{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:20:31Z","timestamp":1790742031275,"version":"4.1.0"},"reference-count":155,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition which develops either due to stress or witnessing a traumatic situation. PTSD is characterized by acute and chronic stress response exhibit anxiety, fear, and an increased inflammatory etiology. Inflammation contributes a critical role in several parts of the brain that control fear and flashback cognatic function. It is known that impairment of the neurological circuit leads to the development of PTSD. Evidence has suggested that dysregulation of the sympathetic nervous system and hypothalamic-pituitary adrenal (HPA) axis and inflammatory responsiveness are pivotal and a greater risk in PTSD. NF-\u03baB, a master regulator for inflammation, has been showed to modulate memory reconsolidation and synaptic plasticity; however, NF-\u03baB\u2019s association with PTSD remain elusive. In this review, we provide relevant findings regarding NF-\u03baB activity in various components of brain and describe a potential mechanism linking PTSD using preclinical and clinical models. We envisage NF-\u03baB signaling as a crucial mediator for inflammation, cognitive function, memory restoration and behavioral actions of stress and suggest that it could be used for therapeutic intervention in PTSD.<\/jats:p>","DOI":"10.3390\/cells11132034","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T22:31:14Z","timestamp":1656369074000},"page":"2034","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Involvement of Nuclear Factor-\u03baB in Inflammation and Neuronal Plasticity Associated with Post-Traumatic Stress Disorder"],"prefix":"10.3390","volume":"11","author":[{"given":"Sudhiranjan","family":"Gupta","sequence":"first","affiliation":[{"name":"Biomarkers & Genetics Core, VISN 17 Center of Excellence for Research on Returning War Veterans, 4800 Memorial Drive (151C), Waco, TX 76711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakeshwar S.","family":"Guleria","sequence":"additional","affiliation":[{"name":"Biomarkers & Genetics Core, VISN 17 Center of Excellence for Research on Returning War Veterans, 4800 Memorial Drive (151C), Waco, TX 76711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1056\/NEJMra1612499","article-title":"Post-Traumatic Stress Disorder","volume":"376","author":"Shalev","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.ahj.2013.07.031","article-title":"Posttraumatic Stress Disorder and Risk for Coronary Heart Disease: A Meta-analytic Review","volume":"166","author":"Edmondson","year":"2013","journal-title":"Am. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1471-4159.2011.07545.x","article-title":"Cells, biomarkers, and post-traumatic stress disorder: Evidence for peripheral involvement in a central disease","volume":"120","author":"Andrews","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.2174\/1381612824666181120094749","article-title":"Synaptic Plasticity in PTSD and associated Comorbidities: The Function and Mechanism for Diagnostics and Therapy","volume":"24","author":"He","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100180","DOI":"10.1016\/j.ynstr.2019.100180","article-title":"HPA axis function and diurnal cortisol in post-traumatic stress disorder: A systematic review","volume":"11","author":"Speer","year":"2019","journal-title":"Neurobiol. Stress"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pnpbp.2018.10.010","article-title":"The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions","volume":"89","author":"Dunlop","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/pcn.12820","article-title":"Inflammation and post-traumatic stress disorder","volume":"73","author":"Hori","year":"2019","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.biopsych.2019.11.005","article-title":"Posttraumatic Stress Disorder and Inflammation: Untangling Issues of Bidirectionality","volume":"87","author":"Sumner","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"ref_9","unstructured":"American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [3rd ed.]. (DSM-III) ed."},{"key":"ref_10","unstructured":"American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [3rd ed.]. revised (DSM-III-R) ed."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"American Psychiatry Association (2013). Diagnostic and Statistical Manual of Mental Health Disorders, American Psychiatric Association. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1851078","DOI":"10.1080\/20008198.2020.1851078","article-title":"Self-reported PTSD symptoms and social support in U.S. military service members and veterans: A meta-analysis","volume":"12","author":"Blais","year":"2021","journal-title":"Eur. J. Psychotraumatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/jts.20487","article-title":"PTSD symptom increases in Iraq-deployed soldiers: Comparison with non-deployed soldiers and associations with baseline symptoms, deployment experiences, and postdeployment stress","volume":"23","author":"Vasterling","year":"2010","journal-title":"J. Trauma. Stress"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Xue, C., Ge, Y., Tang, B., Liu, Y., Kang, P., Wang, M., and Zhang, L.A. (2013). Meta-analysis of risk factors for combat-related PTSD among military personnel and veterans. