{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:25:57Z","timestamp":1790767557816,"version":"4.1.0"},"reference-count":259,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation (SNSF)","doi-asserted-by":"publisher","award":["310030_175470\/1"],"award-info":[{"award-number":["310030_175470\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>In the process of mechanotransduction, the cells in the body perceive and interpret mechanical stimuli to maintain tissue homeostasis and respond to the environmental changes. Increasing evidence points towards dysregulated mechanotransduction as a pathologically relevant factor in human diseases, including inflammatory conditions. Skin is the organ that constantly undergoes considerable mechanical stresses, and the ability of mechanical factors to provoke inflammatory processes in the skin has long been known, with the Koebner phenomenon being an example. However, the molecular mechanisms and key factors linking mechanotransduction and cutaneous inflammation remain understudied. In this review, we outline the key players in the tissue\u2019s mechanical homeostasis, the available data, and the gaps in our current understanding of their aberrant regulation in chronic cutaneous inflammation. We mainly focus on psoriasis as one of the most studied skin inflammatory diseases; we also discuss mechanotransduction in the context of skin fibrosis as a result of chronic inflammation. Even though the role of mechanotransduction in inflammation of the simple epithelia of internal organs is being actively studied, we conclude that the mechanoregulation in the stratified epidermis of the skin requires more attention in future translational research.<\/jats:p>","DOI":"10.3390\/cells11132026","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T10:39:13Z","timestamp":1656153553000},"page":"2026","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Mechanotransduction in Skin Inflammation"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2340-6102","authenticated-orcid":false,"given":"Maria S.","family":"Shutova","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland"},{"name":"Department of Dermatology, Geneva University Hospitals, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-7124","authenticated-orcid":false,"given":"Wolf-Henning","family":"Boehncke","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland"},{"name":"Department of Dermatology, Geneva University Hospitals, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix Elasticity Directs Stem Cell Lineage Specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ceb.2016.03.006","article-title":"Mechanotransduction and nuclear function","volume":"40","author":"Graham","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","author":"Humphrey","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kuehlmann, B., Bonham, C.A., Zucal, I., Prantl, L., and Gurtner, G.C. (2020). Mechanotransduction in Wound Healing and Fibrosis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051423"},{"key":"ref_5","unstructured":"Moll, I. (2016). Duale Reihe Dermatologie, Thieme."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1007\/s00018-015-1853-y","article-title":"An updated review of mechanotransduction in skin disorders: Transcriptional regulators, ion channels, and microRNAs","volume":"72","author":"Wang","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1038\/jid.2011.212","article-title":"Pushing Back: Wound Mechanotransduction in Repair and Regeneration","volume":"131","author":"Wong","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.3389\/fimmu.2018.01682","article-title":"The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond","volume":"9","author":"Brembilla","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/379777a0","article-title":"Pulling the trigger on psoriasis","volume":"379","author":"Boehncke","year":"1996","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3389\/fimmu.2018.00579","article-title":"Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences","volume":"9","author":"Boehncke","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.clindermatol.2010.09.014","article-title":"The Koebner phenomenon","volume":"29","author":"Sagi","year":"2011","journal-title":"Clin. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00424-016-1903-9","article-title":"Tight junctions in skin inflammation","volume":"469","author":"Brandner","year":"2017","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-319-64804-0_3","article-title":"Atopic Dermatitis: Pathophysiology","volume":"1027","author":"Tarbox","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0889-857X(05)70294-5","article-title":"Pathogenesis of scleroderma: Collagen","volume":"22","author":"Jimenez","year":"1996","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","author":"Gabrielli","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1056\/NEJMra1300575","article-title":"Fibrosis\u2014A Common Pathway to Organ Injury and Failure","volume":"372","author":"Rockey","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: The master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"a005124","DOI":"10.1101\/cshperspect.a005124","article-title":"Cell-Extracellular Matrix Interactions in Normal and Diseased Skin","volume":"3","author":"Watt","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Dalton, C.J., and Lemmon, C.A. (2021). Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling. Cells, 10.","DOI":"10.20944\/preprints202108.0010.v1"},{"key":"ref_21","first-page":"682414","article-title":"The Extracellular Matrix in Skin Inflammation and Infection. Front","volume":"9","author":"Pfisterer","year":"2021","journal-title":"Cell Dev. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nrm3112","article-title":"Balancing forces: Architectural control of mechanotransduction","volume":"12","author":"Dufort","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ceb.2010.08.015","article-title":"Dynamic interplay between the collagen scaffold and tumor evolution","volume":"22","author":"Egeblad","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.freeradbiomed.2014.11.020","article-title":"Tumor mechanics and metabolic dysfunction","volume":"79","author":"Tung","year":"2015","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1346-8138.1985.tb02848.x","article-title":"Skin elasticity in psoriasis. In vivo measurement of tensile distensibility, hysteresis and resilient distension with a new method. Comparison with skin thickness as measured with high-frequency ultrasound","volume":"12","author":"Serup","year":"1985","journal-title":"J. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/000155500750012135","article-title":"In vivo Study of Skin Mechanical Properties in Psoriasis Vulgaris","volume":"80","author":"Dobrev","year":"2000","journal-title":"Acta Derm. Venereol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and mechano-regulation of connective tissue remodelling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.3389\/fimmu.2018.02452","article-title":"Unraveling SSc Pathophysiology; The Myofibroblast","volume":"9","author":"Vonk","year":"2018","journal-title":"Front Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Yang, S., and Plotnikov, S. (2021). Mechanosensitive Regulation of Fibrosis. Cells, 10.","DOI":"10.3390\/cells10050994"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nrrheum.2014.53","article-title":"Fibrosis\u2014A lethal component of systemic sclerosis","volume":"10","author":"Ho","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"L344","DOI":"10.1152\/ajplung.00300.2014","article-title":"Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis","volume":"308","author":"Liu","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2133.1991.tb03276.x","article-title":"Tenascin expression in hyperproliferative skin diseases","volume":"124","author":"Schalkwijk","year":"1991","journal-title":"Br. J. