{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:44:17Z","timestamp":1790484257459,"version":"4.1.0"},"reference-count":66,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Plan National Cancer-Inserm","award":["Plan National Cancer-Inserm"],"award-info":[{"award-number":["Plan National Cancer-Inserm"]}]},{"name":"Pfizer (France)","award":["Endocrinology Reserach Price"],"award-info":[{"award-number":["Endocrinology Reserach Price"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Background: Many studies link G protein-coupled receptors (GPCRs) to cancer. Some endocrine tumors are unresponsive to standard treatment and\/or require long-term and poorly tolerated treatment. This study explored, by bioinformatics analysis, the tumoral profiling of the GPCR transcriptome to identify potential targets in these tumors aiming at drug repurposing. Methods: We explored the GPCR differentially expressed genes (DEGs) from public datasets (Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA)). The GEO datasets were available for two medullary thyroid cancers (MTCs), eighty-seven pheochromocytomas (PHEOs), sixty-one paragangliomas (PGLs), forty-seven pituitary adenomas and one-hundred-fifty adrenocortical cancers (ACCs). The TCGA dataset covered 92 ACCs. We identified GPCRs targeted by approved drugs from pharmacological databases (ChEMBL and DrugBank). Results: The profiling of dysregulated GPCRs was tumor specific. In MTC, we found 14 GPCR DEGs, including an upregulation of the dopamine receptor (DRD2) and adenosine receptor (ADORA2B), which were the target of many drugs. In PGL, seven GPCR genes were downregulated, including vasopressin receptor (AVPR1A) and PTH receptor (PTH1R), which were targeted by approved drugs. In ACC, PTH1R was also downregulated in both the GEO and TCGA datasets and was the target of osteoporosis drugs. Conclusions: We highlight specific GPCR signatures across the major endocrine tumors. These data could help to identify new opportunities for drug repurposing.<\/jats:p>","DOI":"10.3390\/cells11040703","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T20:24:26Z","timestamp":1645129466000},"page":"703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Identification of Dysregulated Expression of G Protein Coupled Receptors in Endocrine Tumors by Bioinformatics Analysis: Potential Drug Targets?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-8190","authenticated-orcid":false,"given":"Valentine","family":"Suteau","sequence":"first","affiliation":[{"name":"D\u00e9partement d\u2019Endocrinologie-Diab\u00e9tologie Nutrition, Centre Hospitalier Universitaire (CHU) d\u2019Angers, 49933 Angers, France"},{"name":"Laboratoire MITOVASC, UMR CNRS 6015, INSERM 1083, Universit\u00e9 d\u2019Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7194-6846","authenticated-orcid":false,"given":"Mathilde","family":"Munier","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Endocrinologie-Diab\u00e9tologie Nutrition, Centre Hospitalier Universitaire (CHU) d\u2019Angers, 49933 Angers, France"},{"name":"Laboratoire MITOVASC, UMR CNRS 6015, INSERM 1083, Universit\u00e9 d\u2019Angers, 49100 Angers, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares de la Thyro\u00efde et des R\u00e9cepteurs Hormonaux, Centre Hospitalier Universitaire (CHU) d\u2019Angers, 49933 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3329-1831","authenticated-orcid":false,"given":"Rym","family":"Ben Boubaker","sequence":"additional","affiliation":[{"name":"Laboratoire MITOVASC, UMR CNRS 6015, INSERM 1083, Universit\u00e9 d\u2019Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9line","family":"Wery","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Sant\u00e9, Universit\u00e9 d\u2019Angers, SFR ICAT, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1094-0285","authenticated-orcid":false,"given":"Daniel","family":"Henrion","sequence":"additional","affiliation":[{"name":"Laboratoire MITOVASC, UMR CNRS 6015, INSERM 1083, Universit\u00e9 d\u2019Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-5627","authenticated-orcid":false,"given":"Patrice","family":"Rodien","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Endocrinologie-Diab\u00e9tologie Nutrition, Centre Hospitalier Universitaire (CHU) d\u2019Angers, 49933 Angers, France"},{"name":"Laboratoire MITOVASC, UMR CNRS 6015, INSERM 1083, Universit\u00e9 d\u2019Angers, 49100 Angers, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares de la Thyro\u00efde et des R\u00e9cepteurs Hormonaux, Centre Hospitalier Universitaire (CHU) d\u2019Angers, 49933 Angers, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, Centre Hospitalier Universitaire (CHU) d\u2019Angers, 49933 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Briet","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Endocrinologie-Diab\u00e9tologie Nutrition, Centre Hospitalier Universitaire (CHU) d\u2019Angers, 49933 Angers, France"},{"name":"Laboratoire MITOVASC, UMR CNRS 6015, INSERM 1083, Universit\u00e9 d\u2019Angers, 49100 Angers, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares de la Thyro\u00efde et des R\u00e9cepteurs Hormonaux, Centre Hospitalier Universitaire (CHU) d\u2019Angers, 49933 Angers, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares de l\u2019Hypophyse, Centre Hospitalier Universitaire (CHU) d\u2019Angers, 49933 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ygeno.2006.04.001","article-title":"Comprehensive Repertoire and Phylogenetic Analysis of the G Protein-Coupled Receptors in Human and Mouse","volume":"88","author":"Gloriam","year":"2006","journal-title":"Genomics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature08144","article-title":"The Structure and Function of G-Protein-Coupled Receptors","volume":"459","author":"Rosenbaum","year":"2009","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/mol.117.111062","article-title":"G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?","volume":"93","author":"Sriram","year":"2018","journal-title":"Mol. Pharm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrd.2017.178","article-title":"Trends in GPCR Drug Discovery: New Agents, Targets and Indications","volume":"16","author":"Hauser","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrc2069","article-title":"G-Protein-Coupled Receptors and Cancer","volume":"7","author":"Dorsam","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrd3320","article-title":"G Protein-Coupled Receptors: Novel Targets for Drug Discovery in Cancer","volume":"10","author":"Lappano","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11062","DOI":"10.1074\/jbc.REV119.005601","article-title":"Illuminating the Onco-GPCRome: Novel G Protein-Coupled Receptor-Driven Oncocrine Networks and Targets for Cancer Immunotherapy","volume":"294","author":"Wu","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrc3521","article-title":"The Emerging Mutational Landscape of G-Proteins and G-Protein Coupled Receptors in Cancer","volume":"13","author":"Kufareva","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_9","first-page":"w14183","article-title":"Data Mining The Cancer Genome Atlas in the Era of Precision Cancer Medicine","volume":"145","author":"Cheng","year":"2015","journal-title":"Swiss Med. Wkly."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3389\/fphar.2018.00431","article-title":"GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets","volume":"9","author":"Insel","year":"2018","journal-title":"Front. Pharm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"24882","DOI":"10.18632\/oncotarget.25427","article-title":"Large Set Data Mining Reveals Overexpressed GPCRs in Prostate and Breast Cancer: Potential for Active Targeting with Engineered Anti-Cancer Nanomedicines","volume":"9","author":"Albrecht","year":"2018","journal-title":"Oncotarget"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sriram, K., Moyung, K., Corriden, R., Carter, H., and Insel, P.A. (2019). GPCRs Show Widespread Differential MRNA Expression and Frequent Mutation and Copy Number Variation in Solid Tumors. PLoS Biol., 17.","DOI":"10.1101\/546481"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1096\/fj.201700834R","article-title":"GPR68, a Proton-Sensing GPCR, Mediates Interaction of Cancer-Associated Fibroblasts and Cancer Cells","volume":"32","author":"Wiley","year":"2018","journal-title":"FASEB J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1210\/clinem\/dgab343","article-title":"G Protein-Coupled Receptors in Radioiodine-Refractory Thyroid Cancer in the Era of Precision Medicine","volume":"106","author":"Suteau","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1530\/ERC-17-0004","article-title":"From Pituitary Adenoma to Pituitary Neuroendocrine Tumor (PitNET): An International Pituitary Pathology Club Proposal","volume":"24","author":"Asa","year":"2017","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s12022-016-9418-7","article-title":"Clinical Impact of the Current WHO Classification of Pituitary Adenomas","volume":"27","author":"Saeger","year":"2016","journal-title":"Endocr. