{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:53:07Z","timestamp":1790758387283,"version":"4.1.0"},"reference-count":131,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T00:00:00Z","timestamp":1658016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Austrian Science Fund (FWF)","award":["P315820"],"award-info":[{"award-number":["P315820"]}]},{"name":"the Austrian Science Fund (FWF)","award":["ZAP746010"],"award-info":[{"award-number":["ZAP746010"]}]},{"name":"the Austrian Science Fund (FWF)","award":["F.33827\/10-2021"],"award-info":[{"award-number":["F.33827\/10-2021"]}]},{"name":"Tiroler Wissenschaftsf\u00f6rderung","award":["P315820"],"award-info":[{"award-number":["P315820"]}]},{"name":"Tiroler Wissenschaftsf\u00f6rderung","award":["ZAP746010"],"award-info":[{"award-number":["ZAP746010"]}]},{"name":"Tiroler Wissenschaftsf\u00f6rderung","award":["F.33827\/10-2021"],"award-info":[{"award-number":["F.33827\/10-2021"]}]},{"name":"the University of Innsbruck","award":["P315820"],"award-info":[{"award-number":["P315820"]}]},{"name":"the University of Innsbruck","award":["ZAP746010"],"award-info":[{"award-number":["ZAP746010"]}]},{"name":"the University of Innsbruck","award":["F.33827\/10-2021"],"award-info":[{"award-number":["F.33827\/10-2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The human skin is exposed daily to different environmental factors such as air pollutants and ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin and is known to promote aging and inflammation of this tissue, leading to the onset of skin disorders and to the appearance of wrinkles and pigmentation issues. Besides this, components of air pollution can interact synergistically with ultraviolet light and increase the impact of damage to the skin. However, little is known about the modulation of air pollution on cellular senescence in skin cells and how this can contribute to skin aging. In this review, we are summarizing the current state of knowledge about air pollution components, their involvement in the processes of cellular senescence and skin aging, as well as the current therapeutic and cosmetic interventions proposed to prevent or mitigate the effects of air pollution in the skin.<\/jats:p>","DOI":"10.3390\/cells11142220","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T21:00:28Z","timestamp":1658091628000},"page":"2220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Effects of Air Pollution on Cellular Senescence and Skin Aging"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-704X","authenticated-orcid":false,"given":"Ines","family":"Martic","sequence":"first","affiliation":[{"name":"Institute for Biomedical Aging Research, Universit\u00e4t Innsbruck, 6020 Innsbruck, Austria"},{"name":"Center for Molecular Biosciences Innsbruck (CMBI), Innrain 58, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7771-3429","authenticated-orcid":false,"given":"Pidder","family":"Jansen-D\u00fcrr","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Aging Research, Universit\u00e4t Innsbruck, 6020 Innsbruck, Austria"},{"name":"Center for Molecular Biosciences Innsbruck (CMBI), Innrain 58, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4891-9636","authenticated-orcid":false,"given":"Maria","family":"Cavinato","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Aging Research, Universit\u00e4t Innsbruck, 6020 Innsbruck, Austria"},{"name":"Center for Molecular Biosciences Innsbruck (CMBI), Innrain 58, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,17]]},"reference":[{"key":"ref_1","unstructured":"Ratan, S.I. (2020). Cosmetics and Cosmeceuticals. Reference Module in Biomedical Sciences, Elsevier."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4161\/derm.19858","article-title":"Environmental Influences on Skin Aging and Ethnic-Specific Manifestations","volume":"4","author":"Krutmann","year":"2012","journal-title":"Dermato-Endocrinology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.exger.2017.01.009","article-title":"Molecular Mechanisms of UVB-Induced Senescence of Dermal Fibroblasts and Its Relevance for Photoaging of the Human Skin","volume":"94","author":"Cavinato","year":"2017","journal-title":"Exp. Gerontol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Cavinato, M., Wedel, S., and Jansen-D\u00fcrr, P. (2019). Aging of Cells In Vitro. Reference Module in Biomedical Sciences, Elsevier.","DOI":"10.1016\/B978-0-12-801238-3.11409-6"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.lfs.2016.03.039","article-title":"Air Pollution and Skin Diseases: Adverse Effects of Airborne Particulate Matter on Various Skin Diseases","volume":"152","author":"Kim","year":"2016","journal-title":"Life Sci."},{"key":"ref_6","unstructured":"WHO (2022, April 30). WHO Releases Country Estimates on Air Pollution Exposure and Health Impact (outdoor air pollution) in, Asia and Western Pacific regions. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ambient-."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/jocd.12518","article-title":"Atmospheric Skin Aging-Contributors and Inhibitors","volume":"17","author":"McDaniel","year":"2018","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4103\/0378-6323.199579","article-title":"Effects of Air Pollution on the Skin: A Review","volume":"83","author":"Puri","year":"2017","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jdermsci.2014.08.008","article-title":"Pollution and Skin: From Epidemiological and Mechanistic Studies to Clinical Implications","volume":"76","author":"Krutmann","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.envpol.2007.06.012","article-title":"Human Health Effects of Air Pollution","volume":"151","author":"Kampa","year":"2008","journal-title":"Environ. Pollut."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/bjd.20483","article-title":"Air Pollution-induced Tanning of Human Skin*","volume":"185","author":"Felsner","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"116850","DOI":"10.1016\/j.envpol.2021.116850","article-title":"Particulate Matter Promotes Hyperpigmentation via AhR\/MAPK Signaling Activation and by Increasing \u03b1-MSH Paracrine Levels in Keratinocytes","volume":"278","author":"Shi","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"111534","DOI":"10.1016\/j.biopha.2021.111534","article-title":"Natural Compounds Protect the Skin from Airborne Particulate Matter by Attenuating Oxidative Stress","volume":"138","author":"Diao","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"151108","DOI":"10.1016\/j.ejcb.2020.151108","article-title":"Aging of the Cells: Insight into Cellular Senescence and Detection Methods","volume":"99","author":"Safuan","year":"2020","journal-title":"Eur. J. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100981","DOI":"10.1016\/j.arr.2019.100981","article-title":"Premature Cell Senescence in Human Skin: Dual Face in Chronic Acquired Pigmentary Disorders","volume":"57","author":"Bellei","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fgene.2018.00247","article-title":"Biomarkers of Cellular Senescence and Skin Aging","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"111322","DOI":"10.1016\/j.mad.2020.111322","article-title":"A New Model to Investigate UVB-Induced Cellular Senescence and Pigmentation in Melanocytes","volume":"190","author":"Martic","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111525","DOI":"10.1016\/j.mad.2021.111525","article-title":"Faces of Cellular Senescence in Skin Aging","volume":"198","author":"Ho","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The Role of Senescent Cells in Ageing","volume":"509","year":"2014","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Vasileiou, P., Evangelou, K., Vlasis, K., Fildisis, G., Panayiotidis, M., Chronopoulos, E., Passias, P.-G., Kouloukoussa, M., Gorgoulis, V., and Havaki, S. (2019). Mitochondrial Homeostasis and Cellular Senescence. Cells, 8.","DOI":"10.3390\/cells8070686"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fcell.2019.00143","article-title":"Autophagic Control of Skin Aging","volume":"7","author":"Eckhart","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lee, Y.I., Choi, S., Roh, W.S., Lee, J.H., and Kim, T.-G. (2021). Cellular Senescence and Inflammaging in the Skin Microenvironment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083849"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3565127","DOI":"10.1155\/2016\/3565127","article-title":"ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases","volume":"2016","author":"Davalli","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jid.2020.11.018","article-title":"Principles of the Molecular and Cellular Mechanisms of Aging","volume":"141","author":"Schumacher","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0531-5565(00)00180-7","article-title":"Cellular and Molecular Mechanisms of Stress-Induced Premature Senescence (SIPS) of Human Diploid Fibroblasts and Melanocytes","volume":"35","author":"Toussaint","year":"2000","journal-title":"Exp. Gerontol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: Many Therapeutic Avenues","volume":"34","author":"Birch","year":"2020","journal-title":"Genes Dev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1101\/gad.290635.116","article-title":"The Senescence-Associated Secretory Phenotype Induces Cellular Plasticity and Tissue Regeneration","volume":"31","author":"Ritschka","year":"2017","journal-title":"Genes Dev."