{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:44:16Z","timestamp":1790837056232,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001728","name":"Swedish Foundation for International Cooperation in Research and Higher Education","doi-asserted-by":"publisher","award":["Saving maternal brains; MG2019-8462"],"award-info":[{"award-number":["Saving maternal brains; MG2019-8462"]}],"id":[{"id":"10.13039\/501100001728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["Saving maternal brains; 2020-01640"],"award-info":[{"award-number":["Saving maternal brains; 2020-01640"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Brain Foundation","award":["Saving maternal brains; FO2019-0128"],"award-info":[{"award-number":["Saving maternal brains; FO2019-0128"]}]},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"publisher","award":["SLS-934559"],"award-info":[{"award-number":["SLS-934559"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010751","name":"Fondecyt","doi-asserted-by":"publisher","award":["1200250"],"award-info":[{"award-number":["1200250"]}],"id":[{"id":"10.13039\/501100010751","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Birth Foundation","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Cerebral complications in preeclampsia contribute substantially to maternal mortality and morbidity. There is a lack of reliable and accessible predictors for preeclampsia-related cerebral complications. In this study, plasma from women with preeclampsia (n = 28), women with normal pregnancies (n = 28) and non-pregnant women (n = 16) was analyzed for concentrations of the cerebral biomarkers neurofilament light (NfL), tau, neuron-specific enolase (NSE) and S100B. Then, an in vitro blood\u2013brain barrier (BBB) model, based on the human cerebral microvascular endothelial cell line (hCMEC\/D3), was employed to assess the effect of plasma from the three study groups. Transendothelial electrical resistance (TEER) was used as an estimation of BBB integrity. NfL and tau are proteins expressed in axons, NSE in neurons and S100B in glial cells and are used as biomarkers for neurological injury in other diseases such as dementia, traumatic brain injury and hypoxic brain injury. Plasma concentrations of NfL, tau, NSE and S100B were all higher in women with preeclampsia compared with women with normal pregnancies (8.85 vs. 5.25 ng\/L, p &lt; 0.001; 2.90 vs. 2.40 ng\/L, p &lt; 0.05; 3.50 vs. 2.37 \u00b5g\/L, p &lt; 0.001 and 0.08 vs. 0.05 \u00b5g\/L, p &lt; 0.01, respectively). Plasma concentrations of NfL were also higher in women with preeclampsia compared with non-pregnant women (p &lt; 0.001). Higher plasma concentrations of the cerebral biomarker NfL were associated with decreased TEER (p = 0.002) in an in vitro model of the BBB, a finding which indicates that NfL could be a promising biomarker for BBB alterations in preeclampsia.<\/jats:p>","DOI":"10.3390\/cells11050789","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T07:22:35Z","timestamp":1645687355000},"page":"789","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Cerebral Biomarkers and Blood-Brain Barrier Integrity in Preeclampsia"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9828-7617","authenticated-orcid":false,"given":"Therese","family":"Friis","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesenia","family":"Acurio","sequence":"additional","affiliation":[{"name":"Vascular Physiology Laboratory, Department of Basic Sciences, Faculty of Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n 3810178, Chile"},{"name":"Group of Research and Innovation in Vascular Health (GRIVAS Health), Chill\u00e1n 3810178, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Vascular Physiology Laboratory, Department of Basic Sciences, Faculty of Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n 3810178, Chile"},{"name":"Group of Research and Innovation in Vascular Health (GRIVAS Health), Chill\u00e1n 3810178, Chile"},{"name":"Escuela de Enfermer\u00eda, Facultad de Salud, Universidad Santo Tom\u00e1s, Los \u00c1ngeles 4441171, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 43180 M\u00f6lndal, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 43180 M\u00f6lndal, Sweden"},{"name":"Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1E 6BT, UK"},{"name":"UK Dementia Research Institute at UCL, London WC1E 6BT, UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 43180 M\u00f6lndal, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 43180 M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nelander","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"\u00c5kerud","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Kaihola","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cluver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Stellenbosch University, Cape Town 7500, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Troncoso","sequence":"additional","affiliation":[{"name":"Vascular Physiology Laboratory, Department of Basic Sciences, Faculty of Sciences, University of B\u00edo-B\u00edo, Chill\u00e1n 3810178, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0654-2305","authenticated-orcid":false,"given":"Pablo","family":"Torres-Vergara","sequence":"additional","affiliation":[{"name":"Group of 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