{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:45:48Z","timestamp":1793447148119,"version":"4.5.0"},"reference-count":330,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004166","name":"Publishing Fund of the Medical University of Warsaw","doi-asserted-by":"publisher","award":["1MA\/N\/2022"],"award-info":[{"award-number":["1MA\/N\/2022"]}],"id":[{"id":"10.13039\/501100004166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Despite the significant decline in mortality, cardiovascular diseases are still the leading cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most important. A further decline in the death rate may be achieved by the introduction of molecularly targeted drugs. It seems that the components of the PI3K\/Akt signaling pathway are good candidates for this. The PI3K\/Akt pathway plays a key role in the regulation of the growth and survival of cells, such as cardiomyocytes. In addition, it has been shown that the activation of the PI3K\/Akt pathway results in the alleviation of the negative post-infarct changes in the myocardium and is impaired in the state of diabetes. In this article, the role of this pathway was described in each step of ischemia and subsequent left ventricular remodeling. In addition, we point out the most promising substances which need more investigation before introduction into clinical practice. Moreover, we present the impact of diabetes and widely used cardiac and antidiabetic drugs on the PI3K\/Akt pathway and discuss the molecular mechanism of its effects on myocardial ischemia and left ventricular remodeling.<\/jats:p>","DOI":"10.3390\/cells11091553","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T13:10:26Z","timestamp":1651756226000},"page":"1553","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Insight into the Role of the PI3K\/Akt Pathway in Ischemic Injury and Post-Infarct Left Ventricular Remodeling in Normal and Diabetic Heart"],"prefix":"10.3390","volume":"11","author":[{"given":"Bartosz","family":"Walkowski","sequence":"first","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1562-8450","authenticated-orcid":false,"given":"Marcin","family":"Kleibert","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8305-7779","authenticated-orcid":false,"given":"Mi\u0142osz","family":"Majka","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-1171","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Wojciechowska","sequence":"additional","affiliation":[{"name":"Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"},{"name":"Invasive Cardiology Unit, Independent Public Specialist Western Hospital John Paul II, Daleka 11, 05-825 Grodzisk Mazowiecki, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.12688\/f1000research.15096.1","article-title":"Understanding myocardial infarction","volume":"7","author":"Saleh","year":"2018","journal-title":"F1000Research"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.disamonth.2012.12.004","article-title":"Acute myocardial infarction","volume":"59","author":"Boateng","year":"2013","journal-title":"Dis. Mon."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4330\/wjc.v7.i5.243","article-title":"Recent advances in the diagnosis and treatment of acute myocardial infarction","volume":"7","author":"Reddy","year":"2015","journal-title":"World J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMra1606915","article-title":"Acute Myocardial Infarction","volume":"376","author":"Anderson","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/cvr\/cvz197","article-title":"Statistics on mortality following acute myocardial infarction in 842 897 Europeans","volume":"116","author":"Alabas","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s12013-015-0553-4","article-title":"Myocardial Infarction: Symptoms and Treatments","volume":"72","author":"Lu","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/01.CIR.97.7.645","article-title":"Induction of neoangiogenesis in ischemic myocardium by human growth factors: First clinical results of a new treatment of coronary heart disease","volume":"97","author":"Schumacher","year":"1998","journal-title":"Circulation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jacc.2008.08.067","article-title":"Declining in-hospital mortality and increasing heart failure incidence in elderly patients with first myocardial infarction","volume":"53","author":"Ezekowitz","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3389\/fphar.2020.01231","article-title":"Economic Costs of Cardiovascular Diseases in Poland Estimates for 2015\u20132017 Years","volume":"11","author":"Mela","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"664457","DOI":"10.3389\/fimmu.2021.664457","article-title":"Cells of the Immune System in Cardiac Remodeling: Main Players in Resolution of Inflammation and Repair after Myocardial Infarction","volume":"12","author":"Kologrivova","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCRESAHA.118.312017","article-title":"Metabolic Coordination of Physiological and Pathological Cardiac Remodeling","volume":"123","author":"Gibb","year":"2018","journal-title":"Circ. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Bellis, A., Di Gioia, G., Mauro, C., Mancusi, C., Barbato, E., Izzo, R., Trimarco, B., and Morisco, C. (2021). Reducing Cardiac Injury during ST-Elevation Myocardial Infarction: A Reasoned Approach to a Multitarget Therapeutic Strategy. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132968"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"Collet","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling\u2014Concepts and clinical implications: A consensus paper from an international forum on cardiac remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S452","DOI":"10.1054\/jcaf.2002.129286","article-title":"Noninvasive assessment of left ventricular remodeling: Concepts, techniques, and implications for clinical trials","volume":"8","author":"Anand","year":"2002","journal-title":"J. Card Fail."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Han, B., Trew, M.L., and Zgierski-Johnston, C.M. (2021). Cardiac Conduction Velocity, Remodeling and Arrhythmogenesis. Cells, 10.","DOI":"10.3390\/cells10112923"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jchf.2017.09.015","article-title":"Post-Myocardial Infarction Heart Failure","volume":"6","author":"Bahit","year":"2018","journal-title":"JACC Heart Fail."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ehf2.13144","article-title":"Heart failure after myocardial infarction: Incidence and predictors","volume":"8","author":"Stehlik","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/332644a0","article-title":"Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate","volume":"332","author":"Whitman","year":"1988","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1073\/pnas.84.14.5034","article-title":"Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma","volume":"84","author":"Staal","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","first-page":"169","article-title":"Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase","volume":"13","author":"Bi","year":"2002","journal-title":"Mamm. Genome"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1128\/MCB.01786-07","article-title":"Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase","volume":"28","author":"Marques","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.7150\/ijbs.27173","article-title":"The PI3K\/AKT pathway in obesity and type 2 diabetes","volume":"14","author":"Huang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s12640-019-0003-y","article-title":"The Role of PI3K\/Akt and ERK in Neurodegenerative Disorders","volume":"35","author":"Rai","year":"2019","journal-title":"Neurotox. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.yexcr.2019.05.003","article-title":"Thyroid hormone protects cardiomyocytes from H(2)O(2)-induced oxidative stress via the PI3K-AKT signaling pathway","volume":"380","author":"Zeng","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K Pathway in Human Disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jgg.2015.03.003","article-title":"The PI3K\/AKT Pathway and Renal Cell Carcinoma","volume":"42","author":"Guo","year":"2015","journal-title":"J. Genet. Genom."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrm2882","article-title":"The emerging mechanisms of isoform-specific PI3K signalling","volume":"11","author":"Vanhaesebroeck","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","article-title":"The phosphoinositide 3-kinase pathway","volume":"296","author":"Cantley","year":"2002","journal-title":"Science"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1021\/cr000091i","article-title":"Phosphoinositide-regulated kinases and phosphoinositide phosphatases","volume":"101","author":"Leslie","year":"2001","journal-title":"Chem. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0960-9822(06)00122-9","article-title":"Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B\u03b1","volume":"7","author":"Alessi","year":"1997","journal-title":"Curr. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.1106148","article-title":"Phosphorylation and regulation of Akt\/PKB by the rictor-mTOR complex","volume":"307","author":"Sarbassov","year":"2005","journal-title":"Science"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.celrep.2015.03.010","article-title":"mTORC2 regulates cardiac response to stress by inhibiting MST1","volume":"11","author":"Sciarretta","year":"2015","journal-title":"Cell Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"41189","DOI":"10.1074\/jbc.M406731200","article-title":"Identification of a PKB\/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase","volume":"279","author":"Feng","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0968-0004(01)01958-2","article-title":"Ten years of protein kinase B signalling: A hard Akt to follow","volume":"26","author":"Brazil","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4161\/cbt.3.3.703","article-title":"A portrait of AKT kinases: Human cancer and animal models depict a family with strong individualities","volume":"3","author":"Bellacosa","year":"2004","journal-title":"Cancer Biol. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"17072","DOI":"10.1038\/cddiscovery.2017.72","article-title":"Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells","volume":"3","author":"Toulany","year":"2017","journal-title":"Cell Death Discov."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/CIRCRESAHA.112.300735","article-title":"AKT2 confers protection against aortic aneurysms and dissections","volume":"112","author":"Shen","year":"2013","journal-title":"Circ. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12865","DOI":"10.1073\/pnas.1408472111","article-title":"Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates","volume":"111","author":"Lee","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1200\/JCO.2004.02.141","article-title":"The biology and clinical relevance of the PTEN tumor suppressor pathway","volume":"22","author":"Sansal","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41580-018-0015-0","article-title":"The functions and regulation of the PTEN tumour suppressor: New modes and prospects","volume":"19","author":"Lee","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12943-019-0954-x","article-title":"Targeting PI3K in cancer: Mechanisms and advances in clinical trials","volume":"18","author":"Yang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_45","first-page":"6141","article-title":"Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells","volume":"62","author":"Grunwald","year":"2002","journal-title":"Cancer Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1038\/onc.2008.247","article-title":"The PTEN-PI3K pathway: Of feedbacks and cross-talks","volume":"27","author":"Carracedo","year":"2008","journal-title":"Oncogene"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/jcp.55.11.801","article-title":"Apoptosis in myocardial ischaemia and infarction","volume":"55","author":"Krijnen","year":"2002","journal-title":"J. Clin. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1038\/cddis.2011.130","article-title":"Cardiomyocyte death: Mechanisms and translational implications","volume":"2","author":"Chiong","year":"2011","journal-title":"Cell Death Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: Process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrm3737","article-title":"Regulated necrosis: The expanding network of non-apoptotic cell death pathways","volume":"15","author":"Linkermann","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nrd.2015.6","article-title":"Regulated necrosis: Disease relevance and therapeutic opportunities","volume":"15","author":"Conrad","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1042\/BCJ20170703","article-title":"High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2","volume":"475","author":"Durham","year":"2018","journal-title":"Biochem. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"H105","DOI":"10.1152\/ajpheart.00298.2011","article-title":"Membrane depolarization is the trigger for PI3K\/Akt activation and leads to the generation of ROS","volume":"302","author":"Chatterjee","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.bbabio.2006.06.014","article-title":"Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response","volume":"1757","author":"Festjens","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1046\/j.1471-4159.2003.02113.x","article-title":"Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation","volume":"87","author":"Bijur","year":"2003","journal-title":"J. Neurochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"36027","DOI":"10.1074\/jbc.M304854200","article-title":"Production of reactive oxygen species by mitochondria: Central role of complex III","volume":"278","author":"Chen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1161\/01.RES.59.6.612","article-title":"PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH","volume":"59","author":"Kukreja","year":"1986","journal-title":"Circ. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.freeradbiomed.2016.06.014","article-title":"2-Oxoglutarate dehydrogenase is a more significant source of O2\u2212\/H2O2 than pyruvate dehydrogenase in cardiac and liver tissue","volume":"97","author":"Mailloux","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s00395-011-0199-3","article-title":"Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K\/Akt, p38 MAPK and ERK pathways","volume":"106","author":"Cao","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1254\/jphs.13247FP","article-title":"Cardioprotective effect of protocatechuic acid on myocardial ischemia\/reperfusion injury","volume":"125","author":"Tang","year":"2014","journal-title":"J. Pharmacol. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/BJ20081056","article-title":"The life of a cell: Apoptosis regulation by the PI3K\/PKB pathway","volume":"415","author":"Duronio","year":"2008","journal-title":"Biochem. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB signaling: Navigating downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s10020-020-00241-8","article-title":"PTEN inhibitor improves vascular remodeling and cardiac function after myocardial infarction through PI3k\/Akt\/VEGF signaling pathway","volume":"26","author":"Feng","year":"2020","journal-title":"Mol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"585984","DOI":"10.3389\/fphar.2020.585984","article-title":"Grape Seed Proanthocyanidin Extract Ameliorates Cardiac Remodelling after Myocardial Infarction Through PI3K\/AKT Pathway in Mice","volume":"11","author":"Ruan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1128\/MCB.21.3.893-901.2001","article-title":"Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1","volume":"21","author":"Kim","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev.pharmtox.48.113006.094606","article-title":"Apoptosis signal-regulating kinase 1 in stress and immune response","volume":"48","author":"Takeda","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"9993","DOI":"10.1523\/JNEUROSCI.2057-04.2004","article-title":"Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis","volume":"24","author":"Linseman","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0960-9822(98)70302-1","article-title":"The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136","volume":"8","author":"Janknecht","year":"1998","journal-title":"Curr. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"28004","DOI":"10.1074\/jbc.M109.010702","article-title":"Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: Pore-forming activity of BAD is regulated by phosphorylation","volume":"284","author":"Polzien","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0896-6273(03)00355-6","article-title":"JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis","volume":"38","author":"Putcha","year":"2003","journal-title":"Neuron"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Kotrasova, V., Keresztesova, B., Ondrovicova, G., Bauer, J.A., Havalova, H., Pevala, V., Kutejova, E., and Kunova, N. (2021). Mitochondrial Kinases and the Role of Mitochondrial Protein Phosphorylation in Health and Disease. Life, 11.","DOI":"10.3390\/life11020082"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.yjmcc.2004.05.025","article-title":"Statins inhibit reoxygenation-induced cardiomyocyte apoptosis: Role for glycogen synthase kinase 3beta and transcription factor beta-catenin","volume":"37","author":"Bergmann","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1161\/CIRCRESAHA.111.249532","article-title":"Differential roles of GSK-3beta during myocardial ischemia and ischemia\/reperfusion","volume":"109","author":"Zhai","year":"2011","journal-title":"Circ. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1158\/0008-5472.CAN-16-2356","article-title":"Modulation of Bax and mTOR for Cancer Therapeutics","volume":"77","author":"Li","year":"2017","journal-title":"Cancer Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e45235","DOI":"10.15252\/embr.201745235","article-title":"Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance","volume":"19","author":"Kale","year":"2018","journal-title":"EMBO Rep."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Nagaoka, K., Matoba, T., Mao, Y., Nakano, Y., Ikeda, G., Egusa, S., Tokutome, M., Nagahama, R., Nakano, K., and Sunagawa, K. (2015). A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K\/Akt Pathway and Anti-Inflammation in a Rat Model. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132451"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cbin.10236","article-title":"Simvastatin promotes cardiac microvascular endothelial cells proliferation, migration and survival by phosphorylation of p70 S6K and FoxO3a","volume":"38","author":"Pan","year":"2014","journal-title":"Cell Biol. Int."