{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:38:04Z","timestamp":1787647084430,"version":"build-2736575974"},"reference-count":39,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health (Ministero della Salute-Ricerca Corrente)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>D6 is a scavenger receptor for CC chemokines expressed in the human placenta. It prevents excessive leukocyte tissue infiltration by internalizing chemokines through cytoskeleton-dependent intracellular transport. In preeclampsia (PE), the D6 receptor is overexpressed in trophoblast cells, but functionally impaired, due to cytoskeleton destructuring. Low molecular weight heparin (LMWH) represents a potential treatment for PE based on its anti-thrombotic and anti-inflammatory properties. Here, we investigated the effect of enoxaparin on D6 expression, and cytoskeleton organization primary cytotrophoblast cell cultures were obtained from the placentae of women with PE (n = 9) or uncomplicated pregnancy (n = 9). We demonstrated that enoxaparin is able to (i) increase D6 expression, and (ii) improve cytoskeletal fiber alignment in trophoblast cells from PE patients.<\/jats:p>","DOI":"10.3390\/cells11132036","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T22:31:14Z","timestamp":1656369074000},"page":"2036","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Enoxaparin Increases D6 Receptor Expression and Restores Cytoskeleton Organization in Trophoblast Cells from Preeclampsia"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1590-3942","authenticated-orcid":false,"given":"Chiara","family":"Tersigni","sequence":"first","affiliation":[{"name":"U.O.C. di Ostetricia e Patologia Ostetrica, Fondazione Policlinico Universitario A. Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-319X","authenticated-orcid":false,"given":"Giuseppe","family":"Maulucci","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Sezione di Biofisica, Universit\u00e0 Cattolica del Sacro Cuore, L. go Francesco Vito 1, 00168 Rome, Italy"},{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Castellani","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Ostetrica e Ginecologica, Universit\u00e0 Cattolica del Sacro Cuore, L.go Francesco Vito 1, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1257-2295","authenticated-orcid":false,"given":"Giada","family":"Bianchetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Sezione di Biofisica, Universit\u00e0 Cattolica del Sacro Cuore, L. go Francesco Vito 1, 00168 Rome, Italy"},{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Onori","sequence":"additional","affiliation":[{"name":"U.O.C. di Ostetricia e Patologia Ostetrica, Fondazione Policlinico Universitario A. Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Franco","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Ostetrica e Ginecologica, Universit\u00e0 Cattolica del Sacro Cuore, L.go Francesco Vito 1, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8798-5065","authenticated-orcid":false,"given":"Greta","family":"Barbaro","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Ostetrica e Ginecologica, Universit\u00e0 Cattolica del Sacro Cuore, L.go Francesco Vito 1, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4260-5107","authenticated-orcid":false,"given":"Marco","family":"De Spirito","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Sezione di Biofisica, Universit\u00e0 Cattolica del Sacro Cuore, L. go Francesco Vito 1, 00168 Rome, Italy"},{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lanzone","sequence":"additional","affiliation":[{"name":"U.O.C. di Ostetricia e Patologia Ostetrica, Fondazione Policlinico Universitario A. Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"},{"name":"Istituto di Clinica Ostetrica e Ginecologica, Universit\u00e0 Cattolica del Sacro Cuore, L.go Francesco Vito 1, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Ostetrica e Ginecologica, Universit\u00e0 Cattolica del Sacro Cuore, L.go Francesco Vito 1, 00168 Rome, Italy"},{"name":"U.O.C. di Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, L. go A. Gemelli 8, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-3335","authenticated-orcid":false,"given":"Nicoletta","family":"Di Simone","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Italy"},{"name":"IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"ref_1","unstructured":"Villar, J., Say, L., Gulmezoglu, A.M., Meraldi, M., Lindheimer, M.D., and Betran, A.P.P.G. (2003). Eclampsia and Preeclampsia: A Health Problem for 2000 Years. 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