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-17-0796","article-title":"European Society of Endocrinology Clinical Practice Guidelines for the Management of Aggressive Pituitary Tumours and Carcinomas","volume":"178","author":"Raverot","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.annonc.2020.08.2099","article-title":"Adrenocortical Carcinomas and Malignant Phaeochromocytomas: ESMO\u2013EURACAN Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up\u2020\u2020Approved by the ESMO Guidelines Committee: June 2020. This Publication Supersedes the Previously Published Version\u2014Ann Oncol. 2012;23(Suppl_7):Vii131-Vii138","volume":"31","author":"Fassnacht","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-18-0608","article-title":"European Society of Endocrinology Clinical Practice Guidelines on the Management of Adrenocortical Carcinoma in Adults, in Collaboration with the European Network for the Study of Adrenal Tumors","volume":"179","author":"Fassnacht","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.1038\/sj.onc.1208822","article-title":"Molecular Classification of Papillary Thyroid Carcinoma: Distinct BRAF, RAS, and RET\/PTC Mutation-Specific Gene Expression Profiles Discovered by DNA Microarray Analysis","volume":"24","author":"Giordano","year":"2005","journal-title":"Oncogene"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1158\/1078-0432.CCR-05-2039","article-title":"Delineation, Functional Validation, and Bioinformatic Evaluation of Gene Expression in Thyroid Follicular Carcinomas with the PAX8-PPARG Translocation","volume":"12","author":"Giordano","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1210\/en.2012-1056","article-title":"Genomic Characterization of Human and Rat Prolactinomas","volume":"153","author":"Tong","year":"2012","journal-title":"Endocrinology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40478-015-0211-5","article-title":"Identification of Targets for Rational Pharmacological Therapy in Childhood Craniopharyngioma","volume":"3","author":"Gump","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1038\/s41388-019-0779-5","article-title":"Tumor Microenvironment Defines the Invasive Phenotype of AIP-Mutation-Positive Pituitary Tumors","volume":"38","author":"Barry","year":"2019","journal-title":"Oncogene"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9177","DOI":"10.18632\/oncotarget.24183","article-title":"Multi-Chaperone Function Modulation and Association with Cytoskeletal Proteins Are Key Features of the Function of AIP in the Pituitary Gland","volume":"9","author":"Morgan","year":"2018","journal-title":"Oncotarget"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40478-019-0830-3","article-title":"Chemokines Modulate the Tumour Microenvironment in Pituitary Neuroendocrine Tumours","volume":"7","author":"Marques","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Giubellino, A., Shankavaram, U., Bullova, P., Schovanek, J., Zhang, Y., Shen, M., Patel, N., Elkahloun, A., Lee, M.-J., and Trepel, J. (2014). High-Throughput Screening for the Identification of New Therapeutic Options for Metastatic Pheochromocytoma and Paraganglioma. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090458"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1593\/neo.122132","article-title":"Genotype and Tumor Locus Determine Expression Profile of Pseudohypoxic Pheochromocytomas and Paragangliomas","volume":"15","author":"Shankavaram","year":"2013","journal-title":"Neoplasia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00109-014-1205-7","article-title":"Germ-Line PHD1 and PHD2 Mutations Detected in Patients with Pheochromocytoma\/Paraganglioma-Polycythemia","volume":"93","author":"Yang","year":"2015","journal-title":"J. Mol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1210\/me.2010-0256","article-title":"Research Resource: Transcriptional Profiling Reveals Different Pseudohypoxic Signatures in SDHB and VHL-Related Pheochromocytomas","volume":"24","author":"Schiavi","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1677\/ERC-09-0096","article-title":"Integrative Molecular Bioinformatics Study of Human Adrenocortical Tumors: MicroRNA, Tissue-Specific Target Prediction, and Pathway Analysis","volume":"16","author":"Wiener","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1677\/ERC-08-0237","article-title":"Microarray