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3892\/etm.2021.10516","article-title":"Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K\/Akt pathway","volume":"22","author":"Zhan","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-018-3276-1","article-title":"Eplerenone pretreatment protects the myocardium against ischaemia\/reperfusion injury through the phosphatidylinositol 3-kinase\/Akt-dependent pathway in diabetic rats","volume":"446","author":"Mahajan","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/fcp.12562","article-title":"Bisoprolol, a \u03b2(1) antagonist, protects myocardial cells from ischemia-reperfusion injury via PI3K\/AKT\/GSK3\u03b2 pathway","volume":"34","author":"Wang","year":"2020","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/1440-1681.13535","article-title":"Rosuvastatin and low-dose carvedilol combination protects against isoprenaline-induced myocardial infarction in rats: Role of PI3K\/Akt\/Nrf2\/HO-1 signalling","volume":"48","author":"Baraka","year":"2021","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijcard.2011.03.033","article-title":"Upregulation of heme oxygenase-1 expression by hydroxysafflor yellow A conferring protection from anoxia\/reoxygenation-induced apoptosis in H9c2 cardiomyocytes","volume":"160","author":"Liu","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1440-1681.2007.04814.x","article-title":"Evidence that hydroxysafflor yellow A protects the heart against ischaemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening","volume":"35","author":"Liu","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/FJC.0b013e318181fb02","article-title":"Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2\/Bax","volume":"52","author":"Ji","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000438622","article-title":"Atorvastatin Inhibits Myocardial Apoptosis in a Swine Model of Coronary Microembolization by Regulating PTEN\/PI3K\/Akt Signaling Pathway","volume":"38","author":"Wang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-386039-2.00001-8","article-title":"Programmed necrosis from molecules to health and disease","volume":"289","author":"Galluzzi","year":"2011","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12929-021-00722-w","article-title":"Targeting necroptosis as therapeutic potential in chronic myocardial infarction","volume":"28","author":"Piamsiri","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","article-title":"Myocardial ischaemia-reperfusion injury and cardioprotection in perspective","volume":"17","author":"Heusch","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00018-010-0283-0","article-title":"Tumor necrosis factor-mediated cell death: To break or to burst, that\u2019s the question","volume":"67","author":"Festjens","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/cr.2011.3","article-title":"Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes","volume":"21","author":"Zhang","year":"2011","journal-title":"Cell Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat. Cell. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"155046","DOI":"10.1016\/j.cyto.2020.155046","article-title":"PI3K mediates tumor necrosis factor induced-necroptosis through initiating RIP1-RIP3-MLKL signaling pathway activation","volume":"129","author":"Hu","year":"2020","journal-title":"Cytokine"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.trim.2016.05.001","article-title":"Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion","volume":"37","author":"Tuuminen","year":"2016","journal-title":"Transpl. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"710963","DOI":"10.3389\/fcvm.2021.710963","article-title":"The Link Between Ferroptosis and Cardiovascular Diseases: A Novel Target for Treatment","volume":"8","author":"Hu","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.7150\/thno.54113","article-title":"Ferroptosis as a novel therapeutic target for cardiovascular disease","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"9929687","DOI":"10.1155\/2021\/9929687","article-title":"Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury","volume":"2021","author":"Zhao","year":"2021","journal-title":"Oxid Med. Cell Longev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1186\/s12935-021-02264-5","article-title":"Roles of ferroptosis in urologic malignancies","volume":"21","author":"Zhao","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/21655979.2021.2004980","article-title":"Lapatinib induces mitochondrial dysfunction to enhance oxidative stress and ferroptosis in doxorubicin-induced cardiomyocytes via inhibition of PI3K\/AKT signaling pathway","volume":"13","author":"Sun","year":"2022","journal-title":"Bioengineered"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.ctrv.2015.08.001","article-title":"Mechanisms of lapatinib resistance in HER2-driven breast cancer","volume":"41","author":"Raimondo","year":"2015","journal-title":"Cancer Treat. Rev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1021\/mp400687w","article-title":"Doxorubicin and lapatinib combination nanomedicine for treating resistant breast cancer","volume":"11","author":"Wang","year":"2014","journal-title":"Mol. Pharm."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2019.02.013","article-title":"Oxidative stress injury in doxorubicin-induced cardiotoxicity","volume":"307","author":"Mei","year":"2019","journal-title":"Toxicol. Lett."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1177\/0960327113512342","article-title":"Oxidative stress on cardiotoxicity after treatment with single and multiple doses of doxorubicin","volume":"33","author":"Segredo","year":"2014","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"31189","DOI":"10.1073\/pnas.2017152117","article-title":"Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis","volume":"117","author":"Yi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1111\/jcmm.16318","article-title":"Dysregulation of ferroptosis may involve in the development of non-small-cell lung cancer in Xuanwei area","volume":"25","author":"Li","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"817819","DOI":"10.3389\/fcell.2022.817819","article-title":"Ferroptosis Related Genes in Ischemic and Idiopathic Cardiomyopathy: Screening for Potential Pharmacological Targets","volume":"10","author":"Jiang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: Mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/jcmm.15953","article-title":"Piperine protects against pyroptosis in myocardial ischaemia\/reperfusion injury by regulating the miR-383\/RP105\/AKT signalling pathway","volume":"25","author":"Guo","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41419-021-04143-3","article-title":"Pyroptosis inhibition improves the symptom of acute myocardial infarction","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10557-018-6781-2","article-title":"The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway","volume":"32","author":"Arjun","year":"2018","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijcard.2016.01.100","article-title":"RP105-PI3K-Akt axis: A potential therapeutic approach for ameliorating myocardial ischemia\/reperfusion injury","volume":"206","author":"Guo","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.12659\/MSM.916361","article-title":"Inhibition of microRNA-141-3p Reduces Hypoxia-Induced Apoptosis in H9c2 Rat Cardiomyocytes by Activating the RP105-Dependent PI3K\/AKT Signaling Pathway","volume":"25","author":"Qin","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"105910","DOI":"10.1016\/j.intimp.2019.105910","article-title":"SH2B1 protects cardiomyocytes from ischemia\/reperfusion injury via the activation of the PI3K\/AKT pathway","volume":"83","author":"Guo","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/physrev.00009.2003","article-title":"Preconditioning the myocardium: From cellular physiology to clinical cardiology","volume":"83","author":"Yellon","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/ncpcardio0047","article-title":"Ischemic preconditioning and preinfarction angina in the clinical arena","volume":"1","author":"Rezkalla","year":"2004","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pharmthera.2007.06.005","article-title":"Preconditioning and postconditioning: United at reperfusion","volume":"116","author":"Hausenloy","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/labinvest.2015.64","article-title":"Cardioprotection by PI3K-mediated signaling is required for anti-arrhythmia and myocardial repair in response to ischemic preconditioning in infarcted pig hearts","volume":"95","author":"Su","year":"2015","journal-title":"Lab. Investig."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/jcmm.13394","article-title":"Role of PI3K in myocardial ischaemic preconditioning: Mapping pro-survival cascades at the trigger phase and at reperfusion","volume":"22","author":"Rossello","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00395-012-0277-1","article-title":"Remote ischemic preconditioning confers late protection against myocardial ischemia-reperfusion injury in mice by upregulating interleukin-10","volume":"107","author":"Cai","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10557-010-6236-x","article-title":"Mechanism of cardioprotection by early ischemic preconditioning","volume":"24","author":"Yang","year":"2010","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s00395-014-0452-7","article-title":"Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning","volume":"110","author":"Barsukevich","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"ref_126","first-page":"4565630","article-title":"Remote Ischemic Postconditioning Protects against Myocardial Ischemia-Reperfusion Injury by Inhibition of the RAGE-HMGB1 Pathway","volume":"2018","author":"Wang","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_127","first-page":"15801","article-title":"Myocardial ischemic post-conditioning attenuates ischemia reperfusion injury via PTEN\/Akt signal pathway","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Milano, G., Abruzzo, P.M., Bolotta, A., Marini, M., Terraneo, L., Ravara, B., Gorza, L., Vitadello, M., Burattini, S., and Curzi, D. (2013). Impact of the phosphatidylinositide 3-kinase signaling pathway on the cardioprotection induced by intermittent hypoxia. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076659"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/cbf.3578","article-title":"Ischaemic preconditioning-induced serum exosomes protect against myocardial ischaemia\/reperfusion injury in rats by activating the PI3K\/AKT signalling pathway","volume":"39","author":"Zhang","year":"2020","journal-title":"Cell Biochem. Funct."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00395-021-00856-w","article-title":"Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles","volume":"116","author":"Lassen","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"250867","DOI":"10.1155\/2012\/250867","article-title":"Value of C-reactive protein in predicting left ventricular remodelling in patients with a first ST-segment elevation myocardial infarction","volume":"2012","author":"Swiatkiewicz","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/01.CIR.0000036014.90197.FA","article-title":"Left ventricular remodeling after primary coronary angioplasty: Patterns of left ventricular dilation and long-term prognostic implications","volume":"106","author":"Bolognese","year":"2002","journal-title":"Circulation"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11886-017-0876-4","article-title":"Adverse Remodeling and Reverse Remodeling After Myocardial Infarction","volume":"19","author":"Bhatt","year":"2017","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications","volume":"81","author":"Pfeffer","year":"1990","journal-title":"Circulation"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jcmg.2015.03.007","article-title":"Pathophysiology of LV Remodeling in Survivors of STEMI: Inflammation, Remote Myocardium, and Prognosis","volume":"8","author":"Carrick","year":"2015","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10741-019-09770-9","article-title":"The relevance of microRNA in post-infarction left ventricular remodelling and heart failure","volume":"24","author":"Dutka","year":"2019","journal-title":"Heart Fail. Rev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.jacc.2016.01.069","article-title":"Relationship Between Infarct Size and Outcomes Following Primary PCI: Patient-Level Analysis From 10 Randomized Trials","volume":"67","author":"Stone","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"529075","DOI":"10.3389\/fphys.2020.529075","article-title":"The Dynamic Interplay Between Cardiac Inflammation and Fibrosis","volume":"11","author":"Thomas","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.amjcard.2006.06.011","article-title":"Left ventricular remodeling after anterior wall acute myocardial infarction in modern clinical practice (from the REmodelage VEntriculaire [REVE] study group)","volume":"98","author":"Savoye","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/eurheartj\/ehn529","article-title":"Incidence, determinants, and prognostic value of reverse left ventricular remodelling after primary percutaneous coronary intervention: Results of the Acute Myocardial Infarction Contrast Imaging (AMICI) multicenter study","volume":"30","author":"Funaro","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"10535","DOI":"10.1002\/jcp.27717","article-title":"Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K\/Akt signaling pathway in rats with acute myocardial infarction","volume":"234","author":"Meng","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.yjmcc.2021.04.004","article-title":"Pharmacological and cell-specific genetic PI3Kalpha inhibition worsens cardiac remodeling after myocardial infarction","volume":"157","author":"Chen","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/CIRCRESAHA.111.243162","article-title":"Regulation of the inflammatory response in cardiac repair","volume":"110","author":"Frangogiannis","year":"2012","journal-title":"Circ. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","article-title":"Inflammatory cytokines and postmyocardial infarction remodeling","volume":"94","author":"Nian","year":"2004","journal-title":"Circ. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"H1795","DOI":"10.1152\/ajpheart.00001.2010","article-title":"Increased C-reactive protein expression exacerbates left ventricular dysfunction and remodeling after myocardial infarction","volume":"299","author":"Takahashi","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jacc.2005.10.055","article-title":"Early inflammation and risk of long-term development of heart failure and mortality in survivors of acute myocardial infarction predictive role of C-reactive protein","volume":"47","author":"Suleiman","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Swiatkiewicz, I., Magielski, P., Kubica, J., Zadourian, A., DeMaria, A.N., and Taub, P.R. (2020). Enhanced Inflammation is a Marker for Risk of Post-Infarct Ventricular Dysfunction and Heart Failure. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030807"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Swiatkiewicz, I., Magielski, P., and Kubica, J. (2021). C-Reactive Protein as a Risk Marker for Post-Infarct Heart Failure over a Multi-Year Period. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063169"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.jacc.2016.01.073","article-title":"Inflammation as a Driver of Adverse Left Ventricular Remodeling After Acute Myocardial Infarction","volume":"67","author":"Westman","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-Reactive Protein at Sites of Inflammation and Infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3892\/etm.2020.8840","article-title":"C-reactive protein and cardiovascular disease: From animal studies to the clinic (Review)","volume":"20","author":"Fu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1093\/eurheartj\/ehq238","article-title":"C-reactive protein is a mediator of cardiovascular disease","volume":"31","author":"Bisoendial","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bbrc.2011.06.016","article-title":"C-reactive protein induces p53-mediated cell cycle arrest in H9c2 cardiac myocytes","volume":"410","author":"Choi","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/eurheartj\/ehp070","article-title":"C-reactive protein, infarct size, microvascular obstruction, and left-ventricular remodelling following acute myocardial infarction","volume":"30","author":"Orn","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ijcard.2011.11.004","article-title":"Relationship of cardiac biomarkers and reversible and irreversible myocardial injury following acute myocardial infarction as determined by cardiovascular magnetic resonance","volume":"166","author":"Mather","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.amjcard.2010.06.071","article-title":"Usefulness of serial assessment of B-type natriuretic peptide, troponin I, and C-reactive protein to predict left ventricular remodeling after acute myocardial infarction (from the REVE-2 study)","volume":"106","author":"Fertin","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/nature04672","article-title":"Targeting C-reactive protein for the treatment of cardiovascular disease","volume":"440","author":"Pepys","year":"2006","journal-title":"Nature"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0735-1097(02)02959-5","article-title":"Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure","volume":"41","author":"Abbate","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cyto.2014.05.027","article-title":"Monomeric C-reactive protein and Notch-3 co-operatively increase angiogenesis through PI3K signalling pathway","volume":"69","author":"Boras","year":"2014","journal-title":"Cytokine"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13287-016-0377-1","article-title":"C-reactive protein can upregulate VEGF expression to promote ADSC-induced angiogenesis by activating HIF-1alpha via CD64\/PI3k\/Akt and MAPK\/ERK signaling pathways","volume":"7","author":"Chen","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1161\/CIRCRESAHA.108.192906","article-title":"C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcgammaRIIB and SHIP-1","volume":"104","author":"Tanigaki","year":"2009","journal-title":"Circ. Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1210\/er.2007-0006","article-title":"Cardiovascular actions of insulin","volume":"28","author":"Muniyappa","year":"2007","journal-title":"Endocr. Rev."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Lee, B.S., Kim, S.H., Oh, J., Jin, T., Choi, E.Y., Park, S., Lee, S.H., Chung, J.H., and Kang, S.M. (2014). C-reactive protein inhibits survivin expression via Akt\/mTOR pathway downregulation by PTEN expression in cardiac myocytes. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098113"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00395-012-0248-6","article-title":"Phosphatase PTEN is critically involved in post-myocardial infarction remodeling through the Akt\/interleukin-10 signaling pathway","volume":"107","author":"Parajuli","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"148798","DOI":"10.1155\/2014\/148798","article-title":"Atorvastatin represses the angiotensin 2-induced oxidative stress and inflammatory response in dendritic cells via the PI3K\/Akt\/Nrf 2 pathway","volume":"2014","author":"Ma","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2053149","DOI":"10.1155\/2019\/2053149","article-title":"CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K\/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4077\/CJP.2017.BAF434","article-title":"Attenuation of High Glucose-Induced Rat Cardiomyocyte Apoptosis by Exendin-4 via Intervention of HO-1\/Nrf-2 and the PI3K\/AKT Signaling Pathway","volume":"60","author":"Zhao","year":"2017","journal-title":"Chin. J. Physiol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000460254","article-title":"Interleukin-1beta Plays a Pivotal Role via the PI3K\/Akt\/mTOR Signaling Pathway in the Chronicity of Mesial Temporal Lobe Epilepsy","volume":"23","author":"Xiao","year":"2016","journal-title":"Neuroimmunomodulation"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1210\/jc.2014-1257","article-title":"PI3K\/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: Modulation by PTEN","volume":"99","author":"Li","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jhep.2003.12.018","article-title":"Up-regulation of IL-1 receptor through PI3K\/Akt is essential for the induction of iNOS gene expression in hepatocytes","volume":"40","author":"Teshima","year":"2004","journal-title":"J. Hepatol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1161\/CIRCRESAHA.120.315937","article-title":"Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease","volume":"126","author":"Abbate","year":"2020","journal-title":"Circ. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.amjcard.2013.01.287","article-title":"Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]","volume":"111","author":"Abbate","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/CIRCULATIONAHA.118.038010","article-title":"Anti-Inflammatory Therapy With Canakinumab for the Prevention of Hospitalization for Heart Failure","volume":"139","author":"Everett","year":"2019","journal-title":"Circulation"},{"key":"ref_174","first-page":"1103","article-title":"Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-kappaB and inhibition of HDAC1 and the PI3K\/Akt\/mTOR pathway in RAW264.7 macrophages","volume":"41","author":"Choi","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Xie, S., Chen, M., Yan, B., He, X., Chen, X., and Li, D. (2014). Identification of a role for the PI3K\/AKT\/mTOR signaling pathway in innate immune cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094496"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbrc.2010.04.117","article-title":"Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K\/Akt pathway","volume":"396","author":"Chartoumpekis","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: Renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1205406","article-title":"Autophagy in human health and disease","volume":"368","author":"Choi","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1248\/bpb.b15-00096","article-title":"Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy","volume":"38","author":"Kobayashi","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbadis.2010.02.002","article-title":"Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes","volume":"1802","author":"Marambio","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"13807","DOI":"10.1073\/pnas.0506843102","article-title":"Autophagy in chronically ischemic myocardium","volume":"102","author":"Yan","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-physiol-021317-121427","article-title":"The Role of Autophagy in the Heart","volume":"80","author":"Sciarretta","year":"2018","journal-title":"Annu. Rev. Physiol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/CIRCULATIONAHA.111.078212","article-title":"Rheb is a critical regulator of autophagy during myocardial ischemia: Pathophysiological implications in obesity and metabolic syndrome","volume":"125","author":"Sciarretta","year":"2012","journal-title":"Circulation"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy","volume":"100","author":"Matsui","year":"2007","journal-title":"Circ. Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4161\/auto.19653","article-title":"MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB","volume":"8","author":"Martina","year":"2012","journal-title":"Autophagy"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCRESAHA.114.302022","article-title":"Mammalian target of rapamycin signaling in cardiac physiology and disease","volume":"114","author":"Sciarretta","year":"2014","journal-title":"Circ. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.tibs.2011.03.006","article-title":"The Ras-ERK and PI3K-mTOR pathways: Cross-talk and compensation","volume":"36","author":"Mendoza","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"18398","DOI":"10.1074\/jbc.M111.326538","article-title":"Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation","volume":"287","author":"Kwak","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1476-4598-11-7","article-title":"Wnt signaling pathways in urological cancers: Past decades and still growing","volume":"11","author":"Majid","year":"2012","journal-title":"Mol. Cancer"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Xie, Y., Kang, R., and Tang, D. (2016). Role of the Beclin 1 Network in the Cross-Regulation Between Autophagy and Apoptosis. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Academic Press.","DOI":"10.1016\/B978-0-12-802937-4.00002-8"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1161\/CIRCULATIONAHA.111.041814","article-title":"Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia\/reperfusion injury","volume":"125","author":"Ma","year":"2012","journal-title":"Circulation"},{"key":"ref_194","first-page":"709","article-title":"Is autophagy associated with diabetes mellitus and its complications? A review","volume":"17","author":"Bhattacharya","year":"2018","journal-title":"EXCLI J."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fphar.2020.00042","article-title":"Distinct Types of Cell Death and the Implication in Diabetic Cardiomyopathy","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.jacc.2009.08.031","article-title":"Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction","volume":"54","author":"Buss","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1172\/JCI43008","article-title":"MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice","volume":"120","author":"Zhang","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000057979.36322.88","article-title":"Rapamycin attenuates load-induced cardiac hypertrophy in mice","volume":"107","author":"Shioi","year":"2003","journal-title":"Circulation"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/nm.3322","article-title":"Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2","volume":"19","author":"Maejima","year":"2013","journal-title":"Nat. Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jcp.22322","article-title":"The origin of fibroblasts and mechanism of cardiac fibrosis","volume":"225","author":"Krenning","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ejhf.696","article-title":"Myocardial fibrosis: Biomedical research from bench to bedside","volume":"19","author":"Gyongyosi","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"ref_202","first-page":"4467","article-title":"Elabela alleviates myocardial ischemia reperfusion-induced apoptosis, fibrosis and mitochondrial dysfunction through PI3K\/AKT signaling","volume":"12","author":"Yu","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"693875","DOI":"10.3389\/fcvm.2021.693875","article-title":"Cardiac Shock Wave Therapy Improves Ventricular Function by Relieving Fibrosis Through PI3K\/Akt Signaling Pathway: Evidence From a Rat Model of Post-infarction Heart Failure","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1007\/s11010-021-04219-w","article-title":"Role of PI3K\/Akt signaling pathway in cardiac fibrosis","volume":"476","author":"Qin","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"3000605211031433","DOI":"10.1177\/03000605211031433","article-title":"The mechanism of myocardial fibrosis is ameliorated by myocardial infarction-associated transcript through the PI3K\/Akt signaling pathway to relieve heart failure","volume":"49","author":"Zhao","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1006\/jmcc.2001.1381","article-title":"beta-Adrenergic stimulation of rat cardiac fibroblasts promotes protein synthesis via the activation of phosphatidylinositol 3-kinase","volume":"33","author":"Colombo","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/eurjhf\/hfq113","article-title":"Cardiac remodelling and myocardial recovery: Lost in translation?","volume":"12","author":"Mann","year":"2010","journal-title":"Eur. J. Heart Fail."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/eurjhf\/hfq131","article-title":"A unified view of ventricular remodelling","volume":"12","author":"Shah","year":"2010","journal-title":"Eur. J. Heart Fail."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/eurjhf\/hfr080","article-title":"AKT signalling in the failing heart","volume":"13","author":"Chaanine","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"37670","DOI":"10.1074\/jbc.M204572200","article-title":"Akt signaling mediates postnatal heart growth in response to insulin and nutritional status","volume":"277","author":"Shiojima","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ccr.2006.07.003","article-title":"Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin","volume":"10","author":"Phung","year":"2006","journal-title":"Cancer Cell"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/jcp.21197","article-title":"Activation or inactivation of cardiac Akt\/mTOR signaling diverges physiological from pathological hypertrophy","volume":"214","author":"Kemi","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"6615502","DOI":"10.1155\/2021\/6615502","article-title":"Bcl-2 Is Involved in Cardiac Hypertrophy through PI3K-Akt Pathway","volume":"2021","author":"Meng","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1161\/ATVBAHA.111.244970","article-title":"Comparison of various niches for endothelial progenitor cell therapy on ischemic myocardial repair: Coexistence of host collateralization and Akt-mediated angiogenesis produces a superior microenvironment","volume":"32","author":"Zhang","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11010-009-0154-x","article-title":"PTEN regulates angiogenesis through PI3K\/Akt\/VEGF signaling pathway in human pancreatic cancer cells","volume":"331","author":"Ma","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1089\/ars.2012.4849","article-title":"Angiogenesis in the infarcted myocardium","volume":"18","author":"Cochain","year":"2013","journal-title":"Antioxid. Redox. Signal."