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jdermsci.2005.06.001","article-title":"Tenascin-C is upregulated in the skin lesions of patients with atopic dermatitis","volume":"40","author":"Ogawa","year":"2005","journal-title":"J. Dermatol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2133.2010.09737.x","article-title":"Psoriasis and extra domain A fibronectin loops","volume":"163","author":"McFadden","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.alit.2014.06.001","article-title":"Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis","volume":"64","author":"Arima","year":"2014","journal-title":"Allergol. Int."},{"key":"ref_37","first-page":"533","article-title":"Abnormal regulation of fibronectin production by fibroblasts in psoriasis","volume":"174","author":"Vas","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fcell.2019.00068","article-title":"Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases","volume":"7","author":"Bhattacharjee","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Choi, Y., Song, M., Hara, M., Imanaka-Yoshida, K., Lee, D., Chung, J., and Lee, S.-T. (2020). Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging. Int. J. Mol. Sci., 21.","DOI":"10.20944\/preprints202010.0572.v1"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1242\/jcs.190546","article-title":"Tenascin-C at a glance","volume":"129","author":"Midwood","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Imanaka-Yoshida, K. (2021). Tenascin-C in Heart Diseases\u2014The Role of Inflammation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115828"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/path.1415","article-title":"Tenascins: Regulation and putative functions during pathological stress","volume":"200","author":"Chiquet","year":"2003","journal-title":"J. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1172\/JCI171","article-title":"Fibronectin and alpha5 integrin regulate keratinocyte cell cycling. A mechanism for increased fibronectin potentiation of T cell lymphokine-driven keratinocyte hyperproliferation in psoriasis","volume":"101","author":"Cooper","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1096\/fj.10-154435","article-title":"EDA-containing cellular fibronectin induces fibroblast differentiation through binding to alpha4\u03b27 integrin receptor and MAPK\/Erk 1\/2-dependent signaling","volume":"24","author":"Kohan","year":"2010","journal-title":"FASEB J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"232ra50","DOI":"10.1126\/scitranslmed.3008264","article-title":"FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling","volume":"6","author":"Bhattacharyya","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1956403","DOI":"10.1155\/2018\/1956403","article-title":"The Role of Immune Defects and Colonization of Staphylococcus aureus in the Pathogenesis of Atopic Dermatitis","volume":"2018","author":"Nowicka","year":"2018","journal-title":"Anal. Cell. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-981-13-6657-4_16","article-title":"Periostin and Integrin Signaling in Stem Cell Regulation","volume":"1132","author":"Suresh","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12079-010-0090-2","article-title":"Spatiotemporal expression of periostin during skin development and incisional wound healing: Lessons for human fibrotic scar formation","volume":"4","author":"Zhou","year":"2010","journal-title":"J. Cell Commun. Signal."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"107472","DOI":"10.1016\/j.celrep.2020.03.036","article-title":"Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch","volume":"31","author":"Mishra","year":"2020","journal-title":"Cell Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF01262327","article-title":"Increased collagen synthesis in psoriasis in vivo","volume":"287","author":"Koivukangas","year":"1995","journal-title":"Arch. Dermatol. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/03008209809028901","article-title":"The influence of inflammation-mediated osteopenia (IMO) on the structure of rabbit bone and skin collagen fibrils","volume":"37","author":"Kounadi","year":"1998","journal-title":"Connect. Tissue Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41368-018-0036-8","article-title":"Chronic inflammation deteriorates structure and function of collagen fibril in rat temporomandibular joint disc","volume":"11","author":"Cui","year":"2019","journal-title":"Int. J. Oral Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1073\/pnas.1203127109","article-title":"Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis","volume":"109","author":"Oyoshi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.det.2009.10.001","article-title":"Role of Dermal-Epidermal Basement Membrane Zone in Skin, Cancer, and Developmental Disorders","volume":"28","author":"Ko","year":"2010","journal-title":"Dermatol. Clin."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1523-1747.2000.00138.x","article-title":"Basement Membrane Alterations in Psoriasis are Accompanied by Epidermal Overexpression of MMP-2 and its Inhibitor TIMP-2","volume":"115","author":"Fleischmajer","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1034\/j.1600-0625.2001.010003175.x","article-title":"Metalloelastase (MMP-12) and 92-kDa gelatinase (MMP-9) as well as their inhibitors, TIMP-1 and -3, are expressed in psoriatic lesions","volume":"10","author":"Suomela","year":"2001","journal-title":"Exp. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/boc.201700060","article-title":"Integrin diversity brings specificity in mechanotransduction","volume":"110","author":"Seetharaman","year":"2018","journal-title":"Biol. Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.devcel.2004.08.021","article-title":"Activation of a Signaling Cascade by Cytoskeleton Stretch","volume":"7","author":"Tamada","year":"2004","journal-title":"Dev. Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ccell.2019.01.007","article-title":"Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance","volume":"35","author":"Cooper","year":"2019","journal-title":"Cancer Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1093\/emboj\/cdf399","article-title":"NEW EMBO MEMBER\u2032S REVIEW: Role of integrins in regulating epidermal adhesion, growth and differentiation","volume":"21","author":"Watt","year":"2002","journal-title":"EMBO J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0092-8674(95)90453-0","article-title":"Stem cell patterning and fate in human epidermis","volume":"80","author":"Jones","year":"1995","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1177\/002215549704500611","article-title":"The Epidermal Stem Cell Compartment: Variation in Expression Levels of E\u2013Cadherin and Catenins Within the Basal Layer of Human Epidermis","volume":"45","author":"Watt","year":"1997","journal-title":"J. Histochem. Cytochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1523-1747.1998.00232.x","article-title":"Differential Expression of Activation Epitopes of \u03b21 Integrins in Psoriasis and Normal Skin","volume":"111","author":"Buezo","year":"1998","journal-title":"J. Investig. Dermatol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1172\/JCI115794","article-title":"Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis","volume":"89","author":"Hertle","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0092-8674(95)90211-2","article-title":"Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis","volume":"83","author":"Carroll","year":"1995","journal-title":"Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.276.5309.75","article-title":"Wound Healing--Aiming for Perfect Skin Regeneration","volume":"276","author":"Martin","year":"1997","journal-title":"Science"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1242\/dev.129.9.2303","article-title":"A crucial role of \u03b2 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair","volume":"129","author":"Grose","year":"2002","journal-title":"Development"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1242\/dmm.028662","article-title":"Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins \u03b12 and \u03b21","volume":"10","author":"Staunstrup","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1172\/JCI115782","article-title":"Expression, topography, and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin","volume":"89","author":"Pellegrini","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nm1605","article-title":"\u03b11\u03b21 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis","volume":"13","author":"Conrad","year":"2007","journal-title":"Nat. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"647358","DOI":"10.3389\/fimmu.2021.647358","article-title":"Natural Killer Cell Integrins and Their Functions in Tissue Residency","volume":"12","author":"Shannon","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_73","first-page":"1661","article-title":"Altered vascular endothelium integrin expression in psoriasis","volume":"147","author":"Creamer","year":"1995","journal-title":"Am. J. Pathol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"154","DOI":"10.7150\/thno\/v01p0154","article-title":"Integrin Targeted Therapeutics","volume":"1","author":"Millard","year":"2011","journal-title":"Theranostics"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1016\/j.clinthera.2017.11.002","article-title":"Integrins: Integrating the Biology and Therapy of Cell\u2013cell Interactions","volume":"39","author":"Pandolfi","year":"2017","journal-title":"Clin. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Ho, T.-C., Yeh, S.-I., Chen, S.-L., and Tsao, Y.-P. (2019). The Psoriasis Therapeutic Potential of a Novel Short Laminin Peptide C16. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133144"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00441-016-2407-9","article-title":"\u03b1v integrins: Key regulators of tissue fibrosis","volume":"365","author":"Conroy","year":"2016","journal-title":"Cell Tissue Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"588066","DOI":"10.3389\/fcell.2020.588066","article-title":"Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin","volume":"8","author":"Park","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0002-9440(10)63113-6","article-title":"Increased expression of \u03b26-integrin in skin leads to spontaneous development of chronic wounds","volume":"164","author":"Koivisto","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.bbadis.2012.10.005","article-title":"Integrin-mediated regulation of TGF\u03b2 in fibrosis","volume":"1832","author":"Henderson","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"12384","DOI":"10.1074\/jbc.M208544200","article-title":"Myofibroblast differentiation by transforming growth factor-\u03b21 is dependent on cell adhesion and integrin signaling via focal adhesion kinase","volume":"278","author":"Thannickal","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nature12614","article-title":"Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma","volume":"503","author":"Gerber","year":"2013","journal-title":"Nature"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"183316","DOI":"10.1016\/j.bbamem.2020.183316","article-title":"Cell-cell junctions as sensors and transducers of mechanical forces","volume":"1862","author":"Huveneers","year":"2020","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"12568","DOI":"10.1073\/pnas.1204390109","article-title":"E-cadherin is under constitutive actomyosin-generated tension that is increased at cell\u2013cell contacts upon externally applied stretch","volume":"109","author":"Borghi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"a028761","DOI":"10.1101\/cshperspect.a028761","article-title":"Mechanosensing and Mechanotransduction at Cell\u2013Cell Junctions","volume":"10","author":"Yap","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ncb2055","article-title":"\u03b1-Catenin as a tension transducer that induces adherens junction development","volume":"12","author":"Yonemura","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1083\/jcb.201212140","article-title":"\u03b2-Catenin protects the epidermis from mechanical stresses","volume":"202","author":"Ray","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/(SICI)1096-9896(199808)185:4<413::AID-PATH125>3.0.CO;2-K","article-title":"Expression of catenins and E-cadherin during epithelial restitution in inflammatory bowel disease","volume":"185","author":"Karayiannakis","year":"1998","journal-title":"J. Pathol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1196\/annals.1326.017","article-title":"Inflammatory Bowel Disease and the Apical Junctional Complex","volume":"1072","author":"Bruewer","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/ncb1486","article-title":"VEGF controls endothelial-cell permeability by promoting the \u03b2-arrestin-dependent endocytosis of VE-cadherin","volume":"8","author":"Gavard","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2353\/ajpath.2010.100168","article-title":"Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation","volume":"177","author":"Ivanov","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e25231","DOI":"10.4161\/tisb.25231","article-title":"Novel mechanism of cytokine-induced disruption of epithelial barriers","volume":"1","author":"Naydenov","year":"2013","journal-title":"Tissue Barriers"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Jin, Y., and Blikslager, A.T. (2020). The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase\/Rho Kinases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103550"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/1523-1747.ep12582813","article-title":"Stratum Corneum Structure and Function Correlates with Phenotype in Psoriasis","volume":"107","author":"Ghadially","year":"1996","journal-title":"J. Investig. Dermatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.clindermatol.2011.08.022","article-title":"Abnormal epidermal barrier in the pathogenesis of psoriasis","volume":"30","author":"Wolf","year":"2012","journal-title":"Clin. Dermatol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Montero-Vilchez, T., Segura-Fern\u00e1ndez-Nogueras, M.