{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:30:14Z","timestamp":1790314214578,"version":"4.1.0"},"reference-count":100,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KL 2983\/3-1"],"award-info":[{"award-number":["KL 2983\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The subacromial bursa has long been demolded as friction-reducing tissue, which is often linked to shoulder pain and, therefore, partially removed during shoulder surgery. Currently, the discovery of the stem cell potential of resident bursa-derived cells shed a new light on the subacromial bursa. In the meanwhile, this neglected tissue is gaining more attention as to how it can augment the regenerative properties of adjacent tissues such as rotator cuff tendons. Specifically, the tight fibrovascular network, a high growth factor content, and the large progenitor potential of bursa-derived cells could complement the deficits that a nearby rotator cuff injury might experience due to the fact of its low endogenous regeneration potential. This review deals with the question of whether bursal inflammation is only a pain generator or could also be an initiator of healing. Furthermore, several experimental models highlight potential therapeutic targets to overcome bursal inflammation and, thus, pain. More evidence is needed to fully elucidate a direct interplay between subacromial bursa and rotator cuff tendons. Increasing attention to tendon repair will help to guide future research and answer open questions such that novel treatment strategies could harvest the subacromial bursa\u2019s potential to support healing of nearby rotator cuff injuries.<\/jats:p>","DOI":"10.3390\/cells11040663","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T20:26:42Z","timestamp":1644870402000},"page":"663","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Subacromial Bursa: A Neglected Tissue Is Gaining More and More Attention in Clinical and Experimental Research"],"prefix":"10.3390","volume":"11","author":[{"given":"Franka","family":"Klatte-Schulz","sequence":"first","affiliation":[{"name":"Julius Wolff Institute, Berlin Institute of Health at Charit\u00e9-Universitaetsmedizin Berlin, 13353 Berlin, Germany"},{"name":"BIH-Center for Regenerative Therapies, Berlin Institute of Health, Charit\u00e9-Universitaetsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathi","family":"Thiele","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery, Charit\u00e9-Universitaetsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Scheibel","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery, Charit\u00e9-Universitaetsmedizin Berlin, 13353 Berlin, Germany"},{"name":"Department Shoulder and Elbow Surgery, Schulthess Klinik, 8008 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg N.","family":"Duda","sequence":"additional","affiliation":[{"name":"Julius Wolff Institute, Berlin Institute of Health at Charit\u00e9-Universitaetsmedizin Berlin, 13353 Berlin, Germany"},{"name":"BIH-Center for Regenerative Therapies, Berlin Institute of Health, Charit\u00e9-Universitaetsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8365-1188","authenticated-orcid":false,"given":"Britt","family":"Wildemann","sequence":"additional","affiliation":[{"name":"Julius Wolff Institute, Berlin Institute of Health at Charit\u00e9-Universitaetsmedizin Berlin, 13353 Berlin, Germany"},{"name":"Experimental Trauma Surgery, Department of Trauma, Hand and Reconstructive Surgery, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1302\/0301-620X.73B3.1670436","article-title":"Surgical repair of rotator cuff ruptures. The importance of the subacromial bursa","volume":"73","author":"Uhthoff","year":"1991","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/ard.57.11.649","article-title":"Estimating the burden of musculoskeletal disorders in the community: The comparative prevalence of symptoms at different anatomical sites, and the relation to social deprivation","volume":"57","author":"Urwin","year":"1998","journal-title":"Ann. Rheum. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/sms.13831","article-title":"Shoulder complaints more likely in volleyball players with a thickened bursa or supraspinatus tendon neovessels","volume":"31","author":"Skazalski","year":"2021","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/03009740310004667","article-title":"Prevalence and incidence of shoulder pain in the general population; a systematic review","volume":"33","author":"Luime","year":"2004","journal-title":"Scand. J. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"732","DOI":"10.5435\/JAAOS-D-21-00021","article-title":"Shoulder Injury Related to Vaccine Administration","volume":"29","author":"Wiesel","year":"2021","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1016\/j.radcr.2021.08.019","article-title":"Shoulder injury related to vaccine administration (SIRVA) following mRNA COVID-19 vaccination: Report of 2 cases of subacromial-subdeltoid bursitis","volume":"16","author":"Honarmand","year":"2021","journal-title":"Radiol. Case Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11606-021-07212-7","article-title":"Post-vaccination Subacromial Bursitis","volume":"37","author":"Pearson","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1007\/s00256-021-03803-x","article-title":"Subacromial-subdeltoid bursitis following COVID-19 vaccination: A case of shoulder injury related to vaccine administration (SIRVA)","volume":"50","author":"Hidalgo","year":"2021","journal-title":"Skeletal. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"102819","DOI":"10.1016\/j.amsu.2021.102819","article-title":"Combined subacromial-subdeltoid bursitis and supraspinatus tear following a COVID-19 vaccination: A case report","volume":"69","author":"Boonsri","year":"2021","journal-title":"Ann. Med. Surg."},{"key":"ref_10","unstructured":"Faruqi, T., and Rizvi, T.J. (2021). Subacromial Bursitis. StatPearls, NCBI."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1058-2746(97)90033-1","article-title":"\u201cBursal reactions\u201d in rotator cuff tearing, the impingement syndrome, and calcifying tendinitis","volume":"6","author":"Ishii","year":"1997","journal-title":"J. Shoulder Elbow Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1007\/s00167-015-3650-4","article-title":"The role of tendon and subacromial bursa in rotator cuff tear pain: A clinical and histopathological study","volume":"24","author":"Chillemi","year":"2016","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s00167-016-4379-4","article-title":"Blood supply of the subacromial bursa and rotator cuff tendons on the bursal side","volume":"25","author":"Poldoja","year":"2017","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_14","first-page":"25","article-title":"Immunolocalization of cytokines and growth factors in subacromial bursa of rotator cuff tear patients","volume":"47","author":"Sakai","year":"2001","journal-title":"Kobe J. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1016\/j.arthro.2019.08.019","article-title":"Editorial Commentary: Subacromial Bursa-Friend or Foe Within the Shoulder? An Old Debate with New Insights","volume":"35","author":"Steinert","year":"2019","journal-title":"Arthroscopy"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.2106\/JBJS.RVW.21.00110","article-title":"The Subacromial Bursa: Current Concepts Review","volume":"9","author":"Lanham","year":"2021","journal-title":"JBJS Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1016\/j.arthro.2019.05.024","article-title":"Examining the Potency of Subacromial Bursal Cells as a Potential Augmentation for Rotator Cuff Healing: An In Vitro Study","volume":"35","author":"Morikawa","year":"2019","journal-title":"Arthroscopy"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/ten.tea.2013.0197","article-title":"Multipotent mesenchymal stem cells from human subacromial bursa: Potential for cell based tendon tissue engineering","volume":"20","author":"Song","year":"2014","journal-title":"Tissue Eng. Part A"},{"key":"ref_19","unstructured":"Codman, E.A. (1934). The Shoulder: Rupture of the Supraspinatus Tendon and Other Lesions in or about the Subacromial Bursa, Thomas Todd Company, Printers."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/00000658-195009000-00011","article-title":"Results of treatment of subacromial bursitis in three hundred forty cases","volume":"132","author":"Caldwell","year":"1950","journal-title":"Ann. Surg."},{"key":"ref_21","first-page":"69","article-title":"Acute Calcified Subacromial or Subdeltoid Bursitis","volume":"60","author":"Guido","year":"1944","journal-title":"Cal. West. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1148\/47.6.593","article-title":"Subacromial bursitis: Clinical and roentgen observations","volume":"47","author":"Olin","year":"1946","journal-title":"Radiology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00000658-193702000-00011","article-title":"Painful Shoulder: Arising from Lesions of the Subacromial Bursa and Supraspinatus Tendon","volume":"105","author":"Ferguson","year":"1937","journal-title":"Ann. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"23259671211044715","DOI":"10.1177\/23259671211044715","article-title":"Characterization of Deposits in Calcific Tendinitis of the Shoulder: Deposits Are Composed of Large Aggregates of Highly Crystalline, Rod-Like Crystals","volume":"9","author":"Mateos","year":"2021","journal-title":"Orthop. J. Sports Med."},{"key":"ref_25","first-page":"273","article-title":"Acute Subdeltoid or Subacromial Bursitis-A Suggestion","volume":"41","author":"Weeks","year":"1934","journal-title":"Cal. West. Med."},{"key":"ref_26","first-page":"248","article-title":"Subacromial Bursitis and Supraspinatus Tendinitis: Its Roentgen Treatment","volume":"56","author":"Chapman","year":"1942","journal-title":"Cal. West. Med."},{"key":"ref_27","first-page":"39","article-title":"Subacromial bursitis; a classification and an evaluation of the results of roentgen therapy","volume":"61","author":"Mc","year":"1949","journal-title":"Can. Med. Assoc. J."},{"key":"ref_28","first-page":"79","article-title":"A new approach to the treatment of subdeltoid bursitis","volume":"33","author":"Aldes","year":"1954","journal-title":"Am. J. Phys. Med."},{"key":"ref_29","first-page":"206","article-title":"Effects of ultrasound alone and combined with hydrocortisone injections by needle or hypo-spray","volume":"37","author":"Newman","year":"1958","journal-title":"Am. J. Phys. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1001\/jama.1952.02930330026008","article-title":"Corticotropin (ACTH) in the treatment of acute subacromial bursitis","volume":"149","author":"Steinberg","year":"1952","journal-title":"J. Am. Med. Assoc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s00204-014-1295-6","article-title":"Use of X-rays to treat shoulder tendonitis\/bursitis: A historical assessment","volume":"88","author":"Calabrese","year":"2014","journal-title":"Arch. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"602","DOI":"10.2106\/00004623-195436030-00015","article-title":"The use of hydrocortisone acetate (compound F acetate) in the treatment of some common orthopaedic conditions","volume":"36","author":"Young","year":"1954","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2106\/00004623-197254010-00003","article-title":"Anterior acromioplasty for the chronic impingement syndrome in the shoulder: A preliminary report","volume":"54","author":"Neer","year":"1972","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0749-8063(87)80061-0","article-title":"Arthroscopic subacromial decompression: Analysis of one- to three-year results","volume":"3","author":"Ellman","year":"1987","journal-title":"Arthroscopy"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1016\/j.arthro.2021.03.079","article-title":"Subacromial Platelet-Rich Plasma Injections Decrease Pain and Improve Functional Outcomes in Patients with Refractory Rotator Cuff Tendinopathy","volume":"37","author":"Rossi","year":"2021","journal-title":"Arthroscopy"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"23259671211024937","DOI":"10.1177\/23259671211024937","article-title":"Comparison of a Platelet-Rich Plasma Injection and a Conventional Steroid Injection for Pain Relief and Functional Improvement of Partial Supraspinatus Tears","volume":"9","author":"Thepsoparn","year":"2021","journal-title":"Orthop. J. Sports Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1177\/0363546519851097","article-title":"Efficacy of Platelet-Rich Plasma for the Treatment of Interstitial Supraspinatus Tears: A Double-Blinded, Randomized Controlled Trial","volume":"47","author":"Schwitzguebel","year":"2019","journal-title":"Am. J. Sports Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.arthro.2018.10.115","article-title":"Nonoperative Treatment of Rotator Cuff Disease with Platelet-Rich Plasma: A Systematic Review of Randomized Controlled Trials","volume":"35","author":"Hurley","year":"2019","journal-title":"Arthroscopy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"118699","DOI":"10.1016\/j.carbpol.2021.118699","article-title":"The anti-inflammatory activity of specific-sized hyaluronic acid oligosaccharides","volume":"276","author":"Han","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1177\/02692155211007799","article-title":"Comparison of the corticosteroid injection and hyaluronate in the treatment of chronic subacromial bursitis: A randomized controlled trial","volume":"35","author":"Hsieh","year":"2021","journal-title":"Clin. Rehabil."