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.lfs.2019.04.040","article-title":"Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN\/PI3K\/Akt signaling pathway","volume":"227","author":"Cheng","year":"2019","journal-title":"Life Sci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.atherosclerosis.2010.08.067","article-title":"PTEN overexpression attenuates angiogenic processes of endothelial cells by blockade of endothelin-1\/endothelin B receptor signaling","volume":"221","author":"Kuo","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1073\/pnas.040560897","article-title":"Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells","volume":"97","author":"Jiang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"45643","DOI":"10.1074\/jbc.M404097200","article-title":"Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase\/AKT signaling","volume":"279","author":"Skinner","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1586\/erc.11.148","article-title":"Myocardial therapeutic angiogenesis: A review of the state of development and future obstacles","volume":"9","author":"Robich","year":"2011","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.4244\/EIJY14M08_19","article-title":"Cardiac arrhythmias in acute coronary syndromes: Position paper from the joint EHRA, ACCA, and EAPCI task force","volume":"10","author":"Gorenek","year":"2015","journal-title":"EuroIntervention"},{"key":"ref_224","first-page":"68","article-title":"Research Advances in Sympathetic Remodeling after Myocardial Infarction and Its Significance in Forensic Science","volume":"35","author":"Yu","year":"2019","journal-title":"Fa Yi Xue Za Zhi"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"e001359","DOI":"10.1161\/CIRCEP.115.001359","article-title":"Molecular Mechanisms of Sympathetic Remodeling and Arrhythmias","volume":"9","author":"Gardner","year":"2016","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1161\/01.CIR.101.16.1960","article-title":"Relationship between regional cardiac hyperinnervation and ventricular arrhythmia","volume":"101","author":"Cao","year":"2000","journal-title":"Circulation"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pharmthera.2013.01.004","article-title":"GDNF, NGF and BDNF as therapeutic options for neurodegeneration","volume":"138","author":"Allen","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"83","DOI":"10.7150\/ijms.10101","article-title":"Nerve growth factor protects the ischemic heart via attenuation of the endoplasmic reticulum stress induced apoptosis by activation of phosphatidylinositol 3-kinase","volume":"12","author":"Wei","year":"2015","journal-title":"Int. J. Med. Sci."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"698368","DOI":"10.1155\/2015\/698368","article-title":"Cardiac Sympathetic Nerve Sprouting and Susceptibility to Ventricular Arrhythmias after Myocardial Infarction","volume":"2015","author":"Li","year":"2015","journal-title":"Cardiol. Res. Pract."},{"key":"ref_230","first-page":"5536406","article-title":"LianXia Formula Granule Attenuates Cardiac Sympathetic Remodeling in Rats with Myocardial Infarction via the NGF\/TrKA\/PI3K\/AKT Signaling Pathway","volume":"2021","author":"Li","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1475-2840-11-67","article-title":"Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning","volume":"11","author":"Miki","year":"2012","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jama.298.7.765","article-title":"Diabetes and mortality following acute coronary syndromes","volume":"298","author":"Donahoe","year":"2007","journal-title":"JAMA"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ahj.2007.06.020","article-title":"Infarct size, ejection fraction, and mortality in diabetic patients with acute myocardial infarction treated with thrombolytic therapy","volume":"154","author":"Alegria","year":"2007","journal-title":"Am. Heart J."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.amjcard.2007.02.080","article-title":"Comparison of myocardial reperfusion in patients undergoing percutaneous coronary intervention in ST-segment elevation acute myocardial infarction with versus without diabetes mellitus (from the EMERALD Trial)","volume":"100","author":"Marso","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.bjp.0707155","article-title":"PTEN, the Achilles\u2019 heel of myocardial ischaemia\/reperfusion injury?","volume":"150","author":"Mocanu","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.regpep.2009.03.003","article-title":"Ghrelin inhibits apoptosis induced by high glucose and sodium palmitate in adult rat cardiomyocytes through the PI3K-Akt signaling pathway","volume":"155","author":"Kui","year":"2009","journal-title":"Regul. Pept."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Sun, D., Huang, J., Zhang, Z., Gao, H., Li, J., Shen, M., Cao, F., and Wang, H. (2012). Luteolin limits infarct size and improves cardiac function after myocardium ischemia\/reperfusion injury in diabetic rats. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033491"},{"key":"ref_238","first-page":"2534","article-title":"JNK\/PI3K\/Akt signaling pathway is involved in myocardial ischemia\/reperfusion injury in diabetic rats: Effects of salvianolic acid A intervention","volume":"8","author":"Chen","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"25120","DOI":"10.18632\/aging.104106","article-title":"Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways","volume":"12","author":"An","year":"2020","journal-title":"Aging"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"2750695","DOI":"10.1155\/2018\/2750695","article-title":"Polydatin Protects Diabetic Heart against Ischemia-Reperfusion Injury via Notch1\/Hes1-Mediated Activation of Pten\/Akt Signaling","volume":"2018","author":"Yu","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.2337\/diabetes.54.8.2360","article-title":"Preconditioning the diabetic heart: The importance of Akt phosphorylation","volume":"54","author":"Tsang","year":"2005","journal-title":"Diabetes"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"198048","DOI":"10.1155\/2012\/198048","article-title":"Diabetic inhibition of preconditioning- and postconditioning-mediated myocardial protection against ischemia\/reperfusion injury","volume":"2012","author":"Yin","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1097\/ALN.0b013e31820efafd","article-title":"Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: Phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition","volume":"114","author":"Drenger","year":"2011","journal-title":"Anesthesiology"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"9836302","DOI":"10.1155\/2019\/9836302","article-title":"Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K\/Akt and JAK2\/STAT3 Signaling","volume":"2019","author":"Lei","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"6657529","DOI":"10.1155\/2021\/6657529","article-title":"Inactivation of TOPK Caused by Hyperglycemia Blocks Diabetic Heart Sensitivity to Sevoflurane Postconditioning by Impairing the PTEN\/PI3K\/Akt Signaling","volume":"2021","author":"Gao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/CS20150496","article-title":"Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: Role of the PI3K\/Akt and JAK2\/STAT3 pathways","volume":"130","author":"Xue","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"3071959","DOI":"10.1155\/2018\/3071959","article-title":"Effects of Dexmedetomidine Postconditioning on Myocardial Ischemia\/Reperfusion Injury in Diabetic Rats: Role of the PI3K\/Akt-Dependent Signaling Pathway","volume":"2018","author":"Cheng","year":"2018","journal-title":"J. Diabetes Res."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jss.2012.02.021","article-title":"Diabetes abolishes the cardioprotection induced by sevoflurane postconditioning in the rat heart in vivo: Roles of glycogen synthase kinase-3\u03b2 and its upstream pathways","volume":"178","author":"Tai","year":"2012","journal-title":"J. Surg. Res."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2459\/JCM.0b013e328353694b","article-title":"Cardiac remodeling and heart failure after a first anterior myocardial infarction in patients with diabetes mellitus","volume":"13","author":"Lamblin","year":"2012","journal-title":"J. Cardiovasc. Med."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ahj.2011.07.015","article-title":"Cardiac structure and function, remodeling, and clinical outcomes among patients with diabetes after myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both","volume":"162","author":"Shah","year":"2011","journal-title":"Am. Heart J."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1253\/circj.CJ-08-0579","article-title":"Impact of Diabetes Mellitus on Rehospitalization for Heart Failure Among Survivors of Acute Myocardial Infarction in the Percutaneous Coronary Intervention Era","volume":"73","author":"Nakatani","year":"2009","journal-title":"Circ. J."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00380-021-01827-w","article-title":"Comparison of clinical outcomes and left ventricular remodeling after ST-elevation myocardial infarction between patients with and without diabetes mellitus","volume":"36","author":"Akashi","year":"2021","journal-title":"Heart Vessel."