-V., P\u00e9rez-Rodr\u00edguez, I., Soler-Gongora, M., Martinez-Lopez, A., Fern\u00e1ndez-Gonz\u00e1lez, A., Molina-Leyva, A., and Arias-Santiago, S. (2021). Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity. J. Clin. Med., 10.","DOI":"10.3390\/jcm10020359"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1046\/j.0022-202x.2001.01474.x","article-title":"The Differential Fate of Cadherins during T-Cell-Induced Keratinocyte Apoptosis Leads to Spongiosis in Eczematous Dermatitis","volume":"117","author":"Trautmann","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1046\/j.1365-2133.2003.05464.x","article-title":"Reciprocal altered expression of T-cadherin and P-cadherin in psoriasis vulgaris","volume":"149","author":"Zhou","year":"2003","journal-title":"Br. J. Dermatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-4632.2007.03318.x","article-title":"Decreased expression of E-cadherin and \u03b2-catenin in the lesional skin of patients with active psoriasis","volume":"47","author":"Li","year":"2008","journal-title":"Int. J. Dermatol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/01.XEJ.0000455929.33903.19","article-title":"Role of E-cadherin in psoriasis","volume":"34","author":"Maree","year":"2014","journal-title":"Egypt. J. Pathol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jid.2017.03.036","article-title":"E-Cadherin\u2013Mediated Cell Contact Controls the Epidermal Damage Response in Radiation Dermatitis","volume":"137","author":"Xie","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"628381","DOI":"10.3389\/falgy.2020.628381","article-title":"Epithelial-Mesenchymal Transition in Atopy: A Mini-Review","volume":"1","author":"Anderson","year":"2020","journal-title":"Front. Allergy"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/j.1365-2133.2007.08195.x","article-title":"Increased nuclear \u03b2-catenin in suprabasal involved psoriatic epidermis","volume":"157","author":"Hampton","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4103\/2229-5178.148923","article-title":"Beta-catenin expression in psoriasis","volume":"6","author":"Galbet","year":"2015","journal-title":"Indian Derm. Online J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ncb3290","article-title":"Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction","volume":"18","author":"Nowell","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.7150\/ijms.20809","article-title":"IL-36\u03b3 inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis","volume":"14","author":"Wang","year":"2017","journal-title":"Int. J. Med Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-\u03b2-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/annrheumdis-2011-200568","article-title":"\u03b2-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis","volume":"71","author":"Beyer","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1042\/BST20200026","article-title":"Extracellular matrix stiffness and Wnt\/\u03b2-catenin signaling in physiology and disease","volume":"48","author":"Astudillo","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2005.11.043","article-title":"p120-Catenin Mediates Inflammatory Responses in the Skin","volume":"124","author":"Davis","year":"2006","journal-title":"Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrm.2016.80","article-title":"Tight junctions: From simple barriers to multifunctional molecular gates","volume":"17","author":"Zihni","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000441541","article-title":"Importance of Tight Junctions in Relation to Skin Barrier Function","volume":"49","author":"Brandner","year":"2016","journal-title":"Ski. Barrier Funct."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/s41467-017-01170-7","article-title":"E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning","volume":"8","author":"Mertz","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_114","first-page":"2765","article-title":"Mechanism of cytokine modulation of epithelial tight junction barrier","volume":"14","author":"Boivin","year":"2009","journal-title":"Front. Biosci."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Yuki, T., Tobiishi, M., Kusaka-Kikushima, A., Ota, Y., and Tokura, Y. (2016). Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161759"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jaci.2010.10.018","article-title":"Tight junction defects in patients with atopic dermatitis","volume":"127","author":"Rafaels","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2353\/ajpath.2009.080973","article-title":"Alteration of Tight Junction Proteins Is an Early Event in Psoriasis: Putative Involvement of Proinflammatory Cytokines","volume":"175","author":"Kirschner","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"E4061","DOI":"10.1073\/pnas.1525474113","article-title":"Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis","volume":"113","author":"Tokumasu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Uttagomol, J., Ahmad, U.S., Rehman, A., Huang, Y., Laly, A.C., Kang, A., Soetaert, J., Chance, R., Teh, M.-T., and Connelly, J.T. (2019). Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces. Int. J. Mol. Sci., 20.","DOI":"10.1101\/827725"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/15419061.2014.905930","article-title":"Junctions and Inflammation in the Skin","volume":"21","author":"Kobielak","year":"2014","journal-title":"Cell Commun. Adhes."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/ng.2739","article-title":"Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting","volume":"45","author":"Samuelov","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/10409238.2016.1204980","article-title":"Connexins and their channels in inflammation","volume":"51","author":"Willebrords","year":"2016","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"C1389-95","DOI":"10.1152\/ajpcell.00220.2004","article-title":"Connexins are mechanosensitive","volume":"287","author":"Bao","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fphys.2013.00292","article-title":"ATP Releasing Connexin 30 Hemichannels Mediate Flow-Induced Calcium Signaling in the Collecting Duct","volume":"4","author":"Svenningsen","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e202002154","DOI":"10.1083\/jcb.202002154","article-title":"Mechanosensitive collaboration between integrins and connexins allows nutrient and antioxidant transport into the lens","volume":"219","author":"Liu","year":"2020","journal-title":"J. Cell Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41413-020-00126-w","article-title":"Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels","volume":"9","author":"Riquelme","year":"2021","journal-title":"Bone Res."