{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:25:48Z","timestamp":1790717148797,"version":"4.1.0"},"reference-count":152,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1009\/A5"],"award-info":[{"award-number":["SFB1009\/A5"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>As a consequence of tissue injury or infection, neutrophils are recruited in a stepwise recruitment process from the bloodstream into the surrounding tissue. Selectins are a family of adhesion molecules comprised of L-, E-, and P-selectin. Differences in expression patterns, protein structure, and ligand binding characteristics mediate distinct functions of each selectin. Interactions of selectins and their counter-receptors mediate the first contact of neutrophils with the endothelium, as well as subsequent neutrophil rolling along the endothelial surface. For efficient neutrophil recruitment, activation of \u03b22-integrins on the cell surface is essential. Integrin activation can be elicited via selectin- as well as chemokine-mediated inside-out signaling resulting in integrin conformational changes and clustering. Dysregulation of selectin-induced integrin activation on neutrophils is involved in the development of severe pathological disease conditions including leukocyte adhesion deficiency (LAD) syndromes in humans. Here, we review molecular mechanisms involved in selectin-mediated signaling pathways in neutrophils and their impact on integrin activation, neutrophil recruitment, and inflammatory diseases.<\/jats:p>","DOI":"10.3390\/cells11081310","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T21:15:35Z","timestamp":1649798135000},"page":"1310","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Selectin-Mediated Signaling\u2014Shedding Light on the Regulation of Integrin Activity in Neutrophils"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2158-5784","authenticated-orcid":false,"given":"Anika","family":"Cappenberg","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, 48149 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Kardell","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, 48149 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zarbock","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, 48149 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: The leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1152\/physrev.00012.2018","article-title":"The Neutrophil\u2019s Role during Health and Disease","volume":"99","author":"Liew","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1182\/blood.2021012295","article-title":"Neutrophils in acute inflammation\u2014Current concepts and translational implications","volume":"139","author":"Margraf","year":"2021","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.gendis.2019.07.012","article-title":"Leukocyte adhesion defect: Where do we stand circa 2019?","volume":"7","author":"Das","year":"2020","journal-title":"Genes Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.molimm.2012.11.006","article-title":"The molecular basis of leukocyte recruitment and its deficiencies","volume":"55","author":"Schmidt","year":"2013","journal-title":"Mol. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/cvr\/cvv154","article-title":"Selectins: Initiators of leucocyte adhesion and signalling at the vascular wall","volume":"107","author":"McEver","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.immunol.25.022106.141618","article-title":"Structural basis of integrin regulation and signaling","volume":"25","author":"Luo","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1021\/bi401596q","article-title":"Integrin cytoplasmic tail interactions","volume":"53","author":"Morse","year":"2014","journal-title":"Biochemistry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1242\/jcs.041624","article-title":"Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails","volume":"122","author":"Legate","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"C308","DOI":"10.1152\/ajpcell.00560.2020","article-title":"beta2 integrin activation and signal transduction in leukocyte recruitment","volume":"321","author":"Sun","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.immunol.021908.132554","article-title":"The ins and outs of leukocyte integrin signaling","volume":"27","author":"Abram","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1021\/bi5013782","article-title":"Ligand recognition specificity of leukocyte integrin alphaMbeta2 (Mac-1, CD11b\/CD18) and its functional consequences","volume":"54","author":"Podolnikova","year":"2015","journal-title":"Biochemistry"},{"key":"ref_13","first-page":"G763","article-title":"Cell adhesion and migration. I. Neutrophil adhesive interactions with intestinal epithelium","volume":"273","author":"Parkos","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.intimp.2013.11.010","article-title":"Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways","volume":"17","author":"Futosi","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1084\/jem.194.2.205","article-title":"Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo","volume":"194","author":"Eriksson","year":"2001","journal-title":"J. Exp. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1084\/jem.20021854","article-title":"P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules","volume":"197","author":"Sperandio","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1172\/JCI119556","article-title":"Role of PSGL-1 binding to selectins in leukocyte recruitment","volume":"100","author":"McEver","year":"1997","journal-title":"J. Clin. Invest."