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cuollo, L., Antonangeli, F., Santoni, A., and Soriani, A. (2020). The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases. Biology, 9.","DOI":"10.3390\/biology9120485"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.1469-7580.2000.19740529.x","article-title":"Appearance of Biomarkers of in Vitro Ageing after Successive Stimulation of WI-38 Fibroblasts with IL-1alpha and TNF-Alpha: Senescence Associated Beta-Galactosidase Activity and Morphotype Transition","volume":"197","author":"Dumont","year":"2000","journal-title":"J. Anat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.pathophys.2012.05.001","article-title":"Tertiary Butyl Hydroperoxide Induced Oxidative Damage in Mice Erythrocytes: Protection by Taurine","volume":"19","author":"Roy","year":"2012","journal-title":"Pathophysiology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"glw150","DOI":"10.1093\/gerona\/glw150","article-title":"UVB-Induced Senescence of Human Dermal Fibroblasts Involves Impairment of Proteasome and Enhanced Autophagic Activity","volume":"72","author":"Cavinato","year":"2016","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_32","first-page":"3459","article-title":"The Effects of Phototherapy and Melanocytes on Keratinocytes","volume":"15","author":"Tang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1089\/ars.2020.8048","article-title":"Senescence in Post-Mitotic Cells: A Driver of Aging?","volume":"34","author":"Wan","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1742-4658.2011.08010.x","article-title":"Mitochondrial Oxidative Stress Causes Mitochondrial Fragmentation via Differential Modulation of Mitochondrial Fission-Fusion Proteins","volume":"278","author":"Wu","year":"2011","journal-title":"FEBS J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.redox.2013.12.029","article-title":"The Proteasome and the Degradation of Oxidized Proteins: Part III\u2014Redox Regulation of the Proteasomal System","volume":"2","author":"Jung","year":"2014","journal-title":"Redox Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ygcen.2011.02.005","article-title":"The Role of Ubiquitin\u2013Proteasome System in Ageing","volume":"172","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0891-5849(02)00816-X","article-title":"Impairment of Proteasome Function upon UVA- and UVB-Irradiation of Human Keratinocytes","volume":"32","author":"Bulteau","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in Healthy Aging and Disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.jid.2019.11.023","article-title":"The Role of Autophagy in Skin Fibroblasts, Keratinocytes, Melanocytes, and Epidermal Stem Cells","volume":"140","author":"Jeong","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbrc.2013.11.066","article-title":"Age-Related Disruption of Autophagy in Dermal Fibroblasts Modulates Extracellular Matrix Components","volume":"443","author":"Tashiro","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/jid.2014.439","article-title":"Suppression of Autophagy Dysregulates the Antioxidant Response and Causes Premature Senescence of Melanocytes","volume":"135","author":"Zhang","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/pcmr.12838","article-title":"Autophagy Induction Can Regulate Skin Pigmentation by Causing Melanosome Degradation in Keratinocytes and Melanocytes","volume":"33","author":"Kim","year":"2020","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.3389\/fcell.2021.682414","article-title":"The Extracellular Matrix in Skin Inflammation and Infection","volume":"9","author":"Pfisterer","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s40521-021-00289-9","article-title":"The Role of the Environment and Exposome in Atopic Dermatitis","volume":"8","author":"Stefanovic","year":"2021","journal-title":"Curr. Treat. Options Allergy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/all.15240","article-title":"Epithelial Barrier Hypothesis: Effect of the External Exposome on the Microbiome and Epithelial Barriers in Allergic Disease","volume":"77","author":"Cerci","year":"2022","journal-title":"Allergy"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Gallego, N., S\u00e1nchez-Madrid, F., and Cibrian, D. (2021). Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation. Cells, 10.","DOI":"10.3390\/cells10113176"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jid.2020.11.024","article-title":"CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway","volume":"141","author":"Kyoreva","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00281-013-0394-4","article-title":"Functions of the Aryl Hydrocarbon Receptor in the Skin","volume":"35","author":"Esser","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1016\/j.jid.2016.06.627","article-title":"Aryl Hydrocarbon Receptor in Keratinocytes Is Essential for Murine Skin Barrier Integrity","volume":"136","author":"Haas","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.immuni.2014.04.019","article-title":"Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions","volume":"40","author":"Duarte","year":"2014","journal-title":"Immunity"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/exd.12690","article-title":"Environment-Induced Lentigines: Formation of Solar Lentigines beyond Ultraviolet Radiation","volume":"24","author":"Nakamura","year":"2015","journal-title":"Exp. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u039aB Signaling in Inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mad.2017.12.003","article-title":"Mechanisms of Aging and Development\u2014A New Understanding of Environmental Damage to the Skin and Prevention with Topical Antioxidants","volume":"172","author":"Burke","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"111160","DOI":"10.1016\/j.mad.2019.111160","article-title":"NF-\u039aB Signaling in Skin Aging","volume":"184","author":"Wang","year":"2019","journal-title":"Mech. Ageing Dev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/15419061.2014.905930","article-title":"Junctions and Inflammation in the Skin","volume":"21","author":"Kobielak","year":"2014","journal-title":"Cell Commun. Adhes."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Saha, S., Buttari, B., Panieri, E., Profumo, E., and Saso, L. (2020). An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation. Molecules, 25.","DOI":"10.3390\/molecules25225474"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jdermsci.2018.05.003","article-title":"Proteome-Wide Changes in Primary Skin Keratinocytes Exposed to Diesel Particulate Extract\u2014A Role for Antioxidants in Skin Health","volume":"91","author":"Rajagopalan","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s11033-019-04708-8","article-title":"H2O2 Promotes the Aging Process of Melanogenesis through Modulation of MITF and Nrf2","volume":"46","author":"Ko","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00403-015-1554-2","article-title":"The Role of Transcription Factor Nrf2 in Skin Cells Metabolism","volume":"307","author":"Skrzydlewska","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1093\/gerona\/glv114","article-title":"P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age","volume":"71","author":"Waaijer","year":"2016","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"111318","DOI":"10.1016\/j.mad.2020.111318","article-title":"TBHP Treatment as a Model for Cellular Senescence and Pollution-Induced Skin Aging","volume":"190","author":"Wedel","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Rorteau, J., Chevalier, F.P., Bonnet, S., Barth\u00e9lemy, T., Lopez-Gaydon, A., Martin, L.S., Bechetoille, N., and Lamartine, J. (2022). Maintenance of Chronological Aging Features in Culture of Normal Human Dermal Fibroblasts from Old Donors. Cells, 11.","DOI":"10.3390\/cells11050858"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e101982","DOI":"10.15252\/embj.2019101982","article-title":"Senescent Human Melanocytes Drive Skin Ageing via Paracrine Telomere Dysfunction","volume":"38","author":"Victorelli","year":"2019","journal-title":"EMBO J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000495404","article-title":"Keratinocytic Malfunction as a Trigger for the Development of Solar Lentigines","volume":"6","author":"Barysch","year":"2019","journal-title":"Dermatopathology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.7150\/thno.26975","article-title":"Senescent Fibroblasts Drive Ageing Pigmentation: A Potential Therapeutic Target for Senile Lentigo","volume":"8","author":"Yoon","year":"2018","journal-title":"Theranostics"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"834135","DOI":"10.3389\/fcimb.2022.834135","article-title":"The Human Skin Microbiome in Selected Cutaneous Diseases","volume":"12","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Kim, M., Park, T., Yun, J.I., Lim, H.W., Han, N.R., and Lee, S.T. (2020). Investigation of Age-Related Changes in the Skin Microbiota of Korean Women. Microorganisms, 8.","DOI":"10.3390\/microorganisms8101581"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"D\u2019Mello, S., Finlay, G., Baguley, B., and Askarian-Amiri, M. (2016). Signaling Pathways in Melanogenesis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17071144"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"27557","DOI":"10.1074\/jbc.R700026200","article-title":"The Regulation of Skin Pigmentation","volume":"282","author":"Yamaguchi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/ics.12466","article-title":"Intrinsic and Extrinsic Regulation of Human Skin Melanogenesis and Pigmentation","volume":"40","author":"Serre","year":"2018","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.clindermatol.2019.04.010","article-title":"Aging in Skin of Color","volume":"37","author":"Venkatesh","year":"2019","journal-title":"Clin. Dermatol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jdermsci.2016.05.011","article-title":"Extrinsic Skin Ageing in German, Chinese and Japanese Women Manifests Differently in All Three Groups Depending on Ethnic Background, Age and Anatomical