{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:39:21Z","timestamp":1790959161671,"version":"4.1.0"},"reference-count":90,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Cancer cachexia is a multifactorial, paraneoplastic syndrome that impacts roughly half of all cancer patients. It can negatively impact patient quality of life and prognosis by causing physical impairment, reducing chemotherapy tolerance, and precluding them as surgical candidates. While there is substantial research on cancer-induced skeletal muscle cachexia, there are comparatively fewer studies and therapies regarding cardiac cachexia in the setting of malignancy. A literature review was performed using the PubMed database to identify original articles pertaining to cancer-induced cardiac cachexia, including its mechanisms and potential therapeutic modalities. Seventy studies were identified by two independent reviewers based on inclusion and exclusion criteria. While there are multiple studies addressing the pathophysiology of cardiac-induced cancer cachexia, there are no studies evaluating therapeutic options in the clinical setting. Many treatment modalities including nutrition, heart failure medication, cancer drugs, exercise, and gene therapy have been explored in in vitro and mice models with varying degrees of success. While these may be beneficial in cancer patients, further prospective studies specifically focusing on the assessment and treatment of the cardiac component of cachexia are needed.<\/jats:p>","DOI":"10.3390\/cells11061040","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:25:00Z","timestamp":1647811500000},"page":"1040","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-3771","authenticated-orcid":false,"given":"Vignesh","family":"Vudatha","sequence":"first","affiliation":[{"name":"Department of Surgery, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980011, Richmond, VA 23219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teja","family":"Devarakonda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980011, Richmond, VA 23219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980011, Richmond, VA 23219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9117-0130","authenticated-orcid":false,"given":"Devon C.","family":"Freudenberger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980011, Richmond, VA 23219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-5400","authenticated-orcid":false,"given":"Andrea N.","family":"Riner","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Rd, P.O. Box 100287, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0454-0931","authenticated-orcid":false,"given":"Kelly M.","family":"Herremans","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Rd, P.O. Box 100287, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G.","family":"Trevino","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980011, Richmond, VA 23219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.critrevonc.2010.10.004","article-title":"Cancer cachexia: A systematic literature review of items and domains associated with involuntary weight loss in cancer","volume":"80","author":"Blum","year":"2011","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: An international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Herremans, K.M., Riner, A.N., Cameron, M.E., and Trevino, J.G. (2019). The Microbiota and Cancer Cachexia. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246267"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.2147\/CMAR.S261585","article-title":"Cancer Cachexia: Definition, Staging, and Emerging Treatments","volume":"12","author":"Ni","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.critrevonc.2018.05.006","article-title":"Cancer cachexia: Diagnosis, assessment, and treatment","volume":"127","author":"Sadeghi","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1177\/1534735418781743","article-title":"Lung Cancer Cachexia: Can Molecular Understanding Guide Clinical Management?","volume":"17","author":"Sorensen","year":"2018","journal-title":"Integr. Cancer Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fphys.2014.00088","article-title":"Pancreatic cancer cachexia: A review of mechanisms and therapeutics","volume":"5","author":"Tan","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/jcsm.12528","article-title":"Cancer cachexia and its pathophysiology: Links with sarcopenia, anorexia and asthenia","volume":"11","author":"Santos","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/MAJ.0b013e31818bbb8b","article-title":"Diabetes mellitus and risk of venous thromboembolism","volume":"337","author":"Stein","year":"2009","journal-title":"Am. J. Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/SLA.0000000000002679","article-title":"Sarcopenia and Postoperative Complication Risk in Gastrointestinal Surgical Oncology: A Meta-analysis","volume":"268","author":"Simonsen","year":"2018","journal-title":"Ann. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1038\/oncsis.2016.3","article-title":"Understanding cachexia as a cancer metabolism syndrome","volume":"5","author":"Porporato","year":"2016","journal-title":"Oncogenesis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.clnu.2007.03.011","article-title":"Pathophysiology of cancer cachexia: Much more than host-tumour interaction?","volume":"26","author":"Skipworth","year":"2007","journal-title":"Clin. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s13539-014-0137-y","article-title":"Concurrent evolution of cancer cachexia and heart failure: Bilateral effects exist","volume":"5","author":"Becher","year":"2014","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"H466","DOI":"10.1152\/ajpheart.00720.2015","article-title":"The pathogenesis and treatment of cardiac atrophy in cancer cachexia","volume":"310","author":"Murphy","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_15","first-page":"347","article-title":"Cardiac alterations in cancer-induced cachexia in mice","volume":"37","author":"Tian","year":"2010","journal-title":"Int. J. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Muhlfeld, C., Das, S.K., Heinzel, F.R., Schmidt, A., Post, H., Schauer, S., Papadakis, T., Kummer, W., and Hoefler, G. (2011). Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020424"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molmet.2015.11.004","article-title":"Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia","volume":"5","author":"Schafer","year":"2016","journal-title":"Mol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1172\/JCI116897","article-title":"Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model","volume":"92","author":"Costelli","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1093\/jnci\/85.16.1334","article-title":"Effects of tumor necrosis factor-alpha on muscle-protein turnover in female Wistar rats","volume":"85","author":"Llovera","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"118519","DOI":"10.1016\/j.bbamcr.2019.07.014","article-title":"Modulation of cardiac AKT and STAT3 signalling in preclinical cancer models and their impact on the heart","volume":"1867","author":"Pietzsch","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.18632\/oncotarget.27759","article-title":"Evaluation of cancer-derived myocardial impairments using a mouse model","volume":"11","author":"Miyagawa","year":"2020","journal-title":"Oncotarget"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1158\/0008-5472.CAN-10-3145","article-title":"Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner","volume":"71","author":"Cosper","year":"2011","journal-title":"Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.3892\/ijo.2013.1893","article-title":"Altered cardiac muscle mTOR regulation during the progression of cancer cachexia in the ApcMin\/+ mouse","volume":"42","author":"Manne","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.pathophys.2014.05.003","article-title":"Oxidative and proteolytic profiles of the right and left heart in a model of cancer-induced cardiac cachexia","volume":"21","author":"Borges","year":"2014","journal-title":"Pathophysiology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s13539-013-0116-8","article-title":"Disruption of pro-oxidant and antioxidant systems with elevated expression of the ubiquitin proteosome system in the cachectic heart muscle of nude mice","volume":"4","author":"Hinch","year":"2013","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/rco2.18","article-title":"Cancer-induced Cardiac Atrophy Adversely Affects Myocardial Redox State and Mitochondrial Oxidative Characteristics","volume":"4","author":"Lee","year":"2021","journal-title":"JCSM Rapid Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.ajpath.2010.12.009","article-title":"NF-kappaB inhibition protects against tumor-induced cardiac atrophy in vivo","volume":"178","author":"Wysong","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_28","first-page":"1321","article-title":"Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice","volume":"39","author":"Tian","year":"2011","journal-title":"Int. J. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1002\/ijc.29620","article-title":"Tumor inoculation site affects the development of cancer cachexia and muscle wasting","volume":"137","author":"Matsuyama","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1054\/bjoc.2001.1696","article-title":"Activation of Ca2+-dependent proteolysis in skeletal muscle and heart in cancer cachexia","volume":"84","author":"Costelli","year":"2001","journal-title":"Br. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fphys.2017.00213","article-title":"Interference with Ca2+-Dependent Proteolysis Does Not Alter the Course of Muscle Wasting in Experimental Cancer Cachexia","volume":"8","author":"Pin","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/jcsm.12642","article-title":"ACVR2B antagonism as a countermeasure to multi-organ perturbations in metastatic colorectal cancer cachexia","volume":"11","author":"Huot","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11877","DOI":"10.1038\/s41598-017-10838-5","article-title":"The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy","volume":"7","author":"Samant","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"H685","DOI":"10.1152\/ajpheart.00106.2015","article-title":"Metalloproteinase expression is altered in cardiac and skeletal muscle in cancer cachexia","volume":"309","author":"Devine","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jcsm.12225","article-title":"Establishment and characterization of a novel murine model of pancreatic cancer cachexia","volume":"8","author":"Michaelis","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_36","first-page":"e54893","article-title":"The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia","volume":"117","author":"Bonetto","year":"2016","journal-title":"J. Vis. Exp."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1038\/s41598-018-23669-9","article-title":"Subcutaneous Ehrlich Ascites Carcinoma mice model for studying cancer-induced cardiomyopathy","volume":"8","author":"Mishra","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ehf2.12184","article-title":"Cardiac muscle wasting in individuals with cancer cachexia","volume":"4","author":"Barkhudaryan","year":"2017","journal-title":"ESC Heart Fail."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.lfs.2010.12.010","article-title":"Myocardial dysfunction in an animal model of cancer cachexia","volume":"88","author":"Xu","year":"2011","journal-title":"Life Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.jacc.2014.07.948","article-title":"Cardiovascular function and predictors of exercise capacity in patients with colorectal cancer","volume":"64","author":"Cramer","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijcard.2003.05.050","article-title":"Wasting of the left ventricle in patients with cardiac cachexia: A cardiovascular magnetic resonance study","volume":"97","author":"Florea","year":"2004","journal-title":"Int. J. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4137\/CMO.S30891","article-title":"Cachexia Index in Advanced Non-Small-Cell Lung Cancer Patients","volume":"9","author":"Jafri","year":"2015","journal-title":"Clin. Med. Insights Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"22001","DOI":"10.18632\/oncotarget.25146","article-title":"Proteomic profiling of skeletal and cardiac muscle in cancer cachexia: Alterations in sarcomeric and mitochondrial protein expression","volume":"9","author":"Shum","year":"2018","journal-title":"Oncotarget"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/SPC.0b013e328359b695","article-title":"Translational implications of novel findings in cancer cachexia: The use of metabolomics and the potential of cardiac malfunction","volume":"6","author":"Gourin","year":"2012","journal-title":"Curr. Opin. Supportive Palliat. Care"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7535","DOI":"10.1038\/s41598-020-64282-z","article-title":"An elevated neutrophil-to-lymphocyte ratio associates with weight loss and cachexia in cancer","volume":"10","author":"Barker","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/jcsm.12761","article-title":"Association of systemic inflammation with survival in patients with cancer cachexia: Results from a multicentre cohort study","volume":"12","author":"Zhang","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/jcsm.12451","article-title":"Rapid atrophy of cardiac left ventricular mass in patients with non-small cell carcinoma of the lung","volume":"10","author":"Becher","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_48","first-page":"1129","article-title":"Luteolin reduces cancerinduced skeletal and cardiac muscle atrophy in a Lewis lung cancer mouse model","volume":"40","author":"Chen","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Aquila, G., Re Cecconi, A.D., Forti, M., Frapolli, R., Bello, E., Novelli, D., Russo, I., Licandro, S.A., Staszewsky, L., and Martinelli, G.B. (2020). Trabectedin and Lurbinectedin Extend Survival of Mice Bearing C26 Colon Adenocarcinoma, without Affecting Tumor Growth or Cachexia. Cancers, 12.","DOI":"10.3390\/cancers12082312"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/01635581.2011.563032","article-title":"Oral resveratrol therapy inhibits cancer-induced skeletal muscle and cardiac atrophy in vivo","volume":"63","author":"Shadfar","year":"2011","journal-title":"Nutr. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"H997","DOI":"10.1152\/ajpheart.00660.2008","article-title":"Muscle ring finger 1 mediates cardiac atrophy in vivo","volume":"296","author":"Willis","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.18632\/oncotarget.27748","article-title":"Pharmacological targeting of mitochondrial function and reactive oxygen species production prevents colon 26 cancer-induced cardiorespiratory muscle weakness","volume":"11","author":"Smuder","year":"2020","journal-title":"Oncotarget"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/1099800414543822","article-title":"Ubiquinol reduces muscle wasting but not fatigue in tumor-bearing mice","volume":"17","author":"Clark","year":"2015","journal-title":"Biol. Res. Nurs."},{"key":"ref_54","first-page":"2584","article-title":"Host cathepsin D response to tumor in the normal and pepstatin-treated mouse","volume":"43","author":"Greenbaum","year":"1983","journal-title":"Cancer Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/labinvest.3780222","article-title":"Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy","volume":"81","author":"Roberg","year":"2001","journal-title":"Lab Investig."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.nut.2003.08.004","article-title":"Effects of simvastatin administration in an experimental model of cancer cachexia","volume":"19","author":"Muscaritoli","year":"2003","journal-title":"Nutrition"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1016\/j.ijcard.2013.04.150","article-title":"Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia","volume":"168","author":"Palus","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.yjmcc.2015.05.007","article-title":"Losartan treatment attenuates tumor-induced myocardial dysfunction","volume":"85","author":"Stevens","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kelm, N.Q., Straughn, A.R., and Kakar, S.S. (2020). Withaferin A attenuates ovarian cancer-induced cardiac cachexia. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0236680"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.cell.2010.07.011","article-title":"Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival","volume":"142","author":"Zhou","year":"2010","journal-title":"Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.nut.2013.12.005","article-title":"Rosiglitazone reduces body wasting and improves survival in a rat model of cancer cachexia","volume":"30","author":"Trobec","year":"2014","journal-title":"Nutrition"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jcsm.12100","article-title":"Nutritional leucine supplementation attenuates cardiac failure in tumour-bearing cachectic animals","volume":"7","author":"Toneto","year":"2016","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1111\/cas.14656","article-title":"Combined administration of lauric acid and glucose improved cancer-derived cardiac atrophy in a mouse cachexia model","volume":"111","author":"Nukaga","year":"2020","journal-title":"Cancer Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0002-9610(91)90360-P","article-title":"Clenbuterol plus acivicin decrease tumor growth and increase muscle mass in rats maintained on total parenteral nutrition","volume":"161","author":"Chance","year":"1991","journal-title":"Am. J. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ijcard.2016.05.008","article-title":"Erythropoietin improves cardiac wasting and outcomes in a rat model of liver cancer cachexia","volume":"218","author":"Saitoh","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1016\/j.ijcard.2013.05.063","article-title":"The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy","volume":"168","author":"Springer","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijcard.2013.10.022","article-title":"Tandospirone reduces wasting and improves cardiac function in experimental cancer cachexia","volume":"170","author":"Elkina","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.lfs.2014.11.029","article-title":"Aerobic exercise training as therapy for cardiac and cancer cachexia","volume":"125","author":"Alves","year":"2015","journal-title":"Life Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1249\/MSS.0000000000001544","article-title":"Exercise Protects against Cancer-induced Cardiac Cachexia","volume":"50","author":"Parry","year":"2018","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1249\/MSS.0000000000001916","article-title":"Combined Exercise Training Positively Affects Muscle Wasting in Tumor-Bearing Mice","volume":"51","author":"Ranjbar","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"118392","DOI":"10.1016\/j.lfs.2020.118392","article-title":"Exercise training delays cardiac remodeling in a mouse model of cancer cachexia","volume":"260","author":"Fernandes","year":"2020","journal-title":"Life Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.abb.2014.12.026","article-title":"Endurance training prevents TWEAK but not myostatin-mediated cardiac remodelling in cancer cachexia","volume":"567","author":"Padrao","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"348ra98","DOI":"10.1126\/scitranslmed.aac4976","article-title":"Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice","volume":"8","author":"Winbanks","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"113066","DOI":"10.1016\/j.jep.2020.113066","article-title":"Cryptotanshinone prevents muscle wasting in CT26-induced cancer cachexia through inhibiting STAT3 signaling pathway","volume":"260","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.yjmcc.2016.09.010","article-title":"Minocycline attenuates cardiac dysfunction in tumor-burdened mice","volume":"100","author":"Devine","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/eurheartj\/eht302","article-title":"Prevention of liver cancer cachexia-induced cardiac wasting and heart failure","volume":"35","author":"Springer","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ehf2.12372","article-title":"Cardiac expression of neutrophil gelatinase-associated lipocalin in a model of cancer cachexia-induced cardiomyopathy","volume":"6","author":"Musolino","year":"2019","journal-title":"ESC Heart Fail."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1152\/japplphysiol.00897.2017","article-title":"Skeletal muscle function during the progression of cancer cachexia in the male Apc(Min\/+) mouse","volume":"124","author":"VanderVeen","year":"2018","journal-title":"J. Appl. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Oliveira, A.G., and Gomes-Marcondes, M.C. (2016). Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2424-9"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"119329","DOI":"10.1016\/j.lfs.2021.119329","article-title":"Investigation into the role of anti-diabetic agents in cachexia associated with metastatic cancer","volume":"274","author":"Bora","year":"2021","journal-title":"Life Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/jcsm.12116","article-title":"Megestrol acetate improves cardiac function in a model of cancer cachexia-induced cardiomyopathy by autophagic modulation","volume":"7","author":"Musolino","year":"2016","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s13539-014-0153-y","article-title":"Formoterol in the treatment of experimental cancer cachexia: Effects on heart function","volume":"5","author":"Toledo","year":"2014","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1111\/cas.14520","article-title":"Peptide-2 from mouse myostatin precursor protein alleviates muscle wasting in cancer-associated cachexia","volume":"111","author":"Ojima","year":"2020","journal-title":"Cancer Sci."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Scott, J.M., Dillon, E.L., Kinsky, M., Chamberlain, A., McCammon, S., Jupiter, D., Willis, M., Hatch, S., Richardson, G., and Danesi, C. (2019). Effects of adjunct testosterone on cardiac morphology and function in advanced cancers: An ancillary analysis of a randomized controlled trial. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-6006-5"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3109\/0284186X.2012.724536","article-title":"Non-steroidal anti-inflammatory treatment in cancer cachexia: A systematic literature review","volume":"52","author":"Solheim","year":"2013","journal-title":"Acta Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1007\/s00726-016-2313-1","article-title":"Supplementation with L-glutamine prevents tumor growth and cancer-induced cachexia as well as restores cell proliferation of intestinal mucosa of Walker-256 tumor-bearing rats","volume":"48","author":"Martins","year":"2016","journal-title":"Amino Acids"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.clnu.2013.06.013","article-title":"Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia","volume":"33","author":"Ham","year":"2014","journal-title":"Clin. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1207\/S15327914NC4601_07","article-title":"Cancer cachexia and tumor growth reduction in Walker 256 tumor-bearing rats supplemented with N-3 polyunsaturated fatty acids for one generation","volume":"46","author":"Togni","year":"2003","journal-title":"Nutr. Cancer"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4161\/cbt.12.2.15717","article-title":"L-carnitine ameliorates cancer cachexia in mice by regulating the expression and activity of carnitine palmityl transferase","volume":"12","author":"Liu","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00394-019-01933-6","article-title":"Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling","volume":"59","author":"Cella","year":"2020","journal-title":"Eur. J. 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