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.immuni.2007.03.011","article-title":"Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44","volume":"26","author":"Hidalgo","year":"2007","journal-title":"Immunity"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.immuni.2007.04.011","article-title":"Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1","volume":"26","author":"Zarbock","year":"2007","journal-title":"Immunity"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1182\/blood-2010-01-266122","article-title":"Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils","volume":"116","author":"Kuwano","year":"2010","journal-title":"Blood"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1182\/blood-2011-08-373118","article-title":"Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation","volume":"119","author":"Lefort","year":"2012","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.279.5349.381","article-title":"Chemokines and the arrest of lymphocytes rolling under flow conditions","volume":"279","author":"Campbell","year":"1998","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1182\/blood-2012-09-457085","article-title":"Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling","volume":"121","author":"Herter","year":"2013","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1084\/jem.20060925","article-title":"Intraluminal crawling of neutrophils to emigration sites: A molecularly distinct process from adhesion in the recruitment cascade","volume":"203","author":"Phillipson","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1600-065X.2007.00533.x","article-title":"Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium","volume":"218","author":"Vestweber","year":"2007","journal-title":"Immunol. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nri3908","article-title":"How leukocytes cross the vascular endothelium","volume":"15","author":"Vestweber","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nri.2016.49","article-title":"Neutrophil migration in infection and wound repair: Going forward in reverse","volume":"16","author":"Rosowski","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1189\/jlb.0905496","article-title":"Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration","volume":"79","author":"Buckley","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1126\/science.aam9690","article-title":"Visualizing the function and fate of neutrophils in sterile injury and repair","volume":"358","author":"Wang","year":"2017","journal-title":"Science"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.immuni.2018.10.007","article-title":"Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues","volume":"49","author":"He","year":"2018","journal-title":"Immunity"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.it.2019.03.010","article-title":"Time-of-Day-Dependent Trafficking and Function of Leukocyte Subsets","volume":"40","author":"Pick","year":"2019","journal-title":"Trends Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0092-8674(02)01257-6","article-title":"Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation","volume":"112","author":"Shimaoka","year":"2003","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev.cellbio.21.090704.151217","article-title":"Integrin structure, allostery, and bidirectional signaling","volume":"21","author":"Arnaout","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0092-8674(02)00935-2","article-title":"Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling","volume":"110","author":"Takagi","year":"2002","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3233\/BIR-15085","article-title":"Leukocyte arrest: Biomechanics and molecular mechanisms of beta2 integrin activation","volume":"52","author":"Fan","year":"2015","journal-title":"Biorheology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1038\/emboj.2011.333","article-title":"Regulation of integrin affinity on cell surfaces","volume":"30","author":"Schurpf","year":"2011","journal-title":"EMBO J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1074-7613(04)00082-2","article-title":"Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction","volume":"20","author":"Salas","year":"2004","journal-title":"Immunity"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1083\/jcb.201308083","article-title":"An internal ligand-bound, metastable state of a leukocyte integrin, alphaXbeta2","volume":"203","author":"Sen","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1083\/jcb.200410068","article-title":"Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin","volume":"168","author":"Adair","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s004180000189","article-title":"Outside-in regulation of integrin clustering processes by ECM components per se and their involvement in actin cytoskeleton organization in a colon adenocarcinoma cell line","volume":"114","author":"Honore","year":"2000","journal-title":"Histochem. Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1152\/physrev.1999.79.1.181","article-title":"Mechanisms that regulate the function of the selectins and their ligands","volume":"79","author":"Vestweber","year":"1999","journal-title":"Physiol. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1084\/jem.172.1.263","article-title":"Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1","volume":"172","author":"Watson","year":"1990","journal-title":"J. Exp. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1182\/blood.V88.9.3259.bloodjournal8893259","article-title":"Selectins and their ligands: Current concepts and controversies","volume":"88","author":"Kansas","year":"1996","journal-title":"Blood"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0092-8674(00)81408-7","article-title":"Calmodulin regulates L-selectin adhesion molecule expression and function through a protease-dependent mechanism","volume":"92","author":"Kahn","year":"1998","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1084\/jem.20101545","article-title":"Differential regulation of human and murine P-selectin expression and function in vivo","volume":"207","author":"Liu","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"11025","DOI":"10.1074\/jbc.270.19.11025","article-title":"Leukocyte trafficking mediated by selectin-carbohydrate