","DOI":"10.3390\/cells10081860"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New Insights into the Immunopathogenesis of Systemic Lupus Erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/BOR.0b013e3283534df4","article-title":"Pathogenesis of Spondyloarthritis","volume":"24","author":"Ambarus","year":"2012","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1186\/ar571","article-title":"HLA-B27: Natural Function and Pathogenic Role in Spondyloarthritis","volume":"4","author":"McMichael","year":"2002","journal-title":"Arthritis Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s40744-018-0100-z","article-title":"Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases","volume":"5","author":"Bodis","year":"2018","journal-title":"Rheumatol. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3389\/fimmu.2021.601518","article-title":"Spondyloarthritis and the Human Leukocyte Antigen (HLA)-B*27 Connection","volume":"12","author":"Kavadichanda","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/art.38644","article-title":"HLA-B27 Subtype Oligomerization and Intracellular Accumulation Patterns Correlate with Predisposition to Spondyloarthritis","volume":"66","author":"Jeanty","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.autrev.2016.02.002","article-title":"An Update on Biomarkers in Axial Spondyloarthritis","volume":"15","author":"Pavelka","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.1232685","article-title":"Influence of HLA-C Expression Level on HIV Control","volume":"340","author":"Apps","year":"2013","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/rheumatology\/ket296","article-title":"Killer-Cell Immunoglobulin-like Receptor Gene Polymorphisms and Susceptibility to Psoriatic Arthritis","volume":"53","author":"Chandran","year":"2014","journal-title":"Rheumatology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/acr2.11065","article-title":"HLA-C: An Accomplice in Rheumatic Diseases","volume":"1","author":"Siegel","year":"2019","journal-title":"ACR Open Rheumatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/jid.2014.517","article-title":"A Single SNP Surrogate for Genotyping HLA-C*06:02 in Diverse Populations","volume":"135","author":"Stuart","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1038\/ncomms8146","article-title":"Major Histocompatibility Complex Associations of Ankylosing Spondylitis Are Complex and Involve Further Epistasis with ERAP1","volume":"6","author":"Cortes","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/art.39072","article-title":"ERAP1 Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated with Predisposition to Spondyloarthritis","volume":"67","author":"Costantino","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.3389\/fimmu.2018.02933","article-title":"Genetics and Functional Genomics of Spondyloarthritis","volume":"9","author":"Costantino","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"i44","DOI":"10.1136\/ard.2010.140574","article-title":"The Genetic Basis of Spondyloarthritis","volume":"70","author":"Reveille","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"International Genetics of Ankylosing Spondylitis Consortium (IGAS) (2013). Identification of Multiple Risk Variants for Ankylosing Spondylitis through High-Density Genotyping of Immune-Related Loci. Nat. Genet., 45, 730\u2013738.","DOI":"10.1038\/ng.2667"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1136\/annrheumdis-2015-207490","article-title":"The Genetic Association of RUNX3 with Ankylosing Spondylitis Can Be Explained by Allele-Specific Effects on IRF4 Recruitment that Alter Gene Expression","volume":"75","author":"Vecellio","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1136\/annrheumdis-2015-208640","article-title":"An Ankylosing Spondylitis-Associated Genetic Variant in the IL23R-IL12RB2 Intergenic Region Modulates Enhancer Activity and Is Associated with Increased Th1-Cell Differentiation","volume":"75","author":"Roberts","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-019-1829-7","article-title":"Deregulation of MicroRNA Expression in Monocytes and CD4+ T Lymphocytes from Patients with Axial Spondyloarthritis","volume":"21","author":"Fogel","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/hmg\/ddy008","article-title":"Circulating MicroRNAs as Potential Biomarkers of Disease Activity and Structural Damage in Ankylosing Spondylitis Patients","volume":"27","author":"Barbarroja","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0070939","article-title":"Imbalance between HAT and HDAC Activities in the PBMCs of Patients with Ankylosing Spondylitis or Rheumatoid Arthritis and Influence of HDAC Inhibitors on TNF Alpha Production","volume":"8","author":"Toussirot","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3892\/mmr.2015.4494","article-title":"Role of Histone