{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:22:28Z","timestamp":1784726548283,"version":"3.55.0"},"reference-count":24,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["51NF40- 185544"],"award-info":[{"award-number":["51NF40- 185544"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Background: Hyperuricemia is a common laboratory finding in pregnant women compromised by preeclampsia. A growing body of evidence suggests that uric acid is involved in the pathogenesis of preeclampsia. Glucose transporter 9 (GLUT9) is a high-capacity uric acid transporter. The aim of this study was to investigate the placental uric acid transport system, and to identify the (sub-) cellular localization of GLUT9. Methods: Specific antibodies against GLUT9a and GLUT9b isoforms were raised, and human villous (placental) tissue was immunohistochemically stained. A systemic GLUT9 knockout (G9KO) mouse model was used to assess the placental uric acid transport capacity by measurements of uric acid serum levels in the fetal and maternal circulation. Results: GLUT9a and GLUT9b co-localized with the villous (apical) membrane, but not with the basal membrane, of the syncytiotrophoblast. Fetal and maternal uric acid serum levels were closely correlated. G9KO fetuses showed substantially higher uric acid serum concentrations than their mothers. Conclusions: These findings demonstrate that the placenta efficiently maintains uric acid homeostasis, and that GLUT9 plays a key role in the placental uric acid transport system, at least in this murine model. Further studies investigating the role of the placental uric acid transport system in preeclampsia are eagerly needed.<\/jats:p>","DOI":"10.3390\/cells11040633","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T20:32:30Z","timestamp":1644784350000},"page":"633","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System"],"prefix":"10.3390","volume":"11","author":[{"given":"Benjamin P.","family":"L\u00fcscher","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital of Bern, University of Bern, CH-3010 Bern, Switzerland"},{"name":"Department of Biomedical Research, University Hospital of Bern, University of Bern, CH-3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-6930","authenticated-orcid":false,"given":"Christiane","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Medicine, University of Bern, CH-3012 Bern, Switzerland"},{"name":"Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, CH-3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Stieger","sequence":"additional","affiliation":[{"name":"Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, CH-3012 Bern, Switzerland"},{"name":"Department of Clinical Pharmacology and Toxicology, University Hospital of Z\u00fcrich, University of Zurich, CH-8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel V.","family":"Surbek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital of Bern, University of Bern, CH-3010 Bern, Switzerland"},{"name":"Department of Biomedical Research, University Hospital of Bern, University of Bern, CH-3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc U.","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital of Bern, University of Bern, CH-3010 Bern, Switzerland"},{"name":"Department of Biomedical Research, University Hospital of Bern, University of Bern, CH-3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.placenta.2007.11.001","article-title":"Uric acid as a pathogenic factor in preeclampsia","volume":"29","author":"Bainbridge","year":"2008","journal-title":"Placenta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nrneph.2010.125","article-title":"Could uric acid have a pathogenic role in pre-eclampsia?","volume":"6","author":"Martin","year":"2010","journal-title":"Nat. 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