{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:06:43Z","timestamp":1790730403311,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071791, 31970843, 81972866 and U20A20374"],"award-info":[{"award-number":["82071791, 31970843, 81972866 and U20A20374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"CAMS Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2021-1-I2M-005 and 2021-1-I2M-035"],"award-info":[{"award-number":["2021-1-I2M-005 and 2021-1-I2M-035"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017274","name":"CAMS Central Public Welfare Scientific Research Institute Basal Research Expenses","doi-asserted-by":"publisher","award":["2018PT32004, 2018PT31052 and 3332020035"],"award-info":[{"award-number":["2018PT32004, 2018PT31052 and 3332020035"]}],"id":[{"id":"10.13039\/501100017274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Background: the 18-kDa translocator protein (TSPO) is a mitochondrial outer membrane protein, and its expression tends to increase in response to inflammatory stimulation, rapidly. However, the role of TSPO in inflammation and pyroptosis is not yet clear. Here, we identified TSPO as a novel key regulator of pyroptosis. (2) Methods: TSPO knockout and DSS induced mouse inflammatory bowel disease (IBD) models were employed to assess the roles of TSPO in the pathogenesis of IBD. Primary peritoneal macrophages from TSPO knockout mice were applied to evaluate the mechanism of TSPO in cell pyroptosis. Conclusions: in response to inflammatory injury, TSPO expression is rapidly upregulated and provides a protective function against GSDMD-mediated pyroptosis, which helps us better understand the biological role of TSPO and a novel regulatory mechanism of the pyroptosis process.<\/jats:p>","DOI":"10.3390\/cells11050856","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:37:16Z","timestamp":1646210236000},"page":"856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["TSPO Deficiency Exacerbates GSDMD-Mediated Macrophage Pyroptosis in Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"11","author":[{"given":"Xue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"},{"name":"Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"},{"name":"Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou 213000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghua","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"},{"name":"Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou 213000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"},{"name":"Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou 213000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center on Pediatric Development and Diseases, Chinese Academy of Medical Sciences, Key Laboratory of T Cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, China"},{"name":"Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou 213000, 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