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Penning, L.I., de Bie, R.A., and Walenkamp, G.H. (2014). Subacromial triamcinolone acetonide, hyaluronic acid and saline injections for shoulder pain an RCT investigating the effectiveness in the first days. BMC Musculoskelet. Disord., 15.","DOI":"10.1186\/1471-2474-15-352"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/03007995.2020.1860923","article-title":"Curcuminoids and Boswellia serrata extracts combination decreases tendinopathy symptoms: Findings from an open-label post-observational study","volume":"37","author":"Henrotin","year":"2021","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Loiacono, C., Palermi, S., Massa, B., Belviso, I., Romano, V., Gregorio, A.D., Sirico, F., and Sacco, A.M. (2019). Tendinopathy: Pathophysiology, Therapeutic Options, and Role of Nutraceutics. A Narrative Literature Review. Medicina, 55.","DOI":"10.3390\/medicina55080447"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.32098\/mltj.01.2016.06","article-title":"Nutraceutical supplement in the management of tendinopathies: A systematic review","volume":"6","author":"Fusini","year":"2016","journal-title":"Muscles Ligaments Tendons J."},{"key":"ref_45","first-page":"145","article-title":"A combination of systematic review and clinicians\u2019 beliefs in interventions for subacromial pain","volume":"52","author":"Johansson","year":"2002","journal-title":"Br. J. Gen. Pract."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1177\/0363546518755759","article-title":"Subacromial Decompression Yields a Better Clinical Outcome Than Therapy Alone: A Prospective Randomized Study of Patients with a Minimum 10-Year Follow-up","volume":"46","author":"Farfaras","year":"2018","journal-title":"Am. J. Sports Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1308\/003588414X14055925061478","article-title":"Does arthroscopic subacromial decompression improve quality of life","volume":"97","author":"Butt","year":"2015","journal-title":"Ann. R Coll. Surg. Engl."},{"key":"ref_48","first-page":"10118","article-title":"Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): A multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial","volume":"391","author":"Beard","year":"2017","journal-title":"Lancet"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1302\/0301-620X.99B6.BJJ-2016-0569.R1","article-title":"Arthroscopic decompression not recommended in the treatment of rotator cuff tendinopathy: A final review of a randomised controlled trial at a minimum follow-up of ten years","volume":"99-B","author":"Ketola","year":"2017","journal-title":"Bone Jt. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/bjsports-2018-100486","article-title":"Subacromial decompression surgery for adults with shoulder pain: A systematic review with meta-analysis","volume":"54","author":"Lahdeoja","year":"2020","journal-title":"Br. J. Sports Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF00585494","article-title":"Ultrastructure of the subacromial bursa in painful shoulder syndromes","volume":"400","author":"Sarkar","year":"1983","journal-title":"Virchows Arch. A Pathol. Anat. Histopathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/BF00420062","article-title":"Inflammation of the subacromial bursa in chronic shoulder pain","volume":"111","author":"Santavirta","year":"1992","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Minkwitz, S., Thiele, K., Schmock, A., Bormann, N., Nguyen, T.H., Moroder, P., Scheibel, M., Wildemann, B., Plachel, F., and Klatte-Schulz, F. (2021). Histological and molecular features of the subacromial bursa of rotator cuff tears compared to non-tendon defects: A pilot study. BMC Musculoskelet. Disord., 22.","DOI":"10.1186\/s12891-021-04752-1"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1016\/j.transproceed.2013.07.052","article-title":"Novel supplier of mesenchymal stem cell: Subacromial bursa","volume":"45","author":"Lhee","year":"2013","journal-title":"Transplant. Proc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1177\/0363546512473269","article-title":"Isolation