{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:35:07Z","timestamp":1791758107805,"version":"4.3.4"},"reference-count":67,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["NRF-2019R1G1A1099580"],"award-info":[{"award-number":["NRF-2019R1G1A1099580"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["NRF-2020R1A2C2005012"],"award-info":[{"award-number":["NRF-2020R1A2C2005012"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["NRF-2019R1A6A1A03032888"],"award-info":[{"award-number":["NRF-2019R1A6A1A03032888"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["HI21C1353"],"award-info":[{"award-number":["HI21C1353"]}]},{"name":"Ministry of Education","award":["NRF-2019R1G1A1099580"],"award-info":[{"award-number":["NRF-2019R1G1A1099580"]}]},{"name":"Ministry of Education","award":["NRF-2020R1A2C2005012"],"award-info":[{"award-number":["NRF-2020R1A2C2005012"]}]},{"name":"Ministry of Education","award":["NRF-2019R1A6A1A03032888"],"award-info":[{"award-number":["NRF-2019R1A6A1A03032888"]}]},{"name":"Ministry of Education","award":["HI21C1353"],"award-info":[{"award-number":["HI21C1353"]}]},{"name":"Ministry of Health &amp; Welfare","award":["NRF-2019R1G1A1099580"],"award-info":[{"award-number":["NRF-2019R1G1A1099580"]}]},{"name":"Ministry of Health &amp; Welfare","award":["NRF-2020R1A2C2005012"],"award-info":[{"award-number":["NRF-2020R1A2C2005012"]}]},{"name":"Ministry of Health &amp; Welfare","award":["NRF-2019R1A6A1A03032888"],"award-info":[{"award-number":["NRF-2019R1A6A1A03032888"]}]},{"name":"Ministry of Health &amp; Welfare","award":["HI21C1353"],"award-info":[{"award-number":["HI21C1353"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Asherman\u2019s syndrome (AS) is caused by intrauterine adhesions and inactive endometrium from repeated curettage of the uterine endometrium. AS is a major cause of recurrent implantation failure and miscarriage and is very difficult to treat because of the poor recovery of endometrial basal cells. Platelet-rich plasma (PRP) has abundant growth factors that may induce angiogenesis and cell proliferation. Here, we demonstrate that human PRP (hPRP) significantly enhances angiogenesis to restore embryo implantation, leading to successful pregnancy in mice with AS. In mice with AS, hPRP treatment considerably reduced the expression of fibrosis markers and alleviated oligo\/amenorrhea phenotypes. Mice with AS did not produce any pups, but the hPRP therapy restored their infertility. AS-induced abnormalities, such as aberrantly delayed embryo implantation and intrauterine growth retardation, were considerably eliminated by hPRP. Furthermore, hPRP significantly promoted not only the elevation of various angiogenic factors, but also the migration of endometrial stromal cells. It also increased the phosphorylation of STAT3, a critical mediator of wound healing, and the expression of tissue remodeling genes in a fibrotic uterus. PRP could be a promising therapeutic strategy to promote angiogenesis and reduce fibrosis in impaired uterine environments, leading to successful embryo implantation for better clinical outcomes in patients with AS.<\/jats:p>","DOI":"10.3390\/cells11091549","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T13:10:26Z","timestamp":1651756226000},"page":"1549","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Human Platelet-Rich Plasma Facilitates Angiogenesis to Restore Impaired Uterine Environments with Asherman\u2019s Syndrome for Embryo Implantation and Following Pregnancy in Mice"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-2674","authenticated-orcid":false,"given":"Min Kyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, CHA Fertility Center Gangnam, CHA University School of Medicine, 569 Nonhyun-ro, Gangnam-gu, Seoul 06125, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ah","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, CHA Fertility Center Gangnam, CHA University School of Medicine, 569 Nonhyun-ro, Gangnam-gu, Seoul 06125, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-2899","authenticated-orcid":false,"given":"Sook Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, CHA Fertility Center Gangnam, CHA University School of Medicine, 569 Nonhyun-ro, Gangnam-gu, Seoul 06125, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0690-3828","authenticated-orcid":false,"given":"Mira","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Sik","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, CHA Fertility Center Gangnam, CHA University School of Medicine, 569 Nonhyun-ro, Gangnam-gu, Seoul 06125, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Woo","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, CHA Fertility Center Gangnam, CHA University School of Medicine, 569 Nonhyun-ro, Gangnam-gu, Seoul 06125, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-7310","authenticated-orcid":false,"given":"Haengseok","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1471-0528.1948.tb07045.x","article-title":"Amenorrhoea traumatica (atretica)","volume":"55","author":"Asherman","year":"1948","journal-title":"J. Obstet. Gynaecol. Br. Emp."