interactions","volume":"270","author":"McEver","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1074-7613(01)00166-2","article-title":"The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing","volume":"15","author":"Homeister","year":"2001","journal-title":"Immunity"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/ki.1997.194","article-title":"Selectin ligands, leukocyte trafficking, and fucosyltransferase genes","volume":"51","author":"Lowe","year":"1997","journal-title":"Kidney Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jlb.67.2.196","article-title":"CD11b\/CD18-coated microspheres attach to E-selectin under flow","volume":"67","author":"Crutchfield","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1084\/jem.20042014","article-title":"CD44 is a physiological E-selectin ligand on neutrophils","volume":"201","author":"Katayama","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1172\/JCI0214151","article-title":"P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow","volume":"109","author":"Xia","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1182\/blood.V86.12.4417.bloodjournal86124417","article-title":"Leukocyte Rolling in-Vivo Is Mediated by P-Selectin Glycoprotein Ligand-1","volume":"86","author":"Norman","year":"1995","journal-title":"Blood"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1182\/blood-2004-03-1095","article-title":"Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation","volume":"106","author":"Shrimpton","year":"2005","journal-title":"Blood"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1182\/blood.V90.5.1934","article-title":"The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum","volume":"90","author":"Borges","year":"1997","journal-title":"Blood"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"13771","DOI":"10.1073\/pnas.96.24.13771","article-title":"Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin","volume":"96","author":"Ramachandran","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Westmuckett, A.D., Thacker, K.M., and Moore, K.L. (2011). Tyrosine Sulfation of Native Mouse Psgl-1 Is Required for Optimal Leukocyte Rolling on P-Selectin In Vivo. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020406"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1128\/MCB.01204-07","article-title":"Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity","volume":"27","author":"Tenno","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.4049\/jimmunol.1200392","article-title":"Severe Impairment of Leukocyte Recruitment in ppGalNAcT-1-Deficient Mice","volume":"188","author":"Block","year":"2012","journal-title":"J. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.molimm.2012.10.025","article-title":"Neutrophil rolling at high shear: Flattening, catch bond behavior, tethers and slings","volume":"55","author":"Sundd","year":"2013","journal-title":"Mol. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nmeth.1508","article-title":"Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophil rolling","volume":"7","author":"Sundd","year":"2010","journal-title":"Nat. Methods"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nature01605","article-title":"Direct observation of catch bonds involving cell-adhesion molecules","volume":"423","author":"Marshall","year":"2003","journal-title":"Nature"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1098\/rspb.1988.0038","article-title":"The reaction-limited kinetics of membrane-to-surface adhesion and detachment","volume":"234","author":"Dembo","year":"1988","journal-title":"Proc. R Soc. Lond B Biol. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1074\/jbc.M310396200","article-title":"Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan","volume":"279","author":"Sarangapani","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1182\/blood-2017-05-783027","article-title":"Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow","volume":"130","author":"Morikis","year":"2017","journal-title":"Blood"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.3389\/fimmu.2018.02774","article-title":"Neutrophil Mechanosignaling Promotes Integrin Engagement With Endothelial Cells and Motility Within Inflamed Vessels","volume":"9","author":"Morikis","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"663886","DOI":"10.3389\/fimmu.2021.663886","article-title":"Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients","volume":"12","author":"Morikis","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1016\/S0006-3495(96)79486-9","article-title":"Micropipette suction for measuring piconewton forces of adhesion and tether formation from neutrophil membranes","volume":"71","author":"Shao","year":"1996","journal-title":"Biophy. J."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Cugno, A., Marki, A., and Ley, K. (2021). Biomechanics of Neutrophil Tethers. Life, 11.","DOI":"10.3390\/life11060515"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1189\/jlb.1AB0617-230R","article-title":"Rolling neutrophils form tethers and slings under physiologic conditions in vivo","volume":"103","author":"Marki","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1084\/jem.173.6.1493","article-title":"Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b\/CD18, Mac-1, alpha m beta 2) on human neutrophils","volume":"173","author":"Lo","year":"1991","journal-title":"J. Exp. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1182\/blood-2009-12-259556","article-title":"E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling","volume":"116","author":"Yago","year":"2010","journal-title":"Blood"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1084\/jem.20130664","article-title":"The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow","volume":"210","author":"Stadtmann","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1084\/jem.20072660","article-title":"PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling","volume":"205","author":"Zarbock","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1074-7613(02)00420-X","article-title":"ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1","volume":"17","author":"Urzainqui","year":"2002","journal-title":"Immunity"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1182\/blood.V95.7.2413","article-title":"Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cells","volume":"95","author":"Serrador","year":"2000","journal-title":"Blood"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1182\/blood-2009-11-254185","article-title":"Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways","volume":"115","author":"Mueller","year":"2010","journal-title":"Blood"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1084\/jem.20111493","article-title":"Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury","volume":"209","author":"Block","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1182\/blood-2018-05-850859","article-title":"Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice","volume":"132","author":"Yago","year":"2018","journal-title":"Blood"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.4049\/jimmunol.167.7.4017","article-title":"Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1","volume":"167","author":"DiVietro","year":"2001","journal-title":"J. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/eji.201041196","article-title":"Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling","volume":"41","author":"Stadtmann","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1172\/JCI83470","article-title":"FGF23 signaling impairs neutrophil recruitment and host defense during CKD","volume":"126","author":"Rossaint","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nm.2354","article-title":"GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice","volume":"17","author":"Kempf","year":"2011","journal-title":"Nat. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1074\/jbc.M411262200","article-title":"Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits","volume":"280","author":"Hill","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm.1931","article-title":"Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation","volume":"15","author":"Svensson","year":"2009","journal-title":"Nat. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1126\/science.1163865","article-title":"The tail of integrins, talin, and kindlins","volume":"324","author":"Moser","year":"2009","journal-title":"Science"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1074\/jbc.M807117200","article-title":"RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences","volume":"284","author":"Lee","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"702345","DOI":"10.3389\/fimmu.2021.702345","article-title":"Binding of Rap1 and Riam to Talin1 Fine-Tune beta2 Integrin Activity During Leukocyte Trafficking","volume":"12","author":"Bromberger","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.molcel.2008.09.022","article-title":"The Skap-hom dimerization and PH domains comprise a 3\u2019-phosphoinositide-gated molecular switch","volume":"32","author":"Swanson","year":"2008","journal-title":"Mol. Cell."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1128\/MCB.02011-06","article-title":"RIAM links the ADAP\/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation","volume":"27","author":"Menasche","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1084\/jem.20160647","article-title":"Skap2 is required for beta2 integrin-mediated neutrophil recruitment and functions","volume":"214","author":"Boras","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"26752","DOI":"10.1073\/pnas.1902502116","article-title":"Intermittent rolling is a defect of the extravasation cascade caused by Myosin1e-deficiency in neutrophils","volume":"116","author":"Vadillo","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e149870","DOI":"10.1172\/jci.insight.149870","article-title":"ADAM8 signaling drives neutrophil migration and ARDS severity","volume":"7","author":"Conrad","year":"2022","journal-title":"JCI Insight"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1182\/blood-2008-04-149468","article-title":"Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow","volume":"112","author":"Miner","year":"2008","journal-title":"Blood"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.4049\/jimmunol.1500606","article-title":"Cross-Talk between Shp1 and PIPKIgamma Controls Leukocyte Recruitment","volume":"195","author":"Stadtmann","year":"2015","journal-title":"J. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1083\/jcb.200404160","article-title":"The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2","volume":"167","author":"Kim","year":"2004","journal-title":"J. Cell Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1074\/jbc.M109460200","article-title":"The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: Cell activation-dependent binding of Moesin but not Ezrin","volume":"277","author":"Ivetic","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"8833","DOI":"10.1074\/jbc.M806983200","article-title":"In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin\/Radixin\/Moesin, and L-selectin","volume":"284","author":"Killock","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.biocel.2012.12.023","article-title":"Signals regulating L-selectin-dependent leucocyte adhesion and transmigration","volume":"45","author":"Ivetic","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1084\/jem.189.1.37","article-title":"L-selectin-mediated leukocyte adhesion in vivo: Microvillous distribution determines tethering efficiency, but not rolling velocity","volume":"189","author":"Stein","year":"1999","journal-title":"J. Exp. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1083\/jcb.136.3.707","article-title":"L-selectin from human, but not from mouse neutrophils binds directly to E-selectin","volume":"136","author":"Zollner","year":"1997","journal-title":"J. Cell. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1582-4934.2005.tb00354.x","article-title":"L-selectin: Mechanisms and physiological significance of ectodomain cleavage","volume":"9","author":"Smalley","year":"2005","journal-title":"J. Cell Mol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1126\/science.2551036","article-title":"Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors","volume":"245","author":"Kishimoto","year":"1989","journal-title":"Science"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1083\/jcb.119.1.229","article-title":"Soluble L-selectin is present in human plasma at high levels and retains functional activity","volume":"119","author":"Schleiffenbaum","year":"1992","journal-title":"J. Cell Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.4049\/jimmunol.158.9.4365","article-title":"L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro","volume":"158","author":"Allport","year":"1997","journal-title":"J. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"E1461","DOI":"10.1073\/pnas.1417100112","article-title":"L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro","volume":"112","author":"Rzeniewicz","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1182\/blood.2019000685","article-title":"L-selectin shedding affects bacterial clearance in the lung: A new regulatory pathway for integrin outside-in signaling","volume":"134","author":"Cappenberg","year":"2019","journal-title":"Blood"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1182\/blood-2006-02-005827","article-title":"ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding","volume":"108","author":"Li","year":"2006","journal-title":"Blood"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"119122","DOI":"10.1016\/j.bbamcr.2021.119122","article-title":"Rho signaling inhibition mitigates lung injury via targeting neutrophil recruitment and selectin-AKT signaling","volume":"1868","author":"Singhal","year":"2021","journal-title":"Biochim. Biophys Acta Mol. Cell Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"jcs250340","DOI":"10.1242\/jcs.250340","article-title":"L-selectin regulates human neutrophil transendothelial migration","volume":"134","author":"Rahman","year":"2021","journal-title":"J. Cell Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/380720a0","article-title":"Neutrophil rolling altered by inhibition of L-selectin shedding in vitro","volume":"380","author":"Walcheck","year":"1996","journal-title":"Nature"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1083\/jcb.129.4.1155","article-title":"The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via alpha-actinin: Receptor positioning in microvilli does not require interaction with alpha-actinin","volume":"129","author":"Pavalko","year":"1995","journal-title":"J. Cell Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"15403","DOI":"10.1074\/jbc.270.25.15403","article-title":"Signaling functions of L-selectin. Enhancement of tyrosine phosphorylation and activation of MAP kinase","volume":"270","author":"Waddell","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"7780","DOI":"10.4049\/jimmunol.172.12.7780","article-title":"Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils","volume":"172","author":"Green","year":"2004","journal-title":"J. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.4049\/jimmunol.159.7.3498","article-title":"Ligation of L-selectin on T lymphocytes activates beta1 integrins and promotes adhesion to fibronectin","volume":"159","author":"Giblin","year":"1997","journal-title":"J. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1378\/chest.117.4.1162","article-title":"Anti-inflammatory cytokines","volume":"117","author":"Opal","year":"2000","journal-title":"Chest"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.4049\/jimmunol.2000047","article-title":"ArhGAP15, a RacGAP, Acts as a Temporal Signaling Regulator of Mac-1 Affinity in Sterile Inflammation","volume":"205","author":"Margraf","year":"2020","journal-title":"J. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1073\/pnas.89.3.1123","article-title":"Isolation of a src homology 2-containing tyrosine phosphatase","volume":"89","author":"Plutzky","year":"1992","journal-title":"Proc. Natl. Acad Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/oxfordjournals.jhered.a108625","article-title":"Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology","volume":"66","author":"Green","year":"1975","journal-title":"J. Hered."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.4049\/jimmunol.151.12.6733","article-title":"Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice","volume":"151","author":"Koo","year":"1993","journal-title":"J. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"13464","DOI":"10.1038\/ncomms13464","article-title":"Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response","volume":"7","author":"Rossaint","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"key":"ref_122","first-page":"e51275","article-title":"Myelin oligodendrocyte glycoprotein (MOG35-55) induced experimental autoimmune encephalomyelitis (EAE) in C57BL\/6 mice","volume":"86","author":"Bittner","year":"2014","journal-title":"J. Vis. Exp."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.me.38.020187.001135","article-title":"Leukocyte adhesion deficiency: An inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins","volume":"38","author":"Anderson","year":"1987","journal-title":"Annu. Rev. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1172\/JCI119697","article-title":"Leukocyte adhesion deficiency type 1 (LAD-1)\/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins","volume":"100","author":"Kuijpers","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1749-6632.2011.06389.x","article-title":"Leukocyte adhesion deficiencies","volume":"1250","author":"Hanna","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.jaip.2017.12.008","article-title":"Leukocyte adhesion deficiency-I: A comprehensive review of all published cases","volume":"6","author":"Kasbekar","year":"2018","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1172\/JCI118361","article-title":"Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2","volume":"96","author":"Phillips","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"450738","DOI":"10.1155\/2012\/450738","article-title":"Adaptive immune response to model antigens is impaired in murine leukocyte-adhesion deficiency-1 revealing elevated activation thresholds in vivo","volume":"2012","author":"Peters","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/15419069409004445","article-title":"Adhesion molecule deficiencies and their clinical significance","volume":"2","author":"Etzioni","year":"1994","journal-title":"Cell Adhes Commun."