{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:00:44Z","timestamp":1791234044946,"version":"4.1.0"},"reference-count":167,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AEI-MICIU\/FEDER","award":["RED2018-102723-T"],"award-info":[{"award-number":["RED2018-102723-T"]}]},{"name":"CIBER de C\u00e1ncer","award":["CB16\/12\/00275"],"award-info":[{"award-number":["CB16\/12\/00275"]}]},{"name":"Consejeria de Salud","award":["PI-0397-2017"],"award-info":[{"award-number":["PI-0397-2017"]}]},{"name":"Regional Ministry of Economic Transformation, Industry, Knowledge and Universities","award":["P18-RT-2501"],"award-info":[{"award-number":["P18-RT-2501"]}]},{"name":"Fundacion AECC","award":["PRDSE19002ESPI"],"award-info":[{"award-number":["PRDSE19002ESPI"]}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["FPU18\/01009"],"award-info":[{"award-number":["FPU18\/01009"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades (MCIU) Plan Estatal de I+D+I 2018, a la Agen-cia Estatal de Investigaci\u00f3n (AEI) y al Fondo Europeo de Desarrollo Regional (MCIU\/AEI\/FEDER, UE)","award":["RTI2018-097455-B-I00"],"award-info":[{"award-number":["RTI2018-097455-B-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms. In contrast, chronic senescence activation may be responsible for other events such as age-related disorders, HIV and cancer development. Cellular senescence activation can be triggered by different insults. Regardless of the inducer, there are several phenotypes generally shared among senescent cells: cell division arrest, an aberrant shape, increased size, high granularity because of increased numbers of lysosomes and vacuoles, apoptosis resistance, defective metabolism and some chromatin alterations. Senescent cells constitute an important area for research due to their contributions to the pathogenesis of different diseases such as frailty, sarcopenia and aging-related diseases, including cancer and HIV infection, which show an accelerated aging. Hence, a new pharmacological category of treatments called senotherapeutics is under development. This group includes senolytic drugs that selectively attack senescent cells and senostatic drugs that suppress SASP factor delivery, inhibiting senescent cell development. These new drugs can have positive therapeutic effects on aging-related disorders and act in cancer as antitumor drugs, avoiding the undesired effects of senescent cells such as those from SASP. Here, we review senotherapeutics and how they might affect cancer and HIV disease, two very different aging-related diseases, and review some compounds acting as senolytics in clinical trials.<\/jats:p>","DOI":"10.3390\/cells11071222","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T09:49:41Z","timestamp":1649065781000},"page":"1222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Senotherapeutics in Cancer and HIV"],"prefix":"10.3390","volume":"11","author":[{"given":"Laura","family":"S\u00e1nchez-D\u00edaz","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Roc\u00edo, Universidad de Sevilla, Consejo Superior de Investigaciones Cient\u00edficas, 41013 Seville, Spain"},{"name":"CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n","family":"Espinosa-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Roc\u00edo, Universidad de Sevilla, Consejo Superior de Investigaciones Cient\u00edficas, 41013 Seville, Spain"},{"name":"CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-0150","authenticated-orcid":false,"given":"Jos\u00e9-Ram\u00f3n","family":"Blanco","sequence":"additional","affiliation":[{"name":"Hospital San Pedro\/Centro de Investigaci\u00f3n Biom\u00e9dica de La Rioja (CIBIR), 26006 Logro\u00f1o, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-3979","authenticated-orcid":false,"given":"Amancio","family":"Carnero","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Roc\u00edo, Universidad de Sevilla, Consejo Superior de Investigaciones Cient\u00edficas, 41013 Seville, Spain"},{"name":"CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Exp. 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