Deacetylase 3 in Ankylosing Spondylitis via Negative Feedback Loop with MicroRNA-130a and Enhancement of Tumor Necrosis Factor-1\u03b1 Expression in Peripheral Blood Mononuclear Cells","volume":"13","author":"Jiang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jbspin.2020.06.003","article-title":"Epigenetics of Spondyloarthritis","volume":"87","author":"Cherqaoui","year":"2020","journal-title":"Jt. Bone Spine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(11)60071-8","article-title":"Spondyloarthritis","volume":"377","author":"Dougados","year":"2011","journal-title":"Lancet"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1002\/art.39681","article-title":"Perturbed Mucosal Immunity and Dysbiosis Accompany Clinical Disease in a Rat Model of Spondyloarthritis","volume":"68","author":"Asquith","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/art.40154","article-title":"Role of Gut Inflammation in Altering the Monocyte Compartment and Its Osteoclastogenic Potential in HLA\u2013B27\u2013Transgenic Rats","volume":"69","author":"Ansalone","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/art.41169","article-title":"Interleukin-17 Inhibition in Spondyloarthritis Is Associated with Subclinical Gut Microbiome Perturbations and a Distinctive Interleukin-25\u2013Driven Intestinal Inflammation","volume":"72","author":"Manasson","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Wang, L., Wang, Y., Zhang, P., Song, C., Pan, F., Li, G., Peng, L., Yang, Y., Wei, Z., and Huang, F. (2021). Gut Microbiota Changes in Patients with Spondyloarthritis: A Systematic Review. Semin. Arthritis Rheum., in press.","DOI":"10.1016\/j.semarthrit.2021.11.002"},{"key":"ref_51","first-page":"1","article-title":"Mechanical Strain Determines the Site-Specific Localization of Inflammation and Tissue Damage in Arthritis","volume":"9","author":"Gaublomme","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sharip, A., and Kunz, J. (2020). Understanding the Pathogenesis of Spondyloarthritis. Biomolecules, 10.","DOI":"10.3390\/biom10101461"},{"key":"ref_53","first-page":"322","article-title":"Interactions of the Innate and Adaptive Arms of the Immune System in the Pathogenesis of Spondyloarthritis","volume":"29","author":"Stoll","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/art.40414","article-title":"The Role of Autophagy in the Degradation of Misfolded HLA-B27 Heavy Chains","volume":"70","author":"Navid","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jaut.2016.03.009","article-title":"Non-Conventional Forms of HLA-B27 Are Expressed in Spondyloarthritis Joints and Gut Tissue","volume":"70","author":"Rysnik","year":"2016","journal-title":"J. Autoimmun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.autrev.2018.04.002","article-title":"Nature versus Nurture in the Spectrum of Rheumatic Diseases: Classification of Spondyloarthritis as Autoimmune or Autoinflammatory","volume":"17","author":"Generali","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1136\/ard.61.12.1047","article-title":"Receptor Activator NF-KappaB Ligand (RANKL) Expression in Synovial Tissue from Patients with Rheumatoid Arthritis, Spondyloarthropathy, Osteoarthritis, and from Normal Patients: Semiquantitative and Quantitative Analysis","volume":"61","author":"Crotti","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1182\/blood-2010-12-326355","article-title":"Gene Expression Profiling Reveals the Defining Features of the Classical, Intermediate, and Nonclassical Human Monocyte Subsets","volume":"118","author":"Wong","year":"2011","journal-title":"Blood"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1182\/blood-2010-02-258558","article-title":"Nomenclature of Monocytes and Dendritic Cells in Blood","volume":"116","author":"Ancuta","year":"2010","journal-title":"Blood"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, Mechanisms, and Significance of Macrophage Plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2050-7771-2-1","article-title":"Monocyte and Macrophage Differentiation: Circulation Inflammatory Monocyte as Biomarker for Inflammatory Diseases","volume":"2","author":"Yang","year":"2014","journal-title":"Biomark. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3899\/jrheum.130803","article-title":"Blood Monocyte Heterogeneity and Markers of Endothelial Activation in Ankylosing Spondylitis","volume":"41","author":"Surdacki","year":"2014","journal-title":"J. Rheumatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/art.40582","article-title":"Proinflammatory CX3CR1+CD59+Tumor Necrosis Factor\u2013Like Molecule 1A+Interleukin-23+ Monocytes Are Expanded in Patients with Ankylosing Spondylitis and Modulate Innate Lymphoid Cell 3 Immune Functions","volume":"70","author":"Ciccia","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1136\/ard.2008.097204","article-title":"Ankylosing Spondylitis Monocytes Show Upregulation of Proteins Involved in Inflammation and the Ubiquitin Proteasome Pathway","volume":"68","author":"Wright","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13075-015-0694-2","article-title":"In Vivo Pre-Activation of Monocytes in Patients with Axial Spondyloarthritis","volume":"17","author":"Conrad","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1002\/art.21155","article-title":"Tumor Necrosis Factor \u03b1 Blockade Treatment Down-Modulates the Increased Systemic and Local Expression of Toll-like Receptor 2 and Toll-like Receptor 4 in Spondylarthropathy","volume":"52","author":"Vandooren","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.jaad.2010.02.049","article-title":"Markedly Elevated Serum Levels of Calcium-Binding S100A8\/A9 Proteins in Psoriatic Arthritis Are Due to Activated Monocytes\/Macrophages","volume":"64","author":"Aochi","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.intimp.2018.02.008","article-title":"Relationship between Monocytes to Lymphocytes Ratio and Axial Spondyloarthritis","volume":"57","author":"Huang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Gulino, G.R., Van Mechelen, M., and Lories, R. (2021). Cellular and Molecular Diversity in Spondyloarthritis. Semin. Immunol., 101521.","DOI":"10.1016\/j.smim.2021.101521"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage Plasticity and Polarization: In Vivo Veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the Full Spectrum of Macrophage Activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immuni.2014.06.013","article-title":"Origin and Functions of Tissue Macrophages","volume":"41","author":"Epelman","year":"2014","journal-title":"Immunity"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41586-019-1471-1","article-title":"Locally Renewing Resident Synovial Macrophages Provide a Protective Barrier for the Joint","volume":"572","author":"Culemann","year":"2019","journal-title":"Nature"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jim.2011.10.013","article-title":"Systematic Validation of Specific Phenotypic Markers for in Vitro Polarized Human Macrophages","volume":"375","author":"Ambarus","year":"2012","journal-title":"J. Immunol. Methods"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"102397","DOI":"10.1016\/j.autrev.2019.102397","article-title":"Macrophage M1\/M2 Polarization and Rheumatoid Arthritis: A Systematic Review","volume":"18","author":"Tardito","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-Cell Transcriptomics and Mass Cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"R74","DOI":"10.1186\/ar3796","article-title":"Intimal Lining Layer Macrophages but Not Synovial Sublining Macrophages Display an IL-10 Polarized-like Phenotype in Chronic Synovitis","volume":"14","author":"Ambarus","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/path.1044","article-title":"Macrophages Expressing the Scavenger Receptor CD163: A Link between Immune Alterations of the Gut and Synovial Inflammation in Spondyloarthropathy","volume":"196","author":"Baeten","year":"2002","journal-title":"J. Pathol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.berh.2006.03.010","article-title":"Ankylosing Spondylitis and Bowel Disease","volume":"20","author":"Rudwaleit","year":"2006","journal-title":"Best Practice & Research Clinical Rheumatology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13075-019-1898-7","article-title":"Differential Synovial Tissue Biomarkers among Psoriatic Arthritis and Rheumatoid Factor\/Anti-Citrulline Antibody-Negative Rheumatoid Arthritis","volume":"21","author":"Alivernini","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/art.24406","article-title":"Absence of a Classically Activated Macrophage Cytokine Signature in Peripheral Spondylarthritis, Including Psoriatic Arthritis","volume":"60","author":"Vandooren","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e000025","DOI":"10.1136\/rmdopen-2014-000025","article-title":"What Makes Psoriatic and Rheumatoid Arthritis so Different?","volume":"1","author":"Veale","year":"2015","journal-title":"RMD Open"},{"key":"ref_83","first-page":"362","article-title":"THU0517 Tie2 Signaling Induces A Pro-Inflammatory Phenotype in Rheumatoid Arthritis and Psoriatic Arthritis Macrophages","volume":"73","author":"Tak","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/rheumatology\/kez315","article-title":"Promotion of Macrophage Activation by Tie2 in the Context of the Inflamed Synovia of Rheumatoid Arthritis and Psoriatic Arthritis Patients","volume":"59","author":"Kabala","year":"2020","journal-title":"Rheumatology"},{"key":"ref_85","first-page":"260","article-title":"Angiopoietins, Growth Factors, and Vascular Morphology in Early Arthritis","volume":"30","author":"Fearon","year":"2003","journal-title":"J. Rheumatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1002\/art.38128","article-title":"Local Synovial Engagement of Angiogenic TIE-2 Is Associated with the Development of Persistent Erosive Rheumatoid Arthritis in Patients with Early Arthritis","volume":"65","author":"Wijbrandts","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.4049\/jimmunol.160.7.3513","article-title":"IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-Beta and TNF-Alpha, by Human Macrophages","volume":"160","author":"Jovanovic","year":"1998","journal-title":"J. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","article-title":"S100A8\/A9 in Inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13577-017-0182-x","article-title":"HMGB Proteins and Arthritis","volume":"31","author":"Taniguchi","year":"2018","journal-title":"Hum. Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fimmu.2021.637829","article-title":"Role of the IL-23\/IL-17 Pathway in Rheumatic Diseases: An Overview","volume":"12","author":"Schinocca","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.yexcr.2011.03.014","article-title":"Inhibition of Matrix Metalloproteinase-9 Activity by Doxycycline Ameliorates RANK Ligand-Induced Osteoclast Differentiation in Vitro and in Vivo","volume":"317","author":"Franco","year":"2012","journal-title":"Exp. Cell Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s11926-002-0059-0","article-title":"Mechanisms of Bone Resorption and New Bone Formation in Spondyloarthropathies","volume":"4","author":"Huang","year":"2002","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/art.38291","article-title":"The Interleukin-23\/Interleukin-17 Axis in Spondyloarthritis Pathogenesis: Th17 and Beyond","volume":"66","author":"Smith","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/ar2936","article-title":"Interleukin-17A Upregulates Receptor Activator of NF-\u039aB on Osteoclast Precursors","volume":"12","author":"Adamopoulos","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41584-018-0091-8","article-title":"Effects of the IL-23\u2013IL-17 Pathway on Bone in Spondyloarthritis","volume":"14","author":"Gravallese","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12891-018-2356-4","article-title":"Sera of Patients with Axial Spondyloarthritis (AxSpA) Enhance Osteoclastogenic Potential of Monocytes Isolated from Healthy Individuals","volume":"19","author":"Korkosz","year":"2018","journal-title":"BMC Musculoskelet. Disord."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"R164","DOI":"10.1186\/ar3123","article-title":"Circulating Mediators of Bone Remodeling in Psoriatic Arthritis: Implications for Disordered Osteoclastogenesis and Bone Erosion","volume":"12","author":"Dalbeth","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13075-016-0973-6","article-title":"Colony-Stimulating Factor (CSF) 1 Receptor Blockade Reduces Inflammation in Human and Murine Models of Rheumatoid Arthritis","volume":"18","author":"Garcia","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1136\/annrheumdis-2016-210770","article-title":"2016 Update of the ASAS-EULAR Management Recommendations for Axial Spondyloarthritis","volume":"76","author":"Ramiro","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/art.40726","article-title":"2018 American College of Rheumatology\/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis","volume":"71","author":"Singh","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/art.41042","article-title":"2019 Update of the American College of Rheumatology\/Spondylitis Association of America\/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis","volume":"71","author":"Ward","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1136\/annrheumdis-2020-217159","article-title":"EULAR Recommendations for the Management of Psoriatic Arthritis with Pharmacological Therapies: 2019 Update","volume":"79","author":"Gossec","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/BF02977780","article-title":"Immunomodulatory Effect of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) at the Clinically Available Doses","volume":"30","author":"Cho","year":"2007","journal-title":"Arch. Pharmacal Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1189\/jlb.1202612","article-title":"Mechanism of Glucocorticoid-Induced Depletion of Human CD14+ CD16+ Monocytes","volume":"74","author":"Dayyani","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/rheumatology\/keh583","article-title":"Down-Regulation of Activating Fc\u03b3 Receptors on Monocytes of Patients with Rheumatoid Arthritis upon Methotrexate Treatment","volume":"44","author":"Wijngaarden","year":"2005","journal-title":"Rheumatology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/1529-0131(199811)41:11<2032::AID-ART19>3.0.CO;2-J","article-title":"Effects of Methotrexate on Differentiation of Monocytes and Production of Cytokine Inhibitors by Monocytes","volume":"41","author":"Seitz","year":"1998","journal-title":"Arthritis Rheum."