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0091-6749(98)70104-6","article-title":"Leukocyte adhesion deficiency type II: Long-term follow-up","volume":"102","author":"Etzioni","year":"1998","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ng0501-69","article-title":"The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter","volume":"28","author":"Luhn","year":"2001","journal-title":"Nat. Genet."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1056\/NEJM199212173272505","article-title":"Brief report: Recurrent severe infections caused by a novel leukocyte adhesion deficiency","volume":"327","author":"Etzioni","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1172\/JCI116535","article-title":"In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes","volume":"91","author":"Berger","year":"1993","journal-title":"J. Clin Investig."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0022-3476(99)70281-7","article-title":"Leukocyte adhesion deficiency II syndrome, a generalized defect in fucose metabolism","volume":"134","author":"Marquardt","year":"1999","journal-title":"J. Pediatr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1182\/blood-2008-01-132035","article-title":"Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II\/congenital disorder of glycosylation IIc","volume":"112","author":"Yakubenia","year":"2008","journal-title":"Blood"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1182\/blood-2008-06-163162","article-title":"Kindlin-3: A new gene involved in the pathogenesis of LAD-III","volume":"112","author":"Mory","year":"2008","journal-title":"Blood"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1172\/JCI30575","article-title":"Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III","volume":"117","author":"Bergmeier","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s12016-009-8132-3","article-title":"Defects in the leukocyte adhesion cascade","volume":"38","author":"Etzioni","year":"2010","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000066968","article-title":"Leukocyte adhesion deficiency II: Therapy and genetic defect","volume":"172","author":"Wild","year":"2002","journal-title":"Cells Tissues Organs"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrneurol.2012.236","article-title":"Deciphering the mechanism underlying late-onset Alzheimer disease","volume":"9","author":"Krstic","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1172\/JCI58656","article-title":"The immunology of neurodegeneration","volume":"122","author":"Czirr","year":"2012","journal-title":"J. Clin Investig."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"17587","DOI":"10.1523\/JNEUROSCI.3241-13.2013","article-title":"How do immune cells support and shape the brain in health, disease, and aging?","volume":"33","author":"Schwartz","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nm.3913","article-title":"Neutrophils promote Alzheimer\u2019s disease-like pathology and cognitive decline via LFA-1 integrin","volume":"21","author":"Zenaro","year":"2015","journal-title":"Nat. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1538-7836.2009.03401.x","article-title":"Dynamics of platelet thrombus formation","volume":"7","author":"Jackson","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.ehj.2003.08.021","article-title":"The adhesion molecule P-selectin and cardiovascular disease","volume":"24","author":"Blann","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1161\/ATVBAHA.110.207480","article-title":"Platelet-leukocyte interactions in cardiovascular disease and beyond","volume":"30","author":"Totani","year":"2010","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1084\/jem.20021868","article-title":"Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin","volume":"197","author":"Falati","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1182\/blood.V98.6.1955","article-title":"P-selectin mediates the adhesion of sickle erythrocytes to the endothelium","volume":"98","author":"Matsui","year":"2001","journal-title":"Blood"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.3324\/haematol.2014.108555","article-title":"Prominent role of platelets in the formation of circulating neutrophil-red cell heterocellular aggregates in sickle cell anemia","volume":"99","author":"Dominical","year":"2014","journal-title":"Haematologica"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1182\/bloodadvances.2019000603","article-title":"P-selectin-deficient mice to study pathophysiology of sickle cell disease","volume":"4","author":"Bennewitz","year":"2020","journal-title":"Blood Adv."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1182\/blood.2020009779","article-title":"P-selectin deficiency promotes liver senescence in sickle cell disease mice","volume":"137","author":"Vats","year":"2021","journal-title":"Blood"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1182\/blood.2020007214","article-title":"Platelet gene expression and function in patients with COVID-19","volume":"136","author":"Manne","year":"2020","journal-title":"Blood"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/8\/1310\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:52:49Z","timestamp":1760136769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/8\/1310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,12]]},"references-count":152,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["cells11081310"],"URL":"https:\/\/doi.org\/10.3390\/cells11081310","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,12]]}}}