Gene Expression and Immunohistochemistry Analyses of Adrenocortical Tumors Identify IGF2 and Ki-67 as Useful in Differentiating Carcinomas from Adenomas","volume":"16","author":"Soon","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.surg.2013.06.058","article-title":"PTTG1 Over-Expression in Adrenocortical Cancer Is Associated with Poor Survival and Represents a Potential Therapeutic Target","volume":"154","author":"Demeure","year":"2013","journal-title":"Surgery"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Legendre, C.R., Demeure, M.J., Whitsett, T.G., Gooden, G.C., Bussey, K.J., Jung, S., Waibhav, T., Kim, S., and Salhia, B. (2016). Pathway Implications of Aberrant Global Methylation in Adrenocortical Cancer. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150629"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.ajpath.2012.05.026","article-title":"Progression to Adrenocortical Tumorigenesis in Mice and Humans through Insulin-Like Growth Factor 2 and \u03b2-Catenin","volume":"181","author":"Heaton","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for Functional Genomics Data Sets\u2014Update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Albrecht, H., and K\u00fcbler, E. (2019). Systematic Meta-Analysis Identifies Co-Expressed Kinases and GPCRs in Ovarian Cancer Tissues Revealing a Potential for Targeted Kinase Inhibitor Delivery. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11090454"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Heberle, H., Meirelles, G.V., da Silva, F.R., Telles, G.P., and Minghim, R. (2015). InteractiVenn: A Web-Based Tool for the Analysis of Sets through Venn Diagrams. BMC Bioinform., 16.","DOI":"10.1186\/s12859-015-0611-3"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/nar\/gkm958","article-title":"DrugBank: A Knowledgebase for Drugs, Drug Actions and Drug Targets","volume":"36","author":"Wishart","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkw1074","article-title":"The ChEMBL Database in 2017","volume":"45","author":"Gaulton","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.2174\/0929867327666200625143035","article-title":"Cholecystokinin-2 Receptor Targeting with Radiolabeled Peptides: Current Status and Future Directions","volume":"27","author":"Klingler","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"14605","DOI":"10.18632\/oncotarget.7522","article-title":"Assessment of Cholecystokinin 2 Receptor (CCK2R) in Neoplastic Tissue","volume":"7","author":"Roy","year":"2016","journal-title":"Oncotarget"},{"key":"ref_43","first-page":"937","article-title":"Efficacy of a Novel Second-Generation Somatostatin-Dopamine Chimera (TBR-065) in Human Medullary Thyroid Cancer: A Preclinical Study","volume":"111","author":"Dicitore","year":"2021","journal-title":"NEN"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1055\/s-2007-979989","article-title":"Adenosine A1-Receptors Inhibit CAMP and Ca2+ Mediated Calcitonin Secretion in C-Cells","volume":"27","author":"Zink","year":"1995","journal-title":"Horm. Metab. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/path.4170","article-title":"G-Protein Coupled Receptor 64 Promotes Invasiveness and Metastasis in Ewing Sarcomas through PGF and MMP1","volume":"230","author":"Richter","year":"2013","journal-title":"J. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1016\/j.cellsig.2015.08.015","article-title":"The Adhesion G Protein-Coupled Receptor G2 (ADGRG2\/GPR64) Constitutively Activates SRE and NF\u03baB and Is Involved in Cell Adhesion and Migration","volume":"27","author":"Peeters","year":"2015","journal-title":"Cell. Signal."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1823726","DOI":"10.1155\/2018\/1823726","article-title":"GPRC5A: An Emerging Biomarker in Human Cancer","volume":"2018","author":"Jiang","year":"2018","journal-title":"Biomed Res. Int."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/path.2331","article-title":"Frizzled-1 Is down-Regulated in Follicular Thyroid Tumours and Modulates Growth and Invasiveness","volume":"215","author":"Ulivieri","year":"2008","journal-title":"J. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/(SICI)1096-9896(199905)188:1<87::AID-PATH322>3.0.CO;2-5","article-title":"TSH Receptor Status of Thyroid Neoplasms\u2014TaqMan RT-PCR Analysis of Archival Material","volume":"188","author":"Sheils","year":"1999","journal-title":"J. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1210\/en.2007-0542","article-title":"Wnt Pathway Inhibitors Are Strongly Down-Regulated in Pituitary Tumors","volume":"149","author":"Elston","year":"2008","journal-title":"Endocrinology"},{"key":"ref_51","first-page":"1934","article-title":"Decreased Expression of SFRP2 Promotes Development of the Pituitary Corticotroph Adenoma by Upregulating Wnt Signaling","volume":"52","author":"Ren","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11102-014-0579-4","article-title":"Low Expression of Secreted Frizzled-Related Protein 4 in Aggressive Pituitary Adenoma","volume":"18","author":"Wu","year":"2015","journal-title":"Pituitary"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jss.2008.11.004","article-title":"Antiangiogenic Effect of a Selective 5-HT4 Receptor Agonist","volume":"159","author":"Nishikawa","year":"2010","journal-title":"J. Surg. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10637-019-00790-8","article-title":"Zelnorm, an Agonist of 5-Hydroxytryptamine 4-Receptor, Acts as a Potential Antitumor Drug by Targeting JAK\/STAT3 Signaling","volume":"38","author":"Zhang","year":"2020","journal-title":"Investig. New Drugs"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2478\/v10042-008-0006-7","article-title":"Immunohistochemical Detection of Angiotensin Receptors AT1 and AT2 in Adrenal Tumors","volume":"46","author":"Pawlikowski","year":"2008","journal-title":"Folia Histochem. Et Cytobiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1097\/01.LAB.0000029207.92039.2F","article-title":"Angiotensin II\u2019s Antiproliferative Effects Mediated Through AT2-Receptors Depend On Down-Regulation of SM-20","volume":"82","author":"Wolf","year":"2002","journal-title":"Lab. Investig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"eaaw4636","DOI":"10.1126\/scitranslmed.aaw4636","article-title":"Arginine Vasopressin Receptor 1a Is a Therapeutic Target for Castration-Resistant Prostate Cancer","volume":"11","author":"Zhao","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/ajpendo.2001.280.2.E209","article-title":"PTH and PTH-Related Peptide Enhance Steroid Secretion from Human Adrenocortical Cells","volume":"280","author":"Mazzocchi","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105434","DOI":"10.1016\/j.jsbmb.2019.105434","article-title":"The Crosstalk between Aldosterone and Calcium Metabolism in Primary Aldosteronism: A Possible Calcium Metabolism-Associated Aberrant \u201cNeoplastic\u201d Steroidogenesis in Adrenals","volume":"193","author":"Gao","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1158\/1055-9965.EPI-07-2924","article-title":"Differential Expression of Parathyroid Hormone\u2013Related Protein in Adrenocortical Tumors: Autocrine\/Paracrine Effects on the Growth and Signaling Pathways in H295R Cells","volume":"17","author":"Assie","year":"2008","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1210\/me.2009-0098","article-title":"Endogenous Parathyroid Hormone-Related Protein Regulates the Expression of PTH Type 1 Receptor and Proliferation of Vascular Smooth Muscle Cells","volume":"23","author":"Song","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1038\/onc.2014.217","article-title":"Knockdown of PTHR1 in Osteosarcoma Cells Decreases Invasion and Growth and Increases Tumor Differentiation in Vivo","volume":"34","author":"Ho","year":"2015","journal-title":"Oncogene"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1089\/thy.2006.16.1229","article-title":"Outcomes of Patients with Differentiated Thyroid Carcinoma Following Initial Therapy","volume":"16","author":"Jonklaas","year":"2006","journal-title":"Thyroid"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1369\/0022155414530995","article-title":"Validating Antibodies to the Cannabinoid CB2 Receptor","volume":"62","author":"Marchalant","year":"2014","journal-title":"J. Histochem. Cytochem."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kaiser, F., Morawski, M., Krohn, K., Rayes, N., Hsiao, C.-C., Quaas, M., and Aust, G. (2021). Adhesion GPCR GPR56 Expression Profiling in Human Tissues. Cells, 10.","DOI":"10.3390\/cells10123557"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"10775","DOI":"10.1038\/srep10775","article-title":"Relationship between Differentially Expressed MRNA and MRNA-Protein Correlations in a Xenograft Model System","volume":"5","author":"Koussounadis","year":"2015","journal-title":"Sci. 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