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120270"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S2215-0366(14)70235-4","article-title":"The prevalence of post-traumatic stress disorder (PTSD) in US combat soldiers: A head-to-head comparison of DSM-5 versus DSM-IV-TR symptom criteria with the PTSD checklist","volume":"1","author":"Hoge","year":"2014","journal-title":"Lancet Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/da.22169","article-title":"Cumulative traumas and risk thresholds: 12-month PTSD in the World Mental Health (WMH) surveys","volume":"31","author":"Karam","year":"2014","journal-title":"Depress. Anxiety"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.janxdis.2010.11.010","article-title":"Prevalence and Axis I comorbidity of full and partial posttraumatic stress disorder in the United States: Results from Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"25","author":"Pietrzak","year":"2011","journal-title":"J. Anxiety Disord."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/10253890.2020.1766020","article-title":"Low glucocorticoids in stress-related disorders: The role of inflammation","volume":"6","author":"Sarapultsev","year":"2020","journal-title":"Stress"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.31887\/DCNS.2011.13.2\/jsherin","article-title":"Post-traumatic stress disorder: The neurobiological impact of psychological trauma","volume":"13","author":"Sherin","year":"2011","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1176\/appi.ajp.162.5.992","article-title":"Higher levels of basal serial CSF cortisol in combat veterans with posttraumatic stress disorder","volume":"162","author":"Baker","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0006-3223(03)00571-7","article-title":"Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects","volume":"54","author":"Sautter","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/10253890.2018.1470238","article-title":"Role of Glucocorticoid Negative Feedback in the Regulation of HPA Axis Pulsatility","volume":"21","author":"Gjerstad","year":"2018","journal-title":"Stress"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gola, H., Engler, A., Morath, J., Adenauer, H., Elbert, T., Kolassa, I.T., and Engler, H. (2014). Reduced peripheral expression of the glucocorticoid receptor alpha isoform in individuals with posttraumatic stress disorder: A cumulative effect of trauma burden. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086333"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/da.20605","article-title":"Risk and resilience: Genetic and environmental influences on development of the stress response","volume":"26","author":"Gillespie","year":"2009","journal-title":"Depress. Anxiety"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1001\/archgenpsychiatry.2009.114","article-title":"Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment","volume":"66","author":"Polanczyk","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1155\/2011\/928497","article-title":"Corticotrophin-releasing hormone type 1 receptor gene (CRHR1) variants predict posttraumatic stress disorder onset and course in pediatric injury patients","volume":"30","author":"Amstadter","year":"2011","journal-title":"Dis. Markers"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1196\/annals.1364.012","article-title":"Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implication","volume":"1071","author":"Yehuda","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1749-6632.2009.04979.x","article-title":"Status of Glucocorticoid Alterations in Post-traumatic Stress Disorder","volume":"1179","author":"Yehuda","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e368","DOI":"10.1038\/tp.2014.3","article-title":"Epigenetic modulation of glucocorticoid receptors in posttraumatic stress disorder","volume":"4","author":"Azoulay","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e2842","DOI":"10.1002\/dmrr.2842","article-title":"HPA axis dysregulation, NR3C1 polymorphisms and glucocorticoid receptor isoforms imbalance in metabolic syndrome","volume":"33","author":"Martins","year":"2017","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10274","DOI":"10.1523\/JNEUROSCI.1526-14.2014","article-title":"Epigenetic modification of the glucocorticoid receptor gene is linked to traumatic memory and post-traumatic stress disorder risk in genocide survivors","volume":"34","author":"Vukojevic","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.biopsych.2014.02.006","article-title":"Lower methylation of glucocorticoid receptor gene promoter 1F in periph eral blood of veterans with posttraumatic stress disorder","volume":"77","author":"Yehuda","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neubiorev.2009.12.003","article-title":"Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder","volume":"35","author":"Rohleder","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/sj.mp.4001934","article-title":"Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder","volume":"12","author":"Vermetten","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tins.2011.06.007","article-title":"Fear conditioning, synaptic plasticity and the amygdala: Implications for posttraumatic stress disorder","volume":"35","author":"Mahan","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nn.3900","article-title":"Fear generalization in the primate amygdala","volume":"18","author":"Resnik","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1176\/appi.ajp.2007.07030504","article-title":"Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia","volume":"164","author":"Etkin","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2045-5380-1-8","article-title":"An fMRI study of unconditioned responses in post-traumatic stress disorder","volume":"1","author":"Linnman","year":"2011","journal-title":"Biol. Mood Anxiety Disord."