{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:31:32Z","timestamp":1789151492119,"version":"build-2803163510"},"reference-count":70,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TI 291\/10-2"],"award-info":[{"award-number":["TI 291\/10-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Cells"],"abstract":"<jats:p>Pemphigus vulgaris is an autoimmune blistering disease of the epidermis, caused by autoantibodies against desmosomal proteins, mainly desmogleins 1 and 3, which induce an impairment of desmosomal adhesion and blister formation. Recent findings have shown that inhibition of immunoglobulin G binding on the neonatal Fc receptor, FcRn, results in reduced autoantibody recycling and shortens their half-life, providing a valid treatment option for PV. We have here analyzed the role of FcRn in human keratinocytes treated with antibodies isolated from pemphigus vulgaris patient or with recombinant anti-desmoglein-3 antibodies that induce pathogenic changes in desmosomes, such as loss of monolayer integrity, aberrant desmoglein-3 localization and degradation of desmoglein-3. We show that blocking IgG binding on FcRn by efgartigimod, a recombinant Fc fragment undergoing clinical studies for pemphigus, stabilizes the keratinocyte monolayer, whereas the loss of desmoglein-3 is not prevented by efgartigimod. Our data show that FcRn may play a direct role in the pathogenesis of pemphigus at the level of the autoantibody target cells, the epidermal keratinocytes. Our data suggest that in keratinocytes, FcRn may have functions different from its known function in IgG recycling. Therefore, stabilization of keratinocyte adhesion by FcRn blocking entities may provide a novel treatment paradigm for pemphigus.<\/jats:p>","DOI":"10.3390\/cells11060942","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T11:46:47Z","timestamp":1646912807000},"page":"942","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus?"],"prefix":"10.3390","volume":"11","author":[{"given":"Anna","family":"Zakrzewicz","sequence":"first","affiliation":[{"name":"Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"W\u00fcrth","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Beckert","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Feldhoff","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Vanderheyden","sequence":"additional","affiliation":[{"name":"Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stian","family":"Foss","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway"},{"name":"Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Terje","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway"},{"name":"Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans de","family":"Haard","sequence":"additional","affiliation":[{"name":"Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8760-9158","authenticated-orcid":false,"given":"Peter","family":"Verheesen","sequence":"additional","affiliation":[{"name":"Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Bobkov","sequence":"additional","affiliation":[{"name":"Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-1825","authenticated-orcid":false,"given":"Ritva","family":"Tikkanen","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pathol-042320-092912","article-title":"Desmosomal Cadherins in Health and Disease","volume":"17","author":"Hegazy","year":"2021","journal-title":"Annu. Rev. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fimmu.2018.00136","article-title":"Pemphigus-A Disease of Desmosome Dysfunction Caused by Multiple Mechanisms","volume":"9","author":"Spindler","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1074\/jbc.RA118.006743","article-title":"Synergy among non-desmoglein antibodies contributes to the immunopathology of desmoglein antibody-negative pemphigus vulgaris","volume":"294","author":"Chernyavsky","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"106149","DOI":"10.1016\/j.intimp.2019.106149","article-title":"Mechanisms of synergy of autoantibodies to M3 muscarinic acetylcholine receptor and secretory pathway Ca(2+)\/Mn(2+)-ATPase isoform 1 in patients with non-desmoglein pemphigus vulgaris","volume":"80","author":"Chernyavsky","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.3389\/fimmu.2018.01190","article-title":"Non-Desmoglein Antibodies in Patients With Pemphigus Vulgaris","volume":"9","author":"Amber","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13804","DOI":"10.1074\/jbc.M611365200","article-title":"Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: Characterization of novel signaling pathways downstream of pemphigus vulgaris antigens","volume":"282","author":"Chernyavsky","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/15419061.2013.877000","article-title":"Desmosomal cadherins and signaling: Lessons from autoimmune disease","volume":"21","author":"Spindler","year":"2014","journal-title":"Cell Commun. Adhes"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"701809","DOI":"10.3389\/fmed.2021.701809","article-title":"Autoantibody-Specific Signalling in Pemphigus","volume":"8","author":"Schmitt","year":"2021","journal-title":"Front. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jid.2017.06.022","article-title":"Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus","volume":"138","author":"Spindler","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.4049\/jimmunol.170.4.2170","article-title":"Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3","volume":"170","author":"Tsunoda","year":"2003","journal-title":"J. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1172\/JCI24185","article-title":"Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display","volume":"115","author":"Payne","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/intimm\/13.12.1551","article-title":"Differences in promiscuity for antibody-FcRn interactions across species: Implications for therapeutic antibodies","volume":"13","author":"Ober","year":"2001","journal-title":"Int. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1074\/jbc.M109.081828","article-title":"Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding","volume":"285","author":"Andersen","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Gornowicz-Porowska, J., Kowalczyk, M.J., Seraszek-Jaros, A., Bowszyc-Dmochowska, M., Kaczmarek, E., Zaba, R., and Dmochowski, M. (2020). A Comparative Analysis of CD32A and CD16A Polymorphisms in Relation to Autoimmune Responses in Pemphigus Diseases and Subepithelial Autoimmune Blistering Disorders. Genes, 11.","DOI":"10.3390\/genes11040371"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3389\/fimmu.2018.01788","article-title":"The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts","volume":"9","author":"Recke","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/bjd.20782","article-title":"Treatment of pemphigus vulgaris and foliaceus with efgartigimod, a neonatal Fc receptor inhibitor: A phase 2 multicentre, open-label feasibility trial","volume":"186","author":"Goebeler","year":"2022","journal-title":"Br. J. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1016\/j.jid.2021.04.031","article-title":"Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus","volume":"141","author":"Werth","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nri2155","article-title":"FcRn: The neonatal Fc receptor comes of age","volume":"7","author":"Roopenian","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.4049\/jimmunol.170.7.3528","article-title":"The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs","volume":"170","author":"Roopenian","year":"2003","journal-title":"J. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1084\/jem.20021829","article-title":"The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan","volume":"197","author":"Chaudhury","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/372379a0","article-title":"Crystal structure of the complex of rat neonatal Fc receptor with Fc","volume":"372","author":"Burmeister","year":"1994","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9698","DOI":"10.1021\/bi000749m","article-title":"Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)","volume":"39","author":"West","year":"2000","journal-title":"Biochemistry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1021\/bi052628y","article-title":"Albumin binding to FcRn: Distinct from the FcRn-IgG interaction","volume":"45","author":"Chaudhury","year":"2006","journal-title":"Biochemistry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/19420862.2015.1008353","article-title":"The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity","volume":"7","author":"Abdiche","year":"2015","journal-title":"MAbs"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1002\/eji.200636556","article-title":"The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin","volume":"36","author":"Andersen","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1074\/jbc.M113.537563","article-title":"Structural insights into neonatal Fc receptor-based recycling mechanisms","volume":"289","author":"Oganesyan","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1007\/s00018-010-0318-6","article-title":"The neonatal Fc receptor as therapeutic target in IgG-mediated autoimmune diseases","volume":"67","author":"Sesarman","year":"2010","journal-title":"Cell Mol. Life Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0065-2776(09)03004-1","article-title":"Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn","volume":"103","author":"Ward","year":"2009","journal-title":"Adv. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.tips.2018.07.007","article-title":"Targeting FcRn to Generate Antibody-Based Therapeutics","volume":"39","author":"Ward","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41467-018-03061-x","article-title":"A human endothelial cell-based recycling assay for screening of FcRn targeted molecules","volume":"9","author":"Grevys","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/nbt1143","article-title":"Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels","volume":"23","author":"Vaccaro","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.20020400","article-title":"Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: Functional expression of FcRn in the mammalian lung","volume":"196","author":"Spiekermann","year":"2002","journal-title":"J. Exp. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1172\/JCI6968","article-title":"Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line","volume":"104","author":"Dickinson","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"eabb0580","DOI":"10.1126\/scitranslmed.abb0580","article-title":"An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics","volume":"12","author":"Bern","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"9927","DOI":"10.1073\/pnas.1019037108","article-title":"Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells","volume":"108","author":"Baker","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3389\/fimmu.2014.00408","article-title":"The Role of FcRn in Antigen Presentation","volume":"5","author":"Baker","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1073\/pnas.0801717105","article-title":"Dependence of antibody-mediated presentation of antigen on FcRn","volume":"105","author":"Qiao","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Qi, T., and Cao, Y. (2021). In Translation: FcRn across the Therapeutic Spectrum. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063048"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.0022-202X.2004.23542.x","article-title":"Expression of FcRn, the MHC class I-related receptor for IgG, in human keratinocytes","volume":"124","author":"Cauza","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1172\/JCI97911","article-title":"Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans","volume":"128","author":"Ulrichts","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e2661","DOI":"10.1212\/WNL.0000000000007600","article-title":"Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis","volume":"92","author":"Howard","year":"2019","journal-title":"Neurology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S1474-4422(21)00159-9","article-title":"Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): A multicentre, randomised, placebo-controlled, phase 3 trial","volume":"20","author":"Howard","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/ajh.25680","article-title":"Phase 2 study of efgartigimod, a novel FcRn antagonist, in adult patients with primary immune thrombocytopenia","volume":"95","author":"Newland","year":"2020","journal-title":"Am. J. Hematol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Beckert, B., Panico, F., Pollmann, R., Eming, R., Banning, A., and Tikkanen, R. (2019). Immortalized Human hTert\/KER-CT Keratinocytes a Model System for Research on Desmosomal Adhesion and Pathogenesis of Pemphigus Vulgaris. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133113"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ajpath.2011.04.015","article-title":"Pathogenic relevance of IgG and IgM antibodies against desmoglein 3 in blister formation in pemphigus vulgaris","volume":"179","author":"Tsunoda","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fimmu.2015.00176","article-title":"Fully human monoclonal antibody inhibitors of the neonatal fc receptor reduce circulating IgG in non-human primates","volume":"6","author":"Nixon","year":"2015","journal-title":"Front. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_48","unstructured":"(2021, September 30). Available online: https:\/\/imagej.net\/software\/fiji\/."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Stahley, S.N., Saito, M., Faundez, V., Koval, M., Mattheyses, A.L., and Kowalczyk, A.P. (2014). Desmosome Assembly and Disassembly Are Membrane Raft-Dependent. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087809"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.4049\/jimmunol.159.4.2010","article-title":"Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins","volume":"159","author":"Ishii","year":"1997","journal-title":"J. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.0022-202X.2005.23714.x","article-title":"In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris","volume":"124","author":"Ishii","year":"2005","journal-title":"J. Inv. Dermat."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/archdermatol.2009.9","article-title":"ELISA testing of anti-desmoglein 1 and 3 antibodies in the management of pemphigus","volume":"145","author":"Abasq","year":"2009","journal-title":"Arch. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1038\/s41598-017-03697-7","article-title":"Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus","volume":"7","author":"Walter","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/sj.jid.5700790","article-title":"Targeting pemphigus autoantibodies through their heavy-chain variable region genes","volume":"127","author":"Payne","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"28820","DOI":"10.1038\/srep28820","article-title":"Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes","volume":"6","author":"Vollner","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"18303","DOI":"10.1074\/jbc.M710046200","article-title":"Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism","volume":"283","author":"Delva","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.1074\/jbc.M512447200","article-title":"Desmoglein Endocytosis and Desmosome Disassembly Are Coordinated Responses to Pemphigus Autoantibodies","volume":"281","author":"Calkins","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/jid.2010.389","article-title":"Desmosome Disassembly in Response to Pemphigus Vulgaris IgG Occurs in Distinct Phases and Can Be Reversed by Expression of Exogenous Dsg3","volume":"131","author":"Jennings","year":"2011","journal-title":"J. Inv. Dermat."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"183329","DOI":"10.1016\/j.bbamem.2020.183329","article-title":"The desmosome as a model for lipid raft driven membrane domain organization","volume":"1862","author":"Zimmer","year":"2020","journal-title":"Biochim. Biophys Acta. Biomembr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"23826","DOI":"10.1074\/jbc.M115.668061","article-title":"Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris","volume":"290","author":"Chen","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/mi.2011.53","article-title":"Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice","volume":"5","author":"Yoshida","year":"2012","journal-title":"Mucosal. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3389\/fimmu.2019.01540","article-title":"The Neonatal Fc Receptor (FcRn): A Misnomer?","volume":"10","author":"Pyzik","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.intimp.2016.12.032","article-title":"The expression and function of the neonatal Fc receptor in thyrocytes of Hashimoto\u2019s thyroiditis","volume":"44","author":"Zhao","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.tcb.2004.11.004","article-title":"A passionate kiss, then run: Exocytosis and recycling of IgG by FcRn","volume":"15","author":"Lencer","year":"2005","journal-title":"Trends Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1091\/mbc.e13-04-0174","article-title":"Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules","volume":"24","author":"Weflen","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4049\/jimmunol.181.1.449","article-title":"Activation of the JAK\/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG","volume":"181","author":"Liu","year":"2008","journal-title":"J. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.autrev.2019.03.009","article-title":"Serum and blister fluid levels of cytokines and chemokines in pemphigus and bullous pemphigoid","volume":"18","author":"Kowalski","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"502","DOI":"10.4161\/mabs.27765","article-title":"The effect of the neonatal Fc receptor on human IgG biodistribution in mice","volume":"6","author":"Chen","year":"2014","journal-title":"MAbs"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1208\/s12248-009-9129-9","article-title":"Investigation of the influence of FcRn on the distribution of IgG to the brain","volume":"11","author":"Garg","year":"2009","journal-title":"AAPS J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1172\/JCI24394","article-title":"Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases","volume":"115","author":"Li","year":"2005","journal-title":"J. Clin. 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