and characterization of human mesenchymal stem cells derived from shoulder tissues involved in rotator cuff tears","volume":"41","author":"Utsunomiya","year":"2013","journal-title":"Am. J. Sports Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13287-015-0104-3","article-title":"Characterization of bursa subacromialis-derived mesenchymal stem cells","volume":"6","author":"Steinert","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"657166","DOI":"10.3389\/fcell.2021.657166","article-title":"Bursa-Derived Cells Show a Distinct Mechano-Response to Physiological and Pathological Loading in vitro","volume":"9","author":"Bormann","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/jor.22484","article-title":"Neurogenic differentiation capacity of subacromial bursal tissue-derived stem cells","volume":"32","author":"Aydin","year":"2014","journal-title":"J. Orthop. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.arthro.2019.07.024","article-title":"Comparison of Preparation Techniques for Isolating Subacromial Bursa-Derived Cells as a Potential Augment for Rotator Cuff Repair","volume":"36","author":"Morikawa","year":"2020","journal-title":"Arthroscopy"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e629","DOI":"10.1016\/j.asmr.2020.07.013","article-title":"Analysis of Time to Form Colony Units for Connective Tissue Progenitor Cells (Stem Cells) Harvested From Concentrated Bone Marrow Aspirate and Subacromial Bursa Tissue in Patients Undergoing Rotator Cuff Repair","volume":"2","author":"Landry","year":"2020","journal-title":"Arthrosc. Sports Med. Rehabil."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Klatte-Schulz, F., Pauly, S., Scheibel, M., Greiner, S., Gerhardt, C., Hartwig, J., Schmidmaier, G., and Wildemann, B. (2013). Characteristics and stimulation potential with BMP-2 and BMP-7 of tenocyte-like cells isolated from the rotator cuff of female donors. PLoS ONE, 8.","DOI":"10.1371\/annotation\/d6f80aa3-2ad7-4bf1-a9ff-426b2739b1c6"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"74","DOI":"10.22203\/eCM.v024a06","article-title":"Influence of age on the cell biological characteristics and the stimulation potential of male human tenocyte-like cells","volume":"24","author":"Pauly","year":"2012","journal-title":"Eur. Cell Mater."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Morikawa, D., Hawthorne, B.C., McCarthy, M.B.R., Bellas, N., Johnson, J.D., Trudeau, M.T., Murphy, K.V., Mancini, M.R., LeVasseur, M.R., and Cote, M.P. (2021). Analysis of Patient Factors Affecting In Vitro Characteristics of Subacromial Bursal Connective Tissue Progenitor Cells during Rotator Cuff Repair. J. Clin. Med., 10.","DOI":"10.3390\/jcm10174006"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00003086-199609000-00027","article-title":"Innervation of the human shoulder joint and its implications for surgery","volume":"330","author":"Aszmann","year":"1996","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0749-8063(96)90008-0","article-title":"Neurohistology of the subacromial space","volume":"12","author":"Soifer","year":"1996","journal-title":"Arthroscopy"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0749-8063(95)90064-0","article-title":"Neural anatomy of the glenohumeral ligaments, labrum, and subacromial bursa","volume":"11","author":"Vangsness","year":"1995","journal-title":"Arthroscopy"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Kennedy, M.S., Nicholson, H.D., and Woodley, S.J. (2021). The morphology of the subacromial and related shoulder bursae. An anatomical and histological study. J. Anat., in press.","DOI":"10.1111\/joa.13603"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/jor.1100160515","article-title":"Increased substance P in subacromial bursa and shoulder pain in rotator cuff diseases","volume":"16","author":"Gotoh","year":"1998","journal-title":"J. Orthop. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0736-0266(00)90021-4","article-title":"Vascular endothelial growth factor (VEGF) expression in the subacromial bursa is increased in patients with impingement syndrome","volume":"19","author":"Yanagisawa","year":"2001","journal-title":"J. Orthop. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0736-0266(02)00063-3","article-title":"Interleukin-1-induced glenohumeral synovitis and shoulder pain in rotator cuff diseases","volume":"20","author":"Gotoh","year":"2002","journal-title":"J. Orthop. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/ar1965","article-title":"Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff","volume":"8","author":"Neuwirth","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"84S","DOI":"10.1016\/j.jse.2004.09.022","article-title":"The molecular pathophysiology of subacromial bursitis in rotator cuff disease","volume":"14","author":"Blaine","year":"2005","journal-title":"J. Shoulder Elbow Surg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/jor.21416","article-title":"Interleukin-1beta stimulates stromal-derived factor-1alpha expression in human subacromial bursa","volume":"29","author":"Blaine","year":"2011","journal-title":"J. Orthop. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1002\/jor.20197","article-title":"Stromal cell-derived factor 1 (SDF-1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti-inflammatory agents","volume":"24","author":"Kim","year":"2006","journal-title":"J. Orthop. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1076.e1","DOI":"10.1016\/j.arthro.2005.05.017","article-title":"Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease","volume":"21","author":"Voloshin","year":"2005","journal-title":"Arthroscopy"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jse.2012.06.014","article-title":"Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder","volume":"22","author":"Lho","year":"2013","journal-title":"J. Shoulder Elbow Surg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/jor.20631","article-title":"Increased IL-1beta expression and myofibroblast recruitment in subacromial bursa is associated with rotator cuff lesions with shoulder stiffness","volume":"26","author":"Ko","year":"2008","journal-title":"J. Orthop. Res."},{"key":"ref_78","first-page":"63","article-title":"Epigallocatechin-3-gallate suppresses pain-related and proinflammatory mediators in the subacromial bursa in rotator cuff tendinopathy","volume":"27","author":"Feng","year":"2019","journal-title":"Discov. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1177\/0363546512456519","article-title":"Failed healing of rotator cuff repair correlates with altered collagenase and gelatinase in supraspinatus and subscapularis tendons","volume":"40","author":"Robertson","year":"2012","journal-title":"Am. J. Sports Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1302\/0301-620X.91B1.21058","article-title":"The morphological and immunocytochemical features of impingement syndrome and partial-thickness rotator-cuff tear in relation to outcome after subacromial decompression","volume":"91","author":"Benson","year":"2009","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3109\/17453679308993675","article-title":"The subacromial bursa and the impingement syndrome. A clinical and histological study of 30 cases","volume":"64","author":"Rahme","year":"1993","journal-title":"Acta Orthop. Scand."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1007\/s00167-011-1521-1","article-title":"Rotator cuff re-tear or non-healing: Histopathological aspects and predictive factors","volume":"19","author":"Chillemi","year":"2011","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_83","unstructured":"Marshall, B.P., Song, L., Kovacevic, D., and Thomopoulos, S. (2021, January 12). The Role of the Subacromial Bursa in Rotator Cuff Disease in a Rat Model. Proceedings of the ORS 2021 Annual Meeting, Online."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Kriscenski, D.E., Lebaschi, A., Tamburini, L.M., McCarthy, M.B.R., Cote, M.P., Kumbar, S.G., and Mazzocca, A.D. (2021). Characterization of murine subacromial bursal-derived cells. Connect. Tissue Res., 1\u201311. in press.","DOI":"10.1080\/03008207.2021.1917556"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/03008207.2016.1189910","article-title":"Murine supraspinatus tendon injury model to identify the cellular origins of rotator cuff healing","volume":"57","author":"Yoshida","year":"2016","journal-title":"Connect. Tissue Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1302\/0301-620X.82B7.0821072","article-title":"Early reactions after reimplantation of the tendon of supraspinatus into bone. A study in rabbits","volume":"82","author":"Uhthoff","year":"2000","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0736-0266(01)00015-8","article-title":"Healing of full-thickness tears of avian supracoracoid tendons: In situ hybridization of alpha1(I) and alpha1(III) procollagen mRNA","volume":"19","author":"Kobayashi","year":"2001","journal-title":"J. Orthop. Res."