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2017.01.006","article-title":"Fear extinction and memory reconsolidation as critical components in behavioral treatment for posttraumatic stress disorder and potential augmentation of these processes","volume":"649","author":"Smith","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1001\/archgenpsychiatry.2012.73","article-title":"Amygdala volume in combat-exposed veterans with and without posttraumatic stress disorder: A cross-sectional study","volume":"69","author":"Kuo","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1001\/archgenpsychiatry.2012.50","article-title":"Mid-Atlantic MIRECC Workgroup Amygdala volume changes with posttraumatic stress disorder in a large case-controlled veteran group","volume":"69","author":"Morey","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbi.2014.06.201","article-title":"Greater amygdala activity and dorsomedial prefrontal-amygdala coupling are associated with enhanced inflammatory responses to stress","volume":"43","author":"Muscatell","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/gbb.12255","article-title":"Plasticity-related genes in brain development and amygdala-dependent learning","volume":"15","author":"Ehrlich","year":"2016","journal-title":"Genes Brain Behav."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuropharm.2011.07.014","article-title":"Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress","volume":"62","author":"McEwen","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.jpsychires.2013.05.031","article-title":"Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder","volume":"47","author":"Stevens","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpsyc.61.2.168","article-title":"Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD","volume":"61","author":"Shin","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1177\/070674371405900905","article-title":"Repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex for treating posttraumatic stress disorder: An exploratory meta-analysis of randomized, double-blind and sham-controlled trials","volume":"59","author":"Berlim","year":"2014","journal-title":"Can. J. Psychiatry"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.biopsych.2005.07.033","article-title":"Decreased anterior cingulate volume in combat-related PTSD","volume":"59","author":"Woodward","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1177\/1073858409333072","article-title":"Posttraumatic stress disorder: The role of medial prefrontal cortex and amygdala","volume":"15","author":"Koenigs","year":"2009","journal-title":"Neuroscientist"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1503\/jpn.160129","article-title":"Decreased uncinate fasciculus tract integrity in male and female patients with PTSD: A diffusion tensor imaging study","volume":"42","author":"Koch","year":"2017","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1152\/physrev.00002.2003","article-title":"The amygdaloid complex: Anatomy and physiology","volume":"83","author":"Sah","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.biopsych.2009.06.026","article-title":"Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder","volume":"66","author":"Milad","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/psyp.12699","article-title":"Reduced amygdala responsivity during conditioning to trauma-related stimuli in posttraumatic stress disorder: Conditioning to trauma-related stimuli in PTSD","volume":"53","author":"Diener","year":"2016","journal-title":"Psychophysiology"},{"key":"ref_54","first-page":"1","article-title":"Grey Matter Volume Reductions of the Left Hippocampus and Amygdala in PTSD: A Coordinate-Based Meta-Analysis of Magnetic Resonance Imaging Studies","volume":"14","author":"Ferracuti","year":"2022","journal-title":"Neuropsychobiology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.nicl.2017.11.016","article-title":"Episodic memory after trauma exposure: Medial temporal lobe function is positively related to re-experiencing and inversely related to negative affect symptoms","volume":"17","author":"Stevens","year":"2018","journal-title":"NeuroImage"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1176\/appi.ajp.158.11.1920","article-title":"Neural correlates of traumatic memories in posttraumatic stress disorder: A functional MRI investigation","volume":"158","author":"Lanius","year":"2011","journal-title":"Am. J. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.pscychresns.2009.06.001","article-title":"Smaller amygdala volume and reduced anterior cingulate gray matter density associated with history of post-traumatic stress disorder","volume":"174","author":"Rogers","year":"2009","journal-title":"Psychiatry Res.