{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T02:12:20Z","timestamp":1778206340555,"version":"3.51.4"},"reference-count":191,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Platelets are mainly known for their key role in hemostasis and thrombosis. However, studies over the last two decades have shown their strong implication in mechanisms associated with inflammation, thrombosis, and the immune system in various neoplastic, inflammatory, autoimmune, and infectious diseases. During sepsis, platelets amplify the recruitment and activation of innate immune cells at the site of infection and contribute to the elimination of pathogens. In certain conditions, these mechanisms can lead to thromboinflammation resulting in severe organ dysfunction. Here, we discuss the interactions of platelets with leukocytes, neutrophil extracellular traps (NETs), and endothelial cells during sepsis. The intrinsic properties of platelets that generate an inflammatory signal through the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome are discussed. As an example of immunothrombosis, the implication of platelets in vaccine-induced immune thrombotic thrombocytopenia is documented. Finally, we discuss the role of megakaryocytes (MKs) in thromboinflammation and their adaptive responses.<\/jats:p>","DOI":"10.3390\/cells11091507","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T05:44:07Z","timestamp":1651297447000},"page":"1507","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Platelet Versus Megakaryocyte: Who Is the Real Bandleader of Thromboinflammation in Sepsis?"],"prefix":"10.3390","volume":"11","author":[{"given":"C\u00e9dric","family":"Garcia","sequence":"first","affiliation":[{"name":"Laboratoire d\u2019H\u00e9matologie, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse, France"},{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm UMR1297 and Universit\u00e9 Toulouse 3, 31024 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baptiste","family":"Compagnon","sequence":"additional","affiliation":[{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm UMR1297 and Universit\u00e9 Toulouse 3, 31024 Toulouse, France"},{"name":"P\u00f4le Anesth\u00e9sie-R\u00e9animation, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u00ebl","family":"Po\u00ebtte","sequence":"additional","affiliation":[{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm UMR1297 and Universit\u00e9 Toulouse 3, 31024 Toulouse, France"},{"name":"P\u00f4le Anesth\u00e9sie-R\u00e9animation, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Pierre","family":"Gratacap","sequence":"additional","affiliation":[{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm UMR1297 and Universit\u00e9 Toulouse 3, 31024 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois-Xavier","family":"Lap\u00e9bie","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Vasculaire, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Voisin","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019H\u00e9matologie, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0516-4939","authenticated-orcid":false,"given":"Vincent","family":"Minville","sequence":"additional","affiliation":[{"name":"P\u00f4le Anesth\u00e9sie-R\u00e9animation, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-0190","authenticated-orcid":false,"given":"Bernard","family":"Payrastre","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019H\u00e9matologie, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse, France"},{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm UMR1297 and Universit\u00e9 Toulouse 3, 31024 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Vardon-Bounes","sequence":"additional","affiliation":[{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm UMR1297 and Universit\u00e9 Toulouse 3, 31024 Toulouse, France"},{"name":"P\u00f4le Anesth\u00e9sie-R\u00e9animation, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Ribes","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019H\u00e9matologie, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse, France"},{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Inserm UMR1297 and Universit\u00e9 Toulouse 3, 31024 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.3389\/fimmu.2019.01805","article-title":"Platelets, Thrombo-Inflammation, and Cancer: Collaborating With the Enemy","volume":"10","author":"Crescence","year":"2019","journal-title":"Front. 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