},{"key":"ref_127","first-page":"12","article-title":"Gap junction diseases of the skin","volume":"Volume 131","year":"2004","journal-title":"American Journal of Medical Genetics Part C: Seminars in Medical Genetics"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.bbamem.2011.12.030","article-title":"Effects of mechanical forces and stretch on intercellular gap junction coupling","volume":"1828","author":"Salameh","year":"2013","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.bbamem.2011.09.004","article-title":"Connexins in epidermal homeostasis and skin disease","volume":"1818","author":"Scott","year":"2012","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physiol.00014.2005","article-title":"Myosins: Tails (and Heads) of Functional Diversity","volume":"20","author":"Krendel","year":"2005","journal-title":"Physiology"},{"key":"ref_131","first-page":"1495","article-title":"Non-muscle myosin II in disease: Mechanisms and therapeutic opportunities","volume":"8","author":"Horwitz","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"14744","DOI":"10.1038\/ncomms14744","article-title":"A genome-wide screen identifies YAP\/WBP2 interplay conferring growth advantage on human epidermal stem cells","volume":"8","author":"Walko","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue Cells Feel and Respond to the Stiffness of Their Substrate","volume":"310","author":"Discher","year":"2005","journal-title":"Science"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/ni.1628","article-title":"Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating \u03b22 integrins","volume":"9","author":"Xu","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"015009","DOI":"10.1088\/1478-3975\/8\/1\/015009","article-title":"The role of the cytoskeleton in cellular force generation in 2D and 3D environments","volume":"8","author":"Carey","year":"2011","journal-title":"Phys. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"7374197","DOI":"10.1155\/2016\/7374197","article-title":"Crosstalk between Inflammation and ROCK\/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability","volume":"2016","author":"Du","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.4049\/jimmunol.1800823","article-title":"Differential Influence of IL-9 and IL-17 on Actin Cytoskeleton Regulates the Migration Potential of Human Keratinocytes","volume":"202","author":"Das","year":"2019","journal-title":"J. Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.jid.2019.12.013","article-title":"IL-17E (IL-25) and IL-17A Differentially Affect the Functions of Human Keratinocytes","volume":"140","author":"Borowczyk","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"29834","DOI":"10.1038\/srep29834","article-title":"F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2","volume":"6","author":"Burger","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/JLB.3MIR1118-417R","article-title":"Cells under stress: The mechanical environment shapes inflammasome responses to danger signals","volume":"106","author":"Joshi","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1042\/BST0330891","article-title":"Rho GTPases and the control of cell behaviour","volume":"33","author":"Hall","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ncb796","article-title":"ROCK and Dia have opposing effects on adherens junctions downstream of Rho","volume":"4","author":"Sahai","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejcb.2013.09.002","article-title":"Physiological roles of Rho and Rho effectors in mammals","volume":"92","author":"Thumkeo","year":"2013","journal-title":"Eur. J. Cell Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.cub.2003.11.050","article-title":"Keratinocyte Differentiation Is Regulated by the Rho and ROCK Signaling Pathway","volume":"13","author":"McMullan","year":"2003","journal-title":"Curr. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Lock, F.E., and Hotchin, N.A. (2009). Distinct Roles for ROCK1 and ROCK2 in the Regulation of Keratinocyte Differentiation. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0008190"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.yexcr.2010.01.024","article-title":"Novel regulation and dynamics of myosin II activation during epidermal wound responses","volume":"316","author":"Rai","year":"2010","journal-title":"Exp. Cell Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.ccr.2011.05.008","article-title":"Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and \u03b2-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth","volume":"19","author":"Strachan","year":"2011","journal-title":"Cancer Cell."},{"key":"ref_148","first-page":"1","article-title":"Mechanical regulation of chromatin and transcription","volume":"2022","author":"Dupont","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1091\/mbc.e17-06-0401","article-title":"Activation of ROCK and MLCK tunes regional stress fiber formation and mechanics via preferential myosin light chain phosphorylation","volume":"28","author":"Kassianidou","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biochi.2019.10.010","article-title":"MLCK and ROCK mutualism in endothelial barrier dysfunction","volume":"168","author":"Kazakova","year":"2019","journal-title":"Biochimie"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fphar.2017.00292","article-title":"Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases","volume":"8","author":"Xiong","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.bbrc.2018.03.103","article-title":"Mammalian nonmuscle myosin II comes in three flavors","volume":"506","author":"Shutova","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"46599","DOI":"10.7554\/eLife.46599","article-title":"Myosin II isoforms play distinct roles in adherens junction biogenesis","volume":"8","author":"Narayana","year":"2019","journal-title":"eLife"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3389\/fmicb.2019.00401","article-title":"Non-muscle Myosin II: Role in Microbial Infection and Its Potential as a Therapeutic Target","volume":"10","author":"Tan","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/cmi.2011.41","article-title":"Impairment of non-muscle myosin IIA in human CD4+ T cells contributes to functional deficits in the elderly","volume":"9","author":"Cane","year":"2011","journal-title":"Cell. Mol. Immunol."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Hindman, B., Goeckeler, Z., Sierros, K., and Wysolmerski, R. (2015). Non-Muscle Myosin II Isoforms Have Different Functions in Matrix Rearrangement by MDA-MB-231 Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131920"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/labinvest.2010.181","article-title":"Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling","volume":"91","author":"Bond","year":"2010","journal-title":"Lab. Investig."