-Neuroimaging"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.biopsych.2004.09.015","article-title":"Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder","volume":"56","author":"Wignall","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"ref_59","first-page":"281","article-title":"Amygdala Nuclei Volume and Shape in Military Veterans with Posttraumatic Stress Disorder. VA Mid-Atlantic MIRECC Workgroup, Wagner HR, LaBar KS","volume":"5","author":"Morey","year":"2020","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrn2335","article-title":"The hippocampus and memory: Insights from spatial processing","volume":"9","author":"Bird","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/acps.12920","article-title":"Smaller hippocampal volume following sexual assault in women is associated with post-traumatic stress disorder","volume":"138","author":"Andersson","year":"2018","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/hipo.10183","article-title":"Hippocampal function in posttraumatic stress disorder","volume":"14","author":"Shin","year":"2004","journal-title":"Hippocampus"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2470547017724069","DOI":"10.1177\/2470547017724069","article-title":"The association of PTSD symptom severity with localized hippocampus and amygdala abnormalities","volume":"1","author":"Akiki","year":"2017","journal-title":"Chronic Stress"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41398-022-01976-0","article-title":"Altered hippocampus and amygdala subregion connectome hierarchy in major depressive disorder","volume":"12","author":"Jacob","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1173215","article-title":"A functional role for adult hippocampal neurogenesis in spatial pattern separation","volume":"325","author":"Clelland","year":"2009","journal-title":"Science"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jpsychires.2017.09.007","article-title":"Automated measurement of hippocampal subfields in PTSD: Evidence for smaller dentate gyrus volume","volume":"95","author":"Hayes","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.euroneuro.2014.09.009","article-title":"Distinctive hippocampal and amygdalar cytoarchitectural changes underlie specific patterns of behavioral disruption following stress exposure in an animal model of PTSD","volume":"24","author":"Cohen","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/npp.2013.5","article-title":"Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression","volume":"38","author":"Boldrini","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"15771580","DOI":"10.1001\/archinte.1987.00370090055011","article-title":"Psychiatric complications of long-term interferon alfa therapy","volume":"147","author":"Renault","year":"1987","journal-title":"Arch. Intern. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1378\/chest.118.2.503","article-title":"Proinflammatory cytokines","volume":"118","author":"Dinarello","year":"2000","journal-title":"Chest"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbi.2014.06.003","article-title":"Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress","volume":"42","author":"Lindqvist","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bbi.2016.09.012","article-title":"Increased pro-inflammatory milieu in combat related PTSD: A new cohort replication study","volume":"59","author":"Lindqvist","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e1815","DOI":"10.7205\/MILMED-D-17-00073","article-title":"The role of inflammation in late-life post-traumatic stress disorder","volume":"182","author":"Miller","year":"2017","journal-title":"Mil. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jpsychires.2018.04.009","article-title":"Inflammatory markers and their possible effects on cognitive function in women with posttraumatic stress disorder","volume":"102","author":"Imai","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.psychres.2017.11.061","article-title":"Serum levels of interleukins IL-6 and IL-10 in individuals with posttraumatic stress disorder in a population-based sample","volume":"260","author":"Wiener","year":"2018","journal-title":"Psychiatry Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.comppsych.2017.01.015","article-title":"Genetic and serum biomarker evidence for a relationship between TNF\u03b1 and PTSD in Vietnam War combat veterans","volume":"74","author":"Bruenig","year":"2017","journal-title":"Compr. Psychiatry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S2215-0366(15)00309-0","article-title":"Inflammatory markers in post-traumatic stress disorder: A systematic review, meta-analysis, and meta-regression","volume":"2","author":"Passos","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/mp.2012.113","article-title":"A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus","volume":"18","author":"Logue","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1111\/ejn.15031","article-title":"C-Reactive Protein: Marker of risk for post-traumatic stress disorder and its potential for a mechanistic role in trauma response and recovery","volume":"55","author":"Friend","year":"2020","journal-title":"Eur. J. Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jpsychires.2017.01.007","article-title":"Elevated C-reactive protein and posttraumatic stress pathology among survivors of the 9\/11 World Trade Center attacks","volume":"89","author":"Rosen","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cyto.2013.04.033","article-title":"investigators K. No evidence for an association of posttraumatic stress disorder with circulating levels of CRP and IL-18 in a population-based study","volume":"63","author":"Baumert","year":"2013","journal-title":"Cytokine"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbi.2021.12.025","article-title":"The relations between C-reactive protein and trauma exposure, PTSD and depression symptoms, and PTSD psychotherapy treatment response in treatment seeking veterans and service members","volume":"101","author":"Yasinski","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"145898","DOI":"10.1016\/j.gene.2021.145898","article-title":"PTSD