{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:57:06Z","timestamp":1772463426975,"version":"3.50.1"},"reference-count":92,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Adult hippocampal neurogenesis\u2014the generation of new functional neurones in the adult brain\u2014is impaired in aging and many neurodegenerative disorders. We recently showed that the acylated version of the gut hormone ghrelin (acyl-ghrelin) stimulates adult hippocampal neurogenesis while the unacylated form of ghrelin inhibits it, thus demonstrating a previously unknown function of unacyl-ghrelin in modulating hippocampal plasticity. Analysis of plasma samples from Parkinson\u2019s disease patients with dementia demonstrated a reduced acyl-ghrelin:unacyl-ghrelin ratio compared to both healthy controls and cognitively intact Parkinson\u2019s disease patients. These data, from mouse and human studies, suggest that restoring acyl-ghrelin signalling may promote the activation of pathways to support memory function. In this short review, we discuss the evidence for ghrelin\u2019s role in regulating adult hippocampal neurogenesis and the enzymes involved in ghrelin acylation and de-acylation as targets to treat mood-related disorders and dementia.<\/jats:p>","DOI":"10.3390\/cells11050765","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T22:35:09Z","timestamp":1645569309000},"page":"765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ghrelin Acylation\u2014A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis"],"prefix":"10.3390","volume":"11","author":[{"given":"Martina","family":"Sassi","sequence":"first","affiliation":[{"name":"Molecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea SA2 8QA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alwena H.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea SA2 8QA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4234-0033","authenticated-orcid":false,"given":"Jeffrey S.","family":"Davies","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea SA2 8QA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Smiley","year":"2000","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1006\/bbrc.2000.3568","article-title":"Ghrelin Stimulates Gastric Acid Secretion and Motility in Rats","volume":"908","author":"Masuda","year":"2000","journal-title":"Biochem. 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