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"6657529","DOI":"10.1186\/s12933-019-0904-3","article-title":"Insulin resistance and dysglycemia are associated with left ventricular remodeling after myocardial infarction in non-diabetic patients","volume":"18","author":"Yang","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0735-1097(03)00509-6","article-title":"Streptozotocin-induced hyperglycemia exacerbates left ventricular remodeling and failure after experimental myocardial infarction","volume":"42","author":"Shiomi","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00125-003-1311-5","article-title":"Sustained cardiomyocyte apoptosis and left ventricular remodelling after myocardial infarction in experimental diabetes","volume":"47","author":"Backlund","year":"2004","journal-title":"Diabetologia"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"H2504","DOI":"10.1152\/ajpheart.00322.2006","article-title":"Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction","volume":"291","author":"Thakker","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1475-2840-9-5","article-title":"Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat","volume":"9","author":"Vahtola","year":"2010","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yjmcc.2015.02.029","article-title":"EGFR inhibition protects cardiac damage and remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model","volume":"82","author":"Liang","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00395-007-0691-y","article-title":"Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening","volume":"103","author":"Bhamra","year":"2008","journal-title":"Basic Res. Cardiol."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.7150\/ijbs.29680","article-title":"Metformin Inhibits the NLRP3 Inflammasome via AMPK\/mTOR-dependent Effects in Diabetic Cardiomyopathy","volume":"15","author":"Yang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"E871","DOI":"10.1152\/ajpendo.00623.2009","article-title":"Insulin attenuates myocardial ischemia\/reperfusion injury via reducing oxidative\/nitrative stress","volume":"298","author":"Ji","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.lfs.2010.06.006","article-title":"High-glucose condition reduces cardioprotective effects of insulin against mechanical stress-induced cell injury","volume":"87","author":"Teshima","year":"2010","journal-title":"Life Sci."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"H75","DOI":"10.1152\/ajpheart.00241.2012","article-title":"Cardiac mTOR protects the heart against ischemia-reperfusion injury","volume":"303","author":"Aoyagi","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"100933","DOI":"10.1016\/j.eclinm.2021.100933","article-title":"SGLT2 inhibitors decrease cardiovascular death and heart failure hospitalizations in patients with heart failure: A systematic review and meta-analysis","volume":"36","author":"Cardoso","year":"2021","journal-title":"EClinicalMedicine"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"14459","DOI":"10.1038\/s41598-020-71449-1","article-title":"Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways","volume":"10","author":"Hasan","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s00395-015-0476-7","article-title":"Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix","volume":"110","author":"Robinson","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Majka, M., Kleibert, M., and Wojciechowska, M. (2021). Impact of the Main Cardiovascular Risk Factors on Plasma Extracellular Vesicles and Their Influence on the Heart\u2019s Vulnerability to Ischemia-Reperfusion Injury. Cells, 10.","DOI":"10.3390\/cells10123331"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/cvr\/cvp015","article-title":"MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue","volume":"82","author":"Roy","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cardiores.2005.08.023","article-title":"Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility","volume":"69","author":"Wang","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_271","first-page":"3735","article-title":"Trimetazidine protects against hypoxia-reperfusion-induced cardiomyocyte apoptosis by increasing microRNA-21 expression","volume":"8","author":"Yang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.3892\/mmr.2016.5773","article-title":"Trimetazidine protects against cardiac ischemia\/reperfusion injury via effects on cardiac miRNA-21 expression, Akt and the Bcl-2\/Bax pathway","volume":"14","author":"Ma","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/jcmm.12990","article-title":"MicroRNA-21 protects against cardiac hypoxia\/reoxygenation injury by inhibiting excessive autophagy in H9c2 cells via the Akt\/mTOR pathway","volume":"21","author":"Huang","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_274","doi-asserted-by":"crossref","unstructured":"Tu, Y., Wan, L., Fan, Y., Wang, K., Bu, L., Huang, T., Cheng, Z., and Shen, B. (2013). Ischemic Postconditioning-Mediated miRNA-21 Protects against Cardiac ischemia\/reperfusion Injury via PTEN\/Akt Pathway. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075872"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/ALN.0000000000000807","article-title":"MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia\u2013Reperfusion Injury via Akt\/Nitric Oxide Synthase\/Mitochondrial Permeability Transition Pore Pathway","volume":"123","author":"Qiao","year":"2015","journal-title":"Anesthesiology"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIRCRESAHA.118.312420","article-title":"Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility","volume":"122","author":"Mayourian","year":"2018","journal-title":"Circ. Res."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1172\/JCI123135","article-title":"microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential","volume":"129","author":"Qiao","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"12970","DOI":"10.1111\/jcmm.15892","article-title":"HIF-1\u03b1-induced up-regulation of microRNA-126 contributes to the effectiveness of exercise training on myocardial angiogenesis in myocardial infarction rats","volume":"24","author":"Song","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3892\/etm.2021.11065","article-title":"MicroRNA-126 and VEGF enhance the function of endothelial progenitor cells in acute myocardial infarction","volume":"23","author":"Zhang","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"2415246","DOI":"10.1155\/2017\/2415246","article-title":"Obesity Downregulates MicroRNA-126 Inducing Capillary Rarefaction in Skeletal Muscle: Effects of Aerobic Exercise Training","volume":"2017","author":"Gomes","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yjmcc.2012.04.003","article-title":"Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1","volume":"53","author":"Meng","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00277-015-2567-9","article-title":"MiR-126 inhibits vascular endothelial cell apoptosis through targeting PI3K\/Akt signaling","volume":"95","author":"Chen","year":"2016","journal-title":"Ann. Hematol."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3892\/etm.2021.10242","article-title":"Naringenin alleviates myocardial ischemia reperfusion injury by enhancing the myocardial miR-126-PI3K\/AKT axis in streptozotocin-induced diabetic rats","volume":"22","author":"Li","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1111\/jcmm.16192","article-title":"Exosomes from microRNA-126 overexpressing mesenchymal stem cells promote angiogenesis by targeting the PIK3R2-mediated PI3K\/Akt signalling pathway","volume":"25","author":"Zhang","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_285","first-page":"268","article-title":"Inducible miR-145 expression by HIF-1\u03b1 protects cardiomyocytes against apoptosis via regulating SGK1 in simulated myocardial infarction hypoxic microenvironment","volume":"25","author":"Sun","year":"2013","journal-title":"Cardiol. J."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"H1813","DOI":"10.1152\/ajpheart.00709.2014","article-title":"MicroRNA-145 repairs infarcted myocardium by accelerating cardiomyocyte autophagy","volume":"309","author":"Higashi","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_287","first-page":"1537","article-title":"miRNA145 inhibits myocardial infarctioninduced apoptosis through autophagy via Akt3\/mTOR signaling pathway in vitro and in vivo","volume":"42","author":"Yan","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"11603","DOI":"10.18632\/aging.103320","article-title":"Over-expression of microRNA-145 drives alterations in \u03b2-adrenergic signaling and attenuates cardiac remodeling in heart failure post myocardial infarction","volume":"12","author":"Liu","year":"2020","journal-title":"Aging"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jcb.29843","article-title":"miR-145 attenuates cardiac fibrosis through the AKT\/GSK-3beta\/beta-catenin signaling pathway by directly targeting SOX9 in fibroblasts","volume":"122","author":"Cui","year":"2021","journal-title":"J. Cell. Biochem."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3109\/00365513.2014.981855","article-title":"Prediction of long-term outcome after acute myocardial infarction using circulating miR-145","volume":"75","author":"Dong","year":"2015","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/0366-6999.196573","article-title":"Circulating MicroRNA-145 is Associated with Acute Myocardial Infarction and Heart Failure","volume":"130","author":"Zhang","year":"2017","journal-title":"Chin. Med. J."