Initiative. Investigation of C-reactive protein and AIM2 methylation as a marker for PTSD in Australian Vietnam veterans","volume":"803","author":"Lawford","year":"2021","journal-title":"Gene"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1176\/appi.ajp.2014.14020263","article-title":"Association of CRP genetic variation and CRP level with elevated PTSD symptoms and physiological responses in a civilian population with high levels of trauma","volume":"172","author":"Michopoulos","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbi.2017.08.022","article-title":"CRP polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, PTSD, and C-reactive protein","volume":"67","author":"Miller","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2147\/JIR.S155903","article-title":"Systemic low-grade inflammation in post-traumatic stress disorder: A systematic review","volume":"11","author":"Speer","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.expneurol.2016.07.024","article-title":"New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibility","volume":"284 Pt B","author":"Daskalakis","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ynstr.2018.03.001","article-title":"Evidence for altered brain reactivity to norepinephrine in Veterans with a history of traumatic stress","volume":"8","author":"Hendrickson","year":"2018","journal-title":"Neurobiol. Stress"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/npp.2016.125","article-title":"Danger signals and inflammasomes: Stress- evoked sterile inflammation mood disorders","volume":"42","author":"Fleshner","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bbi.2017.10.025","article-title":"Depression and sterile inflammation: Essential role of danger associated molecular patterns","volume":"72","author":"Franklin","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s11011-014-9551-2","article-title":"Interleukin 6 and cognitive dysfunction","volume":"29","author":"Trapero","year":"2014","journal-title":"Metab. Brain Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.biopsych.2018.02.007","article-title":"Metabolism, motabolomics, and inflammation in posttraumatic stress disorder","volume":"83","author":"Mellon","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0092-8674(86)90807-X","article-title":"Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism","volume":"47","author":"Sen","year":"1986","journal-title":"Cell"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bbamcr.2005.05.009","article-title":"Signaling via NF-kappaB in the nervous system","volume":"1745","author":"Kaltschmidt","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/sj.cdd.4401837","article-title":"Roles for NF-kappa B in nerve cell survival, plasticity, and disease","volume":"13","author":"Mattson","year":"2006","journal-title":"Cell Death Differ."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tins.2004.11.002","article-title":"Physiological functions for brain NF-kappaB","volume":"28","author":"Meffert","year":"2005","journal-title":"Trends Neurosci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3389\/fimmu.2019.01043","article-title":"Cellular Specificity of NF-\u03baB Function in the Nervous System","volume":"10","author":"Dresselhaus","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.3140380","article-title":"Kappa B: A specific inhibitor of the NF-kappa B transcription factor","volume":"242","author":"Baeuerle","year":"1988","journal-title":"Science"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ni0102-20","article-title":"Regulatory functions of ubiquitination in the immune system","volume":"3","year":"2002","journal-title":"Nat. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","article-title":"NF-\u03baB and Rel proteins: Evolutionary conserved mediators of immune responses","volume":"16","author":"Ghosh","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1128\/CMR.15.3.414-429.2002","article-title":"NF-\u03baB family of transcription factors: Central regulators of innate and adaptive immune functions","volume":"15","author":"Caamano","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_104","first-page":"13","article-title":"NF-B: Ten years after","volume":"87","author":"Baeuerle","year":"1996","journal-title":"Cell Death Differ."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1210\/me.2008-0283","article-title":"Minireview: Latest perspectives on antiinflammatory actions of glucocorticoids","volume":"23","author":"Haegeman","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1471-4159.2000.740443.x","article-title":"Roles of nuclear factor \u03baB in neuronal survival and plasticity","volume":"74","author":"Mattson","year":"2000","journal-title":"J. Neurochem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/(SICI)1097-4547(19970915)49:6<681::AID-JNR3>3.0.CO;2-3","article-title":"Activation of NF-\u03baB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration","volume":"49","author":"Mattson","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0169-328X(95)00229-L","article-title":"Gene expression of the transcription factor NF-\u03baB in hippocampus: Regulation by synaptic activity","volume":"38","author":"Meberg","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4155\/tde-2019-0075","article-title":"Targeting the NF-kappaB pathway for therapy of ischemic stroke","volume":"11","author":"Howell","year":"2020","journal-title":"Ther. Deliv."