Site","volume":"83","author":"Yamamoto","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"22075","DOI":"10.1038\/s41598-021-01573-z","article-title":"Defining Skin Aging and Its Risk Factors: A Systematic Review and Meta-Analysis","volume":"11","author":"Wong","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_74","first-page":"31","article-title":"Aging Differences in Ethnic Skin","volume":"9","author":"Vashi","year":"2016","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jid.2018.10.026","article-title":"Aging in Skin of Color: Disruption to Elastic Fiber Organization Is Detrimental to Skin\u2019s Biomechanical Function","volume":"139","author":"Langton","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jaad.2016.05.007","article-title":"Pigmentation in African American Skin Decreases with Skin Aging","volume":"75","author":"Chien","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Del Bino, S., Duval, C., and Bernerd, F. (2018). Clinical and Biological Characterization of Skin Pigmentation Diversity and Its Consequences on UV Impact. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092668"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.3390\/ijerph120202289","article-title":"Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases","volume":"12","author":"Numan","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0305-4","article-title":"Particulate Matter-Induced Senescence of Skin Keratinocytes Involves Oxidative Stress-Dependent Epigenetic Modifications","volume":"51","author":"Ryu","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Shin, K.-O., Uchida, Y., and Park, K. (2022). Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052691"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"27995","DOI":"10.1038\/srep27995","article-title":"Urban Particulate Matter Down-Regulates Filaggrin via COX2 Expression\/PGE2 Production Leading to Skin Barrier Dysfunction","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Park, S.-Y., Byun, E., Lee, J., Kim, S., and Kim, H. (2018). Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092727"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.toxlet.2021.05.003","article-title":"Skin Biological Responses to Urban Pollution in an Ex Vivo Model","volume":"348","author":"Patatian","year":"2021","journal-title":"Toxicol. Lett."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/jid.2010.204","article-title":"Airborne Particle Exposure and Extrinsic Skin Aging","volume":"130","author":"Schikowski","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e15132","DOI":"10.1111\/dth.15132","article-title":"How to Prevent Skin Damage from Air Pollution Part 2: Current Treatment Options","volume":"34","author":"Damevska","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1111\/jdv.13250","article-title":"Recognizing the Impact of Ambient Air Pollution on Skin Health","volume":"29","author":"Mancebo","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/jdv.13834","article-title":"Exposure to Fine Particulate Matter Associated with Senile Lentigo in Chinese Women: A Cross-Sectional Study","volume":"31","author":"Peng","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fenvs.2014.00011","article-title":"Air Pollution and the Skin","volume":"2","author":"Drakaki","year":"2014","journal-title":"Front. Environ. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"496","DOI":"10.5021\/ad.2020.32.6.496","article-title":"Effects of Particulate Matter in a Mouse Model of Oxazolone-Induced Atopic Dermatitis","volume":"32","author":"Bae","year":"2020","journal-title":"Ann. Dermatol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00128-022-03510-w","article-title":"Recent Developments in the Determination of PM2.5 Chemical Composition","volume":"108","author":"Pan","year":"2022","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"42390","DOI":"10.1007\/s11356-020-10574-w","article-title":"Inflammatory Effects of Particulate Matter Air Pollution","volume":"27","author":"Taborda","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jdermsci.2017.01.007","article-title":"Photo-Pollution Stress in Skin: Traces of Pollutants (PAH and Particulate Matter) Impair Redox Homeostasis in Keratinocytes Exposed to UVA1","volume":"86","author":"Soeur","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"116714","DOI":"10.1016\/j.lfs.2019.116714","article-title":"A Keratinocyte and Integrated Fibroblast Culture Model for Studying Particulate Matter-Induced Skin Lesions and Therapeutic Intervention of Fucosterol","volume":"233","author":"Fernando","year":"2019","journal-title":"Life Sci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Estrella, B., Naumova, E.N., Cepeda, M., Voortman, T., Katsikis, P.D., and Drexhage, H.A. (2019). Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16132347"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"C736","DOI":"10.1152\/ajpcell.00529.2009","article-title":"Airborne Particulate Matter Selectively Activates Endoplasmic Reticulum Stress Response in the Lung and Liver Tissues","volume":"299","author":"Laing","year":"2010","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"H1621","DOI":"10.1152\/ajpheart.00359.2015","article-title":"Selective TNF-\u03b1 Targeting with Infliximab Attenuates Impaired Oxygen Metabolism and Contractile Function Induced by an Acute Exposure to Air Particulate Matter","volume":"309","author":"Marchini","year":"2015","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.3389\/fimmu.2018.02746","article-title":"Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon","volume":"9","author":"Mylonas","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1289\/ehp.1509728","article-title":"Biomolecular Markers within the Core Axis of Aging and Particulate Air Pollution Exposure in the Elderly: A Cross-Sectional Study","volume":"124","author":"Pieters","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/jat.3573","article-title":"Nasal Epithelial Barrier Disruption by Particulate Matter \u22642.5 \u039cm via Tight Junction Protein Degradation","volume":"38","author":"Zhao","year":"2018","journal-title":"J. Appl. Toxicol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12989-020-00366-y","article-title":"Impact of Airborne Particulate Matter on Skin: A Systematic Review from Epidemiology to in Vitro Studies","volume":"17","author":"Dijkhoff","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jdermsci.2015.01.011","article-title":"The Impact of Urban Particulate Pollution on Skin Barrier Function and the Subsequent Drug Absorption","volume":"78","author":"Pan","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/phpp.12725","article-title":"Particulate Matter-induced Atmospheric Skin Aging Is Aggravated by UVA and Inhibited by a Topical L-ascorbic Acid Compound","volume":"38","author":"Kim","year":"2022","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12989-022-00454-1","article-title":"Controlled Human Exposure to Diesel Exhaust: A Method for Understanding Health Effects of Traffic-Related Air Pollution","volume":"19","author":"Long","year":"2022","journal-title":"Part. Fibre Toxicol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s13555-021-00644-3","article-title":"Exposome and Skin. Part 2. The Influential Role of the Exposome, Beyond UVR, in Actinic Keratosis, Bowen\u2019s Disease and Squamous Cell Carcinoma: A Proposal","volume":"12","author":"Malvehy","year":"2022","journal-title":"Dermatol. Ther."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00403-008-0893-7","article-title":"TNF-\u03b1 Production in the Skin","volume":"301","author":"Bashir","year":"2009","journal-title":"Arch. Dermatol. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"155432","DOI":"10.1016\/j.cyto.2021.155432","article-title":"Tumor Necrosis Factor-Alpha Affects Melanocyte Survival and Melanin Synthesis via Multiple Pathways in Vitiligo","volume":"140","author":"Singh","year":"2021","journal-title":"Cytokine"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Kim, H., Park, S.-Y., Moon, S., Lee, J., and Kim, S. (2018). Autophagy in Human Skin Fibroblasts: Impact of Age. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082254"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Yoon, S., Lim, C., Chung, H.-J., Kim, J.-H., Huh, Y., Park, K., and Jeong, S. (2019). Autophagy Activation by Crepidiastrum Denticulatum Extract Attenuates Environmental Pollutant-Induced Damage in Dermal Fibroblasts. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030517"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Mokrzy\u0144ski, K., Krzyszty\u0144ska-Kuleta, O., Zawrotniak, M., Sarna, M., and Sarna, T. (2021). Fine Particulate Matter-Induced Oxidative Stress Mediated by UVA-Visible Light Leads to Keratinocyte Damage. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910645"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1111\/exd.14315","article-title":"Vitamin C Prevents Epidermal Damage Induced by PM-associated Pollutants and UVA1 Combined Exposure","volume":"30","author":"Dimitrov","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_111","first-page":"3227","article-title":"PM2.5 Induces Apoptosis, Oxidative Stress Injury and Melanin Metabolic Disorder in Human Melanocytes","volume":"19","author":"Suo","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.jid.2020.03.971","article-title":"Air Particulate Matter Induces Skin Barrier Dysfunction and Water Transport Alteration on a Reconstructed Human Epidermis Model","volume":"140","author":"Hieda","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"803218","DOI":"10.3389\/fbioe.2022.803218","article-title":"In Vitro Disease Models for Understanding Psoriasis and Atopic Dermatitis","volume":"10","author":"Sarama","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1111\/exd.14192","article-title":"Impact of Cigarette Smoke on Physical-chemical and Molecular Proprieties of Human Skin in an Ex Vivo Model","volume":"30","author":"Percoco","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/exd.12148","article-title":"Role of the Aryl Hydrocarbon Receptor in Tobacco Smoke Extract-Induced Matrix Metalloproteinase-1 Expression","volume":"22","author":"Ono","year":"2013","journal-title":"Exp. Dermatol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Hoskin, R., Pambianchi, E., Pecorelli, A., Grace, M., Therrien, J.