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Ko, J.Y., Lian, W.S., Tsai, T.C., Chen, Y.S., Hsieh, C.K., Kuo, C.W., and Wang, F.S. (2019). MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225742"},{"key":"ref_89","unstructured":"Dyrna, F., Zakko, P., McCarthy, M.B., Rowe, D.W., Mazzocca, A., and Dyment, N.A. (2017, January 19). Human subacromial bursa cells display superior engraftment vs. bone marrow stromal cells in murine tendon repair. Proceedings of the ORS 2017 Annual Meeting, San Diego, CA, USA."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jos.2019.02.006","article-title":"IL-1beta mediates NGF and COX-2 expression through transforming growth factor-activating kinase 1 in subacromial bursa cells derived from rotator cuff tear patients","volume":"24","author":"Nagura","year":"2019","journal-title":"J. Orthop. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.3892\/mmr.2015.3985","article-title":"Targeted knockout of TNF-alpha by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats","volume":"12","author":"Wang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e781","DOI":"10.1016\/j.asmr.2021.01.019","article-title":"The Effect of Insulin and Insulin-like Growth Factor 1 (IGF-1) on Cellular Proliferation and Migration of Human Subacromial Bursa Tissue","volume":"3","author":"Muench","year":"2021","journal-title":"Arthrosc. Sports Med. Rehabil."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e741","DOI":"10.1016\/j.eats.2019.03.010","article-title":"Biological Augmentation with Subacromial Bursa in Arthroscopic Rotator Cuff Repair","volume":"8","author":"Freislederer","year":"2019","journal-title":"Arthrosc. Tech."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e1203","DOI":"10.1016\/j.eats.2021.01.013","article-title":"Arthroscopic Bursa-Augmented Rotator Cuff Repair: A Vasculature-preserving Technique for Subacromial Bursal Harvest and Tendon Augmentation","volume":"10","author":"Bhatia","year":"2021","journal-title":"Arthrosc. Tech."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e1519","DOI":"10.1016\/j.eats.2020.06.013","article-title":"Biologic Augmentation of Arthroscopic Rotator Cuff Repair Using Minced Autologous Subacromial Bursa","volume":"9","author":"Pancholi","year":"2020","journal-title":"Arthrosc. Tech."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e1571","DOI":"10.1016\/j.eats.2020.06.022","article-title":"Local Autologous Stem Cells Application in Rotator Cuff Repairs: \"LASCA\" Technique","volume":"9","author":"Castricini","year":"2020","journal-title":"Arthrosc. Tech."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e803","DOI":"10.1016\/j.asmr.2020.07.019","article-title":"Preliminary Clinical Outcomes Following Biologic Augmentation of Arthroscopic Rotator Cuff Repair Using Subacromial Bursa, Concentrated Bone Marrow Aspirate, and Platelet-Rich Plasma","volume":"2","author":"Muench","year":"2020","journal-title":"Arthrosc. Sports Med. Rehabil."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.vetimm.2014.01.007","article-title":"Resolving an inflammatory concept: The importance of inflammation and resolution in tendinopathy","volume":"158","author":"Dakin","year":"2014","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri.2015.4","article-title":"Specialized pro-resolving mediators: Endogenous regulators of infection and inflammation","volume":"16","author":"Basil","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"311ra173","DOI":"10.1126\/scitranslmed.aac4269","article-title":"Inflammation activation and resolution in human tendon disease","volume":"7","author":"Dakin","year":"2015","journal-title":"Sci. Transl. Med."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/4\/663\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:19:34Z","timestamp":1760134774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/4\/663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,14]]},"references-count":100,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["cells11040663"],"URL":"https:\/\/doi.org\/10.3390\/cells11040663","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,14]]}}}