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1038\/s41467-018-06833-7","article-title":"Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease","volume":"9","author":"Kim","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"6692811","DOI":"10.1155\/2021\/6692811","article-title":"Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy","volume":"2021","author":"Zhang","year":"2021","journal-title":"Anal. Cell. Pathol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.devcel.2016.07.021","article-title":"Fascin Regulates Nuclear Movement and Deformation in Migrating Cells","volume":"38","author":"Jayo","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Lamb, M.C., and Tootle, T.L. (2020). Fascin in Cell Migration: More Than an Actin Bundling Protein. Biology, 9.","DOI":"10.3390\/biology9110403"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.jid.5700561","article-title":"Surfactant Protein Expression in Human Skin: Evidence and Implications","volume":"127","author":"Mo","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1091\/mbc.e09-03-0232","article-title":"Identification of MYO18A as a novel interacting partner of the PAK2\/\u03b2PIX\/GIT1 complex and its potential function in modulating epithelial cell migration","volume":"21","author":"Hsu","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e1127493","DOI":"10.1080\/2162402X.2015.1127493","article-title":"Identification of CD245 as myosin 18A, a receptor for surfactant A: A novel pathway for activating human NK lymphocytes","volume":"5","author":"Giustiniani","year":"2016","journal-title":"Oncoimmunology"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ajpath.2015.11.023","article-title":"Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation","volume":"186","author":"Wang","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/cm.21485","article-title":"Regulation of mechanotransduction: Emerging roles for septins","volume":"76","author":"Lam","year":"2018","journal-title":"Cytoskeleton"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajpath.2020.09.007","article-title":"Novel Functions of the Septin Cytoskeleton: Shaping Up Tissue Inflammation and Fibrosis","volume":"191","author":"Ivanov","year":"2021","journal-title":"Am. J. Pathol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.devcel.2011.10.013","article-title":"A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration","volume":"22","author":"Weber","year":"2012","journal-title":"Dev. Cell"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"18513","DOI":"10.1073\/pnas.1313491110","article-title":"Keratins as the main component for the mechanical integrity of keratinocytes","volume":"110","author":"Ramms","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fcell.2017.00081","article-title":"Intermediate Filaments at the Junction of Mechanotransduction, Migration, and Development","volume":"5","author":"Weber","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Sapra, K.T., and Medalia, O. (2021). Bend, Push, Stretch: Remarkable Structure and Mechanics of Single Intermediate Filaments and Meshworks. Cells, 10.","DOI":"10.3390\/cells10081960"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2000119","DOI":"10.1002\/bies.202000119","article-title":"Crosstalk between Cell Adhesion Complexes in Regulation of Mechanotransduction","volume":"42","author":"Zuidema","year":"2020","journal-title":"BioEssays"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Zhang, L.-J. (2018). Keratins in skin epidermal development and diseases. Keratin, IntechOpen.","DOI":"10.5772\/intechopen.79050"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"eabd6187","DOI":"10.1126\/sciadv.abd6187","article-title":"The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction","volume":"7","author":"Laly","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1242\/jcs.099655","article-title":"Keratins and disease at a glance","volume":"125","author":"Haines","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Blumenberg, M. (2018). Regulation of Expression of Keratins and their Pathogenic Roles in Keratinopathies. Keratin, IntechOpen.","DOI":"10.5772\/intechopen.73230"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Leyva-Castillo, J.M., Sun, L., Wu, S.-Y., Rockowitz, S., Sliz, P., and Geha, R. (J. Allergy Clin. Immunol., 2022). Single cell transcriptome profile of mouse skin undergoing antigen driven allergic inflammation recapitulates findings in atopic dermatitis skin lesions, J. Allergy Clin. Immunol., in press.","DOI":"10.1016\/j.jaci.2022.03.002"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1242\/jcs.122929","article-title":"Keratin intermediate filament proteins\u2014novel regulators of inflammation and immunity in skin","volume":"125","author":"Hobbs","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_179","first-page":"5269","article-title":"Keratin 1 maintains skin integrity and participates in an inflammatory network in skin via interleukin-18","volume":"125","author":"Roth","year":"2012","journal-title":"J Cell Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"243956","DOI":"10.1242\/jcs.243956","article-title":"Disease-associated keratin mutations reduce traction forces and compromise adhesion and collective migration","volume":"133","author":"Fujiwara","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/eji.200838884","article-title":"Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin","volume":"39","author":"Barberis","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"862237","DOI":"10.3389\/fcell.2022.862237","article-title":"Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine","volume":"10","author":"Wang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"6574","DOI":"10.1038\/ncomms7574","article-title":"Vimentin regulates activation of the NLRP3 inflammasome","volume":"6","author":"Rogel","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"R1113","DOI":"10.1016\/j.cub.2013.11.009","article-title":"Nuclear Mechanics and Mechanotransduction in Health and Disease","volume":"23","author":"Isermann","year":"2013","journal-title":"Curr. Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"38063","DOI":"10.1038\/srep38063","article-title":"The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity","volume":"6","author":"Alam","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1083\/jcb.201610042","article-title":"Mechanosensing by the nucleus: From pathways to scaling relationships","volume":"216","author":"Cho","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41556-018-0038-y","article-title":"Emerging views of the nucleus as a cellular mechanosensor","volume":"20","author":"Kirby","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1083\/jcb.200509124","article-title":"Coupling of the nucleus and cytoplasm: Role of the LINC complex","volume":"172","author":"Crisp","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Kristiani, L., Kim, M., and Kim, Y. (2020). Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation. Cells, 9.","DOI":"10.3390\/cells9030718"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12013-009-9067-2","article-title":"Mechanotransduction by TRP Channels: General Concepts and Specific Role in the Vasculature","volume":"56","author":"Yin","year":"2009","journal-title":"Cell Biophys."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1111\/bph.12569","article-title":"TRP channels in the skin","volume":"171","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Martinac, B., and Cox, C.D. (2017). Mechanosensory Transduction: Focus on Ion Channels. Reference Module in Life Sciences, Elsevier.","DOI":"10.1016\/B978-0-12-809633-8.08094-8"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1042\/bj20031089","article-title":"Ca2+ waves in keratinocytes are transmitted to sensory neurons: The involvement of extracellular ATP and P2Y2 receptor activation","volume":"380","author":"Koizumi","year":"2004","journal-title":"Biochem. J."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1046\/j.1523-1747.2002.19512.x","article-title":"Modulations in Epidermal Calcium Regulate the Expression of Differentiation-Specific Markers","volume":"119","author":"Elias","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"702264","DOI":"10.3389\/fphar.2021.702264","article-title":"Calcium Channels: Noteworthy Regulators and Therapeutic Targets in Dermatological Diseases","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Leuner, K., Kraus, M., W\u00f6lfle, U., Beschmann, H., Harteneck, C., Boehncke, W.