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuroscience.2008.07.007","article-title":"NF-kappaB signaling in cerebral ischemia","volume":"158","author":"Ridder","year":"2009","journal-title":"Neuroscience"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2174\/1570159X18666200207120949","article-title":"Role of Nuclear Factor Kappa B (NF-kappaB) Signalling in Neurodegenerative Diseases: A Mechanistic Approach","volume":"18","author":"Singh","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1096\/fj.201700826R","article-title":"Wirth T IKK2\/NF-kappaB signaling protects neurons after traumatic brain injury","volume":"32","author":"Mettang","year":"2018","journal-title":"FASEB J."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/8432","article-title":"NF-kappaB is activated and promotes cell death in focal cerebral ischemia","volume":"5","author":"Schneider","year":"1999","journal-title":"Nat. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuro.2014.04.010","article-title":"Repeated exposure to low doses of kainic acid activates nuclear factor kappa B (NF-kappaB) prior to seizure in transgenic NF-kappaB\/EGFP reporter mice","volume":"44","author":"Miller","year":"2014","journal-title":"Neurotoxicology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"8466","DOI":"10.1523\/JNEUROSCI.22-19-08466.2002","article-title":"Constitutive nuclear factor-kappa B activity is required for central neuron survival","volume":"22","author":"Bhakar","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"9403","DOI":"10.1523\/JNEUROSCI.23-28-09403.2003","article-title":"Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection","volume":"23","author":"Fridmacher","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.bbr.2004.03.026","article-title":"NF-kappaB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety","volume":"154","author":"Kassed","year":"2004","journal-title":"Behav. Brain Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1073\/pnas.0910658107","article-title":"Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior","volume":"107","author":"Kook","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1038\/npp.2011.118","article-title":"The characteristic long-term upregulation of hippocampal NF-kappaB complex in PTSD-like behavioral stress response is normalized by high-dose corticosterone and pyrrolidine dithiocarbamate administered immediately after exposure","volume":"36","author":"Cohen","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1176\/ajp.2006.163.9.1630","article-title":"Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress","volume":"163","author":"Pace","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1155\/2011\/560572","article-title":"Neylan Transcriptional control of monocyte gene expression in post-traumatic stress disorder","volume":"30","author":"Sun","year":"2011","journal-title":"Dis. Markers"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.yfrne.2011.12.002","article-title":"Cytokines and brain excitability","volume":"33","author":"Galic","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cellsig.2006.06.007","article-title":"Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms","volume":"19","author":"Tan","year":"2007","journal-title":"Cell. Signal."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/318635a0","article-title":"Primary structure and expression of a functional human glucocorticoid receptor cDNA","volume":"318","author":"Hollenberg","year":"1985","journal-title":"Nature"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1749-6632.2012.06633.x","article-title":"Glucocorticoid regulation of inflammation and its functional correlates: From HPA axis to glucocorticoid receptor dysfunction","volume":"1261","author":"Silverman","year":"2012","journal-title":"Ann. N. Y. Acad Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.psyneuen.2012.08.007","article-title":"Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behavior","volume":"38","author":"Harris","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0092-8674(88)90145-6","article-title":"Multiple and cooperative trans-activation domains of the human glucocorticoid receptor","volume":"55","author":"Hollenberg","year":"1998","journal-title":"Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1128\/MCB.17.5.2735","article-title":"GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors","volume":"17","author":"Hong","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1073\/pnas.91.2.752","article-title":"Physical association and functional antagonism between the p65 subunit of transcription factor NF-\u03baB and the glucocorticoid receptor","volume":"91","author":"Ray","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_130","first-page":"401","article-title":"Negative cross-talk between RelA and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids","volume":"9","author":"Caldenhoven","year":"1995","journal-title":"Mol. Endocrinol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1128\/MCB.15.2.943","article-title":"Characterization of mechanisms involved in transrepression of NF-kB by activated glucocorticoid receptors","volume":"15","author":"Scheinman","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"13504","DOI":"10.1073\/pnas.94.25.13504","article-title":"Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation","volume":"94","author":"Schmitz","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1523\/JNEUROSCI.2456-10.2011","article-title":"A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis","volume":"31","author":"Boersma","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1101\/lm.037291.114","article-title":"Stress