{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:11:32Z","timestamp":1789193492526,"version":"build-2803163510"},"reference-count":134,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Autophagy is a process focused on maintaining the homeostasis of organisms; nevertheless, the role of this process has also been widely documented in viral infections. Thus, xenophagy is a selective form of autophagy targeting viruses. However, the relation between autophagy and viruses is ambiguous\u2014this process may be used as a strategy to fight with a virus, but is also in favor of the virus\u2019s replication. In this paper, we have gathered data on autophagy in viral hepatitis and viral hemorrhagic fevers and the relations impacting its viral pathogenesis. Thus, autophagy is a potential therapeutic target, but research is needed to fully understand the mechanisms by which the virus interacts with the autophagic machinery. These studies must be performed in specific research models other than the natural host for many reasons. In this paper, we also indicate Lagovirus europaeus virus as a potentially good research model for acute liver failure and viral hemorrhagic disease.<\/jats:p>","DOI":"10.3390\/cells11050871","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T09:24:53Z","timestamp":1646299493000},"page":"871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Interplay between Autophagy and Virus Pathogenesis\u2014The Significance of Autophagy in Viral Hepatitis and Viral Hemorrhagic Fevers"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-2381","authenticated-orcid":false,"given":"Dominika","family":"B\u0119bnowska","sequence":"first","affiliation":[{"name":"Institute of Biology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4065-3842","authenticated-orcid":false,"given":"Paulina","family":"Nied\u017awiedzka-Rystwej","sequence":"additional","affiliation":[{"name":"Institute of Biology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.virusres.2017.09.006","article-title":"Role of autophagy in Zika virus infection and pathogenesis","volume":"254","author":"Chiramel","year":"2018","journal-title":"Virus Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3748\/wjg.v22.i1.176","article-title":"Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma","volume":"22","author":"Wu","year":"2016","journal-title":"World J. 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