{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:27:59Z","timestamp":1789648079040,"version":"4.0.0"},"reference-count":103,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The change from viewing noncoding RNA as \u201cjunk\u201d in the genome to seeing it as a critical epigenetic regulator in almost every human condition or disease has forced a paradigm shift in biomedical and clinical research. Small and long noncoding RNA transcripts are now routinely evaluated as putative diagnostic or therapeutic agents. A prominent role for noncoding microRNAs in the central nervous system has uncovered promising new clinical candidates for dementia-related disorders, treatments for which currently remain elusive even as the percentage of diagnosed patients increases significantly. Cognitive decline is a core neurodegenerative process in Alzheimer\u2019s Disease, Frontotemporal Dementia, Lewy body dementia, vascular dementia, Huntington\u2019s Disease, Creutzfeldt\u2013Jakob disease, and a significant portion of Parkinson\u2019s Disease patients. This review will discuss the microRNA-associated networks which influence these pathologies, including inflammatory and viral-mediated pathways (such as the novel SARS-CoV-2 virus implicated in COVID-19), and their current status in clinical trials.<\/jats:p>","DOI":"10.3390\/cells11121882","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T10:49:14Z","timestamp":1654771754000},"page":"1882","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["MicroRNA Networks in Cognition and Dementia"],"prefix":"10.3390","volume":"11","author":[{"given":"Grace S.","family":"Blount","sequence":"first","affiliation":[{"name":"Department of Chemistry, Georgia Southern University, Statesboro, GA 30460, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layton","family":"Coursey","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Georgia Southern University, Statesboro, GA 30460, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannet","family":"Kocerha","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Georgia Southern University, Statesboro, GA 30460, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"(2020). 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