effects on the hippocampus: A critical review","volume":"22","author":"Kim","year":"2015","journal-title":"Learn Mem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11920-017-0829-z","article-title":"Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic","volume":"19","author":"Krystal","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.bbi.2019.07.003","article-title":"Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression","volume":"81","author":"Golia","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.biopsych.2013.03.026","article-title":"Rapid-acting glutamatergic antidepressants: The path to ketamine and beyond","volume":"73","author":"Krystal","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1038\/cdd.2013.108","article-title":"Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation","volume":"20","author":"Maatouk","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nn1110","article-title":"NF-kappa B functions in synaptic signaling and behavior","volume":"6","author":"Meffert","year":"2003","journal-title":"Nat. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1037\/0278-6133.21.6.531","article-title":"Chronic psychological stress and the regulation of proinflammatory cytokines: A glucocorticoid-resistance model","volume":"21","author":"Miller","year":"2002","journal-title":"Health Psychol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbi.2014.05.016","article-title":"Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers","volume":"41","author":"Miller","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s12035-013-8555-y","article-title":"Roles for NF-\u03baB and gene targets of NF-\u03baB in synaptic plasticity, memory, and navigation","volume":"49","author":"Snow","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/hipo.20020","article-title":"Transcription factor NF-kappaB activation after in vivo perforant path LTP in mouse hippocampus","volume":"14","author":"Freudenthal","year":"2004","journal-title":"Hippocampus"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1098-2396(200002)35:2<151::AID-SYN8>3.0.CO;2-P","article-title":"Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity","volume":"35","author":"Albensi","year":"2000","journal-title":"Synapse"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Oikawa, K., Odero, G.L., Platt, E., Neuendorff, M., Hatherell, A., Bernstein, M.J., and Albensi, B.C. (2012). NF-\u03baB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus. BMC Neurosci., 13.","DOI":"10.1186\/1471-2202-13-45"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1523\/JNEUROSCI.4398-05.2006","article-title":"Chronic unpredictable stress exacerbates lipopolysaccharide-induced activation of nuclear factor-kappaB in the frontal cortex and hippocampus via glucocorticoid secretion","volume":"26","author":"Munhoz","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"13436","DOI":"10.1523\/JNEUROSCI.4430-07.2007","article-title":"Activation of hippocampal nuclear factor-kappa B by retrieval is required for memory reconsolidation","volume":"27","author":"Boccia","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1111\/j.1460-9568.2005.04126.x","article-title":"NF-kappaB transcription factor is required for inhibitory avoidance long-term memory in mice","volume":"21","author":"Freudenthal","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bbr.2010.08.047","article-title":"Inhibition of nuclear factor-kappaB impairs reconsolidation of morphine reward memory in rats","volume":"216","author":"Yang","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1101\/lm.866408","article-title":"c-Rel, an NF-kappaB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation","volume":"15","author":"Ahn","year":"2008","journal-title":"Learn Mem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1128\/MCB.26.8.2936-2946.2006","article-title":"NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A\/CREB signaling","volume":"26","author":"Kaltschmidt","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Si, J., Yang, J., Xue, L., Yang, C., Luo, Y., Shi, H., and Lu, L. (2012). Activation of NF-kB in Basolateral Amygdala Is Required for Memory Reconsolidation in Auditory Fear Conditioning. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043973"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"6409","DOI":"10.1007\/s12035-019-1529-y","article-title":"In vitro priming and hyper-activation of brain microglia: An assessment of phenotypes","volume":"56","author":"Koss","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1007\/s12035-020-02213-9","article-title":"Ginsenoside Rg1 prevents PTSD-like behaviors in mice through promoting synaptic proteins, reducing Kir4.1 and TNF-\u03b1 in the hippocampus","volume":"58","author":"Zhang","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12974-020-02069-9","article-title":"Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice","volume":"18","author":"Li","year":"2021","journal-title":"J. Neuroinflamm."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/13\/2034\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:38:57Z","timestamp":1760139537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/13\/2034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,27]]},"references-count":155,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["cells11132034"],"URL":"https:\/\/doi.org\/10.3390\/cells11132034","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,27]]}}}