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In this review, we discuss the contribution of all three domains of cellular life to human naso- and oropharyngeal microbiomes, i.e., bacterial microbiota, eukaryotes (mostly fungi), as well as the archaeome and their relation to respiratory and atopic disorders in infancy and adolescence. With this review, we aim to summarize state-of-the-art contributions to the field published in the last decade. In particular, we intend to build bridges between basic and clinical science.<\/jats:p>","DOI":"10.3390\/cells11081287","type":"journal-article","created":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T23:06:01Z","timestamp":1649631961000},"page":"1287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Relevance of the Bacterial Microbiome, Archaeome and Mycobiome in Pediatric Asthma and Respiratory Disorders"],"prefix":"10.3390","volume":"11","author":[{"given":"Carolin","family":"Baehren","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of Health, Witten\/Herdecke University, 58455 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Buedding","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of Health, Witten\/Herdecke University, 58455 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliyah","family":"Bellm","sequence":"additional","affiliation":[{"name":"Helios Hospital Krefeld, Children\u2019s Hospital, Teaching Hospital of RTWH University Hospital Aachen, 47805 Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schult","sequence":"additional","affiliation":[{"name":"Center for Child and Adolescent Medicine, Center for Clinical and Translational Research (CCTR), Helios University Hospital Wuppertal, Witten\/Herdecke University, 42283 Wuppertal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-1532","authenticated-orcid":false,"given":"Anton","family":"Pembaur","sequence":"additional","affiliation":[{"name":"Clinical Molecular Genetics and Epigenetics, Faculty of Health, Center for Biomedical Education & Research (ZBAF), Helios University Hospital Wuppertal, Witten\/Herdecke University, Alfred-Herrhausen-Str. 50, 58448 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wirth","sequence":"additional","affiliation":[{"name":"Center for Child and Adolescent Medicine, Center for Clinical and Translational Research (CCTR), Helios University Hospital Wuppertal, Witten\/Herdecke University, 42283 Wuppertal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Ehrhardt","sequence":"additional","affiliation":[{"name":"Institute of Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department of Human Medicine, Faculty of Health, Witten\/Herdecke University, 58453 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-0953","authenticated-orcid":false,"given":"Friedrich","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Institute of Functional and Clinical Anatomy, Friedrich Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8562-3316","authenticated-orcid":false,"given":"Jan","family":"Postberg","sequence":"additional","affiliation":[{"name":"Clinical Molecular Genetics and Epigenetics, Faculty of Health, Center for Biomedical Education & Research (ZBAF), Helios University Hospital Wuppertal, Witten\/Herdecke University, Alfred-Herrhausen-Str. 50, 58448 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik","family":"Aydin","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of Health, Witten\/Herdecke University, 58455 Witten, Germany"},{"name":"Center for Child and Adolescent Medicine, Center for Clinical and Translational Research (CCTR), Helios University Hospital Wuppertal, Witten\/Herdecke University, 42283 Wuppertal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R142","DOI":"10.1093\/hmg\/ddr353","article-title":"The human metagenome: Our other genome?","volume":"20","author":"Bruls","year":"2011","journal-title":"Hum. 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