{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:39:17Z","timestamp":1783982357484,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004166","name":"Medical University of Warsaw","doi-asserted-by":"publisher","award":["2W10\/N\/22:MAT"],"award-info":[{"award-number":["2W10\/N\/22:MAT"]}],"id":[{"id":"10.13039\/501100004166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004166","name":"Medical University of Warsaw","doi-asserted-by":"publisher","award":["2017\/01\/X\/NZ3\/00250"],"award-info":[{"award-number":["2017\/01\/X\/NZ3\/00250"]}],"id":[{"id":"10.13039\/501100004166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004166","name":"Medical University of Warsaw","doi-asserted-by":"publisher","award":["2021\/41\/B\/NZ6\/01590"],"award-info":[{"award-number":["2021\/41\/B\/NZ6\/01590"]}],"id":[{"id":"10.13039\/501100004166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Polish National Science Center","award":["2W10\/N\/22:MAT"],"award-info":[{"award-number":["2W10\/N\/22:MAT"]}]},{"name":"Polish National Science Center","award":["2017\/01\/X\/NZ3\/00250"],"award-info":[{"award-number":["2017\/01\/X\/NZ3\/00250"]}]},{"name":"Polish National Science Center","award":["2021\/41\/B\/NZ6\/01590"],"award-info":[{"award-number":["2021\/41\/B\/NZ6\/01590"]}]},{"name":"Polish National Science Center","award":["2W10\/N\/22:MAT"],"award-info":[{"award-number":["2W10\/N\/22:MAT"]}]},{"name":"Polish National Science Center","award":["2017\/01\/X\/NZ3\/00250"],"award-info":[{"award-number":["2017\/01\/X\/NZ3\/00250"]}]},{"name":"Polish National Science Center","award":["2021\/41\/B\/NZ6\/01590"],"award-info":[{"award-number":["2021\/41\/B\/NZ6\/01590"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>SARS-CoV-2 infection leads to severe lung damage due to pneumonia and, in more severe cases, leads to acute respiratory distress syndrome, or ARDS. This affects the viability of bronchoalveolar cells. An important role in the pathogenesis of these complications is the hyperactivation of the renin-angiotensin-aldosterone (RAA) pathway and induction of cytokine storm that occurs in an Nlrp3 inflammasome-dependent manner. To shed more light on the susceptibility of lung tissue to SARS-CoV-2 infection, we evaluated murine bronchioalveolar stem cells (BASC), alveolar type II cells (AT2), and 3D-derived organoids expression of mRNA encoding genes involved in virus entry into cells, components of RAA, and genes that comprise elements of the Nlrp3 inflammasome pathway. We noticed that all these genes are expressed by lung alveolar stem cells and organoids-derived from these cells. Interestingly, all these cells express a high level of ACE2 that, on the one hand, serves as an entry receptor for SARS-CoV-2 and, on the other, converts angiotensin II into its physiological antagonist, angiotensin 1\u20137 (Ang 1\u20137), which has been reported to have a protective role in lung damage. To shed more light on the role of Ang 1\u20137 on lung tissue, we exposed lung-derived BASC and AT2 cells to this mediator of RAA and noticed that it increases the proliferation of these cells. Based on this, Ang 1\u20137 could be employed to alleviate the damage to lung alveolar stem\/progenitor cells during SARS-CoV-2 infection.<\/jats:p>","DOI":"10.3390\/cells11132102","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T11:12:35Z","timestamp":1656760355000},"page":"2102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Angiotensin 1\u20137 Stimulates Proliferation of Lung Bronchoalveolar Progenitors\u2014Implications for SARS-CoV-2 Infection"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-136X","authenticated-orcid":false,"given":"Andrzej K.","family":"Ciechanowicz","sequence":"first","affiliation":[{"name":"Laboratory of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Xin","family":"Lay","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefte","family":"Prado Paulino","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Suchocki","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Leszczak","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Leszczak","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kucia","sequence":"additional","affiliation":[{"name":"Laboratory of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, 02-097 Warsaw, Poland"},{"name":"Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1161\/CIRCULATIONAHA.120.047297","article-title":"Substituting Angiotensin-(1\u20137) to Prevent Lung Damage in SARS-CoV-2 Infection?","volume":"141","author":"Peiro","year":"2020","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1097\/CCM.0b013e31828a6688","article-title":"Angiotensin-(1\u20137) protects from experimental acute lung injury","volume":"41","author":"Klein","year":"2013","journal-title":"Crit. 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