{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:37:25Z","timestamp":1790638645209,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cellavita Pesquisas Cient\u00edficas Ltda."},{"name":"Funda\u00e7\u00e3o Butantan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Huntington\u2019s disease (HD) is a neurodegenerative inherited genetic disorder, which leads to the onset of motor, neuropsychiatric and cognitive disturbances. HD is characterized by the loss of gamma-aminobutyric acid (GABA)ergic medium spiny neurons (MSNs). To date, there is no treatment for HD. Mesenchymal stem cells (MSCs) provide a substantial therapeutic opportunity for the HD treatment. Herein, we investigated the therapeutic potential of human immature dental pulp stem cells (hIDPSC), a special type of MSC originated from the neural crest, for HD treatment. Two different doses of hIDPSC were intravenously administrated in a subacute 3-nitropropionic acid (3NP)-induced rat model. We demonstrated hIDPSC homing in the striatum, cortex and subventricular zone using specific markers for human cells. Thirty days after hIDPSC administration, the cells found in the brain are still express hallmarks of undifferentiated MSC. Immunohistochemistry quantities analysis revealed a significant increase in the number of BDNF, DARPP32 and D2R positive stained cells in the striatum and cortex in the groups that received hIDPSC. The differences were more expressive in animals that received only one administration of hIDPSC. Altogether, these data suggest that the intravenous administration of hIDPSCs can restore the BDNF, DARPP32 and D2R expression, promoting neuroprotection and neurogenesis.<\/jats:p>","DOI":"10.3390\/cells11101664","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T03:20:43Z","timestamp":1652844043000},"page":"1664","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Restoration of BDNF, DARPP32, and D2R Expression Following Intravenous Infusion of Human Immature Dental Pulp Stem Cells in Huntington\u2019s Disease 3-NP Rat Model"],"prefix":"10.3390","volume":"11","author":[{"given":"Cristiane Valverde","family":"Wenceslau","sequence":"first","affiliation":[{"name":"Cellavita Pesquisas Cient\u00edficas Ltda., Valinhos 13271-650, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dener Madeiro","family":"de Souza","sequence":"additional","affiliation":[{"name":"Genetics Laboratory, Instituto Butantan, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Caroline","family":"Mambelli-Lisboa","sequence":"additional","affiliation":[{"name":"Genetics Laboratory, Instituto Butantan, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Hideki","family":"Ynoue","sequence":"additional","affiliation":[{"name":"Azidus Brasil, Valinhos 13271-130, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8288-2577","authenticated-orcid":false,"given":"Rodrigo Pinheiro","family":"Araldi","sequence":"additional","affiliation":[{"name":"Cellavita Pesquisas Cient\u00edficas Ltda., Valinhos 13271-650, SP, Brazil"},{"name":"Genetics Laboratory, Instituto Butantan, S\u00e3o Paulo 05503-900, SP, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Biologia Estrutural e Funcional, Escola Paulista de Medicina (EPM), Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04023-062, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Macedo","family":"da Silva","sequence":"additional","affiliation":[{"name":"Azidus Brasil, Valinhos 13271-130, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Pagani","sequence":"additional","affiliation":[{"name":"Azidus Brasil, Valinhos 13271-130, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Santoro","family":"Haddad","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade Estadual de Campinas (UNICAMP), Campinas 13083-872, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kerkis","sequence":"additional","affiliation":[{"name":"Genetics Laboratory, Instituto Butantan, S\u00e3o Paulo 05503-900, SP, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Biologia Estrutural e Funcional, Escola Paulista de Medicina (EPM), Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04023-062, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kerkis, I., Araldi, R., Wenceslau, C., and Mendes, T. 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