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2016.03.028","article-title":"Modulation of Human Monocyte\/Macrophage Activity by Tocilizumab, Abatacept and Etanercept: An in Vitro Study","volume":"780","author":"Obeng","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/apm.12757","article-title":"M2 Polarization of Monocytes in Ankylosing Spondylitis and Relationship with Inflammation and Structural Damage","volume":"125","author":"Zhao","year":"2017","journal-title":"APMIS"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/annrheumdis-2020-218304","article-title":"Immune Response Profiling of Patients with Spondyloarthritis Reveals Signalling Networks Mediating TNF-Blocker Function in Vivo","volume":"80","author":"Menegatti","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/1759720X18787766","article-title":"The Role of Secukinumab in the Treatment of Psoriatic Arthritis and Ankylosing Spondylitis","volume":"10","year":"2018","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/annrheumdis-2012-202371","article-title":"Effect of IL-17A Blockade with Secukinumab in Autoimmune Diseases","volume":"72","author":"Patel","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/art.40581","article-title":"Brief Report: Interleukin-17 Blockade with Secukinumab in Peripheral Spondyloarthritis Impacts Synovial Immunopathology without Compromising Systemic Immune Responses","volume":"70","author":"Mens","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2021.611656","article-title":"IL-12p40\/IL-23p40 Blockade with Ustekinumab Decreases the Synovial Inflammatory Infiltrate through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt","volume":"12","author":"Fiechter","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"McInnes, I.B., Szekanecz, Z., McGonagle, D., Maksymowych, W.P., Pfeil, A., Lippe, R., Song, I.-H., Lertratanakul, A., Sornasse, T., and Biljan, A. (2021). A Review of JAK\u2013STAT Signalling in the Pathogenesis of Spondyloarthritis and the Role of JAK Inhibition. Rheumatology, 1\u201312.","DOI":"10.1093\/rheumatology\/keab740"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"A67","DOI":"10.1136\/ard.2010.129668f","article-title":"Effects of Abatacept on Monocytes in Patients with Rheumatoid Arthritis","volume":"69","author":"Bonelli","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"725","DOI":"10.4049\/jimmunol.1601808","article-title":"MPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production","volume":"200","author":"Maseda","year":"2018","journal-title":"J. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1136\/annrheumdis-2011-201252","article-title":"Effect of Non-Steroidal Anti-Inflammatory Drugs on Radiographic Spinal Progression in Patients with Axial Spondyloarthritis: Results from the German Spondyloarthritis Inception Cohort","volume":"71","author":"Poddubnyy","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Kroon, F.P., van der Burg, L.R., Ramiro, S., Landew\u00e9, R.B., Buchbinder, R., Falzon, L., and van der Heijde, D. (2015). Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) for Axial Spondyloarthritis (Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis). Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD010952"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1093\/rheumatology\/keab275","article-title":"Glucocorticoids in Spondyloarthritis\u2014Systematic Review and Real-World Analysis","volume":"60","author":"Dhir","year":"2021","journal-title":"Rheumatology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.3389\/fimmu.2019.01591","article-title":"Glucocorticoids Shape Macrophage Phenotype for Tissue Repair","volume":"10","author":"Desgeorges","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Antiinflammatory Action of Glucocorticoids\u2014New Mechanisms for Old Drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jlb.65.3.330","article-title":"Regulation of Arachidonic Acid Release and Cytosolic Phospholipase A2 Activation","volume":"65","author":"Leslie","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1101\/gr.911803","article-title":"Computationally Identifying Novel NF-\u039aB-Regulated Immune Genes in the Human Genome","volume":"13","author":"Liu","year":"2003","journal-title":"Genome Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.3389\/fphar.2018.01229","article-title":"Do Corticosteroids Still Have a Place in the Treatment of Chronic Pain?","volume":"9","author":"Knezevic","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1101\/gr.248187.119","article-title":"Nascent Transcript Analysis of Glucocorticoid Crosstalk with TNF Defines Primary and Cooperative Inflammatory