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.fertnstert.2008.02.096","article-title":"Asherman syndrome--one century later","volume":"89","author":"Yu","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2174\/1574888X14666190213100528","article-title":"Endometrial regeneration in asherman\u2019s syndrome: Clinical and translational evidence of stem cell therapies","volume":"14","author":"Hou","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jmig.2017.09.020","article-title":"Hysteroscopic management of asherman\u2019s syndrome","volume":"25","author":"Khan","year":"2018","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/humrep\/dew042","article-title":"Autologous cell therapy with cd133+ bone marrow-derived stem cells for refractory asherman\u2019s syndrome and endometrial atrophy: A pilot cohort study","volume":"31","author":"Santamaria","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/humrep\/dem342","article-title":"Endometrial endothelial cells are derived from donor stem cells in a bone marrow transplant recipient","volume":"23","author":"Mints","year":"2008","journal-title":"Hum. Reprod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.292.1.81","article-title":"Endometrial cells derived from donor stem cells in bone marrow transplant recipients","volume":"292","author":"Taylor","year":"2004","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Strug, M., and Aghajanova, L. (2021). Making more womb: Clinical perspectives supporting the development and utilization of mesenchymal stem cell therapy for endometrial regeneration and infertility. J. Pers. Med., 11.","DOI":"10.3390\/jpm11121364"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1902\/jop.2007.060302","article-title":"Platelet-rich plasma: Growth factors and pro- and anti-inflammatory properties","volume":"78","author":"Kantarci","year":"2007","journal-title":"J. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0765.2009.01205.x","article-title":"Epidermal growth factor released from platelet-rich plasma promotes endothelial cell proliferation in vitro","volume":"45","author":"Grenier","year":"2010","journal-title":"J. Periodontal Res."},{"key":"ref_11","first-page":"1221","article-title":"The growth receptors and their role in wound healing","volume":"11","author":"Rolfe","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e25611","DOI":"10.1097\/MD.0000000000025611","article-title":"Clinical efficacy and acceptability of panretinal photocoagulation combined with conbercept for patients with proliferative diabetic retinopathy: A protocol for systematic review and meta-analysis","volume":"100","author":"Wang","year":"2021","journal-title":"Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"tkab016","DOI":"10.1093\/burnst\/tkab016","article-title":"Combination of ablative fractional carbon dioxide laser and platelet-rich plasma treatment to improve hypertrophic scars: A retrospective clinical observational study","volume":"9","author":"Dai","year":"2021","journal-title":"Burn. Trauma"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.arthro.2017.06.039","article-title":"Does platelet-rich plasma lead to earlier return to sport when compared with conservative treatment in acute muscle injuries? A systematic review and meta-analysis","volume":"34","author":"Sheth","year":"2018","journal-title":"Arthrosc. J. Arthrosc. Relat. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Boztug, C.Y., Karaagac Akyol, T., Benlice, C., Koc, M.A., Doganay Erdogan, B., Ozcebe, O.I., Kuzu, M.A., and Akyol, C. (2021). Platelet-rich plasma treatment improves postoperative recovery in patients with pilonidal sinus disease: A randomized controlled clinical trial. BMC Surg., 21.","DOI":"10.1186\/s12893-021-01370-5"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s13304-020-00828-0","article-title":"Intrauterine infusion of platelet-rich plasma for severe asherman syndrome: A cutting-edge approach","volume":"73","author":"Vitale","year":"2021","journal-title":"Updates Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s10815-018-1135-3","article-title":"Platelet-rich plasma in the management of asherman syndrome: Case report","volume":"35","author":"Aghajanova","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_18","first-page":"443","article-title":"Effects of autologous platelet-rich plasma on endometrial expansion in patie.ents undergoing frozen-thawed embryo transfer: A double-blind rct","volume":"17","author":"Nazari","year":"2019","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e14062","DOI":"10.1097\/MD.0000000000014062","article-title":"Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium","volume":"98","author":"Chang","year":"2019","journal-title":"Medicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e12597","DOI":"10.1111\/cpr.12597","article-title":"Single cell-derived clonally expanded mesenchymal progenitor cells from somatic cell nuclear transfer-derived pluripotent stem cells ameliorate the endometrial function in the uterus of a murine model with asherman\u2019s syndrome","volume":"52","author":"Jun","year":"2019","journal-title":"Cell Prolif."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Alawadhi, F., Du, H., Cakmak, H., and Taylor, H.S. (2014). Bone marrow-derived stem cell (bmdsc) transplantation improves fertility in a murine model of asherman\u2019s syndrome. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096662"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.ymthe.2020.05.015","article-title":"Perivascular stem cell-derived cyclophilin a improves uterine environment with asherman\u2019s syndrome via hif1\u03b1-dependent angiogenesis","volume":"28","author":"Park","year":"2020","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.1002\/jcb.28014","article-title":"Investigation of platelet-rich plasma in increasing proliferation and migration of endometrial mesenchymal stem cells and improving pregnancy outcome of patients with thin endometrium","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2144\/000114535","article-title":"Imagej macros for the user-friendly analysis of soft-agar and wound-healing assays","volume":"62","author":"Nunes","year":"2017","journal-title":"BioTechniques"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mce.2003.11.011","article-title":"Acth induces timp-1 expression and inhibits collagenase in adrenal cortex cells","volume":"215","author":"Reichenstein","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"Tgf-\u03b2\/smad pathway and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J. Histochem. Cytochem. Off. J. Histochem. Soc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1073\/pnas.1507387112","article-title":"Tnf-alpha-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation","volume":"112","author":"Pilling","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1242\/dev.129.12.2879","article-title":"Cytosolic phospholipase a2alpha is crucial [correction of a2alpha deficiency is crucial] for \u2018on-time\u2019 embryo implantation that directs subsequent development","volume":"129","author":"Song","year":"2002","journal-title":"Development"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"588","DOI":"10.2183\/pjab.86.588","article-title":"The discovery of hepatocyte growth factor (hgf) and its significance for cell biology, life sciences and clinical medicine","volume":"86","author":"Nakamura","year":"2010","journal-title":"Proc. Jpn. Acad. Ser. B."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Gan, Q.F., Lim, Y.T., Foo, C.N., Yu, C.W., Woon, C.K., Cheong, S.K., and Leong, P.P. (2022). Incorporating insulin growth factor-1 into regenerative and personalized medicine for cardiovascular disease: A systematic review. Curr. Stem Cell Res. Ther.","DOI":"10.2174\/1574888X17666220407085901"},{"key":"ref_31","first-page":"387","article-title":"Angiopoietin-1\/tie2 receptor signaling in vascular quiescence and angiogenesis","volume":"25","author":"Fukuhara","year":"2010","journal-title":"Histol. Histopathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3109\/09537104.2012.684730","article-title":"The role of platelet-rich plasma in tissue regeneration","volume":"24","author":"Alsousou","year":"2013","journal-title":"Platelets"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fphys.2020.00105","article-title":"Intrauterine infusion of human platelet-rich plasma improves endometrial regeneration and pregnancy outcomes in a murine model of asherman\u2019s syndrome","volume":"11","author":"Kim","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_34","first-page":"1286","article-title":"Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization","volume":"8","author":"Chang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5935\/1518-0557.20170013","article-title":"Treatment of thin endometrium with autologous platelet-rich plasma: A pilot study","volume":"21","author":"Zadehmodarres","year":"2017","journal-title":"JBRA Assist. Reprod."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.tjog.2018.10.007","article-title":"Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial","volume":"57","author":"Eftekhar","year":"2018","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13287-019-1155-7","article-title":"Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion","volume":"10","author":"Zhang","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3349\/ymj.2017.58.6.1195","article-title":"Effects of autologous platelet-rich plasma on regeneration of damaged endometrium in female rats","volume":"58","author":"Jang","year":"2017","journal-title":"Yonsei Med. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.21037\/apm-21-450","article-title":"A narrative review of research progress on the relationship between hypoxia-inducible factor-2\u03b1 and wound angiogenesis","volume":"10","author":"Xu","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1210\/jc.2004-1918","article-title":"Regulation of proliferation, motility, and contractility of human endometrial stromal cells by platelet-derived growth factor","volume":"90","author":"Matsumoto","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11154-012-9221-9","article-title":"Endometrial regeneration and endometrial stem\/progenitor cells","volume":"13","author":"Gargett","year":"2012","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_42","first-page":"215","article-title":"Catch it before it kills: Progesterone, obesity, and the prevention of endometrial cancer","volume":"14","author":"Carlson","year":"2012","journal-title":"Discov. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mce.2008.02.026","article-title":"Hormone and growth factor signaling in endometrial renewal: Role of stem\/progenitor cells","volume":"288","author":"Gargett","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_44","first-page":"1184","article-title":"Estrogen induces egr1 to fine-tune its actions on uterine epithelium by controlling pr signaling for successful embryo implantation","volume":"32","author":"Kim","year":"2018","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1056\/NEJM199906103402304","article-title":"Time of implantation of the conceptus and loss of pregnancy","volume":"340","author":"Wilcox","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.rbmo.2010.11.018","article-title":"Management of asherman\u2019s syndrome","volume":"23","author":"March","year":"2011","journal-title":"Reprod. Biomed. Online"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e11797","DOI":"10.1097\/MD.0000000000011797","article-title":"The birth weight in pregnant women with asherman syndrome compared to normal intrauterine cavity: A case-control study","volume":"97","author":"Baradwan","year":"2018","journal-title":"Medicine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fendo.2019.00061","article-title":"Effect of autologous platelet-rich plasma treatment on refractory thin endometrium during the frozen embryo transfer cycle: A pilot study","volume":"10","author":"Kim","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/rmb2.12334","article-title":"Intrauterine administration of platelet-rich plasma improves embryo implantation by increasing the endometrial thickness in women with repeated implantation failure: A single-arm self-controlled trial","volume":"19","author":"Kusumi","year":"2020","journal-title":"Reprod. Med. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5935\/1518-0557.20210037","article-title":"Autologous platelet-rich plasma optimizes endometrial thickness and pregnancy outcomes in women with refractory thin endometrium of varied aetiology during fresh and frozen-thawed embryo transfer cycles","volume":"26","author":"Dogra","year":"2022","journal-title":"JBRA Assist. Reprod."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/plac.2000.0588","article-title":"Angiogenesis during implantation, and placental and early embryonic development","volume":"22","author":"Sherer","year":"2001","journal-title":"Placenta"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41467-017-02375-6","article-title":"Hypoxia and hypoxia inducible factor-1\u03b1 are required for normal endometrial repair during menstruation","volume":"9","author":"Maybin","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Guo, X., Yi, H., Li, T.C., Wang, Y., Wang, H., and Chen, X. (2021). Role of vascular endothelial growth factor (vegf) in human embryo implantation: Clinical implications. Biomolecules, 11.","DOI":"10.3390\/biom11020253"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/biolre\/ioy205","article-title":"Intentional endometrial injury increases embryo implantation potentials through enhanced endometrial angiogenesis","volume":"100","author":"Yang","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/humrep\/den296","article-title":"Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions","volume":"24","author":"Plaisier","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s10815-018-1130-8","article-title":"In vitro evidence that platelet-rich plasma stimulates cellular processes involved in endometrial regeneration","volume":"35","author":"Aghajanova","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1093\/humrep\/dew235","article-title":"Autologous menstrual blood-derived stromal cells transplantation for severe asherman\u2019s syndrome","volume":"31","author":"Tan","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1242\/jcs.203687","article-title":"E-cadherin cleavage by mt2-mmp regulates apical junctional signaling and epithelial homeostasis in the intestine","volume":"130","author":"Moreno","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1101\/gad.1451806","article-title":"A cancer cell metalloprotease triad regulates the basement membrane transmigration program","volume":"20","author":"Hotary","year":"2006","journal-title":"Genes Dev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ccr.2008.11.012","article-title":"Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche","volume":"15","author":"Erler","year":"2009","journal-title":"Cancer Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/en.2018-00272","article-title":"Hif2a-lox pathway promotes fibrotic tissue remodeling in thyroid-associated orbitopathy","volume":"160","author":"Hikage","year":"2019","journal-title":"Endocrinology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/mc.20678","article-title":"Transcriptional upregulation of mt2-mmp in response to hypoxia is promoted by hif-1\u03b1 in cancer cells","volume":"50","author":"Zhu","year":"2011","journal-title":"Mol. Carcinog."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"FSO453","DOI":"10.2144\/fsoa-2019-0147","article-title":"Higher adrenomedullin levels during implantation are associated with successful pregnancy","volume":"6","author":"Karli","year":"2020","journal-title":"Future Sci. OA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1172\/JCI98931","article-title":"Hif2alpha in the uterine stroma permits embryo invasion and luminal epithelium detachment","volume":"128","author":"Matsumoto","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"15523","DOI":"10.1038\/s41598-020-72640-0","article-title":"Differential roles of uterine epithelial and stromal stat3 coordinate uterine receptivity and embryo attachment","volume":"10","author":"Hiraoka","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Choi, Y., Kim, H.R., Lim, E.J., Park, M., Yoon, J.A., Kim, Y.S., Kim, E.K., Shin, J.E., Kim, J.H., and Kwon, H. (2016). Integrative analyses of uterine transcriptome and micrornaome reveal compromised lif-stat3 signaling and progesterone response in the endometrium of patients with recurrent\/repeated implantation failure (rif). PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157696"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e87591","DOI":"10.1172\/jci.insight.87591","article-title":"Stat3 accelerates uterine epithelial regeneration in a mouse model of decellularized uterine matrix transplantation","volume":"1","author":"Hiraoka","year":"2016","journal-title":"JCI Insight"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/9\/1549\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:06:16Z","timestamp":1760137576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/9\/1549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":67,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["cells11091549"],"URL":"https:\/\/doi.org\/10.3390\/cells11091549","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,5]]}}}