{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:59:10Z","timestamp":1791917950119,"version":"4.3.4"},"reference-count":114,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Heart failure is a major global health concern. Noncoding RNAs (ncRNAs) are involved in physiological processes and in the pathogenesis of various diseases, including heart failure. ncRNAs have emerged as critical components of transcriptional regulatory pathways that govern cardiac development, stress response, signaling, and remodeling in cardiac pathology. Recently, studies of ncRNAs in cardiovascular disease have achieved significant development. Here, we discuss the roles of ncRNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) that modulate the cardiac hypertrophy and heart failure.<\/jats:p>","DOI":"10.3390\/cells11050777","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T09:34:38Z","timestamp":1645608878000},"page":"777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Noncoding RNAs in Cardiac Hypertrophy and Heart Failure"],"prefix":"10.3390","volume":"11","author":[{"given":"Peilei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Kevin","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meimi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41440-021-00826-8","article-title":"Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension","volume":"45","author":"Grabowski","year":"2021","journal-title":"Hypertens. 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