Repression","volume":"29","author":"Sasse","year":"2019","journal-title":"Genome Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2222.2004.01824.x","article-title":"Glucocorticoids Up-Regulate Constitutive Interleukin-10 Production by Human Monocytes","volume":"34","author":"Mozo","year":"2004","journal-title":"Clin. Exp. Allergy"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nrrheum.2016.91","article-title":"Macrophage Heterogeneity in the Context of Rheumatoid Arthritis","volume":"12","author":"Udalova","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrrheum.2013.160","article-title":"Role of Cytokines in Intervertebral Disc Degeneration: Pain and Disc Content","volume":"10","author":"Risbud","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41584-020-0373-9","article-title":"Methotrexate and Its Mechanisms of Action in Inflammatory Arthritis","volume":"16","author":"Cronstein","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrrheum.2016.178","article-title":"Adenosine and Adenosine Receptors in the Pathogenesis and Treatment of Rheumatic Diseases","volume":"13","author":"Cronstein","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1186\/ar4444","article-title":"Methotrexate Induces Production of IL-1 and IL-6 in the Monocytic Cell Line U937","volume":"16","author":"Olsen","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1002\/art.20518","article-title":"Reduction of Synovial Sublining Layer Inflammation and Proinflammatory Cytokine Expression in Psoriatic Arthritis Treated with Methotrexate","volume":"50","author":"Kane","year":"2004","journal-title":"Arthritis Rheum."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor Necrosis Factor-\u03b1 Signaling in Macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3389\/fimmu.2019.00382","article-title":"Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses","volume":"10","author":"Menegatti","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/1529-0131(200101)44:1<186::AID-ANR25>3.0.CO;2-B","article-title":"Immunomodulatory Effects of Anti-Tumor Necrosis Factor? Therapy on Synovium in Spondylarthropathy: Histologic Findings in Eight Patients from an Open-Label Pilot Study","volume":"44","author":"Baeten","year":"2001","journal-title":"Arthritis Rheum."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1136\/ard.2008.091389","article-title":"A Prospective, Randomised, Placebo-Controlled Study to Identify Biomarkers Associated with Active Treatment in Psoriatic Arthritis: Effects of Adalimumab Treatment on Synovial Tissue","volume":"68","author":"Gerlag","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1002\/art.20181","article-title":"Antiangiogenic Effects of Anti-Tumor Necrosis Factor \u03b1 Therapy with Infliximab in Psoriatic Arthritis","volume":"50","author":"Pablos","year":"2004","journal-title":"Arthritis Rheum."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1136\/ard.2003.018549","article-title":"Histological Evidence that Infliximab Treatment Leads to Downregulation of Inflammation and Tissue Remodelling of the Synovial Membrane in Spondyloarthropathy","volume":"64","author":"Kruithof","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Batko, B., Schramm-Luc, A., Skiba, D., Mikolajczyk, T., and Siedlinski, M. (2019). TNF-\u03b1 Inhibitors Decrease Classical CD14hiCD16\u2212 Monocyte Subsets in Highly Active, Conventional Treatment Refractory Rheumatoid Arthritis and Ankylosing Spondylitis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020291"},{"key":"ref_140","first-page":"1122","article-title":"TNF-Anti-TNF Immune Complexes Inhibit IL-12\/IL-23 Secretion by Inflammatory Macrophages via an Fc-Dependent Mechanism","volume":"12","author":"Bloemendaal","year":"2018","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/ard.2007.076711","article-title":"Infliximab Inhibits Bone Resorption by Circulating Osteoclast Precursor Cells in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis","volume":"67","author":"Gengenbacher","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/j.gastro.2010.10.008","article-title":"AntiTumor Necrosis Factor-\u03b1 Antibodies Induce Regulatory Macrophages in an Fc Region-Dependent Manner","volume":"140","author":"Vos","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1056\/NEJMoa1505066","article-title":"Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis","volume":"373","author":"Baeten","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0140-6736(15)61134-5","article-title":"Secukinumab, a Human Anti-Interleukin-17A Monoclonal Antibody, in Patients with Psoriatic Arthritis (FUTURE 2): A Randomised, Double-Blind, Placebo-Controlled, Phase 3 Trial","volume":"386","author":"McInnes","year":"2015","journal-title":"Lancet"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1136\/annrheumdis-2019-215386","article-title":"A Head-to-Head Comparison of the