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"BSR20170899","DOI":"10.1042\/BSR20170899","article-title":"miR-19a protects cardiomyocytes from hypoxia\/reoxygenation-induced apoptosis via PTEN\/PI3K\/p-Akt pathway","volume":"37","author":"Sun","year":"2017","journal-title":"Biosci. Rep."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/jcmm.12858","article-title":"miR-19b controls cardiac fibroblast proliferation and migration","volume":"20","author":"Zhong","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"ref_294","doi-asserted-by":"crossref","unstructured":"Dehaini, H., Awada, H., El-Yazbi, A., Zouein, F.A., Issa, K., Eid, A.A., Ibrahim, M., Badran, A., Baydoun, E., and Pintus, G. (2019). MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes. Cells, 8.","DOI":"10.3390\/cells8020152"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"e001403","DOI":"10.1136\/bmjdrc-2020-001403","article-title":"Effect of diabetes on exosomal miRNA profile in patients with obesity","volume":"8","author":"Kim","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jcma.2014.11.002","article-title":"Circulating microRNA as a diagnostic marker in populations with type 2 diabetes mellitus and diabetic complications","volume":"78","author":"Chien","year":"2015","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gene.2016.01.039","article-title":"Role of microRNA 21 in diabetes and associated\/related diseases","volume":"582","author":"Sekar","year":"2016","journal-title":"Gene"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"17615","DOI":"10.1073\/pnas.1206432109","article-title":"Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function","volume":"109","author":"Bernardo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1515\/hsz-2018-0195","article-title":"miR-34a-5p aggravates hypoxia-induced apoptosis by targeting ZEB1 in cardiomyocytes","volume":"400","author":"Shi","year":"2019","journal-title":"Biol. Chem."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1080\/21691401.2019.1687492","article-title":"Astragaloside-IV protects H9C2(2-1) cardiomyocytes from high glucose-induced injury via miR-34a-mediated autophagy pathway","volume":"47","author":"Zhu","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1530\/EJE-14-0867","article-title":"Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults","volume":"172","author":"Wang","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"104325","DOI":"10.1016\/j.yexmp.2019.104325","article-title":"LncRNA MALAT1 knockdown alleviates oxygen-glucose deprivation and reperfusion induced cardiomyocyte apoptotic death by regulating miR-122","volume":"111","author":"Gong","year":"2019","journal-title":"Exp. Mol. Pathol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1080\/21691401.2019.1652630","article-title":"Long non-coding RNA UCA1 relieves cardiomyocytes H9c2 injury aroused by oxygen-glucose deprivation via declining miR-122","volume":"47","author":"Zhang","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12933-016-0367-8","article-title":"Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus","volume":"15","author":"Jansen","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"E828","DOI":"10.1152\/ajpendo.00056.2016","article-title":"The effects of microvesicles on endothelial progenitor cells are compromised in type 2 diabetic patients via downregulation of the miR-126\/VEGFR2 pathway","volume":"310","author":"Wu","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4172\/2155-9929.1000251","article-title":"Diagnostic Value of Cell-free Circulating Micrornas for Obesity and Type 2 Diabetes: A Meta-analysis","volume":"6","author":"Villard","year":"2015","journal-title":"J. Mol. Biomark. Diagn."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.2337\/dc13-1847","article-title":"Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization","volume":"37","author":"Ortega","year":"2014","journal-title":"Diabetes Care"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1161\/CIRCRESAHA.110.226357","article-title":"Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes","volume":"107","author":"Zampetaki","year":"2010","journal-title":"Circ. Res."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/CIRCULATIONAHA.119.042640","article-title":"Small Extracellular Microvesicles Mediated Pathological Communications between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanisms Exacerbating Ischemia\/Reperfusion Injury in Diabetic Mice","volume":"141","author":"Gan","year":"2020","journal-title":"Circulation"},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/1753-0407.12643","article-title":"Identification of stress-related microRNA biomarkers in type 2 diabetes mellitus: A systematic review and meta-analysis","volume":"12","author":"Liang","year":"2020","journal-title":"J. Diabetes"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.yjmcc.2015.10.011","article-title":"Attenuation of cardiac dysfunction and remodeling of myocardial infarction by microRNA-130a are mediated by suppression of PTEN and activation of PI3K dependent signaling","volume":"89","author":"Lu","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_312","doi-asserted-by":"crossref","unstructured":"Shahrokhi, S.Z., Saeidi, L., Sadatamini, M., Jafarzadeh, M., Rahimipour, A., and Kazerouni, F. (2020). Can miR-145-5p be used as a marker in diabetic patients?. Arch. Physiol. Biochem.","DOI":"10.1080\/13813455.2020.1762657"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.2337\/db09-0216","article-title":"Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance","volume":"58","author":"Deng","year":"2009","journal-title":"Diabetes"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1159\/000452512","article-title":"Cell-Derived Microparticles in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis","volume":"39","author":"Li","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.bbadis.2019.02.014","article-title":"Long non-coding RNA cytoskeleton regulator RNA (CYTOR) modulates pathological cardiac hypertrophy through miR-155-mediated IKKi signaling","volume":"1865","author":"Yuan","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3892\/mmr.2021.12540","article-title":"Schisandrin A protects against isoproterenol-induced chronic heart failure via miR-155","volume":"25","author":"Gao","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.omtn.2021.01.014","article-title":"miR-223-3p as a potential biomarker and player for adipose tissue dysfunction preceding type 2 diabetes onset","volume":"23","author":"Camargo","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.12998\/wjcc.v8.i10.1923","article-title":"Four-microRNA signature for detection of type 2 diabetes","volume":"8","author":"Yan","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"5057328","DOI":"10.1155\/2016\/5057328","article-title":"Qi-Shen-Yi-Qi Dripping Pills Promote Angiogenesis of Ischemic Cardiac Microvascular Endothelial Cells by Regulating MicroRNA-223-3p Expression","volume":"2016","author":"Dai","year":"2016","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"15700","DOI":"10.1074\/jbc.M116.715805","article-title":"Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy","volume":"291","author":"Yang","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1159\/000489185","article-title":"MicroRNA-223 Regulates Cardiac Fibrosis After Myocardial Infarction by Targeting RASA1","volume":"46","author":"Liu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3892\/mmr.2020.11190","article-title":"miR-320-3p is involved in morphine pre-conditioning to protect rat cardiomyocytes from ischemia\/reperfusion injury through targeting Akt3","volume":"22","author":"Cao","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3892\/mmr.2013.1872","article-title":"Expression and DNA methylation status of microRNA-375 in patients with type 2 diabetes mellitus","volume":"9","author":"Sun","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.2147\/DMSO.S298735","article-title":"Assessing MicroRNA-375 Levels in Type 2 Diabetes Mellitus (T2DM) Patients and Their First-Degree Relatives with T2DM","volume":"14","author":"Wu","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/cvr\/cvx052","article-title":"Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis","volume":"113","author":"Garikipati","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_326","first-page":"77","article-title":"Long Noncoding RNA LNC_000898 Alleviates Cardiomyocyte Apoptosis and Promotes Cardiac Repair After Myocardial Infarction Through Modulating the miR-375\/PDK1 Axis","volume":"76","author":"Yan","year":"2020","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"14978","DOI":"10.18632\/oncotarget.14785","article-title":"Activation of Akt by SC79 protects myocardiocytes from oxygen and glucose deprivation (OGD)\/re-oxygenation","volume":"8","author":"Zheng","year":"2017","journal-title":"Oncotarget"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12967-015-0444-x","article-title":"A small molecule activator of AKT does not reduce ischemic injury of the rat heart","volume":"13","author":"Moreira","year":"2015","journal-title":"J. Transl. Med."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/01.CIR.104.3.330","article-title":"Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo","volume":"104","author":"Matsui","year":"2001","journal-title":"Circulation"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"819128","DOI":"10.3389\/fonc.2022.819128","article-title":"PI3K\/Akt\/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?","volume":"12","author":"Peng","year":"2022","journal-title":"Front. 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