{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:50:45Z","timestamp":1789501845819,"version":"build-2803163510"},"reference-count":64,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Molecular Medicine of the University of Pavia, Italy"},{"name":"University of Piemonte Orientale, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Malignant pleural mesothelioma (MPM) is an aggressive cancer of the pleural surface and is associated with previous asbestos exposure. The chemotherapy drug is one of the main treatments, but the median survival ranges from 8 to 14 months from diagnosis. The redox homeostasis of tumor cells should be carefully considered since elevated levels of ROS favor cancer cell progression (proliferation and migration), while a further elevation leads to ferroptosis. This study aims to analyze the functioning\/role of aquaporins (AQPs) as a hydrogen peroxide (H2O2) channel in epithelial and biphasic MPM cell lines, as well as their possible involvement in chemotherapy drug resistance. Results show that AQP-3, -5, -6, -9, and -11 were expressed at mRNA and protein levels. AQP-6 was localized in the plasma membrane and intracellular structures. Compared to normal mesothelial cells, the water permeability of mesothelioma cells is not reduced by exogenous oxidative stress, but it is considerably increased by heat stress, making these cells resistant to ferroptosis. Functional experiments performed in mesothelioma cells silenced for aquaporin-6 revealed that it is responsible, at least in part, for the increase in H2O2 efflux caused by heat stress. Moreover, mesothelioma cells knocked down for AQP-6 showed a reduced proliferation compared to mock cells. Current findings suggest the major role of AQP-6 in providing mesothelioma cells with the ability to resist oxidative stress that underlies their resistance to chemotherapy drugs.<\/jats:p>","DOI":"10.3390\/cells11121892","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T10:25:12Z","timestamp":1654856712000},"page":"1892","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Aquaporin-6 May Increase the Resistance to Oxidative Stress of Malignant Pleural Mesothelioma Cells"],"prefix":"10.3390","volume":"11","author":[{"given":"Giorgia","family":"Pellavio","sequence":"first","affiliation":[{"name":"Human Physiology Unit, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-1810","authenticated-orcid":false,"given":"Simona","family":"Martinotti","sequence":"additional","affiliation":[{"name":"DiSIT-Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, viale Teresa Michel 11, 15121 Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-2396","authenticated-orcid":false,"given":"Mauro","family":"Patrone","sequence":"additional","affiliation":[{"name":"DiSIT-Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, viale Teresa Michel 11, 15121 Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-8215","authenticated-orcid":false,"given":"Elia","family":"Ranzato","sequence":"additional","affiliation":[{"name":"DiSIT-Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, viale Teresa Michel 11, 15121 Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-5983","authenticated-orcid":false,"given":"Umberto","family":"Laforenza","sequence":"additional","affiliation":[{"name":"Human Physiology Unit, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"ref_1","unstructured":"PDQ Cancer Information Summaries (2022, April 28). Malignant Mesothelioma Treatment (Adult) (PDQ\u00ae)\u2013Health Professional Version. PDQ Adult Treatment Editorial Board. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002\u20132022. Bookshelf ID: NBK65983, Available online: https:\/\/www.cancer.gov\/types\/mesothelioma\/hp\/mesothelioma-treatment-pdq."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1016\/S1470-2045(18)30100-1","article-title":"Novel therapies for malignant pleural mesothelioma","volume":"19","author":"Scherpereel","year":"2018","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12995-016-0127-4","article-title":"Malignant mesothelioma incidence by nation-wide cancer registry: A population-based study","volume":"11","author":"Tomasson","year":"2016","journal-title":"J. Occup. Med. Toxicol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1200\/JCO.2002.20.1.274","article-title":"Phase II trial of a single weekly intravenous dose of ranpirnase in patients with unresectable malignant mesothelioma","volume":"20","author":"Mikulski","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"R566","DOI":"10.1152\/ajpregu.90464.2008","article-title":"The evolutionary aspects of aquaporin family","volume":"300","author":"Ishibashi","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1242\/jcs.079467","article-title":"Aquaporins at a glance","volume":"124","author":"Verkman","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nrm1469","article-title":"From structure to disease: The evolving tale of aquaporin biology","volume":"5","author":"King","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.bbagen.2013.09.017","article-title":"Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide","volume":"1840","author":"Bienert","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1089\/ars.2016.6636","article-title":"Stress regulates aquaporin-8 permeability to impact cell growth and survival","volume":"24","author":"Bestetti","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"15681","DOI":"10.1073\/pnas.1005776107","article-title":"Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling","volume":"107","author":"Miller","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbrc.2016.01.153","article-title":"Aquaporin-9 facilitates membrane transport of hydrogen peroxide in mammalian cells","volume":"471","author":"Watanabe","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Rodrigues, C., M\u00f3sca, A.F., Martins, A.P., Nobre, T., Prista, C., Antunes, F., Cipak Gasparovic, A., and Soveral, G. (2016). Rat aquaporin-5 is pH-gated induced by phosphorylation and is implicated in oxidative stress. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17122090"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"101326","DOI":"10.1016\/j.redox.2019.101326","article-title":"Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane","volume":"28","author":"Bestetti","year":"2020","journal-title":"Redox Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1084\/jem.20112398","article-title":"Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake","volume":"209","author":"Chikuma","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1128\/MCB.00971-15","article-title":"Aquaporin-3 controls breast cancer cell migration by regulating hydrogen peroxide transport and its downstream cell signaling","volume":"36","author":"Satooka","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1136\/gut.2006.104620","article-title":"Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis","volume":"56","author":"Thiagarajah","year":"2007","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.redox.2016.12.035","article-title":"Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress","volume":"11","author":"Sies","year":"2017","journal-title":"Redox Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nature03460","article-title":"Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption","volume":"434","author":"Saadoun","year":"2005","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1016\/j.bbamem.2014.09.001","article-title":"Key roles of aquaporins in tumor biology","volume":"1848","author":"Papadopoulos","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13046-016-0310-6","article-title":"Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro","volume":"35","author":"Dorward","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-94-024-1057-0_16","article-title":"Aquaporin-targeted therapeutics: State-of-the-field","volume":"969","author":"Tradtrantip","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1172\/JCI118659","article-title":"Aquaporin-1 water channel protein in lung: Ontogeny, steroid-induced expression, and distribution in rat","volume":"97","author":"King","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.resp.2003.08.001","article-title":"Role of aquaporin and sodium channel in pleural water movement","volume":"139","author":"Jiang","year":"2003","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1002\/cncr.26497","article-title":"Aquaporin 1 is an independent prognostic factor in pleural malignant mesothelioma","volume":"118","author":"Kao","year":"2012","journal-title":"Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"C1744","DOI":"10.1152\/ajpcell.2000.279.6.C1744","article-title":"Role of aquaporin water channels in pleural fluid dynamics","volume":"279","author":"Song","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Angelico, G., Caltabiano, R., Loreto, C., Ieni, A., Tuccari, G., Ledda, C., and Rapisarda, V. (2018). Immunohistochemical expression of aquaporin-1 in fluoro-edenite-induced malignant mesothelioma: A preliminary report. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030685"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"286719","DOI":"10.1155\/2015\/286719","article-title":"Blockade of aquaporin 1 inhibits proliferation, motility, and metastatic potential of mesothelioma in vitro but not in an in vivo model","volume":"2015","author":"Klebe","year":"2015","journal-title":"Dis. Markers"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"L489","DOI":"10.1152\/ajplung.00410.2015","article-title":"Influence of AQP1 on cell adhesion, migration, and tumor sphere formation in malignant pleural mesothelioma is substratum- and histological-type dependent","volume":"310","author":"Jagirdar","year":"2016","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Driml, J., Pulford, E., Moffat, D., Karapetis, C., Kao, S., Griggs, K., Henderson, D.W., and Klebe, S. (2016). Usefulness of aquaporin 1 as a prognostic marker in a prospective cohort of malignant mesotheliomas. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17071041"},{"key":"ref_30","first-page":"979","article-title":"Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma","volume":"134","author":"Ke","year":"1989","journal-title":"Am. J. Pathol."},{"key":"ref_31","first-page":"2055","article-title":"Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: An effective in vitro drug sensitization system","volume":"54","author":"Smythe","year":"1994","journal-title":"Cancer Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1432-0436.1988.tb00806.x","article-title":"Characterization of the state of differentiation of six newly established human non-small-cell lung cancer cell lines","volume":"37","author":"Bepler","year":"1988","journal-title":"Differentiation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/BC20100023","article-title":"Solute transporters and aquaporins are impaired in celiac disease","volume":"102","author":"Laforenza","year":"2010","journal-title":"Biol. Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ab.2009.03.017","article-title":"A solution for stripping antibodies from polyvinylidene fluoride immunoblots for multiple reprobing","volume":"389","author":"Yeung","year":"2009","journal-title":"Anal. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2818.2006.01706.x","article-title":"A guided tour into subcellular colocalization analysis in light microscopy","volume":"224","author":"Bolte","year":"2006","journal-title":"J. Microsc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2818.1993.tb03313.x","article-title":"Measurement of co-localization of objects in dual-colour confocal images","volume":"169","author":"Manders","year":"1993","journal-title":"J. Microsc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1242\/jcs.109.4.787","article-title":"Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons","volume":"109","author":"Hornsby","year":"1996","journal-title":"J. Cell Sci."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Pellavio, G., Rui, M., Caliogna, L., Martino, E., Gastaldi, G., Collina, S., and Laforenza, U. (2017). Regulation of aquaporin functional properties mediated by the antioxidant effects of natural compounds. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122665"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF01869470","article-title":"Rabbit distal colon epithelium: I. Isolation and characterization of basolateral plasma membrane vesicles from surface and crypt cells","volume":"110","author":"Wiener","year":"1989","journal-title":"J. Membr. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cmet.2020.02.003","article-title":"Ultrasensitive genetically encoded indicator for hydrogen peroxide identifies roles for the oxidant in cell migration and mitochondrial function","volume":"31","author":"Pak","year":"2020","journal-title":"Cell Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0021-9258(18)54108-9","article-title":"The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel","volume":"268","author":"Preston","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1021\/bi00355a011","article-title":"p-(Chloromercuri)benzenesulfonate binding by membrane proteins and the inhibition of water transport in human erythrocytes","volume":"25","author":"Benga","year":"1986","journal-title":"Biochemistry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/46045","article-title":"Rapid gating and anion permeability of an intracellular aquaporin","volume":"402","author":"Yasui","year":"1999","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1183\/16000617.0063-2016","article-title":"Malignant pleural mesothelioma: An update on investigation, diagnosis and treatment","volume":"25","author":"Bibby","year":"2016","journal-title":"Eur. Respir. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.semcdb.2017.05.023","article-title":"ROS signalling in the biology of cancer","volume":"80","author":"Moloney","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrd4002","article-title":"Modulation of oxidative stress as an anticancer strategy","volume":"12","author":"Gorrini","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fchem.2018.00135","article-title":"Mechanisms of aquaporin-facilitated cancer invasion and metastasis","volume":"6","author":"Yool","year":"2018","journal-title":"Front. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ledda, C., Senia, P., and Rapisarda, V. (2018). Biomarkers for early diagnosis and prognosis of malignant pleural mesothelioma: The quest goes on. Cancers, 10.","DOI":"10.3390\/cancers10060203"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1073\/pnas.96.10.5808","article-title":"Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia","volume":"96","author":"Yasui","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Prata, C., Hrelia, S., and Fiorentini, D. (2019). Peroxiporins in Cancer. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061371"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"36392","DOI":"10.18632\/oncotarget.26351","article-title":"Water transport proteins-aquaporins (AQPs) in cancer biology","volume":"9","author":"Dajani","year":"2018","journal-title":"Oncotarget"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10911-013-9312-6","article-title":"Aquaporin water channels in the mammary gland: From physiology to pathophysiology and neoplasia","volume":"19","author":"Mobasheri","year":"2014","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"869","DOI":"10.33594\/000000060","article-title":"Benign pleural mesothelial cells have higher osmotic water permeability than malignant pleural mesothelioma cells and differentially respond to hyperosmolality","volume":"52","author":"Katkova","year":"2019","journal-title":"Cell Physiol. Biochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.4161\/cbt.7.12.7067","article-title":"Cancer cell killing via ROS: To increase or decrease, that is the question","volume":"7","author":"Wang","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","article-title":"Reactive oxygen species in cancer","volume":"44","author":"Liou","year":"2010","journal-title":"Free Radic. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13046-018-0909-x","article-title":"The role of cellular reactive oxygen species in cancer chemotherapy","volume":"37","author":"Yang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Rodrigues, C., Pimp\u00e3o, C., M\u00f3sca, A.F., Coxixo, A.S., Lopes, D., da Silva, I.V., Pedersen, P.A., Antunes, F., and Soveral, G. (2019). Human Aquaporin-5 facilitates hydrogen peroxide permeation affecting adaption to oxidative stress and cancer cell migration. Cancers, 11.","DOI":"10.3390\/cancers11070932"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/13102818.2016.1264275","article-title":"Aquaporin 1, Aquaporin 3 and Aquaporin 5 expression and EGFR mutation in malignant pleural mesotheliomas: An imunohistochemical and molecular study","volume":"31","year":"2017","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3389\/fncel.2017.00412","article-title":"The oxidative stress-induced increase in the membrane expression of the water-permeable channel aquaporin-4 in astrocytes is regulated by caveolin-1 phosphorylation","volume":"11","author":"Bi","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2061830","DOI":"10.1155\/2019\/2061830","article-title":"Lipid profile and pquaporin expression under oxidative stress in breast cancer cells of different malignancies","volume":"2019","author":"Rodrigues","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.bbrc.2017.03.168","article-title":"Aquaporin 3 facilitates tumor growth in pancreatic cancer by modulating mTOR signaling","volume":"486","author":"Huang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.bbamcr.2014.01.011","article-title":"Specific aquaporins facilitate Nox-produced hydrogen peroxide transport through plasma membrane in leukaemia cells","volume":"1843","author":"Zambonin","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4149\/neo_2018_161019N487","article-title":"RNA interference-mediated silencing of aquaporin (AQP)-5 hinders angiogenesis of colorectal tumor by suppressing the production of vascular endothelial growth factor","volume":"65","author":"Wang","year":"2018","journal-title":"Neoplasma"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/12\/1892\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:27:58Z","timestamp":1760138878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/12\/1892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,10]]},"references-count":64,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["cells11121892"],"URL":"https:\/\/doi.org\/10.3390\/cells11121892","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,10]]}}}