Efficacy and Safety of Ixekizumab and Adalimumab in Biological-Na\u00efve Patients with Active Psoriatic Arthritis: 24-Week Results of a Randomised, Open-Label, Blinded-Assessor Trial","volume":"79","author":"Mease","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1016\/S0140-6736(18)31946-9","article-title":"Ixekizumab, an Interleukin-17A Antagonist in the Treatment of Ankylosing Spondylitis or Radiographic Axial Spondyloarthritis in Patients Previously Untreated with Biological Disease-Modifying Anti-Rheumatic Drugs (COAST-V): 16 Week Results of a Phase 3 Ra","volume":"392","author":"Dougados","year":"2018","journal-title":"Lancet"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"247","DOI":"10.5114\/ada.2016.61599","article-title":"Interleukin-17 Inhibitors. A New Era in Treatment of Psoriasis and Other Skin Diseases","volume":"33","author":"Wasilewska","year":"2016","journal-title":"Postepy Dermatol. I Alergol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/PTT.S225339","article-title":"Emerging Treatment Options for the Treatment of Moderate to Severe Plaque Psoriasis and Psoriatic Arthritis: Evaluating Bimekizumab and Its Therapeutic Potential","volume":"9","author":"Chiricozzi","year":"2019","journal-title":"Psoriasis Targets Ther."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Rafael-Vidal, C., P\u00e9rez, N., Altab\u00e1s, I., Garcia, S., and Pego-Reigosa, J.M. (2020). Blocking IL-17: A Promising Strategy in the Treatment of Systemic Rheumatic Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197100"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/eji.201141737","article-title":"Macrophages Participate in IL-17-Mediated Inflammation","volume":"42","author":"Barin","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.micinf.2004.02.012","article-title":"What Kind of Message Does IL-12\/IL-23 Bring to Macrophages and Dendritic Cells?","volume":"6","author":"Bastos","year":"2004","journal-title":"Microbes Infect."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.it.2005.10.003","article-title":"Understanding the IL-23\u2013IL-17 Immune Pathway","volume":"27","author":"McKenzie","year":"2006","journal-title":"Trends Immunol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4161\/mabs.3.6.17815","article-title":"Discovery and Mechanism of Ustekinumab: A Human Monoclonal Antibody Targeting Interleukin-12 and Interleukin-23 for Treatment of Immune-Mediated Disorders","volume":"3","author":"Benson","year":"2011","journal-title":"mAbs"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1093\/rheumatology\/keab024","article-title":"JAK1: Number One in the Family; Number One in Inflammation?","volume":"60","author":"Spinelli","year":"2021","journal-title":"Rheumatology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/pro.3519","article-title":"The Molecular Details of Cytokine Signaling via the JAK\/STAT Pathway","volume":"27","author":"Morris","year":"2018","journal-title":"Protein Sci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/341308","article-title":"Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage \u201cSwitch\u201d Phenotype","volume":"2015","author":"Malyshev","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"(2018). EMA announcement Tofacitinib for Psoriatic Arthritis (PsA) Is Now Approved by the European Commission. Rheumatology, 57, e55.","DOI":"10.1093\/rheumatology\/key248"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1136\/annrheumdis-2020-219601","article-title":"Tofacitinib for the Treatment of Ankylosing Spondylitis: A Phase III, Randomised, Double-Blind, Placebo-Controlled Study","volume":"80","author":"Deodhar","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/ard.2008.097030","article-title":"Abatacept in Spondyloarthritis Refractory to Tumour Necrosis Factor \u03b1 Inhibition: Figure 1","volume":"68","author":"Olivieri","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/art.37787","article-title":"Abatacept (CTLA-4IG) Treatment Reduces the Migratory Capacity of Monocytes in Patients with Rheumatoid Arthritis","volume":"65","author":"Bonelli","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1136\/annrheumdis-2011-200348","article-title":"Abatacept Modulates Proinflammatory Macrophage Responses upon Cytokine-Activated T Cell and Toll-like Receptor Ligand Stimulation","volume":"71","author":"Wenink","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s13075-021-02691-9","article-title":"CTLA4-Ig Treatment Induces M1\u2013M2 Shift in Cultured Monocyte-Derived Macrophages from Healthy Subjects and Rheumatoid Arthritis Patients","volume":"23","author":"Cutolo","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/annrheumdis-2013-203559","article-title":"Assessment of Short-Term Symptomatic Efficacy of Tocilizumab in Ankylosing Spondylitis: Results of Randomised, Placebo-Controlled