{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:02:09Z","timestamp":1790427729391,"version":"4.1.0"},"reference-count":91,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur et de la Recherche and CNRS, Programme Investissements d\u2019Avenir, Initiative d\u2019Excellence d\u2019Aix-Marseille Universit\u00e9","award":["AMX-19-IET-004 and ANR-17-EURE-0029"],"award-info":[{"award-number":["AMX-19-IET-004 and ANR-17-EURE-0029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that a short-term L-T4 treatment reduced the vestibular syndrome and significantly promoted vestibular compensation. Thyroid hormone receptors (TR\u03b1 and TR\u03b2) and type II iodothyronine deiodinase (DIO2) were present in the vestibular nuclei (VN), supporting a local action of L-T4. We confirmed the T4-induced metabolic effects by demonstrating an increase in the number of cytochrome oxidase-labeled neurons in the VN three days after the lesion. L-T4 treatment modulated glial reaction by decreasing both microglia and oligodendrocytes in the deafferented VN three days after UVN and increased cell proliferation. Survival of newly generated cells in the deafferented vestibular nuclei was not affected, but microglial rather than neuronal differentiation was favored by L-T4 treatment.<\/jats:p>","DOI":"10.3390\/cells11040684","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T20:26:41Z","timestamp":1645043201000},"page":"684","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["L-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects"],"prefix":"10.3390","volume":"11","author":[{"given":"Guillaume","family":"Rastoldo","sequence":"first","affiliation":[{"name":"Aix Marseille Universit\u00e9-CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, 13331 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7143-3220","authenticated-orcid":false,"given":"Emna","family":"Marouane","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9-CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, 13331 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"El-Mahmoudi","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9-CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, 13331 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"P\u00e9ricat","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse, CNRS, 31400 Toulouse, 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Esteve","family":"Fraysse","sequence":"additional","affiliation":[{"name":"Service d\u2019Oto-Rhino-Laryngologie, d\u2019Oto-Neurologie et d\u2019ORL P\u00e9diatrique, Centre Hospitalier Universitaire de Toulouse, 31400 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Chabbert","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9-CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, 13331 Marseille, France"},{"name":"GDR Physiopathologie Vestibulaire\u2014Unit\u00e9 GDR2074, CNRS, 13003 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zwergal","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital, LMU Munich, 80539 Munich, Germany"},{"name":"German Center for Vertigo and Balance Disorders, DSGZ, LMU Munich, 80539 Munich, 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