-H., Schempp, C.M., and M\u00fcller, W.E. (2011). Reduced TRPC Channel Expression in Psoriatic Keratinocytes Is Associated with Impaired Differentiation and Enhanced Proliferation. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0014716"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Lakk, M., and Kri\u017eaj, D. (2020). Mechanically induced cytoskeletal remodeling in trabecular meshwork cells requires TRPV4-Rho signaling interactions. bioRxiv.","DOI":"10.1101\/2020.08.11.247171"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Cambria, E., Arlt, M., Wandel, S., Krupkova, O., Hitzl, W., Passini, F., Hausmann, O., Snedeker, J., Ferguson, S., and Wuertz-Kozak, K. (2020). TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells. Cells, 9.","DOI":"10.3390\/cells9071736"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"816149","DOI":"10.3389\/fimmu.2022.816149","article-title":"Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41586-019-1485-8","article-title":"Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity","volume":"573","author":"Solis","year":"2019","journal-title":"Nature"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"767319","DOI":"10.3389\/fimmu.2021.767319","article-title":"Stretching the Function of Innate Immune Cells","volume":"12","author":"Orsini","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s42003-019-0514-3","article-title":"Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca(2+) flickers","volume":"2","author":"Ellefsen","year":"2019","journal-title":"Commun. Biol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3389\/fphys.2020.00958","article-title":"Inside Out Integrin Activation Mediated by PIEZO1 Signaling in Erythroblasts","volume":"11","author":"Aglialoro","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"110342","DOI":"10.1016\/j.celrep.2022.110342","article-title":"Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-\u03b2-catenin mechanotransduction complex","volume":"38","author":"Wang","year":"2022","journal-title":"Cell Rep."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"e65415","DOI":"10.7554\/eLife.65415","article-title":"Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing","volume":"10","author":"Holt","year":"2021","journal-title":"eLife"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"120948","DOI":"10.1016\/j.biomaterials.2021.120948","article-title":"Electricity auto-generating skin patch promotes wound healing process by activation of mechanosensitive ion channels","volume":"275","author":"Kim","year":"2021","journal-title":"Biomaterials"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.celrep.2012.07.014","article-title":"Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents","volume":"2","author":"Schmidt","year":"2012","journal-title":"Cell Rep."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1126\/science.aar5703","article-title":"Piezo2 channel\u2013Merkel cell signaling modulates the conversion of touch to itch","volume":"360","author":"Feng","year":"2018","journal-title":"Science"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1515\/hsz-2018-0328","article-title":"Unforgettable force\u2014crosstalk and memory of mechanosensitive structures","volume":"400","author":"Kanoldt","year":"2018","journal-title":"Biol. Chem."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/jid.2010.414","article-title":"The Calcium-Sensing Receptor-Dependent Regulation of Cell\u2013Cell Adhesion and Keratinocyte Differentiation Requires Rho and Filamin, A","volume":"131","author":"Tu","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"e973760","DOI":"10.4161\/21541248.2014.973760","article-title":"Epithelial junctions and Rho family GTPases: The zonular signalosome","volume":"5","author":"Citi","year":"2014","journal-title":"Small GTPases"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"245","DOI":"10.21037\/atm.2018.04.09","article-title":"Molecular mechanisms of mechanotransduction in psoriasis","volume":"6","author":"Malakou","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Heim, J.B., McDonald, C.A., Wyles, S.P., Sominidi-Damodaran, S., Squirewell, E.J., Li, M., Motsonelidze, C., B\u00f6ttcher, R.T., Van Deursen, J., and Meves, A. (2018). FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0200558"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1242\/jcs.175539","article-title":"Focal adhesion-independent integrin \u03b1v regulation of FAK and c-myc is necessary for 3D skin formation and tumor invasion","volume":"128","author":"Duperret","year":"2015","journal-title":"J. Cell Sci."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2015.09.001","article-title":"Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity","volume":"163","author":"Serrels","year":"2015","journal-title":"Cell"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"36214","DOI":"10.1038\/srep36214","article-title":"Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis","volume":"6","author":"Chung","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/j.0022-202X.2005.23701.x","article-title":"Constitutive Phosphorylation of Focal Adhesion Kinase Is Involved in the Myofibroblast Differentiation of Scleroderma Fibroblasts","volume":"124","author":"Mimura","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm.2574","article-title":"Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling","volume":"18","author":"Wong","year":"2011","journal-title":"Nat. Med."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"19276","DOI":"10.1038\/srep19276","article-title":"Focal Adhesion Kinase Regulates Fibroblast Migration via Integrin \u03b2-1 and Plays a Central Role in Fibrosis","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-kappa B in the immune system","volume":"12","author":"Baeuerle","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1600-065X.2012.01109.x","article-title":"Role of NF-\u03baB in epithelial biology","volume":"246","author":"Pasparakis","year":"2012","journal-title":"Immunol. Rev."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1172\/JCI118106","article-title":"Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress","volume":"96","author":"Khachigian","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1016\/j.yexcr.2013.09.018","article-title":"Substrate stiffness regulates temporary NF-\u03baB activation via actomyosin contractions","volume":"319","author":"Ishihara","year":"2013","journal-title":"Exp. Cell Res."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Nam, J., Aguda, B.D., Rath, B., and Agarwal, S. (2009). Biomechanical thresholds regulate inflammation through the NF-kappaB pathway: Experiments and modeling. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005262"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"e00115","DOI":"10.1042\/BSR20140021","article-title":"Rho protein GTPases and their interactions with NF\u03baB: Crossroads of inflammation and matrix biology","volume":"34","author":"Tong","year":"2014","journal-title":"Biosci. Rep."