Trials","volume":"73","author":"Sieper","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/annrheumdis-2013-204963","article-title":"Sarilumab for the Treatment of Ankylosing Spondylitis: Results of a Phase II, Randomised, Double-Blind, Placebo-Controlled Study (ALIGN)","volume":"74","author":"Sieper","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1136\/annrheumdis-2016-209275","article-title":"Evidence of Response to IL-6 Inhibition in Some Cases of Refractory Spondyloarthritis-Associated Peripheral Synovitis","volume":"75","author":"Merashli","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/annrheumdis-2016-209454","article-title":"A20 Inhibition of STAT1 Expression in Myeloid Cells: A Novel Endogenous Regulatory Mechanism Preventing Development of Enthesitis","volume":"76","author":"Martens","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/s41467-017-01771-2","article-title":"Unique Transcriptome Signatures and GM-CSF Expression in Lymphocytes from Patients with Spondyloarthritis","volume":"8","author":"Chen","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/art.40736","article-title":"Expansion of Interleukin-22\u2013 and Granulocyte\u2013Macrophage Colony-Stimulating Factor\u2013Expressing, but Not Interleukin-17A\u2013Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis","volume":"71","author":"Blijdorp","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41467-019-13853-4","article-title":"GM-CSF Drives Dysregulated Hematopoietic Stem Cell Activity and Pathogenic Extramedullary Myelopoiesis in Experimental Spondyloarthritis","volume":"11","author":"Swann","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.3389\/fimmu.2020.01520","article-title":"GM-CSF Primes Proinflammatory Monocyte Responses in Ankylosing Spondylitis","volume":"11","author":"Shi","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/1759720X17752036","article-title":"Investigational Therapies Targeting the Granulocyte Macrophage Colony-Stimulating Factor Receptor-\u03b1 in Rheumatoid Arthritis: Focus on Mavrilimumab","volume":"10","author":"Cook","year":"2018","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/ar318","article-title":"Blockade of Collagen-Induced Arthritis Post-Onset by Antibody to Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF): Requirement for GM-CSF in the Effector Phase of Disease","volume":"3","author":"Cook","year":"2001","journal-title":"Arthritis Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e99249","DOI":"10.1172\/jci.insight.99249","article-title":"TNF and Granulocyte Macrophage-Colony Stimulating Factor Interdependence Mediates Inflammation via CCL17","volume":"3","author":"Cook","year":"2018","journal-title":"JCI Insight"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/annrheumdis-2016-210624","article-title":"A Randomised Phase IIb Study of Mavrilimumab, a Novel GM\u2013CSF Receptor Alpha Monoclonal Antibody, in the Treatment of Rheumatoid Arthritis","volume":"76","author":"Burmester","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13075-017-1267-3","article-title":"Phase 1b Randomized, Double-Blind Study of Namilumab, an Anti-Granulocyte Macrophage Colony-Stimulating Factor Monoclonal Antibody, in Mild-to-Moderate Rheumatoid Arthritis","volume":"19","author":"Huizinga","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13075-019-1879-x","article-title":"Efficacy and Safety of Namilumab, a Human Monoclonal Antibody against Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Ligand in Patients with Rheumatoid Arthritis (RA) with Either an Inadequate Response to Background Methotrexate Therapy or an Inadequate Response or Intolerance to an Anti-TNF (Tumour Necrosis Factor) Biologic Therapy: A Randomized, Controlled Trial","volume":"21","author":"Taylor","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1136\/annrheumdis-2013-204816","article-title":"MOR103, a Human Monoclonal Antibody to Granulocyte\u2013Macrophage Colony-Stimulating Factor, in the Treatment of Patients with Moderate Rheumatoid Arthritis: Results of a Phase Ib\/IIa Randomised, Double-Blind, Placebo-Controlled, Dose-Escalation Trial","volume":"74","author":"Behrens","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/1346-8138.13975","article-title":"Therapeutic Depletion of Myeloid Lineage Leukocytes by Adsorptive Apheresis for Psoriatic Arthritis: Efficacy of a Non-Drug Intervention for Patients Refractory to Pharmacologics","volume":"44","author":"Kanekura","year":"2017","journal-title":"J. Dermatol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/1346-8138.14471","article-title":"Clinical and Immunological Effects of Adsorptive Myeloid Lineage Leukocyte Apheresis in Patients with Immune Disorders","volume":"45","author":"Kanekura","year":"2018","journal-title":"J. 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