-P., Valacchi, G., and Lila, M.A. (2021). Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage. Molecules, 26.","DOI":"10.3390\/molecules26133781"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-4274(99)00268-4","article-title":"Induction of Alopecia in Mice Exposed to Cigarette Smoke","volume":"114","author":"Balansky","year":"2000","journal-title":"Toxicol. Lett."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.toxlet.2016.07.026","article-title":"In Vitro Model Adapted to the Study of Skin Ageing Induced by Air Pollution","volume":"259","author":"Lecas","year":"2016","journal-title":"Toxicol. Lett."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/path.5476","article-title":"The Systemic Influence of Chronic Smoking on Skin Structure and Mechanical Function","volume":"251","author":"Langton","year":"2020","journal-title":"J. Pathol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"105121","DOI":"10.1016\/j.chemphyslip.2021.105121","article-title":"Effects of Ozone on Stratum Corneum Lipid Integrity and Assembly","volume":"240","author":"Petracca","year":"2021","journal-title":"Chem. Phys. Lipids"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.freeradbiomed.2003.12.005","article-title":"In Vivo Ozone Exposure Induces Antioxidant\/Stress-Related Responses in Murine Lung and Skin","volume":"36","author":"Valacchi","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0300-483X(02)00240-8","article-title":"Ozone Exposure Activates Oxidative Stress Responses in Murine Skin","volume":"179","author":"Valacchi","year":"2002","journal-title":"Toxicology"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Valacchi, G., Sticozzi, C., Belmonte, G., Cervellati, F., Demaude, J., Chen, N., Krol, Y., and Oresajo, C. (2015). Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131097"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jdermsci.2016.09.015","article-title":"The Skin Aging Exposome","volume":"85","author":"Krutmann","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jid.2017.01.034","article-title":"Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin","volume":"137","author":"Valacchi","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1039\/d0mt00121j","article-title":"Elemental and Molecular Imaging of Human Full Thickness Skin after Exposure to Heavy Metals","volume":"12","author":"Chavatte","year":"2020","journal-title":"Metallomics"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Juliano, C., and Magrini, G. (2018). Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products. Cosmetics, 5.","DOI":"10.3390\/cosmetics5010019"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"151654","DOI":"10.1016\/j.scitotenv.2021.151654","article-title":"Air Pollution and Endocrine Disruptors Induce Human Microbiome Imbalances: A Systematic Review of Recent Evidence and Possible Biological Mechanisms","volume":"816","author":"Mousavi","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/ced.15179","article-title":"Ultraviolet Radiation-induced Degradation of Dermal Extracellular Matrix and Protection by Green Tea Catechins: A Randomized Controlled Trial","volume":"47","author":"Charoenchon","year":"2022","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/jid.2013.362","article-title":"The New Aryl Hydrocarbon Receptor Antagonist E\/Z-2-Benzylindene-5,6-Dimethoxy-3,3-Dimethylindan-1-One Protects against UVB-Induced Signal Transduction","volume":"134","author":"Tigges","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/jocd.13176","article-title":"A Novel Multifunctional Skin Care Formulation with a Unique Blend of Antipollution, Brightening and Antiaging Active Complexes","volume":"19","author":"Khmaladze","year":"2020","journal-title":"J. Cosmet. Dermatol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/14\/2220\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:52:17Z","timestamp":1760140337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/11\/14\/2220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,17]]},"references-count":131,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["cells11142220"],"URL":"https:\/\/doi.org\/10.3390\/cells11142220","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742254472.793594685","asserted-by":"object"}]},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,17]]}}}