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jcp.10477","article-title":"Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells","volume":"200","author":"Deitch","year":"2004","journal-title":"J. Cell Physiol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/jcb.22067","article-title":"Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1","volume":"106","author":"Cowell","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1042\/BST20130286","article-title":"Nucleocytoplasmic shuttling: A common theme in mechanotransduction","volume":"42","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/ncb2074","article-title":"Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions","volume":"12","author":"Connelly","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1242\/jcs.014456","article-title":"Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling","volume":"121","author":"Busche","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1182\/blood-2013-06-507582","article-title":"SRF is required for neutrophil migration in response to inflammation","volume":"123","author":"Taylor","year":"2014","journal-title":"Blood"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/jid.2012.378","article-title":"Serum Response Factor Controls Transcriptional Network Regulating Epidermal Function and Hair Follicle Morphogenesis","volume":"133","author":"Lin","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.cell.2011.02.031","article-title":"Yap1 Acts Downstream of \u03b1-Catenin to Control Epidermal Proliferation","volume":"144","author":"Schlegelmilch","year":"2011","journal-title":"Cell"},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Rognoni, E., and Walko, G. (2019). The Roles of YAP\/TAZ and the Hippo Pathway in Healthy and Diseased Skin. Cells, 8.","DOI":"10.3390\/cells8050411"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"14513","DOI":"10.1038\/s41598-018-32522-y","article-title":"Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway","volume":"8","author":"Jia","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Yu, Z., Yu, Q., Xu, H., Dai, X., Yu, Y., Cui, L., Chen, Y., Gu, J., Zhang, X., and Guo, C. (2022). IL-17A Promotes Psoriasis-Associated Keratinocyte Proliferation through ACT1-Dependent Activation of YAP-AREG Axis. J. Investig. Dermatol.","DOI":"10.1016\/j.jid.2022.02.016"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jid.2017.08.024","article-title":"Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis","volume":"138","author":"Toyama","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12079-020-00596-x","article-title":"Verteporfin inhibits the persistent fibrotic phenotype of lesional scleroderma dermal fibroblasts","volume":"15","author":"Racanelli","year":"2021","journal-title":"J. Cell Commun. Signal."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cell.2014.06.013","article-title":"YAP\/TAZ Incorporation in the \u03b2-Catenin Destruction Complex Orchestrates the Wnt Response","volume":"158","author":"Azzolin","year":"2014","journal-title":"Cell"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fimmu.2020.00323","article-title":"The Crosstalk Between Hippo-YAP Pathway and Innate Immunity","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_244","first-page":"1218","article-title":"Genome-wide association between YAP\/TAZ\/TEAD and AP-1 at enhancers drives oncogenic growth. Nat","volume":"17","author":"Zanconato","year":"2015","journal-title":"Cell Biol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"e12409","DOI":"10.15252\/emmm.202012409","article-title":"Psoriatic skin inflammation is promoted by c-Jun\/AP-1-dependent CCL2 and IL-23 expression in dendritic cells","volume":"13","author":"Novoszel","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature03963","article-title":"Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins","volume":"437","author":"Zenz","year":"2005","journal-title":"Nature"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5021\/ad.2009.21.1.35","article-title":"Comparison of the Expression Profile of JunB, c-Jun, and S100A8 (Calgranulin A) in Psoriasis Vulgaris and Guttate Psoriasis","volume":"21","author":"Park","year":"2009","journal-title":"Ann. Dermatol."},{"key":"ref_248","first-page":"367","article-title":"Understanding psoriasis: Role of miRNAs (Review)","volume":"9","author":"Timis","year":"2018","journal-title":"Biomed. Rep."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41556-019-0272-y","article-title":"MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis","volume":"21","author":"Moro","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_250","unstructured":"Sanchez, D.P., and Sonthalia, S. (2022). Koebner Phenomenon, StatPearls Publishing LLC."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.clindermatol.2013.05.012","article-title":"Isomorphic phenomenon of Koebner: Facts and controversies","volume":"31","author":"Camargo","year":"2013","journal-title":"Clin. Dermatol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature05824","article-title":"Universal physical responses to stretch in the living cell","volume":"447","author":"Trepat","year":"2007","journal-title":"Nature"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.0022-202X.2004.22328.x","article-title":"Mechanical Stretching In Vitro Regulates Signal Transduction Pathways and Cellular Proliferation in Human Epidermal Keratinocytes","volume":"122","author":"Yano","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.0906-6705.2006.00425.x","article-title":"Activation of Akt by mechanical stretching in human epidermal keratinocytes","volume":"15","author":"Yano","year":"2006","journal-title":"Exp. Dermatol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature09765","article-title":"A tension-induced mechanotransduction pathway promotes epithelial morphogenesis","volume":"471","author":"Zhang","year":"2011","journal-title":"Nature"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s001670100217","article-title":"Cyclic mechanical stretching enhances secretion of Interleukin 6 in human tendon fibroblasts","volume":"9","author":"Skutek","year":"2001","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.gene.2005.08.006","article-title":"Repetitive mechanical stretching modulates IL-1\u03b2 induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts","volume":"363","author":"Yang","year":"2005","journal-title":"Gene"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/01.ATV.18.6.894","article-title":"Cyclic Stretch Upregulates Production of Interleukin-8 and Monocyte Chemotactic and Activating Factor\/Monocyte Chemoattractant Protein-1 in Human Endothelial Cells","volume":"18","author":"Okada","year":"1998","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/jcmm.12060","article-title":"Mechanobiological dysregulation of the epidermis and dermis in skin disorders and in degeneration","volume":"17","author":"Ogawa","year":"2013","journal-title":"J. Cell. Mol. Med."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/13\/2026\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:38:22Z","timestamp":1760139502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/13\/2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,25]]},"references-count":259,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["cells11132026"],"URL":"https:\/\/doi.org\/10.3390\/cells11132026","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,25]]}}}