{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:53:16Z","timestamp":1791816796596,"version":"4.3.4"},"reference-count":227,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovation Fund Denmark","doi-asserted-by":"publisher","award":["4108-00008A"],"award-info":[{"award-number":["4108-00008A"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Danish Parkinson Foundation, the Jascha Foundation","award":["4108-00008A"],"award-info":[{"award-number":["4108-00008A"]}]},{"name":"the Faculty of Health Sciences at the University of Southern Denmark","award":["4108-00008A"],"award-info":[{"award-number":["4108-00008A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an important role for RhoA signaling in neurons and glial cells. Indeed, emerging evidence points toward a role of aberrant RhoA signaling in neurodegenerative diseases such as Parkinson\u2019s disease, Alzheimer\u2019s disease, Huntington\u2019s disease, and amyotrophic lateral sclerosis. In this review, we summarize the current knowledge of RhoA regulation and downstream cellular functions with an emphasis on the role of RhoA signaling in neurodegenerative diseases and the therapeutic potential of RhoA inhibition in neurodegeneration.<\/jats:p>","DOI":"10.3390\/cells11091520","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T06:23:08Z","timestamp":1651386188000},"page":"1520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["RhoA Signaling in Neurodegenerative Diseases"],"prefix":"10.3390","volume":"11","author":[{"given":"Sissel Ida","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, DK-5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Blaabjerg","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, DK-5000 Odense, Denmark"},{"name":"Department of Neurology, Odense University Hospital, DK-5000 Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, DK-5000 Odense, Denmark"},{"name":"BRIDGE\u2014Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, DK-5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-2386","authenticated-orcid":false,"given":"Kristine","family":"Freude","sequence":"additional","affiliation":[{"name":"Section for Pathobiological Sciences, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-1336","authenticated-orcid":false,"given":"Morten","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, DK-5000 Odense, Denmark"},{"name":"Department of Neurology, Odense University Hospital, DK-5000 Odense, Denmark"},{"name":"BRIDGE\u2014Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, DK-5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3389\/fncel.2014.00314","article-title":"Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegeneration","volume":"8","author":"Stankiewicz","year":"2014","journal-title":"Front. 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